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| 1 | Striking elevation in incidence and prevalence of inflammatory bowel disease in a province of western Hungary between 1977-2001显示文摘AIM:An investigation into inflammatory bowel disease and colorectal cancer in Veszprem Province was conducted from 1977 to 2001.METHODS: Both hospital and outpatient records were collected and reviewed comprehensively. The majority of patients were followed up regularly.RESULTS:The population of the province was decreased from 386000 to 376000 during the period. Five hundred sixty new cases of ulcerative colitis (UC), 212 of Crohn's disease (CD), and 40 of indeterminate colitis (IC) were diagnosed. The incidence rates increased from 1.66 to 11.01 cases per 100 000 persons for UC, from 0.41 to 4.68 for CD and from 0.26 to 0.74 for IC. The prevalence rate at the end of 2001 was 142.6 for UC and 52.9 cases per 100 000 persons for CD. The peak onset age in UC patients was between 30 and 40 years, in CD between 20 and 30 years. A family history of IBD was present in 3.4% in UC and 9.9% in CD patients.Smoking increased the risk for CD (OR=1.94) while it decreased the risk for UC (OR=0.25). Twelve colorectal carcinomas were observed in this cohort, the cumulative colorectal cancer risk after 10 years in UC was 2%, after 20 years 8.8%, after 30 years 13.3%.CONCLUSION:The incidence and prevalence rates of IBD have increased steadily in Veszprem Province, now equivalent to that in Western European countries. Rapid increase in incidence rates supports a probable role for environmental factors. The rate of colorectal cancers in IBD is similar to that observed in Western countries. | Laszlo Lakatos Gabor Mester Zsuzsanna Erdelyi Mihaly Balogh Istvan Szipocs Gyorgy Kamaras Peter Laszlo Lakatos | 2004 | World Journal of Gastroenterology2004，10，3： | 17 |
| 2 | 儿童肱骨髁上骨折模型克氏针固定构型的三维有限元分析显示文摘目的:建立带骺软骨儿童肱骨远端新力学模型,模拟肱骨髁上骨折并进行三维有限元分析,研究克氏针的数量、针道、出口高度及穿针构型对固定稳定性的影响。方法:于图片存档及通信系统(picture archiving and communications system,PACS)中挑选1名6岁男孩的正常肱骨远端三维CT,将图像数据导入Simpleware及SolidWorks 2016软件,构建1个含有肱骨小头骨化中心及远端骺软骨的儿童肱骨远端模型。制作常见伸直型儿童肱骨髁上骨折模型,并模拟交叉克氏针及单纯外侧克氏针的多种固定构型,在屈伸、内外翻方向施加30 N,内外旋方向施加5 N的力,通过远折端的位移情况分析其稳定性。结果:2枚克氏针固定构型中,出口在骨干-干骺端交界区(metaphyseal-diaphyseal junction,MDJ)上缘的2枚交叉针最稳定,可对抗超过2585 Nmm/°的旋转应力;而在对抗屈伸及内外翻应力测试中,低位针经过肱骨小头骨化中心的2枚外侧针最稳定,分别可对抗接近45 N/mm及190 N/mm的应力。在最稳定的外侧2枚克氏针构型中加入第3根针,所有方向上的稳定性显著增加,其中3枚交叉针最稳定,屈伸、内外翻及内外旋时分别可对抗198 N/mm、395 N/mm及6251 Nmm/°的应力。结论:2枚外侧分散针可为儿童肱骨髁上骨折提供足够的稳定性。在2枚交叉针构型中,出口高度在MDJ区域上缘的交叉针最稳定。3枚交叉针构型在所有研究构型中最稳定。 | 刘祥飞 Allieu Kamara 刘闯 王恩波 季相禄 刘天婧 李麒麟 | 2020 | 中国骨伤2020，33，10： | 8 |
