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| 1 | 急性缺血性卒中患者早期处理指南:美国心脏协会/美国卒中协会对医疗专业人员的指南(续前)显示文摘7静脉溶栓
7.1静脉rtPA
急性卒中的静脉溶栓治疗现已得到普遍接受。美国FDA于1996年批准静脉应用rtPA,部分基于NINDSrtPA卒中试验结果。 | Edward C. Jauch Jeffrey L. Saver Harold P. Adams Askiel Bruno J.J. (Buddy) Connors Bart M. Demaerschalk Pooja Khatri Paul W. McMullan Adnan I. Qureshi Kenneth Rosenfield Phillip A. Scott Debbie R. Summers David Z. Wang Max Wintermark Howard Yonas 李海峰(译) 岳耀先(译) 王琦(译) 张贤军(译) 丁晓君(译) | 2013 | 国际脑血管病杂志2013，21，8： | 975 |
| 2 | Aggressive blood pressure treatment of hypertensive intracerebral hemorrhage may lead to global cerebral hypoperfusion:Case report and imaging perspective显示文摘Hypoperfusion injury related to blood pressure decrease in acute hypertensive intracerebral hemorrhage continues to be a controversial topic. Aggressive treatment is provided with the intent to stop the ongoing bleeding. However, there may be additional factors, including autoregulation and increased intracranial pressure, that may limit this approach. We present here a case of acute hypertensive intracerebral hemorrhage, in which aggressive blood pressure management to levels within the normal range led to global cerebral ischemia within multiple border zones. Global cerebral ischemia may be of concern in the management of hypertensive hemorrhage in the presence of premorbid poorly controlled blood pressure and increased intracranial pressure. | Jose Gavito-Higuera Rakesh Khatri Ihtesham A Qureshi Alberto Maud Gustavo J Rodriguez | 2017 | World Journal of Radiology2017，9，12： | 49 |
| 3 | Current oncologic applications of radiofrequency ablation therapies显示文摘Radiofrequency ablation (RFA) uses high frequency alternating current to heat a volume of tissue around a needle electrode to induce focal coagulative necrosis with minimal injury to surrounding tissues. RFA can be performed via an open, laparoscopic, or image guided percutaneous approach and be performed under general or local anesthesia. Advances in delivery mechanisms, electrode designs, and higher power generators have increased the maximum volume that can be ablated, while maximizing oncological outcomes. In general, RFA is used to control local tumor growth, prevent recurrence, palliate symptoms, and improve survival in a subset of patients that are not candidates for surgical resection. It's equivalence to surgical resection has yet to be proven in large randomized control trials. Currently, the use of RFA has been well described as a primary or adjuvant treatment modality of limited but unresectable hepatocellular carcinoma, liver metastasis, especially colorectal cancer metastases, primary lung tumors, renal cell carcinoma, boney metastasis and osteoid osteomas. The role of RFA in the primary treatment of early stage breast cancer is still evolving. This review will discuss the general features of RFA and outline its role in commonly encountered solid tumors. | Dhruvil R Shah Sari Green Angelina Elliot John P McGahan Vijay P Khatri | 2013 | World Journal of Gastrointestinal Oncology2013，5，4： | 33 |
| 4 | Complications in the management of closed high-energy proximal tibial plateau fractures显示文摘 | Kavin Khatri Vijay Sharma Darsh Goyal Kamran Farooque | 2016 | Chinese Journal of Traumatology2016，19，6： | 18 |
