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| 1 | Tumor necrosis factor-α and interleukin-6 in cirrhotic patients with spontaneous bacterial peritonitis显示文摘AIM:To evaluate the role of tumor necrosis factor-α(TNF-α) and interleukin-6(IL-6) in cirrhotic patients who have hepatic and renal impairment with spontaneous bacterial peritonitis(SBP).METHODS:We prospectively studied 120 cirrhotic patients with SBP and 80 cirrhotic patients with sterile ascitic fluid.They included 144 males and 56 females with ages ranging between 34 and 62 years.The diagnosis of cirrhosis was established by clinical and laboratory criteria that did not require histological confirmation.The severity of underlying liver disease was evaluated using Pugh's modification of Child's criteria(Child-Pugh scores).Ascitic fluid was sent to the laboratory for cell count,culture,sensitivity testing,and measurement of chemical elements(i.e.,albumin,glucose).Specimens were inoculated into aerobic and anaerobic blood culture bottles.Serum and ascitic fluid were also collected in sterile tubes at study entry(before the initiation of antibiotic treatment) and 48 h later.Assays for TNF-α and IL-6 in the serum and ascitic fluid were performed with an immunoenzymometric assay using manufacture's instructions.RESULTS:Cytokine levels in serum and ascitic fluid were significantly higher in the patients with SBP.(plasma TNF-α:135.35 ng/mL ± 11.21 ng/mL vs 92.86 ng/mL ± 17.56 ng/mL,P < 0.001;plasma IL-6:32.30 pg/mL ± 7.07 pg/mL vs 12.11 pg/mL ± 6.53 pg/mL,P < 0.001;ascitic fluid TNF-α:647.54 ± 107.11 ng/mL vs 238.43 ng/mL ± 65.42 ng/mL,P < 0.001);ascitic fluid IL-6:132.84 ng/mL ± 34.13 vs 40.41 ± 12.85 pg/mL,P < 0.001).About 48(40%) cirrhotic patients with SBP developed renal and hepatic impairment and showed significantly higher plasma and ascitic fluid cytokine levels at diagnosis of infection.[(plasma TNF-α:176.58 ± 17.84 vs 135.35 ± 11.21 ng/mL)(P < 0.001) and(IL-6:57.83 ± 7.85 vs 32.30 ± 7.07 pg/mL)(P < 0.001);ascitic fluid TNF-α:958.39 ± 135.72 vs 647.54 ± 107.11 ng/mL,(P < 0.001),ascitic fluid IL-6:654.74 ± 97.43 vs 132.84 ± 34.13 pg/mL,(P < 0.001)].Twenty nine patients(60.4%) with SBP and renal impairment died whereas,only four patients(5.55%) with SBP but without renal impairment died from gastrointestinal hemorrhage(P < 0.0005).CONCLUSION:It appears that TNF-α production may enhance liver cell injury and lead to renal impairment.This correlated well with the poor prognosis and significantly increased mortality associated with SBP in cirrhotic patients. | Muhammed AM Suliman Fawzy MH Khalil Salam SA Alkindi Anil V Pathare Ali AA Almadhani Neveen AAI Soliman | 2012 | World Journal of Gastrointestinal Pathophysiology2012，3，5： | 39 |
| 2 | The genotoxic and cytotoxic activities of inorganic fluoride in cultured rat bone marrow cells 显示文摘 | Khalil AM Da'dara AA | 1994 | Arch Environ Contam Toxicol1994，26，1： | 1 |
| 3 | RNA-protein interactions in human health and disease显示文摘 | Khalil AM Rinn JL | | 0，，04： | 1 |
| 4 | Is trade good for environment? A unit, root, cointe^ation analysis 显示文摘 | KHALIL S IN AM Z | 2006 | Pakistan Development Review2006，，4： | 1 |
| 5 | Expression of a non- coding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase 显示文摘 | Faghihi MA Modarresi F Khalil AM | 2008 | Nat Med2008，14，： | 1 |
| 6 | Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression显示文摘 | Khalil AM Guttman M Huarte M | 2009 | Proc N atl Acad Sci USA2009，106，11： | 1 |
| 7 | Squamous cell carcino- ma of the cervix implanting in the episiotomy site 显示文摘 | Khalil AM Khatib RA Mufarrij AA | 1993 | Gynecol 0nco11993，51，： | 1 |
| 8 | Expression of a noncoding RNA is elevated in Alzheimer' s disease and drives rapid feed-forward regulation of beta-secretase显示文摘 | Faghihi MA Modarresi F Khalil AM | | 0，，07： | 1 |
| 9 | Emerging Roles for Long Non- Coding RNAs in Cancer and Neurological Disorders 显示文摘 | Niland CN Merry CR Khalil AM | 2012 | FrontGenet2012，3，： | 1 |
| 10 | Microcystin induced 8-hydroxydeoxyguanosine in DNA and its reduction by melatonin, vitamin C, and vitamin E in mice显示文摘 | Al-Jassabi S Khalil AM | 2006 | Biochem2006，71，10： | 1 |
| 11 | Emerging roles for long non-coding RNAs in cancer and neurological disorders 显示文摘 | Niland CN Merry CR Khalil AM | 2012 | Front Genet2012，3，： | 1 |
| 12 | Primary malignant lymphoma of the uterine cervix:is radiotherapy the best therapeutic choice for stage I E?显示文摘 | Awwad JT Khalil AM Shamseddine AI | 1994 | Gynecol Oncol1994，52，： | 1 |
| 13 | Review of nonsurgical and surgical treatment and role of insulin sensitizi-ng in the management of infertile women with polycystic ovary snydrome显示文摘 | Saleh AM Khalil HS | 2004 | Acta Obstet Gyneco-l Scand2004，83，7： | 1 |
| 14 | Expression of noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase 显示文摘 | Faghihi MA Modarresi F Khalil AM | 2008 | Nat Med2008，14，7： | 1 |
| 15 | Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase 显示文摘 | Faghihi MA Modarresi F Khalil AM | 2008 | Nat Med2008，14，7： | 1 |
| 16 | Transforming growth factor-beta1 SNPs: genetic and phenotypic correlations in progressive kidney insufficiency显示文摘 | Khalil MS El Nahas AM Blakemore AI | 2005 | Nephron Exp Nephrol2005，101，： | 1 |
| 17 | Effect of dehydroepiandros- terone (dhea) on memory and brain derived neurotrophic factor (bdnf) in a rat model of vascular dementia 显示文摘 | Sakr HF Khalil KI Hussein AM | 2014 | J Physiol Pharma- col2014，65，1： | 1 |
| 18 | Emerging functional and mechanistic paradigms of mammalian long non-coding RNAs显示文摘 | Moran VA Perera RJ Khalil AM | 2012 | Nucleic Acids Res2012，40，14： | 1 |
| 19 | Running induces widespread structural alterations in the hippocampus and entorhinal cortex显示文摘 | Stranahan AM Khalil D Gould E | 2009 | Hippocampus2009，17，11： | 1 |
| 20 | Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase 显示文摘 | Faghihi MA Modarresi F Khalil AM | 2008 | Nat Med2008，14，7： | 1 |
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