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| 1 | Methylprednisolone for acute spinal cord injury: an increasingly philosophical debate显示文摘Following publication of NASCIS Ⅱ, methylprednisolone sodium succinate(MPSS) was hailed as a breakthrough for patients with acute spinal cord injury(SCI). MPSS use for SCI has since become very controversial and it is our opinion that additional evidence is unlikely to break the stalemate amongst clinicians. Patient opinion has the potential to break this stalemate and we review our recent findings which reported that spinal cord injured patients informed of the risks and benefits of MPSS reported a preference for MPSS administration. We discuss the implications of the current MPSS debate on translational research and seek to address some misconceptions which have evolved. As science has failed to resolve the MPSS debate we argue that the debate is an increasingly philosophical one. We question whether SCI might be viewed as a serious condition like cancer where serious side effects of therapeutics are tolerated even when benefits may be small. We also draw attention to the similarity between the side effects of MPSS and isotretinoin which is prescribed for the cosmetic disorder acne vulgaris. Ultimately we question how patient autonomy should be weighed in the context of current SCI guidelines and MPSS's status as a historical standard of care. | Christian A.Bowers Bornali Kundu Gregory W.J.Hawryluk | 2016 | Neural Regeneration Research2016，11，6： | 8 |
| 2 | Identification and expression profiling of Vigna mungo microRNAs from leaf small RNA transcriptome by deep sequencing显示文摘MicroRNAs(miRNAs) represent a class of small non-coding RNA molecules that play a crucial role in post-transcriptional gene regulation. Several conserved and species-specific miRNAs have been characterized to date, predominantly from the plant species whose genome is well characterized. However, information on the variability of these regulatory RNAs in economically important but genetically less characterized crop species are limited. Vigna mungo is an important grain legume, which is grown primarily for its protein-rich edible seeds. miRNAs from this species have not been identified to date due to lack of genome sequence information. To identify miRNAs from V. mungo, a small RNA library was constructed from young leaves. High-throughput Illumina sequencing technology and bioinformatic analysis of the small RNA reads led to the identification of 66 miRNA loci represented by 45 conserved miRNAs belonging to 19 families and eight non-conserved miRNAs belonging to seven families. Besides, 13 novel miRNAcandidates in V. mungo were also identified. Expression patterns of selected conserved, non-conserved, and novel miRNA candidates have been demonstrated in leaf, stem, and root tissues by quantitative polymerase chain reaction, and potential target genes were predicted for most of the conserved miRNAs. This information offers genomic resources for better understanding of miRNA mediated post-transcriptional gene regulation. | Sujay Paul Anirban Kundu Amita Pal | 2014 | Journal of Integrative Plant Biology2014，56，1： | 5 |
| 3 | Garcinol sensitizes human head and neck carcinoma to cisplatin in a xenograft mouse model despite downregulation of proliferative biomarkers显示文摘OBJECTIVE Platinum compounds such as cisplatin and carboplatin are frequently used as the first-line chemotherapy for the treatment of the head and neck squamous cell carcinoma(HNSCC).In the present study,we investigated whether garcinol,apolyisoprenylated benzophenone can chemosensitize HNSCC to cisplatin.METHODS The effect of garcinol and cisplatin on HNSCC was assessed by MTT,Western blotting,real time PCR,FACS,immunohistochemistry,DNA binding assay and xenograft mouse model.RESULTS We found that garcinol inhibited the viability of a panel of diverse HNSCC cell lines,enhanced the apoptotic effect of cisplatin,suppressed constitutive as well as cisplatin-induced NF-κB activation,and downregulated the expression of various oncogenic gene products(cyclin D1,Bcl-2,survivin and VEGF).In vivo study showed that administration of garcinol alone(0.5 mg·kg-1,ip five times/week)significantly suppressed the growth of the tumor,and this effect was further increased by cisplatin.Both the markers of proliferation index(Ki-67)and microvessel density(CD31)were downregulated