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| 1 | 甲基化抗肿瘤药物治疗中的DNA修复:治疗效果与健康结局(英文)显示文摘在甲基化抗肿瘤药物治疗中,DNA修复是决定治疗效果与不良生物效应(如突变、癌变和致畸)的一个关键机制。本文主要对甲基化抗肿瘤药物在DNA修复过程的作用进行综述。尽管这些抗肿瘤药物无选择性地靶向作用于癌细胞和正常细胞的DNA,但因其削弱了癌细胞内某些特异的DNA修复活动,从而更多地杀死癌细胞。单功能的烷化剂显示出甲基化改变特性(丙卡巴肼、达卡巴嗪、链脲佐菌素、替莫唑胺),或者氯乙基化形成单加合物并在下一步反应中引起DNA链内交联(洛莫司汀、尼莫地6平、卡莫司汀、福莫司汀)。癌细胞对抗肿瘤药物的一个主要机制是通过自杀酶O-甲基鸟嘌呤-DNA甲基转移酶(MGMT)直接逆转6 6DNA损伤,形成O-甲基鸟嘌呤和O-氯化鸟嘌呤。由于MGMT对恶性肿瘤治疗的结局有显著影响,它被认为是一个耐药的重要标志,特别是在高级恶性胶质瘤。MGMT也被认为是甲基化抗肿瘤药物有效性的预测标志,许多临床试验正在分析MGMT抑制对治疗效果的影响。其他涉及甲基化抗肿瘤药物耐药的DNA修复因素包括错配修复、通过同源重组和DNA双链断裂(DSB)信号启动的相关修复。碱基切除修复和alk B同源蛋白(如ABH2)也可能与烷化类药物耐药有关,该现象在高表达MGMT的细胞株异常明显。对于这些机制的进一步了解,将有助于设计更为有效的治疗方案,同时减少副作用。 | Bernd Kaina | 2016 | 癌变.畸变.突变2016，28，5： | 3 |
| 2 | Low temperature embrittlement of duplex stainless steel: Correlation between mechanical and electrochemical behavior显示文摘 | Chandraa K Rahul Singhal Kaina V | 2010 | Materials Science and Engineering A2010，527，： | 1 |
| 3 | Ganciclorvir-induced apoptosis in HSV-1 tymidine kinase expressing cells:critical role of DNA breaks,Bcl-2 decline and capase-9activation显示文摘 | Omicic M T Thust R Kaina B | 2002 | Oncogene2002，21，14： | 1 |
| 4 | Phosphorylafion of the DNA repair protein APE/REF21 by CKII affects redox regulation of AP-1 显示文摘 | FRITZ G KAINA B | 1999 | Oncogene1999，18，4： | 1 |
| 5 | DNA damage-triggered apoptosis:critical role of DNA repair, double-strand breaks, cell proliferation and signaling 显示文摘 | Kaina B | 2003 | Biochem Pharmacol2003，66，8： | 1 |
| 6 | Phospborylation of mismatch repair proteins MSH2 and MSH6 affecting MutSalpha mismatch-binding activity显示文摘 | Christmann M Tomicic MT Kaina B | 2002 | Nucleic Acids Res2002，30，9： | 1 |
| 7 | DNA damage-induced cell death by apoptosis显示文摘 | ROOS W P KAINA B | 2006 | Trends in Molecular Medicine2006，12，： | 1 |
| 8 | BER,MGMT, and MMRin defense against alkylation-induced genotoxicity and apoptosis显示文摘 | Kaina B Ochs K Grosch S | 2001 | Prog Nucleic Acid Res Mol Biol2001，68，： | 1 |
| 9 | DNA damage-induced cell death: from specific DNA lesions to the DNA damage response and apoptosis显示文摘 | Roos W P Kaina B | 2013 | Cancer Lett2013，332，： | 1 |
| 10 | DNA damage-triggered apoptosis : critical role of DNArepair,double-strand breaks,cell proliferation and signaling显示文摘 | Kaina B | 2003 | Biochem Pharmacol2003，66，8： | 1 |
| 11 | Toxicities by herbal medicines with emphasis to traditional Chinese medicine显示文摘 | Efferth T Kaina B | 2011 | Curr Drug Metab2011，12，10： | 1 |
| 12 | Chromosomal instability,reproductive cell death and apoptosis induced by O6-methylguanine in M ex,Mex+ and methylation-tolerant mismatchrepair compromised cells: facts and models显示文摘 | Kaina B Ziouta A Ochs K | 1997 | Mutation Res1997，381，： | 1 |
| 13 | Apoptotic death induced by the cyclophosphamide analogue mafosfamide in human lymphoblastoid cells: Contribution of DNA replication, transcription inhibition and Chk/p53 signaling显示文摘 | GOLDSTEIN M ROOS W KAINA B | 2008 | Toxicol Appl Pharmacol2008，229，1： | 1 |
| 14 | DNA damage-induced cell death by apoptosis 显示文摘 | Roos WP Kaina B | 2006 | Trends Mol Med2006，12，9： | 1 |
| 15 | DNA repair in resistance to alkylating anticancer drugs显示文摘 | Kaina B Christmann M | 2002 | Int J Clin Pharmacol Ther2002，40，8： | 1 |
| 16 | DNA damage-induced cell death by apoptosis显示文摘 | Kaina | 2006 | Trends Mol Med2006，12，9： | 1 |
| 17 | Late activation of stress kinases (SAPK/JNK) by genotoxins requires the DNA repair Proteins DNA-PKcs and CSB 显示文摘 | Fritz G Kaina B | 2006 | Mol Bio Cell2006，17，： | 1 |
| 18 | BER,MGMT,and MMR in defense against alkylation-induced genotoxicity and apoptosis显示文摘 | Kaina B Ochs K Grosch S | 2001 | Prog Nucleic Acid Res Mol Biol2001，68，： | 1 |
| 19 | DNA damage-induced cell death by apotosis显示文摘 | Roos WP Kaina B | | 0，，： | 1 |
| 20 | Apoptosis induced by DNA damage O6-methylguanine is Bcl-2 and caspase-9/-3 regulated andFas/caspase-8 independent显示文摘 | Ochs K Kaina B | 2000 | Cancer Res2000，60，： | 1 |
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