| 5 | 急性缺血性卒中患者早期处理指南:美国心脏协会/美国卒中协会对医疗专业人员的指南显示文摘背景和目的作者提供了关于成年急性缺血性卒中患者评估和治疗方面的现有证据和处理推荐的一份概述。目标读者为涉及急性缺血性卒中患者发病48h内诊治的院前诊疗人员、医生、综合医疗保健人员和医院管理者。该指南将取代先前的2007年版指南及其2009年更新版。方法著述委员会成员由美国卒中协会卒中委员会的科学声明监督委员会指定,代表各个领域的医疗专家。在形成共识的整个过程中,严格遵循美国心脏协会的利益冲突原则。委员会成员被分配给与其专业领域相关的内容,对卒中文献进行回顾,重点为前一版指南发表之后的文献,然后按照美国心脏协会卒中委员会的证据强度分级方案起草推荐意见。结果本指南的目的是减少卒中相关的残疾和死亡。本指南支持卒中医疗体系的全局性概念以及从患者识别、急救医疗服务激活、转送和分诊到急诊室和卒中单元内最初数小时诊治的卒中诊治细节。本指南讨论了早期卒中评估和一般治疗、缺血性卒中治疗、特殊干预措施,如再灌注策略以及脑复苏的一般生理学干预原则。结论由于许多推荐意见基于有限的证据,还迫切需要对急性缺血性卒中的治疗做进一步的研究。 | Edward C. Jauch Jeffrey L. Saver Harold P. Adams Askiel Bruno J.J. (Buddy) Connors Bart M. Demaerschalk Pooja Khatri Paul W. McMullan Jr, Adnan I. Qureshi Kenneth Rosenfield Phillip A. Scott Debbie R. Summers David Z. Wang Max Wintermark Howard Yonas 李海峰(译) 岳耀先(译) 王琦(译) 张贤军(译) 丁晓君(译) | 2013 | 国际脑血管病杂志2013，21，7： | 17 |
| 6 | 口服抗栓药物预防非瓣膜性房颤患者的卒中:美国心脏协会/美国卒中协会的科学建议显示文摘成年房颤患者的卒中发生率,依据合并症和既往脑血管事件史,为每年1%~20%不等(平均每年为4.5%)。对卒中风险的分层非常重要,因为用抗栓药降低房颤导致卒中的主要风险是出血。如华法令在减少缺血性事件风险的同时,每年有1%~12% | 戴若莲 糜建华 华驾略 董荃 苏爱萍 李焰生 Furie KL Goldstein LB Albers GW Khatri P Neyens R Turakhia MP Turan TN Wood KA | 2012 | 神经病学与神经康复学杂志2012，9，3： | 12 |
| 7 | Minimally invasive osteosynthesis of distal tibial fractures using anterolateral locking plate: Evaluation of results and complications显示文摘 | Devendra Lakhotia Gaurav Sharma Kavin Khatri G.N. Kiran Kumar Vijay Sharma Kamran Farooque | 2016 | Chinese Journal of Traumatology2016，19，1： | 11 |
| 8 | Laparoscopic 肝切除术: 当前的角色和限制显示文摘 Laparoscopic liver resection (LLR) for the treatment of benign and malignant liver lesions is often performed at specialized centers. Technological advances, such as laparoscopic ultrasonography and electrosurgical tools, have afforded surgeons simultaneous improvements in surgical technique. The utilization of minimally invasive techniques for liver resection has been reported to reduce operative time, decrease blood loss, and shorten length of hospital stay with equivalent postoperative mortality and morbidity rates compared to open liver resection (OLR). Non-anatomic liver resection and left lateral sectionectomy are now routinely performed laparoscopically at many institutions. Furthermore, major hepatic resections are performed by pure laparoscopy, hand-assisted technique, and the hybrid method. In addition, robotic surgery and single port surgery are revealing early promising results. The consensus recommendation for the treatment of benign liver disease and malignant lesions remains unchanged when considering a laparoscopic approach, except when comorbidities and anatomic limitations of the liver lesion preclude this technique. Disease free and survival rates after LLR for hepatocellular carcinoma and metastatic colon cancer correspond to OLR. Patient selection is a significant factor for these favorable outcomes. The limitations include LLR of superior and posterior liver lesions; however, adjustments in technique may now consider a laparoscopic approach as a viable option. As growing data continue to reveal the feasibility and efficacy of laparoscopic liver surgery, this skill is increasingly being adopted by hepatobiliary surgeons. Although the full scope of laparoscopic liver surgery remains infrequently used by many general surgeons, this technique will become a standard in the treatment of liver diseases as studies continue to show favorable outcomes. | Rouzbeh Mostaedi Zoran Milosevic Ho-Seong Han Vijay P Khatri | 2012 | World Journal of Gastrointestinal Oncology2012，4，8： | 8 |