in tumor tissues by the combination of cisplatin and garcinol.The pharmacokinetic results of garcinol indicated that good systemic exposure was achievable after ip administration of garcinol at 0.5and 2mg·kg-1 with mean peak concentration(cmax)of 1825.4 and 6635.7nmol·L-1 in the mouse serum,respectively.CONCLUSION Overall,our results suggest that garcinol can indeed potentiate the effects of cisplatin by negative regulation of various inflammatory and proliferative biomarkers. | Feng Li Muthu K. Shanmugam Kodappully Sivaraman Siveen Fan Wang Tina H. Ong Ser Yue Loo Mahadeva M.M. Swamy Somnath Mandal Alan Prem Kumar Boon Cher Goh Tapas Kundu Kwang Seok Ahn Ling Zhi Wang Kam Man Hui Gautam Sethi | 2015 | 中国药理学与毒理学杂志2015，29，S1： | 4 |
| 4 | Wheat streak mosaic virus: incidence in field crops, potential reservoir within grass species and uptake in winter wheat cultivars显示文摘Wheat streak mosaic virus(WSMV)has become a re-emerging pathogen in cereal crops in the Czech Republic.WSMV was first reported in the former Czechoslovakia in the early 1980s,and then no record of the virus was documented until 2009.The incidence of the virus was recorded in recent years in several winter wheat fields and many grass species.Here,we surveyed the incidence of WSMV in cereal crops.The results demonstrated the existence of the virus in winter wheat and volunteer wheat during each year of the monitoring period,which spanned from 2013–2016.Although the range of infected samples was low(6.4%of the total tested samples),a high incidence of well-distributed virus was recorded.In at least six fields,the virus reached severe and potentially epidemic levels.In accordance with our previous report detailing WSMV infection of native grasses,we tested several grass species commonly grown in the Czech Republic.We found that some grass species acted as experimental hosts and possible reservoirs of the virus;these included Anthoxanthum odoratum(sweet vernal grass),Arrhenatherum elatius(false oat-grass),Lolium multiflorum(Italian rye-grass),Bromus japonicus(Japanese chess),Echinochloa crus-galli(barnyard grass),Holcus lanatus(meadow soft grass)and Holcus mollis(creeping soft grass).Some of these grass species are also important weeds of cereals,which may be the potential source of WSMV infection in cereal crops.Several widely used winter wheat cultivars were tested in the field after artificial inoculation with WSMV to evaluate virus titre by RT-qPCR.Overall,the tested cultivars had a low virus titre,which is associated with mild disease symptoms and may provide a good level of crop resistance to WSMV. | Jana Chalupniková Jiban Kumar Kundu Khushwant Singh Pavla Bartaková Eva Beoni | 2017 | Journal of Integrative Agriculture2017，16，3： | 4 |
| 5 | 1,3-Bis(2-chloroethyl)-1-nitrosourea enhances the inhibitory effect of Resveratrol on 5-fluorouracil sensitive/resistant colon cancer cells显示文摘AIM:To study the mechanism of 5-fluorouracil(5-FU)resistance in colon cancer cells and to develop strategies for overcoming such resistance by combination treatment.METHODS:We established and characterized a 5-FU resistance(5-FU-R)cell line derived from continuous exposure(25μmol/L)to 5-FU for 20 wk in 5-FU sensitive HCT-116 cells.The proliferation and expression of different representative apoptosis and anti-apoptosis markers in 5-FU sensitive and 5-FU resistance cells were measured by the MTT assay and by Western blotting,respectively,after treatment with Resveratrol(Res)and/or 1,3-Bis(2-chloroethyl)-1-nitrosourea(BCNU).Apoptosis and cell cycle arrest was measured by 4',6'-diamidino-2-phenylindole hydrochloride staining and fluorescence-activated cell sorting analysis,respectively.The extent of DNA damage was measured by the Comet assay.We measured the visible changes in the DNA damage/repair cascade by Western blotting.RESULTS:The widely used chemotherapeutic agents BCNU and Res decreased the growth of 5-FU sensitive HCT-116 cells in a dose dependent manner.Combined application of BCNU and Res caused more apoptosis in5-FU sensitive cells in comparison to individual treatment.In addition,the combined application of BCNU and Res caused a significant decrease of major DNA base excision repair components in 5-FU sensitive cells.We established a 5-FU resistance cell line(5-FU-R)from 5-FU-sensitive HCT-116(mismatch repair deficient)cells that was not resistant to other chemotherapeutic