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1Clinical therapeutic strategies for early stage of diabetic kidney disease显示文摘Diabetic kidney disease(DKD) is the most common cause of chronic kidney disease, leading to end-stage renal disease and cardiovascular disease. The overall number of patients with DKD will continue to increase in parallel with the increasing global pandemic of type 2 diabetes. Based on landmark clinical trials, DKD has become preventable by controlling conventional factors, including hyperglycemia and hypertension, with multifactorial therapy; however, the remaining risk of DKD progression is still high. In this review, we show the importance of targeting remission/regression of microalbuminuria in type 2 diabetic patients, which may protect against the progression of DKD and cardiovascular events. To achieve remission/regression of microalbuminuria, several steps are important, including the early detection of microalbuminuria with continuousscreening, targeting HbA1c < 7.0% for glucose control, the use of renin angiotensin system inhibitors to control blood pressure, the use of statins or fibrates to control dyslipidemia, and multifactorial treatment. Reducing microalbuminuria is therefore an important therapeutic goal, and the absence of microalbuminuria could be a pivotal biomarker of therapeutic success in diabetic patients. Other therapies, including vitamin D receptor activation, uric acid-lowering drugs, and incretin-related drugs, may also be promising for the prevention of DKD progression.Munehiro Kitada Keizo Kanasaki Daisuke Koya 2014World Journal of Diabetes2014,5,3:12
2Spindle cell carcinoma of the breast as complex cystic lesion: a case report显示文摘Spindle cell carcinoma of the breast is a rare tumor. This tumor can proliferate rapidly and cause cystic changes because of internal tissue necrosis. We evaluated a 54-year-old woman with right breast lump. Mammography showed a category four mass with a diameter of 2.5 cm. Ultrasonography(US) revealed a complex cystic lesion, and fine-needle aspiration(FNA) cytology demonstrated bloody fluid and malignant cells. Partial breast resection and sentinel lymph node biopsy were performed. Immunohistology revealed spindle cells with positive results for cytokeratin(AE1/AE3) and vimentin, partially positive results for s-100, and negative results for desmin and α-actin. The pathological stage was IIA, and biochemical characterization showed that the tumor was triple negative. Six courses of FEC-100 chemotherapy(5-fluorouracil 500 mg/m2, epirubicin 100 mg/m2, and cyclophosphamide 500 mg/m2) were administered. Radiotherapy was performed. This case is discussed with reference to the literature.Masahiro Kitada Satoshi Hayashi Yoshinari Matsuda Kei Ishibashi Keisuke Oikawa Naoyuki Miyokawa 2014Cancer Biology & Medicine2014,11,2:6
3有为决定早阶段的区分的胃的癌的扩展区域的 NBI 的在我的 DL 的实用性显示文摘 AIM: To investigate whether magnifying endoscopy with narrow band imaging (ME-NBI) is useful for evaluating the area of superficial, depressed- or flat-type differentiated adenocarcinoma of the stomach. METHODS: This procedure was performed in Saitama Medical University International Medical Center, Japanese Red Cross Kumamoto Hospital and Kitakyushu Municipal Medical Center. The subjects were 31 patients in whom biopsy findings, from superficial, depressed- or flat-type gastric lesion, suggested differentiated adenocarcinoma in the above 3 hospitals between January and December 2009. Biopsy was performed on the lesion and non-lesion sides of a boundary (imaginary boundary) visualized on ME-NBI. The results were pathologically investigated. We evaluated the accuracy of estimating a demarcation line (DL) on ME-NBI in comparison with biopsy findings as a gold standard. RESULTS: The DL that could be recognized at 2 points on the orifice and anal sides of each lesion during ME-NBI was consistent with the pathological findings in 22 patients with 0-Ⅱc lesions, 7 with 0-Ⅱb lesions, and 2 with 0-Ⅱb + Ⅱc lesions, showing an accuracy of 100%. CONCLUSION: The results suggest the usefulness of ME-NBI for evaluating the area of superficial, depressed- and flat-type differentiated adenocarcinoma of the stomach.Kouichi Nonaka Masaaki Namoto Hideki Kitada Michio Shimizu Yasutoshi Ochiai Osamu Togawa Masamitsu Nakao Makoto Nishimura Keiko Ishikawa Shin Arai Hiroto Kita 2012World Journal of Gastrointestinal Endoscopy2012,4,8:6
