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| 1 | A fiber optoacoustic guide with augmented reality for precision breastconserving surgery显示文摘Lumpectomy,also called breast-conserving surgery,has become the standard surgical treatment for early-stage breast cancer.However,accurately locating the tumor during a lumpectomy,especially when the lesion is small and nonpalpable,is a challenge.Such difficulty can lead to either incomplete tumor removal or prolonged surgical time,which result in high re-operation rates(~25%)and increased surgical costs.Here,we report a fiber optoacoustic guide(FOG)with augmented reality(AR)for sub-millimeter tumor localization and intuitive surgical guidance with minimal interference.The FOG is preoperatively implanted in the tumor.Under external pulsed light excitation,the FOG omnidirectionally broadcasts acoustic waves through the optoacoustic effect by a specially designed nano-composite layer at its tip.By capturing the acoustic wave,three ultrasound sensors on the breast skin triangulate the FOG tip’s position with 0.25-mm accuracy.An AR system with a tablet measures the coordinates of the ultrasound sensors and transforms the FOG tip’s position into visual feedback with<1-mm accuracy,thus aiding surgeons in directly visualizing the tumor location and performing fast and accurate tumor removal.We further show the use of a head-mounted display to visualize the same information in the surgeons’first-person view and achieve hands-free guidance.Towards clinical application,a surgeon successfully deployed the FOG to excise a“pseudo tumor”in a female human cadaver.With the high-accuracy tumor localization by FOG and the intuitive surgical guidance by AR,the surgeon performed accurate and fast tumor removal,which will significantly reduce re-operation rates and shorten the surgery time. | Lu Lan Yan Xia Rui Li Kaiming Liu Jieying Mai Jennifer Anne Medley Samilia Obeng-Gyasi Linda K.Han Pu Wang Ji-Xin Cheng | 2018 | Light(Science & Applications)2018，7，1： | 4 |
| 2 | Application of waste frying oils in the biosynthesis of biodemulsifier by a demulsifying strain Alcaligenes sp.S-XJ-1显示文摘Exploration of biodemulsifiers has become a new research aspect.Using waste frying oils(WFOs) as carbon source to synthesize biodemulsifiers has a potential prospect to decrease production cost and to improve the application of biodemulsifiers in the oilfield.In this study,a demulsifying strain,Alcaligenes sp.S-XJ-1,was investigated to synthesize a biodemulsifier using waste frying oils as carbon source.It was found that the increase of initial pH of culture medium could increase the biodemulsifier yield but decrease the demulsification ratio compared to that using paraffin as carbon source.In addition,a biodemulsifier produced by waste frying oils and paraffin as mixed carbon source had a lower demulsification capability compared with that produced by paraffin or waste frying oil as sole carbon source.Fed-batch fermentation of biodemulsifier using waste frying oils as supplementary carbon source was found to be a suitable method.Mechanism of waste frying oils utilization was studied by using tripalmitin,olein and tristearin as sole carbon sources to synthesize biodemulsifier.The results showed saturated long-chain fatty acid was diffcult for S-XJ-1 to utilize but could effectively enhance the demulsification ability of the produced biodemulsifier.Moreover,FT-IR result showed that the demulsification capability of biodemulsifiers was associated with the content of C=O group and nitrogen element. | Jia Liu Kaiming Peng Xiangfeng Huang Lijun Lu Hang Cheng Dianhai Yang Qi Zhou Huiping Deng | 2011 | Journal of Environmental Sciences2011，23，6： | 4 |
| 3 | Trending IC design directions in 2022显示文摘For the non-stop demands for a better and smarter society, the number of electronic devices keeps increasing exponentially;and the computation power, communication data rate, smart sensing capability and intelligence are always not enough. Hardware supports software, while the integrated circuit(IC) is the core of hardware. In this long review paper, we summarize and discuss recent trending IC design directions and challenges, and try to give the readers big/cool pictures on each selected small/hot topics. We divide the trends into the following six categories, namely, 1) machine learning and artificial intelligence(AI) chips, 2) communication ICs, 3) data converters, 4) power converters, 5) imagers and range sensors, 6) emerging directions. Hope you find this paper useful for your future research and works. | Chi-Hang Chan Lin Cheng Wei Deng Peng Feng Li Geng Mo Huang Haikun Jia Lu Jie Ka-Meng Lei Xihao Liu Xun Liu Yongpan Liu Yan Lu Kaiming Nie Dongfang Pan Nan Qi Sai-Weng Sin Nan Sun Wenyu Sun Jiangtao Xu Jinshan Yue Milin Zhang Zhao Zhang | 2022 | Journal of Semiconductors2022，43，7： | 3 |