agents(e.g.,BCNU,Res)except 5-FU.The 5-FU resistance of 5-FU-R cells was assessed by exposure to increasing concentrations of 5-FU followed by the MTT assay.There was no significant cell death noted in5-FU-R cells in comparison to 5-FU sensitive cells after5-FU treatment.This resistant cell line overexpressed anti-apoptotic[e.g.,AKT,nuclear factorκB,FLICE-like inhibitory protein),DNA repair(e.g.,DNA polymerase beta(POL-β),DNA polymerase eta(POLH),protein Flap endonuclease 1(FEN1),DNA damage-binding protein 2(DDB2)]and 5-FU-resistance proteins(thymidylate synthase)but under expressed pro-apoptotic proteins(e.g.,DAB2,CK1)in comparison to the parental cells.Increased genotoxicity and apoptosis were observed in resistant cells after combined application of BCNU and Res in comparison to untreated or parental cells.BCNU increased the sensitivity to Res of 5-FU resistant cells compared with parental cells.Fifty percent cell death were noted in parental cells when 18μmol/L of Res was associated with fixed concentration(20μmol/L)of BCNU,but a much lower concentration of Res(8μmol/L)was needed to achieve the same effect in 5-FU resistant cells.Interestingly,increased levels of adenomatous polyposis coli and decreased levels POL-β,POLH,FEN1 and DDB2 were noted after the same combined treatment in resistant cells.CONCLUSION:BCNU combined with Res exerts a synergistic effect that may prove useful for the treatment of colon cancer and to overcome drug resistance. | Dipon Das Ranjan Preet Purusottam Mohapatra Shakti Ranjan Satapathy Chanakya Nath Kundu | 2013 | World Journal of Gastroenterology2013，19，42： | 4 |
| 6 | Future changes in rainfall, temperature and reference evapotranspiration in the central India by least square support vector machine显示文摘Climate change affects the environment and natural resources immensely.Rainfall,temperature and evapotranspiration are major parameters of climate affecting changes in the environment.Evapotranspiration plays a key role in crop production and water balance of a region,one of the major parameters affected by climate change.The reference evapotranspiration or ETo is a calculated parameter used in this research.In the present study,changes in the future rainfall,minimum and maximum temperature,and ETo have been shown by downscaling the HadCM3(Hadley Centre Coupled Model version 3) model data.The selected study area is located in a part of the Narmada river basin area in Madhya Pradesh in central India.The downscaled outputs of projected rainfall,ET_0 and temperatures have been shown for the 21 st century with the HADCM3 data of A2 scenario by the Least Square Support Vector Machine(LS-SVM)model.The efficiency of the LS-SVM model was measured by different statistical methods.The selected predictors show considerable correlation with the rainfall and temperature and the application of this model has been done in a basin area which is an agriculture based region and is sensitive to the change of rainfall and temperature.Results showed an increase in the future rainfall,temperatures and ETo.The temperature increase is projected in the high rise of minimum temperature in winter time and the highest increase in maximum temperature is projected in the pre-monsoon season or from March to May.Highest increase is projected in the 2080 s in 2081-2091 and 2091-2099 in maximum temperature and 2091-2099 in minimum temperature in all the stations.Winter maximum temperature has been observed to have increased in the future.High rainfall is also observed with higher ETo in some decades.Two peaks of the increase are observed in ET_0 in the April-May and in the October.Variation in these parameters due to climate change might have an impact on the future water resource of the study area,which is mainly an agricultural based region,and will help in proper planning and management. | Sananda Kundu Deepak Khare Arun Mondal | 2017 | Geoscience Frontiers2017，8，3： | 4 |
