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| 1 | Association between heavy metals and antibiotic-resistant human pathogens in environmental reservoirs: A review显示文摘Antibiotic resistance in human pathogens can proliferate under selective pressures. Heavy metals in environmental reservoirs may contribute to selecting antibiotic-resistant strains. To determine the associations between heavy metals and antibiotic resistance, a literature review was conducted to systematically collect and categorize evidence for co-occurrence of resistance to heavy metals and antibiotics within human pathogenic bacteria in water, wastewater, and soil. In total, 42 publications adhered to inclusion criteria. Across the reservoirs, zinc and cadmium were the most commonly observed heavy metals associated with resistance to antibiotics. Pseudomonas aeruginosa and Escherichia coli were the most commonly studied bacteria with reported co-occurrence of resistance to several heavy metals and antibiotic classes. As co-selecting agents, prevalence of heavy metals in the environment can proliferate resistance to heavy metals and antibiotics through co-resistance and crossresistance mechanisms. In comparing different reservoirs, soils and sediments harbor higher heavy metal and antibiotic resistances compared to water environments. Additionally, abiotic factors such as pH can affect the solubility and hence, the availability of heavy metals to bacterial pathogens. Overall, our review demonstrates heavy metals act as co-selecting agents in the proliferation of antibiotic resistance in human pathogens in multiple environmental reservoirs. More studies that include statistical data are needed to further describe the exposure-response relationships between heavy metals and antibiotic resistance in different environmental media. Moreover, integration of culturebased and molecular-based methods in future studies are recommended to better inform our understanding of bacterial co- and cross-resistance mechanisms to heavy metals and antibiotics. | Christine C. Nguyen Cody N. Hugie Molly L. Kile Tala Navab-Daneshmand | 2019 | Frontiers of Environmental Science & Engineering2019，13，3： | 5 |
| 2 | Naturally occurring hepatitis B virus X deletions and insertions among Korean chronic patients显示文摘 | Seoung‐AeLee Ho‐SukMun HongKim Hyung‐KiLee Buyng‐JunKim Eung‐SooHwang Yoon‐HohKook Bum‐JoonKim | 2010 | J. Med. Virol2010，，1： | 2 |
| 3 | Partition of nonpolar organic pollutants from water to soil and sediment organic matters 显示文摘 | Kile D E Chiou C T Zhou H | 1995 | Environ Sci Technol1995，29，： | 1 |
| 4 | Estimating the insertion site daring retrograde intramedullary tibiotaloealeaneal arthrodesis 显示文摘 | Stephenson K A Kile T A Graves S C | 1996 | Foot Ankle Int1996，17，12： | 1 |
| 5 | Naturally occurring hepatitis B virus X deletions and insertions among Korean chronic patients显示文摘 | Seoung‐AeLee Ho‐SukMun HongKim Hyung‐KiLee Buyng‐JunKim Eung‐SooHwang Yoon‐HohKook Bum‐JoonKim | 2010 | J Med Virol2010，，1： | 1 |
| 6 | Sorption of Selected Organic Compounds from Water to a Peat Soil and Its Humic-Acid and Humin Fractions: Potential Sources of the Sorption Nonlinearity显示文摘 | Chiou C T Kile D E Rutherford D W | 2000 | Environ Sci Technol2000，34，： | 1 |
| 7 | Water solubility enhancements of DDT and trichlorobenzene by some surfactants below and above the critical micelle concentration 显示文摘 | Kile Daniel E Chiou Cary T | 1989 | Environmental Science & Technology1989，23，7： | 1 |
| 8 | Deviations from sorption linearity on soils of polar and nonpolar organic compounds at low relative concentrations显示文摘 | Chiou C T Kile D E | 1998 | Environmental Selence & Technology1998，32，3： | 1 |
| 9 | Partition Characteristics of Polycyclic Aromatic Hydrocarbons on Soils and Sediments 显示文摘 | Chiou C T McGroddy R L Kile D E | 1998 | Environ Sci Technol1998，32，： | 1 |
| 10 | Water solubility enhancements of DDT and trichlorobenzene by some surfactants below and above the critical micelle concentration显示文摘 | Kile D E Chiou C T | 1989 | Environ Sci Technol1989，23，： | 1 |
| 11 | Negative regulators of cytokine signaling显示文摘 | KILE BT NICOLA NA ALEXANDER WS | | 0，，： | 1 |
| 12 | Deviation from sorption linearity on soils of polar and nonpolar organic compounds at low relative concentrations 显示文摘 | CHIOU C T KILE D E | 1998 | Environmental Science and Technology1998，32，3： | 1 |
| 13 | The SOCS box: a tale of destruction and degradation显示文摘 | Kile BT Schulman BA Alexander WS | 2002 | Trends Biochem Sci2002，27，5： | 1 |
| 14 | Sorption of selected organic compounds from water to a peat soil and its humic-acid and humin fractions: Potential sources of the sorption no linearity显示文摘 | CHIOU C T KILE D E RUTHEFORDd D W | 2000 | Environmental Science and Technology2000，34，7： | 1 |
| 15 | The genus Armillaria Nomenclature,Typification,the identity of Armillaria mellea and species differentiation显示文摘 | Watting R G A Kile N M Gregory | 1982 | Trans Brithish Mycol Soc1982，78，： | 1 |
| 16 | Modified chevron osteotomy for hallux valgus显示文摘 | Donnelly RE Saltzman CL Kile TA Johnson KA | 1994 | {H}FOOT & ANKLE INTERNATIONAL1994，，12： | 1 |
| 17 | Deviation from sorption linearity of popular and nonpolar organic compounds at low relative concentration显示文摘 | CHIOU C T KILE D E | 1998 | Environment Science and Technology1998，32，： | 1 |
| 18 | The SOCS box: a tale of destruction and degradation显示文摘 | Kile B T Schulman B A Alexander W S etal | 2002 | Trends Biochem Sci2002，27，： | 1 |
| 19 | Mutational inhibition of c-Myb or p300 ameliorates treatmentinduced thrombocytopenia显示文摘 | Hilton DJ Kile BT Alexander WS | 2009 | Blood2009，113，22： | 1 |
| 20 | Sorption of selected organic compounds from water to a peat soil and its humic-acid and humin fractions:Potential sources of the sorption nonlinearity显示文摘 | Chiou C T Kile D E Rutherford D W | 2000 | Environmental Science & Technology2000，34，7： | 1 |
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