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| 1 | 半再生重整分子水平反应动力学模型显示文摘根据实验数据建立了半再生重整分子水平反应动力学模型。模型包括305个C1-C12分子组分及864个化学反应,其中包括数十种烯烃及C6-C9所有芳烃异构体的生成与转化。以Langmuir-Hinshelwood-Hougen-Watson(LHHW)方程模拟反应速率,采用线性自由能关联方法(LFER)获取动力学参数,利用实验数据对模型进行了校正及检验。结果表明,芳烃脱烷基速率较低,应区分于加氢裂化反应;芳烃甲基迁移速率不容忽视,对C8+芳烃产物分布有影响;模型对贫、富芳烃2种原料在10组不同反应条件下的C5+液收、正构烷烃和环烷烃产率的预测较为准确,对C6-C9芳烃组分产率(质量分数)的预测偏差平均值小于3%。 | 周祥 王杰广 侯震 BENNET Craing A 马爱增 KLEIN Michael T 郭锦标 | 2016 | 石油学报(石油加工)2016，32，4： | 5 |
| 2 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003，，9： | 4 |
| 3 | Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer. | Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki | 2006 | World Journal of Gastroenterology2006，12，40： | 3 |
| 4 | 2型糖尿病患者及其一级亲属和非糖尿病者骨骼肌的胰岛素信号传导显示文摘2型糖尿病与骨骼肌和其他组织的葡萄糖利用能力下降有关。胰岛素抵抗可能与遗传因素和糖尿病本身的代谢异常如高血糖或非脂化脂肪酸(NEFA)升高有关。遗传因素和继发的胰岛素抵抗代谢异常可能是由于调节葡萄糖代谢的胰岛素受体和受体后信号传导的改变引起。胰岛素与其受体结合后,受体自身磷酸化,受体激酶活化,一些细胞间的底物磷酸化,其中在骨骼肌细胞中胰岛素受体底物-1(IRS-1)最重要。酪氨酸磷酸化的IRS与脂肪激酶磷脂酚肌醇3’(PI3’) | Meyer MM Levin K Grimmsmann T Beck-Nielsen H Klein HH Diabetologia 叶华 | 2003 | 中国糖尿病杂志2003，11，2： | 3 |
| 5 | Bovine immunoglobulin protein isolates for the nutritional management of enteropathy显示文摘The gastrointestinal tract is responsible for a multitude of digestive and immune functions which depend upon the balanced interaction of the intestinal microbiota, diet, gut barrier function, and mucosal immune response. Disruptions in one or more of these factors can lead to intestinal disorders or enteropathies which are characterized by intestinal inflammation, increased gut permeability, and reduced capacity to absorb nutrients. Enteropathy is frequently associated with human immunodeficiency virus(HIV) infection, inflammatory bowel disease, autoimmune enteropathy, radiation enteritis, and irritable bowel syndrome(IBS), where pathologic changes in the intestinal tract lead to abdominal discomfort, bloating, abnormal bowel function(e.g., diarrhea, urgency, constipation and malabsorption). Unfortunately, effective therapies for the management ofenteropathy and restoring intestinal health are still not available. An accumulating body of preclinical studies has demonstrated that oral administration of plasmaor serum-derived protein concentrates containing high levels of immunoglobulins can improve weight, normalize gut barrier function, and reduce the severity of enteropathy in animal models. Recent studies in humans, using serum-derived bovine immunoglobulin/protein isolate, demonstrate that such protein preparations are safe and improve symptoms, nutritional status, and various biomarkers associated with enteropathy. Benefits have been shown in patients with HIV infection or diarrhea-predominant IBS. This review summarizes preclinical and clinical studies with plasma/serum protein concentrates and describes the effects on host nutrition, intestinal function, and markers of intestinal inflammation. It supports the concept that immunoglobulin-containing protein preparations may offer a new strategy for restoring functional homeostasis in the intestinal tract of patients with enteropathy. | Bryon W Petschow Anthony T Blikslager Eric M Weaver Joy M Campbell Javier Polo Audrey L Shaw Bruce P Burnett Gerald L Klein J Marc Rhoads | 2014 | World Journal of Gastroenterology2014，20，33： | 2 |
| 6 | Proposed international clinical diabetic retinopathy and diabetic macular edema disease severity scales显示文摘 | C.P Wilkinson Frederick L Ferris Ronald E Klein Paul P Lee Carl David Agardh Matthew Davis Diana Dills Anselm Kampik R Pararajasegaram Juan T Verdaguer | 2003 | Ophthalmology2003，，9： | 2 |
| 7 | Soil dehydrogenase activity 显示文摘 | Casida L C Jr Klein D A Santoro T | 1964 | Soil Science1964，98，： | 2 |