| 3 | 金堆城露天矿空气间隔装药减震控制爆破试验研究显示文摘为确保金堆城露天矿东川河隧洞的安全,采用空气间隔装药爆破方式来控制爆破震动。采用连续装药爆破和空气间隔装药爆破两种方式进行现场试验,分别选取离隧洞60 m、80 m、100 m、120 m、140 m的爆心距下爆破振动速度进行对比分析,得出空气间隔装药爆破试验具有明显的减震效果,减震率分别为22.76%、33.94%、27.59%、29.85%和31.91%。采用块度分析软件对爆破后的破碎效果进行分析比较,结果表明采用空气间隔装药比连续装药爆破产生的岩石块度分布均匀、平均块度和最大块度小、大块率低、破碎度高。 | 徐文文 叶海旺 张迎吉 王永康 王建军 艾晓宗 兰振 张建华 Alieu Kamara | 2013 | 爆破2013，30，3： | 7 |
| 4 | 儿童肱骨远端骨干干骺端交界区骨折不同固定方法生物力学的比较显示文摘目的比较儿童肱骨远端骨干干骺端交界区骨折不同固定方法的生物力学稳定性。方法采用复合人工骨36根,模拟制作高、中、低位骨干-干骺端交界区横行骨折线,对不同骨折模型分别行克氏针、单臂外固定架和弹性髓内钉固定,并将模型骨安装在计算机控制万能试验机上进行屈曲、伸直、外翻、内翻应力试验,将模型安装在机电扭力试验机上,进行内旋转、外旋转应力试验,比较不同固定方法力学稳定性。结果高位骨折模型采用弹性髓内针固定力学稳定性最佳,中位骨折采用3枚交叉克氏针(1枚内侧克氏针和2枚外侧克氏针)固定力学稳定性最佳,低位骨折采用枚交叉克氏针(1枚内侧克氏针和2枚外侧克氏针)固定力学稳定性最佳。结论弹性髓内钉固定对儿童肱骨远端骨干干骺端交界区上半区(高、中位骨折线区间)骨折的整体稳定性最好,而克氏针固定在稳定下半区(中、低位骨折线区间)骨折方面稳定性最好。2枚外侧针固定、1枚内侧针固定可以获得最佳的力学稳定性。 | 李麒麟 Allieu Kamara 王恩波 刘天婧 李建军 | 2020 | 中国骨与关节损伤杂志2020，35，9： | 7 |
| 5 | Good laboratory practices guarantee biosafety in the Sierra Leone-China friendship biosafety laboratory显示文摘Background:The outbreak of Ebola virus disease(EVD)in West Africa between 2014 and 2015 was the largest EDV epidemic since the identification of Ebola virus(EBOV)in 1976,and the countries most strongly affected were Sierra Leone,Guinea,and Liberia.Findings:The Sierra Leone-China Friendship Biological Safety Laboratory(SLE-CHN Biosafety Lab),a fixed Biosafety Level 3 laboratory in the capital city of Sierra Leone,was established by the Chinese government and has been active in EBOV detection since 11 March 2015.Complete management and program documents were created for the SLE-CHN Biosafety Lab,and it was divided into four zones(the green,yellow,brown,and red zones)based on the risk assessment.Different types of safe and appropriate personnel protection equipment(PPE)are used in different zones of the laboratory,and it fully meets the Biosafety Level 3 laboratory standards of the World Health Organization.Conclusion:Good preparedness,comprehensive risk assessment and operation documents,appropriate PPE,effective monitoring and intensive training,together with well-designed and reasonable laboratory sectioning are essential for guaranteeing biosafety. | Qin Wang Wei-Min Zhou Yong Zhang Huan-Yu Wang Hai-Jun Du Kai Nie Jing-Dong Song Kang Xiao Wen-Wen Lei Jian-Qiang Guo He-Jiang Wei Kun Cai Yan-Hai Wang Jiang Wu Gerard Kamara Idrissa Kamara Qiang Wei Mi-Fang Liang Gui-Zhen Wu Xiao-Ping Dong | 2016 | Infectious Diseases of Poverty2016，5，1： | 5 |
| 6 | 中塞友好生物安全实验室埃博拉病毒核酸检测质量控制体系的建立显示文摘详细地阐述了中塞友好生物安全实验室实施埃博拉病毒核酸检测整个质量控制的过程,全面地展示固定P3实验室第一批检测队在埃博拉病毒病实验室检测中表现出的科学、严谨、准确与高效,为实验室检测工作提供参考和依据。首先描述了质控体系要点,包括了组织和人员管理、质量管理文件体系、仪器设备、检测试剂和耗材、审核、实验室空间和功能、实验室维护与安全保障等各个方面的质控要点。其次,从埃博拉病毒核酸检测前、检测中到检测后过程,分述了质控在埃博拉病毒检测整个流程的各个环节中的应用。技术精良的专业检测队伍和实行人性化管理是援非抗埃成功的基石;做好生物安全防护是有效质控和完成检测任务的前提;配备专业的后勤保障确实非常必要;中塞友好生物安全实验室的建立对于中塞友谊具有划时代的意义,该实验室将成为塞拉利昂今后最为重要的埃博拉病毒实验室检测基地。 | 王芹 张勇 聂凯 王环宇 杜海军 宋敬东 肖康 雷雯雯 郭建强 隗合江 蔡琨 王衍海 吴江 Gerald Bangura Idrissa Laybohr Kamara 梁米芳 武桂珍 董小平 | 2016 | 病毒学报2016，32，2： | 5 |