| 9 | Use of three-dimensional printing in preoperative planning in orthopaedic trauma surgery: A systematic review and meta-analysis显示文摘BACKGROUND With the increasing complexity of surgical interventions performed in orthopaedic trauma surgery and the improving technologies used in threedimensional(3D)printing,there has been an increased interest in the concept.It has been shown that 3D models allow surgeons to better visualise anatomy,aid in planning and performing complex surgery.It is however not clear how best to utilise the technique and whether this results in better outcomes.AIM To evaluate the effect of 3D printing used in pre-operative planning in orthopaedic trauma surgery on clinical outcomes.METHODS We performed a comprehensive systematic review of the literature and a metaanalysis.Medline,Ovid and Embase were searched from inception to February 8,2018.Randomised controlled trials,case-control studies,cohort studies and case series of five patients or more were included across any area of orthopaedic trauma.The primary outcomes were operation time,intra-operative blood loss and fluoroscopy used.RESULTS Seventeen studies(922 patients)met our inclusion criteria and were reviewed.The use of 3D printing across all specialties in orthopaedic trauma surgery demonstrated an overall reduction in operation time of 19.85%[95%confidence intervals(CI):(-22.99,-16.71)],intra-operative blood loss of 25.73%[95%CI:(-31.07,-20.40)],and number of times fluoroscopy was used by 23.80%[95%CI:(-38.49,-9.10)].CONCLUSION Our results suggest that the use of 3D printing in pre-operative planning in orthopaedic trauma reduces operative time,intraoperative blood loss and the number of times fluoroscopy is used. | Catrin Morgan Chetan Khatri Sammy A Hanna Hutan Ashrafian Khaled M Sarraf | 2020 | World Journal of Orthopedics2020，11，1： | 7 |
| 10 | Out of hospital cardiac arrest resuscitation outcome in North India—CARO study显示文摘BACKGROUND: To evaluate the outcome of cardiopulmonary resuscitation(CPR) in out-ofhospital cardiac arrests(OHCA) in India and factors infl uencing the outcome.METHODS: The outcome and related factors like demographics, aspects of the OHCA event, return of spontaneous circulation(ROSC) and survival to discharge, among the 80 adult patients presenting to emergency department experiencing OHCA considered for resuscitation between January 2014 to April 2015, were analyzed, according to the guidelines of the Utstein consensus conference.RESULTS: The survival rate to hospital admission was 32.5%, the survival rate to hospital discharge was 8.8% and with good cerebral performance category(CPC1) neurological status was 3.8%. Majority of OHCA was seen in elderly individuals between 51 to 60 years, predominately in males. Majority of OHCA were witnessed arrests(56.5%) with 1.3% bystander CPR rate, 92.5% arrests occurred at home, 96% presented with initial non-shockable rhythm and 92.5% with presumed cardiac etiology but survival was better in those who experienced OHCA at public place, in witnessed arrests, in patients who had shockable presenting rhythm and in those where CPR duration was ≤20 minutes.CONCLUSION: Witnessed arrests, early initiation of CPR by bystanders, CPR duration ≤20 minutes, initial presenting shockable rhythm, OHCA with non-cardiac etiology are associated with a good outcome. To improve the outcome of CPR and the low survival rates after an OHCA event in India, focused strategies should be designed to set up an emergency medical system(EMS), to boost the rates of bystander CPR and education of the lay public in basic CPR. | Chennappa Kalvatala Krishna Hakim Irfan Showkat Meenakshi Taktani Vikram Khatri | 2017 | World Journal of Emergency Medicine2017，8，3： | 7 |