| 7 | Reactive Navigation of Underwater Mobile Robot Using ANFIS Approach in a Manifold Manner显示文摘Learning and self-adaptation ability is highly required to be integrated in path planning algorithm for underwater robot during navigation through an unspecified underwater environment. High frequency oscillations during underwater motion are responsible for nonlinearities in dynamic behavior of underwater robot as well as uncertainties in hydrodynamic coefficients. Reactive behaviors of underwater robot are designed considering the position and orientation of both target and nearest obstacle from robot s current position. Human like reasoning power and approximation based learning skill of neural based adaptive fuzzy inference system(ANFIS)has been found to be effective for underwater multivariable motion control. More than one ANFIS models are used here for achieving goal and obstacle avoidance while avoiding local minima situation in both horizontal and vertical plane of three dimensional workspace.An error gradient approach based on input-output training patterns for learning purpose has been promoted to spawn trajectory of underwater robot optimizing path length as well as time taken. The simulation and experimental results endorse sturdiness and viability of the proposed method in comparison with other navigational methodologies to negotiate with hectic conditions during motion of underwater mobile robot. | Shubhasri Kundu Dayal R. Parhi | 2017 | International Journal of Automation and computing2017，14，3： | 4 |
| 8 | Electrospinning: A fascinating fiber fabrication technique显示文摘 | Nandana Bhardwaj Subhas C. Kundu | 2010 | Biotechnology Advances2010，，3： | 4 |
| 9 | Bayesian inference and life testing plans for generalized exponential distribution显示文摘Recently generalized exponential distribution has received considerable attentions.In this paper,we deal with the Bayesian inference of the unknown parameters of the progressively censored generalized exponential distribution.It is assumed that the scale and the shape parameters have independent gamma priors.The Bayes estimates of the unknown parameters cannot be obtained in the closed form.Lindley's approximation and importance sampling technique have been suggested to compute the approximate Bayes estimates.Markov Chain Monte Carlo method has been used to compute the approximate Bayes estimates and also to construct the highest posterior density credible intervals.We also provide different criteria to compare two different sampling schemes and hence to ?nd the optimal sampling schemes.It is observed that ?nding the optimum censoring procedure is a computationally expensive process.And we have recommended to use the sub-optimal censoring procedure,which can be obtained very easily.Monte Carlo simulations are performed to compare the performances of the different methods and one data analysis has been performed for illustrative purposes. | KUNDU Debasis PRADHAN Biswabrata | 2009 | Science China Mathematics2009，52，6： | 4 |
| 10 | Ipsilateral dislocation of the radial head associated with fracture of distal end of the radius: a case report and review of the literature显示文摘在成年人的光线的头的脱臼是不平常的。光线的头的同时的脱臼和 ipsilateral 的骨折没有另外的联系损害的半径的远侧的结束是极其稀罕的。根据我们知道,在损害的一个不平常的模式以后的如此的损害很少在英语文学被报导了。没有任何联系损害或 comorbidity,我们报导如此的一个案例。关上的减小在损害以后在二个小时以内被执行,结果是令人满意的。Immobilisation 被继续 3 个星期。渐渐的动员在 physiotherapist 的管理下面在灰浆的移动以后被开始。在 6 months’后续病人没有剩余疼痛非常近与完整的屈曲与扩展。有限制的几乎完整的旋后上次,内转的 10 度被完成。没有肘的不稳定性的证据。 | Vinay Gupta Zile Singh Kundu Maneet Kaur Pradeep Kamboj Jitesh Gawande | 2013 | Chinese Journal of Traumatology2013，16，3： | 3 |
| 11 | Rapid improvement in post-infectious gastroparesis symptoms with mirtazapine显示文摘We report the case of a 34-year-old woman with severe post-infectious gastroparesis who was transferred from an outside medical facility for a second opinion regarding management.This patient had no prior history of gastrointestinal symptoms.However,in the aftermath of a viral illness,she developed two months of intractable nausea,vomiting,and oral intake intolerance that resulted in numerous hospitalizations for dehydration and electrolyte disturbances.A solid-phase gastric emptying scan had confirmed delayed emptying,confirming gastroparesis.Unfortunately,conventional pro-kinetic agents and numerous anti-emetic drugs provided little or no relief of the patient’s symptoms.At our institution,the patient experienced a cessation of vomiting,reported a significant reduction in nausea,and toler-ated oral intake shortly after taking mirtazapine.Based on mirtazapine’s primary action as a serotonin(5-HT)1a receptor agonist,we infer that this receptor system mediated the clinical improvement through a combination of peripheral and central neural mechanisms.This report highlights the potential utility of 5-HT1a agonists in the management of nausea and vomiting.We conclude that mirtazapine may be effective in treating symptoms associated with non-diabetic gastroparesis that are refractory to conventional therapies. | Shinjini Kundu Shari Rogal Abdulkader Alam David J Levinthal | 2014 | World Journal of Gastroenterology2014，20，21： | 3 |