| 4 | Interdiffusion and atomic mobility studies in Ni-rich fcc Ni?Al?Mn alloys显示文摘 | Kaiming Cheng Dandan Liu Lijun Zhang Yong Du Shuhong Liu Chengying Tang | 2013 | Journal of Alloys and Compounds2013，，： | 1 |
| 5 | Phase equilibria and crystal structure of ternary compounds in Al-rich corner of Al-Er-Y system at 673 and 873 K显示文摘Phase equilibria in the Al-rich corner of the Al-Er-Y ternary system from 65 at.% to 100 at.% Al at 673 and873 K were investigated,and the two isothermal sections were established by X-ray diffraction(XRD),scanning electron microscope(SEM) and electron probe micro analysis(EPMA).Three ternary-phase regions are observed and the phase relations are similar at both isothermal sections.There are two ternary compounds,and a complete crystal structures and composition ranges of the two ternary compounds are determined as τ_(1)(Al_(75-76)Er_(15-22)Y_(2-10),R-3 m) and τ_(2)(Al_(75-76)Er_(11-17)Y_(7-14),P6_(3)/mmc) via XRD,focused ion beam coupled with transmission electron microscope(FIB-TEM) and EPMA.Meanwhile,the solubilities of the third element in the binary compounds at both temperatures are measured.The solubility of Er inβ-Al_(3) Y phase reaches to 6.6 at.% and that of Y in Al_(3) Er phase reaches to 1.5 at.% after annealing at 873 K.The temperature effect is not obvious for the phase equilibria at 673 and 873 K,but it increases the solubility of Er in β-Al_(3) Y,while it is not obvious for both the solubility of Y in Al_(3) Er and that of Er and Y in(Al).The phase equilibria of the Al-Er-Y ternary system determined by the present work have provided new phase diagram data for a future thermodynamic assessment of this system. | Xiaoxu Liu Yong Du Shuhong Liu Kaiming Cheng Zhihong Zhang | 2021 | Journal of Materials Science & Technology2021，，1： | 1 |
| 6 | Analysis of the Cermak-Rothova Method for Determining the Concentration De- pendence of Ternary Interdiffusion Coefficients with A Single Diffusion Couple 显示文摘 | Cheng Kaiming Chen Weimin Liu Dandan | 2014 | Scripta Materialia2014，76，： | 1 |
| 7 | Atomistic Investigation of the Influence of Hydrogen on Mechanical Response during Nanoindentation in Pure Iron显示文摘The effects of hydrogen on the mechanical response of pure iron with randomly distributed hydrogen atoms under nanoindentation were systematically investigated by molecular dynamics simulations with the aim to further understand hydrogen embrittlement mechanism in the steels.The simulations results revealed that,for the three models with[001],[110]and[111]surface normal,hydrogen reduced the critical load of the pop-in event,promoted the dislocation slipping and reduced the plastic region size and dislocation density around the indenter compared to the hydrogen free model.Meanwhile,the different mechanical responses of the three models with different surface normal were further explained in the perspective of Schmid factor. | Wenjing Lou Lin Cheng Runsheng Wang Chengyang Hu Kaiming Wu | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，7： | 1 |
| 8 | Application of CALPHAD approach in simulation of liquid phase migration of cellular cemented carbide显示文摘 | Cheng Kaiming Xu Tao Zhang Hao | 2014 | International Journal of Refractory Metals and Hard Materials2014，42，： | 1 |
| 9 | The chemical environment and structural ordering in liquid Mg-Y-Zn system:An ab-initio molecular dynamics investigation of melt for the formation mechanism of LPSO structure显示文摘In an effort to clarify the formation mechanism of LPSO structure in Mg-Y-Zn alloy,the chemical environment and structural ordering in liquid Mg-rich Mg-Y-Zn system are investigated with the aid of ab-initio molecular dynamics simulation.In liquid Mg-rich Mg-Y alloys,the strong Mg-Y interaction is determined,which promotes the formation of fivefold symmetric local structure.For Mg-Zn alloys,the weak Mg-Zn interaction results in the fivefold symmetry weakening in the liquid structure.Due to the coexistence of Y and Zn,the strong attractive interaction is introduced in liquid Mg-Y-Zn ternary alloy,and contributes to the clustering of Mg,Y,Zn launched from Zn.What is more,the distribution of local structures becomes closer to that in pure Mg compared with that in binary Mg-Y and Mg-Zn alloys.These results should relate to the origins of the Y/Zn segregation zone and close-packed stacking mode in LPSO structure,which provides a new insight into the formation mechanism of LPSO structure at atomic level. | Tangpeng Ma Jin Wang Kaiming Cheng Chengwei Zhan Jixue Zhou Jingyu Qin Guochen Zhao Xinfang Zhang | 2024 | Journal of Magnesium and Alloys2024，12，2： | 0 |