| 11 | A deep convolutional neural network for real-time full profile analysis of big powder diffraction data显示文摘We present Parameter Quantification Network(PQ-Net),a regression deep convolutional neural network providing quantitative analysis of powder X-ray diffraction patterns from multi-phase systems.The network is tested against simulated and experimental datasets of increasing complexity with the last one being an X-ray diffraction computed tomography dataset of a multi-phase Ni-Pd/CeO_(2)-ZrO_(2)/Al_(2)O_(3) catalytic material system consisting of ca.20,000 diffraction patterns.It is shown that the network predicts accurate scale factor,lattice parameter and crystallite size maps for all phases,which are comparable to those obtained through full profile analysis using the Rietveld method,also providing a reliable uncertainty measure on the results.The main advantage of PQNet is its ability to yield these results orders of magnitude faster showing its potential as a tool for real-time diffraction data analysis during in situ/operando experiments. | Hongyang Dong Keith T.Butler Dorota Matras Stephen W.T.Price Yaroslav Odarchenko Rahul Khatry Andrew Thompson Vesna Middelkoop Simon D.M.Jacques Andrew M.Beale Antonis Vamvakeros | 2021 | npj Computational Materials2021，，1： | 5 |
| 12 | Fluoroalcohol-mediated reductive iodonio-Claisen rearrangement: Synthesis of complex ortho-substituted-allyl iodoarenes显示文摘在 fluoroalcohols 包含 3-iodanes 和 allyl 或 substituted-allyl silanes 的减少的 iodonio-Claisen 重新整理(RICR ) 例如 1,1,1,3,3,3-hexafluoroisopropanol (HFIP ) 和 2,2,2-trifluoroethanol (TFE ) ,为复杂 ortho-allyl 或 substituted-allyl iodoarenes 的合成被学习。与包含硼 trifluoride diethyl etherate 的以前报导的条件相比, RICR 由 fluoroalcohols 调停了被发现更有效地继续。产生复杂 ortho-allyl iodoarenes 是有用合成中介并且能乐意地被变换成各种各样的杂环的混合物。 | Hem Raj Khatri Hai Nguyen James K. Dunaway Jianglong Zhu | 2015 | Frontiers of Chemical Science and Engineering2015，9，3： | 4 |
| 13 | 口服抗栓药预防非瓣膜性心房颤动患者卒中:美国心脏协会/美国卒中协会对医疗卫生专业人员的科学建议显示文摘成年心房颤动(atrial fibrillation,AF)患者的卒中发生率存在很大差异,其范围为每年1%~20%(平均4.5%/年),取决于合并症和既往脑血管事件病史。卒中风险分层十分重要,因为用于降低AF相关性卒中发生率的抗栓药的主要风险是出血。对于华法林而言,这涉及到对出血风险(每年1%~12%)与缺血性事件风险的权衡,它通常被用于血栓栓塞风险最高的那些患者。 | Karen L. Furie LarryB. Goldstein Gregory W. Albers Pooja Khatri Ron Neyens Mintu P. Turakhia Tanya N. Turan Kathryn A. Wood 严晓铭(译) 何晟(译) 丁妹(译) 柯开富(译) | 2012 | 国际脑血管病杂志2012，20，12： | 3 |
| 14 | Matrix Metalloproteinases in Vascular Remodeling and Atherogenesis: The Good, the Bad, and the Ugly显示文摘 | Zorina S. Galis Jaikirshan J. Khatri | 2002 | Circulation Research: Journal of the American Heart Association2002，，3： | 3 |
| 15 | 印度结核病控制的现状与展望显示文摘背景:有关结核病控制的全球策略多数是在印度建立。但是,在印度每年估计有200万结核病人发生。 目的:本文报导了印度在修订后的国家结核病控制规划内,应用DOTS原则作为控制政策及其初步的结果。 设计:修订后的国家结核病控制规划于1993年开始设计和实施,资金来源于印度政府、邦政府、世界银行和双边支持的赞助商。常规的药品供应和后勤服务得到了保证。有呼吸道症状的人都能到卫生机构并转到显微镜检查中心进行诊断,病人分类根据WHO的大纲,病人治疗采用督导化疗,实施了系统的登记和队列报告。 结果:自1993年10月至1999年中,规划内治疗病人146012例,病人诊断的质量得到改善,涂阳病人与涂阴病人的比例为1:1。病人发现率在项目地区之间有不同程度的进步,与接受诊断检查的人群中涂阳病人百分比有关,提示疾病的不均衡性。新涂阳病人的治疗成功率达81%,新涂阴病人达82%,肺外结核病人达89%,复治病人的成功率为70%。 结论:在印度15个邦的20个区,大约80%的病人在国家规划中获得成功的治疗。治疗成功率比以前的规划提高一倍,死亡率得到下降,为原先的1/7。自1998年后期开始,新规划逐渐扩展,至今已覆盖1.3亿人口,在进一步扩展期间,保持实施质量是进一步的挑战。 | G. R. Khatri T. R. Frieden 赵丰曾 | 2001 | 国际结核病与肺部疾病杂志2001，，3： | 2 |