| 12 | Helicobacter pylori secreted peptidyl prolyl cis , trans -isomerase drives Th17 inflammation in gastric adenocarcinoma显示文摘 | Amedeo Amedei Fabio Munari Chiara Della Bella Elena Niccolai Marisa Benagiano Lapo Bencini Fabio Cianchi Marco Farsi Giacomo Emmi Giuseppe Zanotti Marina Bernard Manikuntala Kundu Mario Milco D’Elios | 2014 | Internal and Emergency Medicine2014，，3： | 2 |
| 13 | Cobalt-containing covalent organic frameworks for visible light-driven hydrogen evolution显示文摘Covalent organic frameworks(COFs) have recently emerged as a new class of photocatalysts.However,integrated design is crucial to maximizing the performance of COF-incorporating photocatalytic systems.Herein,we compare two strategies of installing earth-abundant metal-based catalytic centers into the matrice of a 2 D COF named NUS-55.Compared to NUS-55(Co)prepared from the post-synthetic metalation of coordination sites within the COF,the molecular co-catalyst impregnated NUS-55/[Co(bpy)3]Cl2 achieves a seven-fold improvement in visible light-driven H2 evolution rate to 2,480 μmol g^-1h^-1,with an apparent quantum efficiency(AQE) of 1.55% at 450 nm.Our results show that the rational design of molecular anchoring sites in COFs for the introduction of catalytic metal sites can be a viable strategy for the development of highly efficient photocatalysts with enhanced stability and photocatalytic activities. | Jian Wang Jian Zhang Shing Bo Peh Guoliang Liu Tanay Kundu Jinqiao Dong Yunpan Ying Yuhong Qian Dan Zhao | 2020 | Science China Chemistry2020，63，2： | 2 |
| 14 | Apoptotic and autophagic death union by Thuja occidentalis homeopathic drug in cervical cancer cells with thujone as the bioactive principle显示文摘Objective‘Multi-targeting’drugs can prove fruitful to combat drug-resistance of multifactorial disease—cervical cancer.This study envisioned to reveal if Thuja homeopathic mother tincture(MT)and its bioactive component could combat human papillomavirus(HPV)-16-infected SiHa cervical cancer cells since it is globally acclaimed for HPV-mediated warts.Methods Thuja MT was studied for its antiproliferative and antimigratory properties in SiHa cells followed by microscopic determination of reactive oxygen species(ROS)generation by 2’,7’-dichlorodihydrofluorescein diacetate(DCFDA)staining and loss in mitochondrial membrane potential(MMP)by rhodamine(Rh)123 staining.Apoptosis and autophagy inductions were studied by acridine orange(AO)ethidium bromide(EB)staining and immunoblot analyses of marker proteins.The bioactive component of Thuja MT detected by gas chromatography-mass spectrometry was studied for antiproliferative and antimigratory properties along with in silico prediction of its cellular targets by molecular docking and oral drug forming competency.Results Thuja MT showed significant antiproliferative and antimigratory potential in SiHa cells at a 50%inhibitory concentration(IC50)dosage of 17.3μL/mL.An increase in DCFDA fluorescence and loss in Rh123 fluorescence prove that Thuja MT acted through the burst of ROS and loss in MMP respectively.AO/EB-stained cells under the microscope and immunoblot analyses supported Thuja-induced cellular demise via dual pathways—apoptosis and autophagy.Immunoblots showed cleavage of caspase-3 and poly adenosine diphosphate-ribose polymerase-1(PARP-1)along with upregulation of Beclin-1,microtubule-associated protein 1 light chain 3B(LC3B)-II,and p62 proteins.Hence,the apoptotic cascade followed a caspase-3-dependent pathway supported by PARP-1 cleavage,while autophagic death was Beclin-1-dependent and mediated by accumulation of LC3BII and p62 proteins.Thujone,detected as the bioactive principle of Thuja MT showed greater anti-proliferative and anti-migratory potential at an IC5077μg/mL along with excellent oral drug competency with the ability for gastrointestinal absorption and blood-brain-barrier permeation with nil toxicity.Molecular docking depicted thujone with the strongest affinity for mammalian target of rapamycin,phosphoinositide 3-kinase,and protein kinase B followed by B-cell lymphoma 2,murine double minute 2 and adenosine monophosphate-activated protein kinase,which might act as upstream triggers of apoptotic-autophagic crosstalk.Conclusion Robust‘multi-targeting’anticancer potential of Thuja drug and thujone for HPV-infected cervical cancer ascertain its therapeutic efficacy for HPV infections. | Asmita Pal Sucharita Das Soumalee Basu Rita Kundu | 2022 | Journal of Integrative Medicine2022，20，5： | 2 |