| 8 | Strategies to tackle the challenges of external beam radiotherapy for liver tumors显示文摘Primary and metastatic liver cancer is an increasingly common and difficult to control disease entity.Radiation offers a non-invasive treatment alternative for these patients who often have few options and a poor prognosis.However,the anatomy and aggressiveness of liver cancer poses significant challenges such as accurate localization at simulation and treatment,management of motion and appropriate selection of dose regimen.This article aims to review the options available and provide information for the practical implementation and/or improvement of liver cancer radiation programs within the context of stereotactic body radiotherapy and image-guided radiotherapy guidelines.Specific patient inclusion and exclusion criteria are presented given the significant toxicity found in certain sub-populations treated with radiation.Indeed,certain sub-populations,such as those with tumor thrombosis or those with larger lesions treated with transarterial chemoembolization,have been shown to have significant improvements in outcome with the addition of radiation and merit special consideration.Implementing a liver radiation programrequires three primary challenges to be addressed:(1) immobilization and motion management;(2) localization;and(3) dose regimen and constraint selection.Strategies to deal with motion include simple internal target volume(ITV) expansions,non-gated ITV reduction strategies,breath hold methods,and surrogate marker methods to enable gating or tracking.Localization of the tumor and organs-at-risk are addressed using contrast infusion techniques to take advantage of different normal liver and cancer vascular anatomy,imaging modalities,and margin management.Finally,a dose response has been demonstrated and dose regimens appear to be converging.A more uniform approach to treatment in terms of technique,dose selection and patient selection will allow us to study liver radiation in larger and,hopefully,multicenter randomized studies. | Michael I Lock Jonathan Klein Hans T Chung Joseph M Herman Edward Y Kim William Small Nina A Mayr Simon S Lo | 2017 | World Journal of Hepatology2017，9，14： | 2 |
| 9 | Soil dehydrogenase activity显示文摘 | CASIDA LC KLEIN DA SANTORO T | 1964 | Soil Science1964，98，： | 1 |
| 10 | New Aspects of Score-shell Emulsion Polymerization Polybutylacrylate and Styrene Pair Systems显示文摘 | Min T I Klein A El-Aasser M S Vanderhoff J W | 1981 | Org Coat Appl Polym Sci Proc1981，46，： | 1 |
| 11 | Investigation of solid adsorbents for humidity control in display cases显示文摘 | YU D KLEIN S A REINDLE D T | 2002 | ASHRAE Transactions2002，108，1： | 1 |
| 12 | BiOhemical factors underlying the age - related sensitivity of turkeys to aflatoxin B1显示文摘 | Klein P J Van - Vleet T R Hall J O | | 0，，： | 1 |
| 13 | Automatic retrieval of frequent idiomatic and collocational expressions in a large corpus显示文摘 | Y Choueka S T Klein E Neuwitz | 1983 | Journal of the Association for Literary and Linguistic Computing1983，4，1： | 1 |
| 14 | Genetic heterogeneity of single disseminated turnout cells in minimal residual cancer显示文摘 | Klein C A Blankenstein T J Schmidt-Kittler O Petronio M Polzer B Stoecklein N H | 2002 | Lancet2002，2360，： | 1 |
| 15 | Resilience to natural hazards: how useful is this concept 显示文摘 | Klein R J T Nicholls R J Thomalla F | 2003 | Global Environmental Change Part B: Environmental Hazards2003，5，12： | 1 |
| 16 | A new energy-integrated pervaporation distillation approach显示文摘 | Del Pozo GOMEZ M T KLEIN A REPKE J | 2008 | Desalination2008，224，： | 1 |
| 17 | Circulating concentrations of growth-differentiation factor 15 in apparently healthy elderly individuals and patients with chronic heart failure as assessed by a new immunoradiometric sandwich assay显示文摘 | Kempf T Horn-Wichmann R Brabant G Peter T Allhoff T Klein G | 2007 | Clin Chem2007，53，： | 1 |
| 18 | Impaired modulation of the saccadic contingent negative variation preceding antisaccades in schizophrenia显示文摘 | Hoinks T Andresen B | 2000 | Biol Psychiatry2000，47，： | 1 |
| 19 | Rapid accretion and early core formation on asteroid and the terrestrial planets from Hf-W chronometry显示文摘 | Kleine T Manker C Mezger K | 2002 | Nature2002，418，： | 1 |
| 20 | Selective inhibition of cyclooxygenase 2 显示文摘 | Klein T Nusing RM Pfeilschlfter J | 1994 | Biochem Pharmacol1994，48，8： | 1 |
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