| 16 | Sitagliptin,sitagliptin and metformin,or sitagliptin and amitriptyline attenuate streptozotocin-nicotinamide induced diabetic neuropathy in rats显示文摘Diabetic neuropathies are a family of nerve disorders caused by diabetes.Symptoms of the disease include nerve palsy,mononeuropathy,mononeuropathy multiplex,diabetic amyotrophy,painful polyneuropathy,autonomic neuropathy,and thoracoabdominal neuropathy.In this study,type 2 diabetes in rats was induced with nicotinamidestreptozotocin.Drug treatment was initiated on the d 15,with the combination regimen of metformin,pioglitazone and glimipiride or metformin and sitagliptin or sitagliptin,amitriptyline and sitagliptin and led to significantly improved glycemic control,increased grip strength and paw jumping response on d 21,28 and 35(P < 0.001).Significant increases in blood protein levels and decreases in urinary protein levels were observed in the animals treated with the different regimens on d 21,28 and 35(P < 0.001).Combined treatment of streptozotocin and nicotinamide caused marked degeneration of nerve cells,while administration of metformin and sitagliptin showed tissue regeneration and no body weight gain.In conclusion,treatment with sitagliptin and sitagliptin combined with metformin or amitriptyline results in no body weight gain,but causes an increase in grip strength and pain sensitivity,exhibits neural protection,and reverses the alteration of biochemical parameters in rats with streptozotocin-nicotinamide induced type 2 diabetes. | Ashish Kumar Sharma Akash Sharma Rita Kumari Kunal Kishore Divya Sharma Bharthu Parthsarthi Srinivasan Ashok Sharma Santosh Kumar Singh Samir Gaur Vijay Singh Jatav Prashant Sharma Varnika Srivastava Sneha Joshi Megha Joshi Prashant Kumar Dhakad Davender Singh Kanawat Akanksha Mishra Anil Sharma Dharmendra Singh Ravinder Pal Singh Himmat Singh Chawda Rambir Singh Sachin Kumar Raikwar Muneem Kumar Kurmi Pankaj Khatri Ashutosh Agarwal Arshee Munajjam | 2012 | The Journal of Biomedical Research2012，26，3： | 2 |
| 17 | Combined fracture dislocation of the navicular bone along with cuboid, cuneiform and longitudinal split fracture of the lateral malleolus: a rare combination of fractures显示文摘船形的骨头,长方体的破裂,楔形文字,和侧面的踝的纵的裂口骨折的破裂脱臼是破裂的稀罕联合。这是高速度损害破裂并且能被脚的强迫的脚底的屈曲和倒置在影响的时候引起到地面上。这里,我们在被开的减小和固定为侧面的踝与三分之一个管状的盘子为船形的骨头,和二个 interfragmentary 螺丝钉与一个部分线程的螺丝钉和二 K 电线对待的一个 35 岁的男病人报导了如此的一个案例。K 电线被移开 6 在外科以后的星期由部分重量适用列在后面。在 6 以后;月,病人能最小的疼痛地通常走并且脚胀大。 | Kapil Mani Khatri Chhetri Parimal Acharya Dirgha Raj Rokaya Chhetri | 2014 | Chinese Journal of Traumatology2014，17，6： | 2 |
| 18 | Reliability and reproducibility issues in DNA microarray measurements显示文摘 | Draghici S Khatri P Eklund AC | 2006 | Trends Genet2006，22，2： | 1 |
| 19 | Ontological analysis of gene expression data: current tools, limitations, and open problems显示文摘 | KHATRI P DRAGHICI S | 2005 | Bioinformatics2005，21，18： | 1 |
| 20 | Evidence- based guideline update: Plasmapheresis in neurologic disorders 显示文摘 | Khatri BO McQuillen MP Kaminski H | 2011 | Neurology2011，77，： | 1 |
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