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| 1 | Prevention and management of hepatitis B virus reactivation in patients with hematological malignancies treated with anticancer therapy显示文摘Hepatitis due to hepatitis B virus(HBV) reactivation can be severe and potentially fatal, but is preventable. HBV reactivation is most commonly reported in patients receiving cancer chemotherapy, especially rituximabcontaining therapy for hematological malignancies and those receiving stem cell transplantation. All patients with hematological malignancies receiving anticancer therapy should be screened for active or resolved HBV infection by blood tests for hepatitis B surface antigen(HBs Ag) and antibody to hepatitis B core antigen(antiHBc). Patients found to be positive for HBs Ag should be given prophylactic antiviral therapy to prevent HBV reactivation. For patients with resolved HBV infection, no standard strategy has yet been established to prevent HBV reactivation. There are usually two options. One is pre-emptive therapy guided by serial HBV DNA monitoring, whereby antiviral therapy is given as soon as HBV DNA becomes detectable. However, there is little evidence regarding the optimal interval and period of monitoring. An alternative approach is prophylactic antiviral therapy, especially for patients receiving highrisk therapy such as rituximab, newer generation of anti-CD20 monoclonal antibody, obinutuzumab or hematopoietic stem cell transplantation. This strategy may effectively prevent HBV reactivation and avoid the inconvenience of repeated HBV DNA monitoring. Entecavir or tenofovir are preferred over lamivudine as prophylactic therapy. Although there is no well-defined guideline on the optimal duration of prophylactic therapy, there is growing evidence to recommend continuing prophylactic antiviral therapy for at least 12 mo after cessation of chemotherapy, and even longer for those who receive rituximab or who had high serum HBV DNA levels before the start of immunosuppressive therapy. Many novel agents have recently become available for the treatment of hematological malignancies, and these agents may be associated with HBV reactivation. Although there is currently limited evidence to guide the optimal preventive measures, we recommend antiviral prophylaxis in HBs Ag-positive patients receiving novel treatments, especially the Bruton tyrosine kinase inhibitors and the phosphatidylinositol 3-kinase inhibitors, which are B-cell receptor signaling modulators and reduce proliferation of malignant B-cells. Further studies are needed to clarify the risk of HBV reactivation with these agents and the best prophylactic strategy in the era of targeted therapy for hematological malignancies. | Man Fai Law Rita Ho Carmen KM Cheung Lydia HP Tam Karen Ma Kent CY So Bonaventure Ip Jacqueline So Jennifer Lai Joyce Ng Tommy HC Tam | 2016 | World Journal of Gastroenterology2016，22，28： | 10 |
| 2 | Use of chlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and infection: a meta-analysis显示文摘 | Ho Km Litton E | 2006 | J Antimicrob Chemother2006，58，2： | 1 |
| 3 | A comparison of continuous and bi-level positive airway pressure non-invasive ventilation in patients with acute eardiogenic pulmonary oedema: a meta-analysis 显示文摘 | Ho KM Wong K | 2006 | Crit Care2006，10，2： | 1 |
| 4 | Co-localization of carbon monoxide and nitric oxide synthesizing enzymes in the human urethral sphincter显示文摘 | Ho KM Ny L MeMurray G et ol | 1999 | J Urol1999，161，6： | 1 |
| 5 | Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta-analysis 显示文摘 | Tan JA Ho KM | 2010 | Intensive Care Med2010，36，： | 1 |
| 6 | Benefits and risks of furesemide in acute kidney injury显示文摘 | Ho KM Power BM | 2010 | Anaesthesia2010，65，3： | 1 |
| 7 | A phase II, single-alan study of the anti-α5β1 integrin antibody volociximab as monotherapy in patients with platinum-resistant advanced epithelial ovarian or primary peritoneal cancer 显示文摘 | Bell-McGuinn KM Matthews CM Ho SN | 2011 | Gynecologic Oncology2011，121，： | 1 |
| 8 | Use of chlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and infection:a meta-analysis显示文摘 | Ho KM Litton E | 2006 | J Antimicrob Chemother2006，58，2： | 1 |
| 9 | The effect of comorbidities on risk of intensive care readmission during the same hospitalization:a linked data cohort study显示文摘 | Ho KM Dobb GJ Lee KY | | 0，，01： | 1 |
| 10 | An epididymis-specific beta-defensin is important for the initiation of sperm maturation显示文摘 | Zhou CX Zhang YL Xiao L Zheng M Leung KM Chan MY Lo PS Tsang LL Wong HY Ho LS | | 0，，05： | 1 |
| 11 | Expression of CD44s, vascular endothelial growth factor, matrix metalloproteinase-2 and Ki-67 in peritoneal, rectovaginal and ovarian endometriosis 显示文摘 | Kim HO Yang KM Kang IS | 2007 | J Reprod Med2007，52，： | 1 |
| 12 | Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients: a meta-analysis 显示文摘 | Tan JA Ho KM | 2010 | Intensive Care Med2010，36，： | 1 |
| 13 | Expression of human estrogen receptor-alpha and-beta, progesterone receptor, and androgen receptor mRNA in normal and malignant ovariant epithelial cells 显示文摘 | Lau KM Mok SC Ho SM | 1999 | Proe Natl Acad Sci1999，96，8： | 1 |
| 14 | Use of intravenous tranexamic acid to reduce allogencic blood transfusion in total hip and knee arthroplasty: a meta -analysis 显示文摘 | Ho KM Ismail H | 2003 | Anaesthesia and Intensive Care2003，31，5： | 1 |
| 15 | Use of chlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and infection: a meta-analysis 显示文摘 | Ho KM Litton E | 2006 | J Antimicrob Chemother2006，58，2： | 1 |
| 16 | Combining sequential score with acute physiology organ failure assessment (SOFA) and chronic health evaluation (APACHE) II score to predict hospital mortality of critically ill patients显示文摘 | Ho KM | 2007 | Anaesth Intensive Care2007，35，4： | 1 |
| 17 | Genetic control of chromosome elimination during haploid formation in barley显示文摘 | HO KM KASHA KJ | 1975 | Genetics1975，81，： | 1 |
| 18 | Use of ehlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and in-fection:a meta analysis显示文摘 | Ho KM Litton E | 2006 | J Antimicrob Chemother2006，58，2： | 1 |
| 19 | Use of dexmedetomidine as a sedative and analgesic agent in critically ill adult patients:a meta-analysis显示文摘 | Tan JA Ho KM | 2010 | lntensive Care Med2010，56，6： | 1 |
| 20 | Use of chlorhexidine-impregnated dressing to prevent vascular and epidural catheter colonization and infection:a meta-analysis显示文摘 | Ho KM Litton E | 2006 | J Antimicrob Chemother2006，58，2： | 1 |
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