| 15 | A Multi-scalemorphologicaledge detector 显示文摘 | Chanda B Kundu M K Vanipadmaja Y | 1998 | Pattern Recognition1998，31，10： | 2 |
| 16 | Estimating parameters in the damped exponential model显示文摘 | Kannan N Kundu D | 2001 | Signal processing2001，81，： | 2 |
| 17 | Flood susceptibility modelling using advanced ensemble machine learning models显示文摘Floods are one of nature's most destructive disasters because of the immense damage to land,buildings,and human fatalities.It is difficult to forecast the areas that are vulnerable to flash flooding due to the dynamic and complex nature of the flash floods.Therefore,earlier identification of flash flood susceptible sites can be performed using advanced machine learning models for managing flood disasters.In this study,we applied and assessed two new hybrid ensemble models,namely Dagging and Random Subspace(RS)coupled with Artificial Neural Network(ANN),Random Forest(RF),and Support Vector Machine(SVM)which are the other three state-of-the-art machine learning models for modelling flood susceptibility maps at the Teesta River basin,the northern region of Bangladesh.The application of these models includes twelve flood influencing factors with 413 current and former flooding points,which were transferred in a GIS environment.The information gain ratio,the multicollinearity diagnostics tests were employed to determine the association between the occurrences and flood influential factors.For the validation and the comparison of these models,for the ability to predict the statistical appraisal measures such as Freidman,Wilcoxon signed-rank,and t-paired tests and Receiver Operating Characteristic Curve(ROC)were employed.The value of the Area Under the Curve(AUC)of ROC was above 0.80 for all models.For flood susceptibility modelling,the Dagging model performs superior,followed by RF,the ANN,the SVM,and the RS,then the several benchmark models.The approach and solution-oriented outcomes outlined in this paper will assist state and local authorities as well as policy makers in reducing flood-related threats and will also assist in the implementation of effective mitigation strategies to mitigate future damage. | Abu Reza Md Towfiqul Islam Swapan Talukdar Susanta Mahato Sonali Kundu Kutub Uddin Eibek Quoc Bao Pham Alban Kuriqi Nguyen Thi Thuy Linh | 2021 | Geoscience Frontiers2021，12，3： | 2 |
| 18 | A modified Prony algorithm for sum of damped or undamped exponential signals显示文摘 | Kundu D | 1994 | Sankhya Ser1994，56，： | 2 |
| 19 | Thermodynamic interdiffusion coefficient in binary systems with intermediate phases显示文摘 | Garg S P Kale G B Patil R V Kundu T | 1999 | Intermetallics1999，7，： | 2 |
| 20 | Seismoelectric wave propagation modeling in a borehole in water-saturated porous medium having an electrochemical interface显示文摘Water-saturated porous media often exhibit a seismoelectric effect due to the existence of an electrical double layer and a relative flow of pore fluid. Here we consider the seismoelectric waves in an open borehole surrounded by water-saturated porous formation which exhibits discontinuity of electrochemical properties at a cylindrical interface. We carefully analyze the seismoelectric interface response since these signals show sensitivity to contrasts in electrochemical properties across an interface. Both coupled and approximate methods are used to compute borehole seismoelectric fields. The simulation results show that the radiated electromagnetic wave from the electrochemical interface is generated due to the change of salinity in pore fluid in the porous formation. However, the elastic properties of the formation remain unchanged across such an electrochemical interface. As a result it is difficult to recognize such a change in electrochemical properties using only elastic waves. Therefore, the seismoelectric interface response is potentially used to detect the changes of the electrochemical properties in the formation. | 丁浩然 刘金霞 崔志文 Tribikram Kundu | 2017 | Chinese Physics B2017，26，12： | 2 |
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