| 10 | Diffusion growth of Φ ternary intermetallic compound in the Mg-Al-Zn alloy system:In-situ observation and modeling显示文摘Study on the diffusion growth of ternary intermetallic compounds in Mg-Al-Zn based light-weight alloys is important due to its close interrelation with alloy property.However,there is a very lack of existing data due to difficulties in both experimental and computational aspects.The current work aims at presenting the experimental observation on the diffusion growth behavior of Φ phase at 360℃ as well as calculating its composition-dependent interdiffu sion coefficients.We designed and succes s fully fabricated four Mg-τ ternary diffusion couples annealed at 360℃ for different times,where the diffusion path goes across the Φ phase region and the diffusion growth of ternary intermetallic compound can be solely detected.In-situ observation of the time-dependent growth of Φ phase was performed to accurately determine the parabolic growth constant.The experimental data were then subjected to a numerical inverse method to generate a set of self-consistent interdiffusivities of the ternary intermetallic compounds,which can reproduce the presently observed diffusion growth behavior of Φ ternary intermetallic compound in Mg-τ diffusion couples. | Kaiming Cheng Jiaxing Sun Huixia Xu Jin Wang Chengwei Zhan Reza Ghomashchi Jixue Zhou Shouqiu Tang Lijun Zhang Yong Du | 2021 | Journal of Materials Science & Technology2021，，1： | 0 |
| 11 | One step hot-pressing method for hybrid Li metal anode of solid-state lithium metal batteries显示文摘Safety issues induced by infinite anode volume change and uncontrolled lithium(Li)dendrite growth have become the biggest obstacle to the practical application of Li metal batteries.In addition,the tra-ditional rolling method makes it difficult to manufacture thin Li foil with high mechanical strength and low Li content.Herein,a three-dimensional(3D)lithophilic carbon paper/copper(Cu)current collector hybrid anode with ultra-low Li metal content is prepared by a hot-pressing method.The highly re-versible and stable lithiophilic layer LiC_(x) formed in situ by heating/pressing treatment provides abun-dant nucleation sites and reduces the Li nucleation overpotential,thereby effectively suppressing Li den-drite growth.Moreover,the volume change and pulverization problems of Li metal anode during depo-sition/stripping also can be accommodated by the 3D skeleton.The optimization effect has been directly confirmed by in-situ optical and ex-situ scanning electron microscope observation.Therefore,highly sta-ble performance(158.4 mA h g^(-1) at 2 C after 200 cycles with a capacity retention of 95.24%)in Li@LCP-Cu||NCM811 coin cell can be achieved.Furthermore,the solid-state battery assembled with the hybrid anode,poly(vinylidene fluoride)(PVDF)-based polymer electrolyte and polyethylene oxide(PEO)interface functional layer also exhibits the best electrochemical and safety performance,which also proves that the Li@LCP-Cu anode has great potential for application in solid-state batteries. | Kaiming Wang Yifei Chen Liang Zhang Qihang Zhang Zhi Cheng Yining Su Fei Shen Xiaogang Han | 2023 | Journal of Materials Science & Technology2023，，22： | 0 |
