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| 1 | A nuclear import inhibitory peptide ameliorates the severity of cholecystokinin-induced acute pancreatitis显示文摘AIM: To assess the effect of our novel cell-permeable nuclear factor-kappaB (NF-κB) inhibitor peptide PN50 in an experimental model of acute pancreatitis. PN50 was produced by conjugating the cell-penetrating penetratin peptide with the nuclear localization signal of the NF-κB p50 subunit.METHODS: Pancreatitis was induced in male Wistar rats by administering 2×100 μg/kg body weight of cholecystokininoctapeptide (CCK) intraperitoneally (IP) at an interval of 1 h. PN50-treated animals received 1 mg/kg of PN50 IP 30 min before or after the CCK injections. The animals were sacrificed 4 h after the first injection of CCK.RESULTS: All the examined laboratory (the pancreatic weight/body weight ratio, serum amylase activity,pancreatic levels of TNF-α and IL-6, degree of lipid peroxidation, reduced glutathione levels, NF-κB binding activity, pancreatic and lung myeloperoxidase activity) and morphological parameters of the disease were improved before and after treatment with the PN50 peptide.According to the histological findings, PN50 protected the animals against acute pancreatitis by favoring the induction of apoptotic, as opposed to necrotic acinar cell death associated with severe acute pancreatitis.CONCLUSION: Our study implies that reversible inhibitors of stress-responsive transcription factors like NF-κB might be clinically useful for the suppression of the severity of acute pancreatitis. | Tamás Letoha Csaba Somlai Tamáas Takács Annamária Szabolcs Katalin Jármay Zoltán Rakonczay Jr Péter Hegyi Ilona Varga József Kaszaki István Krizbai Imre Boros Ern(?) Duda Erzsébet Kusz Botond Penke | 2005 | World Journal of Gastroenterology2005，11，7： | 15 |
| 2 | Use of Luminex xMAP derived Bio-Plex bead based suspension array for specific detection of PPV W and characterization of epitopes on the coat protein of the virus显示文摘 | Croft H Malinowski T Krizbai L | 2008 | J Virol Methods2008，153，2： | 1 |
| 3 | Changes Induced by Hyperosmotic Mannitol in Cerebral Endothelial Cells:An Atomic Force Microscopic Study显示文摘 | Bálint Z Krizbai I Wilhelm I | | 0，，02： | 1 |
| 4 | Characterization of Hungarian isolates of apple chlorotic leaf spot virus显示文摘 | KRIZBAI L EMDER I NEMETH M | 2001 | Acta Horticulturae2001，1，1： | 1 |
| 5 | Use of Luminex xMAP-derived Bio-Plex bead-based suspension array for specific detection of PPV W and characterization of epitopes on the coat protein of the virus显示文摘 | Croft H Malinowski T Krizbai L | 2008 | Journal of Virological Methods2008，153，2： | 1 |
| 6 | Functional expression of the serotonin transporter in immortalized rat brain microvessel endothelial cells显示文摘 | Brust P Friedrich A Krizbai I A | 2000 | Journal of Neurochemistry2000，74，3： | 1 |
| 7 | Detectability of Prunus necrotic ringspot and plum pox viruses by RT-PCR,multiPlex RT-PCR, ELISA and indexing on woody indicators显示文摘 | Kolber M Nemeth M Krizbai L | 1998 | Acta Horticuhurae1998，472，： | 1 |
| 8 | 3-1n vitro models of the blood-brain barrier显示文摘 | WILHELM I FAZAKAS C KRIZBAI IA | 2011 | Acta Neurobiol Exp ( Wars)2011，71，1： | 1 |
| 9 | Use of Luminex xMAP - derived Bio - Plex bead - based suspension array for spe- cificdetection of PPVW and characterization of epitopes on the coat- protein of the vires显示文摘 | CROFT H MALINOWSKI T KRIZBAI L | 2008 | J Viral Methods2008，153，2： | 1 |
| 10 | Systemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis显示文摘 | Pardutz A Krizbai I Multon S | 2000 | Neuroreport2000，11，14： | 1 |
| 11 | Use of Luminex xMAP-derived Bio Plex bead-based suspension array for specific detection of PPV and characterization of epitopes on the coat protein of the virus显示文摘 | CROFT H MALINOWSKI T KRIZBAI L | 2008 | J VirolMethods2008，153，2： | 1 |
| 12 | Systemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudails显示文摘 | Arpad Pardutz Istvan Krizbai Sylvie Multon | 2000 | Neuroreptor2000，11，14： | 1 |
| 13 | Oxidative stress in cultured cerebral endothelial cells induces chromosomal aberrations, micronuclei, and apoptosis 显示文摘 | Bresgen N Karlhuber G Krizbai I | 2003 | J Neurosci Res2003，72，： | 1 |
| 14 | Use of Luminex xMAP-derived Bio-Plex bead-based suspension array for specific detection of PPV W and characterization of epitopes on the coat protein of the virus 显示文摘 | CROFT H MALINOWSKI T KRIZBAI L | 2008 | J Virol Methods2008，153，2： | 1 |
| 15 | Growth factor-induced morphological,physiological and molecular characteristics in cerebral endothelial cells显示文摘 | Bauer H Amberger A | 2000 | Eur J Cell Biol2000，79，9： | 1 |
| 16 | Functional expression of the serotonin transporter in immortalized rat brain microvessel endothelial cells显示文摘 | Anne Friedrich Istvan A Krizbai | 2000 | Journal of Neurochemistry2000，74，3： | 1 |
| 17 | Expression of glutamate receptors on cultured cerebral endothelial cells显示文摘 | Krizbai IA Deli MA Pestenacz A | 1998 | J Neurosci Res1998，54，6： | 1 |
| 18 | Characterization of Hungar ian isolates of apple chlorotic leaf spot virus显示文摘 | KRIZBAI L EMBER I N(E)METH M | | 0，，01： | 1 |
| 19 | Systemic nitroglycerin increases nNOS levels in rat trigeminal nucleus caudalis显示文摘 | Pardutz A Krizbai I Multon S | 2000 | Neuroreport2000，11，14： | 1 |
| 20 | The tight junction protein ZO-2 localizes to the nucleus and interacts with the heterogeneous nuclear ribonucleoprotein scaffold attachment factor-B 显示文摘 | Traweger A Fuchs R Krizbai IA | 2003 | J Biol Chem2003，278，： | 1 |
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