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| 1 | Recent advances in the diagnosis and treatment of acute myocardial infarction显示文摘The Third Universal Definition of Myocardial Infarction(MI) requires cardiac myocyte necrosis with an increase and/or a decrease in a patient's plasma of cardiac troponin(cT n) with at least one cT n measurement greater than the 99 th percentile of the upper normal reference limit during:(1) symptoms of myocardialischemia;(2) new significant electrocardiogram(ECG) ST-segment/T-wave changes or left bundle branch block;(3) the development of pathological ECG Q waves;(4) new loss of viable myocardium or regional wall motion abnormality identified by an imaging procedure; or(5) identification of intracoronary thrombus by angiography or autopsy.Myocardial infarction,when diagnosed,is now classified into five types.Detection of a rise and a fall of troponin are essential to the diagnosis of acute MI.However,high sensitivity troponin assays can increase the sensitivity but decrease the specificity of MI diagnosis.The ECG remains a cornerstone in the diagnosis of MI and should be frequently repeated,especially if the initial ECG is not diagnostic of MI.There have been significant advances in adjunctive pharmacotherapy,procedural techniques and stent technology in the treatment of patients with MIs.The routine use of antiplatelet agents such as clopidogrel,prasugrel or ticagrelor,in addition to aspirin,reduces patient morbidity and mortality.Percutaneous coronary intervention(PCI) in a timely manner is the primary treatment of patients with acute ST segment elevation MI.Drug eluting coronary stents are safe and beneficial with primary coronary intervention.Treatment with direct thrombin inhibitors during PCI is non-inferior to unfractionated heparin and glycoprotein Ⅱb/Ⅲa receptor antagonists and is associated with a significant reduction in bleeding.The intra-coronary use of a glycoprotein Ⅱb/Ⅲa antagonist can reduce infarct size.Pre- and post-conditioning techniques can provide additional cardioprotection.However,the incidence and mortality due to MI continues to be high despite all these recent advances.The initial ten year experience with autologous human bone marrow mononuclear cells(BMCs) in patients with MI showed modest but significant increases in left ventricular(LV) ejection fraction,decreases in LV endsystolic volume and reductions in MI size.These studies established that the intramyocardial or intracoronary administration of stem cells is safe.However,many of these studies consisted of small numbers of patients who were not randomized to BMCs or placebo.The recent LateT ime,Time,and Swiss Multicenter Trials in patientswith MI did not demonstrate significant improvement in patient LV ejection fraction with BMCs in comparison with placebo.Possible explanations include the early use of PCI in these patients,heterogeneous BMC populations which died prematurely from patients with chronic ischemic disease,red blood cell contamination which decreases BMC renewal,and heparin which decreases BMC migration.In contrast,cardiac stem cells from the right atrial appendage and ventricular septum and apex in the SCIPIO and CADUCEUS Trials appear to reduce patient MI size and increase viable myocardium.Additional clinical studies with cardiac stem cells are in progress. | Koushik Reddy Asma Khaliq Robert J Henning | 2015 | World Journal of Cardiology2015，7，5： | 107 |
| 2 | Dual behavior of HCV Core gene in regulation of apoptosis is important in progression of HCC显示文摘 | Shah Jahan Usman A. Ashfaq Saba Khaliq Baila Samreen Nadeem Afzal | 2012 | Infection Genetics and Evolution2012，，2： | 4 |
| 3 | Gene-gene,gene-environment,gene-nutrient interactions and single nucleotide polymorphisms of inflammatory cytokines显示文摘Inflammation plays a significant role in the etiology of type 2 diabetes mellitus(T2DM).The rise in the pro-inflammatory cytokines is the essential step in glucotoxicity and lipotoxicity induced mitochondrial injury,oxidative stress and beta cell apoptosis in T2 DM.Among the recognized markers are interleukin(IL)-6,IL-1,IL-10,IL-18,tissue necrosis factor-alpha(TNF-α),C-reactive protein,resistin,adiponectin,tissue plasminogen activator,fibrinogen and heptoglobins.Diabetes mellitus has firm genetic and very strong environmental influence; exhibiting a polygenic mode of inheritance.Many single nucleotide polymorphisms(SNPs) in various genes including those of pro and