| 7 | HPV16 E5蛋白免疫优势肽段分析及其多克隆抗体的制备显示文摘目的预测人乳头瘤病毒16型(human papillomavirus 16,HPV16)E5蛋白的免疫优势肽段,并制备其多克隆抗体。方法以人HPV16 E5蛋白全长氨基酸序列为基础,采用Hopp&Woods的亲水性方案、Zimmerman极性参数、Jameson-Wolf抗原指数方案和Emini表面可及性方案及抗原性指数(antigenic index,AI)等生物信息学方法,综合分析E5蛋白免疫优势肽段。通过免疫日本大耳白兔进行E5蛋白免疫优势肽段的免疫原性验证并制备多克隆抗体;进一步采用ELISA法和间接免疫荧光试验分别检测多克隆抗体的效价及特异性。结果HPV16 E5蛋白N-端1~17氨基酸序列(MTNLDTASTTLLACFLL)为免疫优势肽段,可诱导兔产生高水平的E5蛋白特异性IgG抗体,抗体滴度随免疫次数增加而升高;间接细胞免疫荧光试验结果显示,制备的多克隆抗体可特异性识别TC-1-E5细胞胞浆内表达的E5蛋白。结论HPV16 E5蛋白氨基酸肽段(MTNLDTASTTLLACFLL)具有良好的免疫原性;成功制备了HPV16 E5蛋白多克隆抗体,为进一步研究HPV16 E5蛋白的生物学特性奠定了基础。 | 唐婉林 王路得 顾美萍 Kamara SAIDU 汪琪 李明洋 陈韶 张丽芳 | 2021 | 中国生物制品学杂志2021，34，6： | 4 |
| 8 | 发育性髋关节脱位闭合复位新判定方法的初步探讨显示文摘目的探讨术中髋关节造影结合再脱位角对2岁以内发育性髋关节脱位(developmental dislocation of the hip,DDH)患儿治疗的影响及新判定方法的可行性。方法回顾性分析2013年7月至2016年12月收治的符合条件的53例(56髋)发育性髋关节脱位患儿相关资料。髋关节脱位程度按国际髋关节发育不良协会(International Hip Dysplasia Institute,IHDI)提出的IHDI分型标准分型:Ⅱ型6髋,Ⅲ型27髋,Ⅳ型23髋。按Bowen造影标准判断手术方式,其中行闭合复位25例26髋(闭合复位组),闭合复位失败行单纯切开复位28例30髋(切开复位组)。尝试采用再脱位角≤35°、股骨头位于盂唇外缘下方及"安全带征"阳性的新DDH闭合复位成功判定方法与Bowen标准进行一致性检验,判断其临床可行性,并应用Salter标准判断有无股骨头缺血性坏死(avscular necrosis,AVN)。结果闭合复位组24髋(92.3%)"安全带征"阳性且股骨头位于盂唇外缘下方,再脱位角为18.4°±14.0°;1髋盂唇严重内翻,1髋"安全带征"阴性。切开复位组28髋(93.3%)符合切开复位标准,再脱位角为46.7°±13.4°,其中26髋再脱位角≥35°,2髋"安全带征"阴性;另2髋符合闭合复位新判定方法,复位成功。新方法与Bowen标准一致性检验结果Kappa值最小为0.858(P〈0.01),组内最小ICC值为0.867(P〈0.001)。随访超过一年的39髋中,有4髋(10.3%)股骨头坏死。随访超过2年的16例患儿中,有2例(12.5%)患儿在MRI上出现股骨头密度不均,但股骨头形态尚未出现改变;9例(56.3%)患儿出现盂唇软骨复合体密度不均,全部患儿盂唇呈现持续内翻状态。结论2岁以内患儿新闭合复位成功定性判定方法更有利于术中迅速判断手术方案,可行性佳。 | 贾国强 王恩波 Allieu Kamara 史立伟 张立军 | 2018 | 中华小儿外科杂志2018，39，3： | 4 |
| 9 | 新型冠状病毒E蛋白结构与免疫优势表位的信息学预测分析显示文摘目的:应用生物信息学方法预测和分析新型冠状病毒(SARS-CoV-2)包膜蛋白(E蛋白)的结构及免疫优势表位。方法:从NCBI GenBank数据库中检索SARS-CoV-2 E蛋白的氨基酸序列,通过Expas y服务器上的软件分析预测其理化性质、二级结构、跨膜区域;并结合其亲水性、表面可及性、极性、抗原性和柔韧性等综合分析,预测其可能的B细胞表位;利用Net CTL1.2 server预测CTL表位;通过Vector NTI对冠状病毒属E蛋白进行同源性分析;同时应用Swiss Model对E蛋白进行三维结构同源建模及功能结构域预测分析。结果:SARS-CoV-2 E蛋白由75个氨基酸残基组成,为跨膜蛋白,跨膜区域以α螺旋为主;E蛋白可能含有2个B细胞表位和6个CTL表位,其免疫优势表位区域分别位于其N端16-34aa和C端50-70aa区段;SARS-CoV-2与SARS-CoV和Bat-SARS-like-CoV E蛋白的免疫优势表位存在极高的同源性;其疏水性跨膜结构和PDZ结合基序分别位于N端12-34aa和C端72-75aa区段。结论:E蛋白为跨膜蛋白,其氨基酸序列的16-34和50-70区段可能为免疫优势表位。 | 李明洋 SAIDU Kamara 汪琪 郭艳茹 李青峰 朱珊丽 陈俊 蒋朋飞 张丽芳 | 2021 | 温州医科大学学报2021，51，3： | 3 |
| 10 | Serological Investigation of Laboratory-Confirmed and Suspected Ebola Virus Disease Patients During the Late Phase of the Ebola Outbreak in Sierra Leone显示文摘This study aimed to investigate the serological characteristics of Ebola virus(EBOV) infection during the late phase of the Ebola outbreak in Sierra Leone. In total, 877 blood samples from 694 suspected Ebola virus disease(EVD) cases assessed from March to December 