| 12 | Intranasal administration of a single dose of a candidate live attenuated vaccine derived from an NSP16-deficient SARS-CoV-2 strain confers sterilizing immunity in animals显示文摘Live attenuated vaccines might elicit mucosal and sterilizing immunity against SARS-CoV-2 that the existing mRNA,adenoviral vector and inactivated vaccines fail to induce.Here,we describe a candidate live attenuated vaccine strain of SARS-CoV-2 in which the NSP16 gene,which encodes 2′-O-methyltransferase,is catalytically disrupted by a point mutation.This virus,designated d16,was severely attenuated in hamsters and transgenic mice,causing only asymptomatic and nonpathogenic infection.A single dose of d16 administered intranasally resulted in sterilizing immunity in both the upper and lower respiratory tracts of hamsters,thus preventing viral spread in a contact-based transmission model.It also robustly stimulated humoral and cell-mediated immune responses,thus conferring full protection against lethal challenge with SARS-CoV-2 in a transgenic mouse model.The neutralizing antibodies elicited by d16 effectively cross-reacted with several SARS-CoV-2 variants.Secretory immunoglobulin A was detected in the blood and nasal wash of vaccinated mice.Our work provides proof-of-principle evidence for harnessing NSP16-deficient SARS-CoV-2 for the development of live attenuated vaccines and paves the way for further preclinical studies of d16 as a prototypic vaccine strain,to which new features might be introduced to improve safety,transmissibility,immunogenicity and efficacy. | Zi-Wei Ye Chon Phin Ong Kaiming Tang Yilan Fan Cuiting Luo Runhong Zhou Peng Luo Yun Cheng Victor Sebastien Gray Pui Wang Hin Chu Jasper Fuk-Woo Chan Kelvin Kai-Wang To Honglin Chen Zhiwei Chen Kwok-Yung Yuen Guang Sheng Ling Shuofeng Yuan Dong-Yan Jin | 2022 | Cellular & Molecular Immunology2022，19，5： | 0 |
| 13 | Effect of Retained Austenite on Corrosion Behavior of Ultrafine Bainitic Steel in Marine Environment显示文摘In this study,the impact of retained austenite on corrosion initiation,propagation,and resistance of ultrafine bainitic steels in marine environments based on the one-step and two-step bainitic isothermal transformation was investigated using a combination of theoretical calculations and experimental methods.According to the results,the microstructure of ultrafine bainitic steels was composed of parallel arranged bainite ferrite(BF)and retained austenite(RA).The fraction of the block RA was significantly reduced,whereas the amount of the film RA increased through the two-step bainitic transformation.In the initial stage of corrosion,micro-galvanic effects occurred between the multiphases due to the difference in nobility,leading to the selective dissolution of BF sheaves,which is adjacent to the block RA in the one-step bainitic steel.However,uniformly distributed film RA in the two-step bainitic steel acted as a barrier against corrosion propagation.The electrochemical measurements and neutral salt spray tests revealed a relatively lower corrosion rate for the two-step bainitic steel,indicating a higher corrosion resistance than the one-step bainitic steel.The corrosion products layer mainly consisted ofα-FeOOH,γ-FeOOH,and Fe_(3)O_(4),which were stable and favorable for the formation of a protective rust layer. | Xian Zhang Li Gong Yanpeng Feng Zhihui Wang Miao Yang Lin Cheng Jing Liu Kaiming Wu | 2023 | Acta Metallurgica Sinica(English Letters)2023，36，5： | 0 |
| 14 | Computational engineering of the oxygen electrode-electrolyte interface in solid oxide fuel cells显示文摘The Ce_(0.8)Gd_(0.2)O_(2)−δ(CGO)interlayer is commonly applied in solid oxide fuel cells(SOFCs)to prevent chemical reactions between the(La_(1−x)Sr_(x))(Co_(1−y)Fe_(y))O_(3−δ)(LSCF)oxygen electrode and the Y_(2)O_(3)-stabilized ZrO_(2)(YSZ)electrolyte.However,formation of the YSZ–CGO solid solution with low ionic conductivity and the SrZrO_(3)(SZO)insulating phase still happens during cell production and long-term operation,causing poor performance and degradation.Unlike many experimental investigations exploring these phenomena,consistent and quantitative computational modeling of the microstructure evolution at the oxygen electrode–electrolyte interface is scarce.We combine thermodynamic,1D kinetic,and 3D phase-field modeling to computationally reproduce the element redistribution,microstructure evolution,and corresponding ohmic loss of this interface.The influences of different ceramic processing techniques for the CGO interlayer,i.e.,screen printing and physical laser deposition(PLD),and of different processing and long-term operating parameters are explored,representing a successful case of quantitative computational engineering of the oxygen electrode–electrolyte interface in SOFCs. | Kaiming Cheng Huixia Xu Lijun Zhang Jixue Zhou Xitao Wang Yong Du Ming Chen | 2021 | npj Computational Materials2021，，1： | 0 |
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