antiinflammatory cytokines have been reported as a risk for T2 DM.Not all the SNPs have been confirmed by unifying results in different studies and wide variations have been reported in various ethnic groups.The inter-ethnic variations can be explained by the fact that gene expression may be regulated by gene-gene,gene-environment and gene-nutrient interactions.This review highlights the impact of these interactions on determining the role of single nucleotide polymorphism of IL-6,TNF-α,resistin and adiponectin in pathogenesis of T2 DM. | Amina Nadeem Sadaf Mumtaz Abdul Khaliq Naveed Muhammad Aslam Arif Siddiqui Ghulam Mustafa Lodhi Tausif Ahmad | 2015 | World Journal of Diabetes2015，6，4： | 4 |
| 4 | BiVO4-Cu2O/CuO双光电极自偏压光电催化降解苯酚研究显示文摘基于费米能级差,构建了以BiVO_4为光阳极,Cu_2O/CuO为光阴极的双光电极可见光响应光催化燃料电池体系,研究了该体系在不同氧化剂的辅助作用下光电催化降解苯酚的效率与动力学.结果表明,向该体系中投加H_2O_2可以显著促进苯酚的降解,且反应过程光电流稳定,铜溶出量低.详细探究了H_2O_2初始浓度、pH对降解的影响,结果表明在H_2O_2投加量为5 mmol·L^(-1),初始pH为3.5条件下利于苯酚降解,5 mg·L^(-1)的苯酚可在120 min内完全去除.顺磁共振和猝灭实验表明该体系的主要氧化物种为·OH、·O^-_2和光生空穴.该催化体系实现了苯酚在可见光下的高效催化降解. | 李霞 崔玥昕 王雁 Abdul khaliq Jan 赵旭 | 2018 | 环境科学学报2018，38，11： | 2 |
| 5 | Identification of novel TYR and TYRP1 mutations in oculocutaneous albinism显示文摘 | Forshew T Khaliq S Tee L | 2005 | Clin Genet2005，68，2： | 1 |
| 6 | Increasing the efficiency of sorghum water extract by mixing with lower doses of isoproturon to control weeds in wheat 显示文摘 | Jamil M Cheema Z A Khaliq A | 2005 | International Journal of Agriculture & Biology2005，7，5： | 1 |
| 7 | Syn-thesis and crystal structures of three pyrazine-2-car-boxylate containing isostructural complexes : M ( 2-pyrazine-carboxylate ) 3 ( M = Co3+,Cr3+,and Rli3+ )显示文摘 | Ellsworth J M Khaliq Z M Seward K L | 2007 | J Chem Crystallogr2007，37，： | 1 |
| 8 | 13C-NMR spectroscopy of Dand B,dring seco-limonoids of Meliaceae family显示文摘 | Narender T Khaliq T Shweta | 2008 | NatProd Res2008，22，9： | 1 |
| 9 | Effects of vesicular-arbuscular mycorrhizalinoculation on the yield and phosphorus uptake of field-grownbarley 显示文摘 | Khaliq A Sanders F E | 2000 | Soil Biology and Biochemistry2000，32，： | 1 |
| 10 | Solitary ex- tramedullary plasmacytoma of the bladder:a case report and literature 显示文摘 | Khaliq W Uzoaru l Konchanin RP | 2010 | Oncology (Williston Park)2010，24，9： | 1 |
| 11 | The effects of growth factors and conditioned media on the proliferation of human corneal epithelial cells and keratocytes显示文摘 | Sunil Pancholi Andrew Tullo Asud Khaliq David Foreman Mike Boulton | 1998 | Graefe’s Archive for Clinical and Experimental Ophthalmology1998，，1： | 1 |
| 12 | A fourth-order compact algorithm for nonlinear reaction-diffusion with Neumann boundary conditions 显示文摘 | LIAO W ZHU J KHALIQ A Q M | 2006 | Numerical Methods of Partial Differential Equations2006，22，： | 1 |
| 13 | Evaluation and improvement of CDS-based topology control for wireless sensor networks显示文摘 | Hassaan Khaliq Qureshi Sajjad Rizvi Muhammad Saleem Syed Ali Khayam Veselin Rakocevic Muttukrishnan Rajarajan | 2013 | Wireless Networks2013，，1： | 1 |
| 14 | Antimicrobial susceptibili- ty pattern of clinical isolates of Pseudomonas aeruginosa isolat- ed from patients of lower respiratory tract infections显示文摘 | Fatima A Naqvi S B Khaliq S A | 2012 | Spring- erplus2012，1，1： | 1 |
| 15 | Introducing problem-based learning in physiology in the conventional Indian medical curriculum显示文摘 | Bhattacharya N Shankar N Khaliq F | 2005 | Natl Med J India2005，18，2： | 1 |
| 16 | RP1 protein truncating mutations predominate at the RP1 adRP locus显示文摘 | Vithana E Khaliq S Hameed A Deller J Abu-Safieh L | 2000 | Invest Ophthalmol Vis Sci2000，41，13： | 1 |
| 17 | Hypoxia down-regulates placenta growth factor,whereas fetal growth restriction up -regulates placenta growth factor expression:molecular evidence for 'placental hyperoxia' in intrauterine growth restriction显示文摘 | Khaliq A Dunk C Jiang J | 1999 | Lab Invest1999，79，2： | 1 |
| 18 | A fourth-order compact algorithm for nonlinear reac- tion diffusion equations with Neumann boundary conditions显示文摘 | Liao W Y Zhu J P and Khaliq A Q M | 2006 | Numerical Methods for Partial Differential Equations2006，22，： | 1 |
| 19 | Inhibition of hepatitis C virus genotype 3a by siRNAs targeting envelope genes显示文摘 | Khaliq S Jahan S Ljaz B | 2011 | Arch Virol2011，156，3： | 1 |
| 20 | Inhibition of hepatitis C virus geno- type 3 a by siRNAs targeting envelope genes 1 显示文摘 | Khaliq S Jahan S Ljaz B | 2011 | Arch Virol2011，156，3： | 1 |
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