2015, were analyzed via real-time reverse transcription polymerase chain reaction(RT-PCR) for viral RNA and enzyme-linked immunosorbent assay(ELISA) and Luminex to detect antibodies against EBOV. Viral load and EBOV-specific IgM/IgG titers displayed a declining trend during March to December 2015. Viral RNA load decreased rapidly at earlier stages after disease onset, while EBOV-specific IgM and IgG still persisted in 58.1%(18/31) and 93.5%(29/31) of the confirmed EVD patients and in 3.8%(25/663) and 17.8%(118/663) of the RNA-negative suspected patients in the later phase, respectively. Dynamic analysis of longitudinally collected samples from eight EVD patients revealed typically reversed trends of declining viral load and increasing IgM and/or IgG titers in response to the EBOV infection.The present results indicate that certain populations of Sierra Leone developed immunity to an EBOV infection in the late phase of the outbreak, providing novel insights into the risk assessment of EBOV infections among human populations. | Yang Liu YuLan Sun Wei Wu AQian Li XianDa Yang Shuo Zhang Chuan Li QiuDong Su ShaoJian Cai DaPeng Sun HaiYang Hu Zhe Zhang XiuXu Yang Idrissa Kamara Sheku Koroma Gerald Bangura Alie Tia Abdul Kamara Matt Lebby Brima Kargbo Jiandong Li Shiwen Wang XiaoPing Dong YueLong Shu WenBo Xu George F. Gao GuiZhen Wu DeXin Li William J. Liu MiFang Liang | 2018 | Virologica Sinica2018，33，4： | 2 |
| 11 | Detection and Analysis of Ebola Virus in Sierra Leone-China Friendship Biosafety Laboratory from March 11 to April 20, 2015显示文摘Ebola virus disease reemerged in Western Africa in 2014.Chinese Center for Disease Control and Prevention dispatched the first Ebola virus(EBOV)detection team to run newly established Sierra Leone-China Friendship Biological Safety Laboratory.The aims of study were to understand epidemiology,clinical manifestations and survival time of EBOV in patient’s blood.A total of 913specimens were tested between March 11 and | WANG Qin ZHANG Yong WANG Huan Yu DU Hai Jun NIE Kai SONG Jing Dong XIAO Kang LEI Wen Wen GUO Jian Qiang WEI He Jiang CAI Kun WANG Yan Hai WU Jiang Gerald BANGURA Idrissa Laybohr KAMARA DONG Xiao Ping | 2016 | Biomedical and Environmental Sciences2016，29，6： | 2 |
| 12 | Next-generation Sequencing Study of Pathogens in Serum from Patients with Febrile Jaundice in Sierra Leone显示文摘Objective People in Western Africa suffer greatly from febrile jaundice, which is caused by a variety of pathogens. However, yellow fever virus(YFV) is the only pathogen under surveillance in Sierra Leone owing to the undeveloped medical and public health system there. Most of the results of YFV identification are negative. Elucidation of the pathogen spectrum is