4A comparison of intraoperative celiac plexus block with pharmacological therapy as a treatment for pain of unresectable pancreatic cancer显示文摘Masaki Okuyama Takashi Shibata Tetsushi Morita Masashi Kitada Yasuo Tukahara Yukio Fukushima Kimimasa Ikeda Junya Fuzita Takashi Shimano 2002Journal of Hepato - Biliary - Pancreatic Surgery2002,,3:2
5Evaluation of HER2-based biology in 1,006 cases of gastric cancer in a Japanese population显示文摘Masaki Aizawa Akiko K. Nagatsuma Koji Kitada Takeshi Kuwata Satoshi Fujii Taira Kinoshita Atsushi Ochiai 2014Gastric Cancer2014,,1:2
6Crystal structures of mitochondrial processing peptidase reveal the mode for specific cleavage of import signal sequences 显示文摘Taylor AB Smith BS Kitada SJ 2001Structure Cambridge2001,9,7:1
7Committed Neural Progenitor Cells Derived from Genetically Modified Bone Marrow Stromal Cells Ameliorate Deficits in a Rat Model of Stroke显示文摘Hayase M Kitada M Wakao S 2009J Cereb Blood Flow Metab (S0271-678X)2009,29,8:1
8Management of mandibular osteoradionecrosis corresponding to the severity of osteoradionecrosis and the method of radiotherapy显示文摘Notani K Yamazaki Y Kitada H 2003Head Neck2003,25,3:1
9Mesenchymal cell populations: development of the induction systems for Schwann cells and neuronal cells and finding the unique stem cell population显示文摘Kitada M 2012Anat Sci Int2012,87,1:1
10IgG4-related lung disease showing high standardized uptake values on FDG-PET:report of two cases显示文摘Kitada M Matuda Y Hayashi S 2013J Cardiothorac Surg2013,25,:1
11Four cases of central nervous system involvement of breast malignant lymphoma显示文摘Yamazaki H Hanada M Kitada M 0,,08:1
12Accumulation of N-acetyl-L-aspartate in the brain of the tremor rat,a mutant exhibiting absence-like seizure and spongiform degeneration in the central nervous system显示文摘Kitada K Akimitsu T Shigematsu Y 0,,06:1
13SIRTl inactivation induces inflammation through the dysregulation of autophagy in human THP-I cells显示文摘Takeda-Watanabe A Kitada M Kanasaki K 2012Biochem Biophys Res Commun2012,427,1:1
14Comparative results of conservative treatments for isolated anterior talofibular ligament (ATFL) injury and injury to both the ATFL and calcaneofibular ligament of the ankle as assessed by subtalar arthrography显示文摘Norihiro Samoto Kazuya Sugimoto Takanori Takaoka Tadashi Fujita Chikara Kitada Yoshinori Takakura 2007Journal of Orthopaedic Science2007,,1:1
15Grafting of detergent-denatured skeletal muscles provides effective conduits for extension of regenerating axons in the rat sciatic nerve显示文摘Mligiliche N Kitada M lde C 2001Arch Histol Cytol2001,64,1:1
16Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism显示文摘 Asakawa S Hattori N 1998Nature1998,392,6676:1
17Properties of ultra fine grain binderless cemented carbide 'RCCFN' 显示文摘Imasato S Tokumoto K Kitada T 1995Intentional Journal of Refractory Metals and Hard Materials1995,13,5:1
18Effect of diamine treatment on the conversion efficiency of PbSe colloidal quantum dot solar cells显示文摘Kitada S Kikuchi E Ohno A 2009Solid State Commun2009,149,:1
19Mapping of four simple sequence repeat (SSR) markers on rat chromosome 4显示文摘Mashimo T Nabika T Kitada K 2000Hypertens Res2000,23,1:1
20The triter- penoid CDDO induces apoptosis in refractory CLL B cells 显示文摘PEDERSEN I M KITADA S SCHIMMER A 2002Blood2002,100,8:1
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