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| 1 | Logistic chaotic maps for binary numbers generations显示文摘 | Kanso A Smaoui N | 2009 | Chaos Solitons & Fractals2009，40，5： | 1 |
| 2 | Dynamics of pseudo-rigid ball impact on rigid foundation显示文摘 | Kanso E Papadopoulos P | 2004 | International Journal of Non-Linear Mechanics2004，39，2： | 1 |
| 3 | Cross-coupling errors of micromachined gyroscopes显示文摘 | Kanso E Szeri A J Pisano A P | 2004 | Journal of Microelectro-mechanical Systems2004，13，2： | 1 |
| 4 | Retroperitoneal laparoscopic radical nephrectomy:intermediate oncological results显示文摘 | LarréS Kanso C De La Taille A | 2008 | World J Urol2008，26，： | 1 |
| 5 | Logistic chaotic maps for binary numbers generations显示文摘 | KANSO A SMAOUI N | 2009 | Chaos Solitons & Fractals2009，40，5： | 1 |
| 6 | A novel image encryption algorithm based on a 3D chaotic map显示文摘 | KANSO A GHEBLEH M | 2012 | Communications in Nonlinear Science and Numerical Simulation2012，17，4： | 1 |
| 7 | Cross-Coupling Errors of Micromachined Gyroscopes显示文摘 | Kanso E Szeri A J Pisano A P | 2004 | Journal of Microelectromechanical Systems2004，13，2： | 1 |
| 8 | Logistic chaotic maps for binary numbers generations 显示文摘 | Kanso A Smaoui N | 2009 | Chaos Solitons & Fractals2009，40，5： | 1 |
| 9 | A fast and efficient chaos-based keyed hash function 显示文摘 | Kanso A Ghebleh M | 2013 | Communications in Nonlinear Science & Numerical Simulation2013，18，1： | 1 |
| 10 | Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and threedimensional in vitro models显示文摘BACKGROUND Colorectal cancer(CRC) is the second leading cause of cancer-related mortality.Cancer stem cells(CSCs) in CRC, which are spared by many chemotherapeutics,have tumorigenic capacity and are believed to be the reason behind cancer relapse. So far, there have been no effective drugs to target colon CSCs. Diiminoquinone(DIQ) has shown promising effects on targeting colon cancer.However, there is limited research on the effects of DIQ on eradicating CSCs in CRC.AIM To investigate the anticancer potential of DIQ on colon CSCs in two-dimensional(2D) and three-dimensional(3D) models using colonospheres and patient-derived organoids.METHODS Various 2D methods have been used to assess the effect and the mechanism of DIQ on HCT116and HT29 cell lines including cell proliferation and viability assays, migration and invasion assays,immunofluorescence staining, and flow cytometry. The potency of DIQ was also assessed in 3D culture using the sphere formation assay and colon cancer patient-derived organoid model.RESULTS Our results showed that DIQ significantly inhibited cell proliferation, migration, and invasion in HCT116 and HT29 cell lines. DIQ treatment induced apoptosis along with an accumulation of HCT116 and HT29 cancer cells in the sub-G1 region and an increase in reactive oxygen species in both CRC cell lines. DIQ reduced sphere-forming and self-renewal ability of colon cancer HCT116and HT29 stem/progenitor cells at sub-toxic doses of 1 μmol/L. Mechanistically, DIQ targets CSCs by downregulating the main components of stem cell-related-catenin, AKT, and ERK oncogenic signaling pathways. Potently, DIQ displayed a highly significant decrease in both the count and the size of the organoids derived from colon cancer patients as compared to control and 5-fluorouracil conditions.CONCLUSION This study is the first documentation of the molecular mechanism of the novel anticancer therapeutic DIQ via targeting CSC, a promising compound that needs further investigation. | Alissar Monzer Kevork Wakimian Farah Ballout Samar Al Bitar Amani Yehya Mariam Kanso Nour Saheb Ayman Tawil Samer Doughan Maher Hussein Deborah Mukherji Walid Faraj Hala Gali-Muhtasib Wassim Abou-Kheir | 2022 | World Journal of Gastroenterology2022，28，33： | 1 |
| 11 | A Review of EEG, ERP,and Neuroimaging Studies o~ Creativity and Insight显示文摘 | Arne Dietrich Riam Kanso | 2010 | Psy- chological Bulletin2010，136，5： | 1 |
| 12 | Evidence-based approach for prevention of radiocontrast-induced nephropathy 显示文摘 | Abu Jawdeh BG Kanso AA Schelling JR | 2009 | J Hosp Med2009，4，8： | 1 |
| 13 | Bayesian approach for the calibration of models: application to an urban stormwater pollution model显示文摘 | Kanso A Gromaire M C Gaume E | 2003 | Water Science and Technology2003，47，4： | 1 |
| 14 | Major royal jelly protein 3 modulates immune responses in vitro and in vivo显示文摘 | Iwao Okamoto Yoshifumi Taniguchi Toshio Kunikata Keizo Kohno Kanso Iwaki Masao Ikeda Masashi Kurimoto | 2003 | Life Sciences2003，，16： | 1 |
| 15 | A novel image encryption algorithm based on a 3D chaotic map显示文摘 | Kanso A Ghebleh M | 2012 | Communications in Nonlinear Science and Numerical Simulation2012，17，7： | 1 |
| 16 | Application of MCMC-GSA model calibration method to urban runoff quality modeling显示文摘 | Kanso A Chebbo G Tassin B | 2006 | Reliability Engineering & System Safety2006，91，1011： | 1 |
| 17 | Keyed Hash function based on a chaotic map 显示文摘 | Kanso A Yahyaoui H Almulla M | 2012 | Information Sciences2012，186，1： | 1 |
| 18 | Modified self-shrinking generator显示文摘 | Kanso A | 2010 | Computers and Engineering2010，36，9： | 1 |
| 19 | Oral administration of royal jelly inhibits the development of atopic dermatitis-like skin lesions in NC/Nga mice显示文摘 | Yoshifumi Taniguchi Keizo Kohno Shin-ichiro Inoue Satomi Koya-Miyata Iwao Okamoto Norie Arai Kanso Iwaki Masao Ikeda Masashi Kurimoto | 2003 | International Immunopharmacology2003，，9： | 1 |
| 20 | A review of EEG,ERP,and neuroimaging studies of creativity and insight显示文摘 | Dietrich A Kanso R | | 0，，05： | 1 |
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