required to reduce the prevalence of febrile jaundice. Methods In the present study, we used Ion Torrent semiconductor sequencing to profile the pathogen spectrum in archived YFV‐negative sera from 96 patients in Sierra Leone who presented with unexplained febrile jaundice. Results The most frequently identified sequencing reads belonged to the following pathogens: cytomegalovirus(89.58%), Epstein‐Barr virus(55.21%), hepatitis C virus(34.38%), rhinovirus(28.13%), hepatitis A virus(20.83%), coxsackievirus(10.42%), Ebola virus(8.33%), hepatitis E virus(8.33%), lyssavirus(4.17%), leptospirosis(4.17%), chikungunya virus(2.08%), Crimean‐Congo hemorrhagic fever virus(1.04%), and hepatitis B virus(1.04%). Conclusion The distribution of sequencing reads suggests a broader spectrum of pathogens for consideration in clinical diagnostics and epidemiological surveillance in Sierra Leone. | ZHANG Yi YE Fei XIA Lian Xu ZHU Ling Wei IDRISSA Laybohr Kamara HUANG Ke Qiang ZHANG Yong LIU Jun BRIMA Kargbo WANG Ji LIANG Mi Fang SONG Jing Dong MA Xue Jun WU Gui Zhen | 2019 | Biomedical and Environmental Sciences2019，32，5： | 2 |
| 13 | Isolation and synthesis of a dimmeric dihydrochalcone from Agapanthus Africanus 显示文摘 | Kamara B I Manong D T L Brandt E V | 2005 | Phytoc- hemistry2005，10，66： | 1 |
| 14 | Daily and intradaily tests of European put -call parity显示文摘 | Kamara A Miller T W | 1995 | Journal of Financial and Quantitative Analysis1995，30，04： | 1 |
| 15 | Integration in the project development process of a Private Finance Initiative (PFI) project 显示文摘 | Kamara John M | 2012 | Architectural Engineering & Design Management2012，8，4： | 1 |
| 16 | Why the poor paymore:household curative expenditures in rural Sierra Leone显示文摘 | Fabricant S J Kamara C W Mills A | 1999 | The International Journal of Health Planning angManagement1999，14，3： | 1 |
| 17 | Characterization, in vitrotrypsin digestibility and antioxidant activity of fermented soybean protein meal with Lactobacillus plantarum Lp6显示文摘 | Amadou I J Sun M T Kamara Y H | 2009 | Am J Food Technol2009，4，3： | 1 |
| 18 | Searchable symmetric encryption: Improved definitions and efficient constructions显示文摘 | Reza Curtmola Juan Garay Seny Kamara Rafail Ostrovsky | 2011 | Journal of Computer Security2011，，5： | 1 |
| 19 | World Health Organization perspectives on the contribution of the Global Alliance for Vaccines and Immunization on reducing child mortality 显示文摘 | Bustreo F Okwo-Bele JM Kamara L | 2015 | Arch Dis Child2015，1001，： | 1 |
| 20 | Vaginal infections in p regnant women in Jamaica:prevalence and risk factors显示文摘 | Kamara P HyltonKong T Brathwaite A | 2000 | Int J STD A IDS2000，11，1： | 1 |
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