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| 1 | Expression of the oxygen-sensitive transcription factor subunit HIF-1α in patients suffering from secondary Raynaud syndrome显示文摘Anti-ischemic therapy remains a challenge due to the complexity of hypoxia response pathways. Hypoxia-inducible factor (HIF)-1 is a heterodimer tran scription factor con sisti ng of 2 sub units, HIF-1α and HIF-1β. Hypoxia-depe ndent activatio n of HIF-1α regulates cellular 02 homeostasis. Raynaud syndrome (RS), as a comorbidity of the autoimmune disease systemic sclerosis (SS), is characterized by vasospasms that limit blood flow to the limbs, resulting in hypoxia. A single-center randomized study was con ducted to compare prostagla ndin E1 (PgEI) therapy with a treatme nt combi ning PgE1 and an en dotheli n-1 blocker, bosentan. A total of 30 patients suffering from SS with RS were enrolled. We examined the regulation of HIF-1α, its target heme oxygenase-1 (HMOX-1), and the serum levels of the HIF-1α protein in a subset of patients as well as in ten healthy individuals. The expression of HIF-1α and HMOX-1 in monocytes was measured using absolute plasmid-based quantitative real-time PCR, whereas serum HIF-1α levels were measured with ELISA. Samples were taken at the time of randomization and after 24 weeks. We found that HIF-1α and HMOX-1 mRNA expression in monocytes and serum HIF-1α protein levels were significantly higher in the SS/RS patients compared to the healthy control group. Single-drug therapy significantly increased HIF-1α and HMOX-1 mRNA expression in monocytes and serum HIF-1α protein levels in the SS/RS patients compared to those at the time of randomization, whereas combining PgE1 with an en dotheli n-1 blocker preve nted the further in creases in HIF-1α and HMOX-1 expressi on. We propose HIF-1α and HMOX-1 as novel markers for anti-ischemic therapy in RS. | Lukas Andreas Heger Mark Kerber Marcus Hortmann Samuel Robinson Maximilian Mauler Daniela Stallmann Daniel Duerschmied Christoph Bode Christoph Hehrlein Ingo Ahrens | 2019 | Acta Pharmacologica Sinica2019，40，4： | 5 |
| 2 | Origin of the threshold voltage instability in SiO2/HfO2 dual layer gate dielectrics 显示文摘 | KERBER A CARTIER E PANTISANO L | 2003 | IEEE EDL2003，24，2： | 1 |
| 3 | Phase I study of highly selective supradose cisplatin infusions for advanced head and neck cancer显示文摘 | Robbins KT Storniolo AM Kerber C | 1994 | J Clin Oncol1994，12，10： | 1 |
| 4 | Familial pre- disposition to developmental dysplasia of the hip 显示文摘 | Stevenson DA Mineau G Kerber RA | 2009 | J Ped- iatr Orthop2009，29，： | 1 |
| 5 | The anatomy of the cau- da equina on CT scans and MRI显示文摘 | Cohen MS Wall EJ Kerber CW | 1991 | J Bone Joint Surg Br1991，73，3： | 1 |
| 6 | Dynamic adhesive strength of fiber-polymer systems显示文摘 | T. V. Brantseva A. V. Antonov Yu. A. Gorbatkina M. L. Kerber T. P. Kravchenko A. A. Rybin | 1999 | Mechanics of Composite Materials1999，，6： | 1 |
| 7 | Stroke Among Patients With Dizziness, Vertigo, and Imbalance in the Emergency Department: A Population-Based Study显示文摘 | Kevin A. Kerber Devin L. Brown Lynda D. Lisabeth Melinda A. Smith Lewis B. Morgenstern | 2006 | Stroke2006，，10： | 1 |
| 8 | Flt-1 signaling in macrophages promotes glioma growth in vivo显示文摘 | Kerber M Reiss Y Wickersheim A | 2008 | Cancer Res2008，68，18： | 1 |
| 9 | Exercise-Induced Left Ventricular Systolic Dysfunction in Women Heterozygous for Dystrophinopathy显示文摘 | Robert M. Weiss Richard E. Kerber Jane K. Jones Carrie M. Stephan Christina J. Trout Paul D. Lindower Kimberly S. Staffey Kevin P. Campbell Katherine D. Mathews | 2010 | Journal of the American Society of Echocardiography2010，，8： | 1 |
| 10 | Stroke among patients with dizziness, vertigo, and imbalance in the emergency department: a population-based study 显示文摘 | Kerber KA Brown DL Lisabeth LD | 2006 | Stroke2006，37，10： | 1 |
| 11 | Disequilibrium in older people: a prospective study显示文摘 | KERBER KA | 1997 | Phys Ther1997，77，8： | 1 |
| 12 | Your Role in Hard- wiring EBP Strategies显示文摘 | Amato S Kerber K Yurko L | 2009 | Nurs Manage2009，40，6： | 1 |
| 13 | Kinetic Model and Computer Simulation for a pulsed DF-CO2 Chemical Transfer Laser显示文摘 | Kerber R L Cohen N Emanuel G | | 0，，01： | 1 |
| 14 | Probing disk properties with open clusters显示文摘 | BONATTO C KERBER L O BICA E | 2006 | A&A2006，446，1： | 1 |
| 15 | Origin of the threshing character in hexaploid wheat显示文摘 | Kerber R E Rowland G G | 1974 | Can J Genet Cytol1974，16，： | 1 |
| 16 | Rapid prototyping to create vascular replicas from CT scan data:making tools to teach ,rehearse,and choose treatment strategies 显示文摘 | Knox K Kerber CW Singel SA | 2005 | Catheter Cardiovasc Interv2005，65，1： | 1 |
| 17 | Passivation and interface state density of SiO/HfO-based/polycrystalline-Si gate stacks 显示文摘 | Carter R J Cartier E Kerber A | 2003 | Applied Physics Letters2003，，： | 1 |
| 18 | Stenting of vertebral artery origin atherosclerosis in high-risk patients:bare or coated? A single-center consecutive case series显示文摘 | Akins PT Kerber CW Pakbaz RS | 2008 | J Invasive Cardiol2008，20，1： | 1 |
| 19 | Stroke among patients with dizziness, vertigo, and imbalance in the emergency department : a population - based study 显示文摘 | Kerber KA Brown DL Lisabeth LD | 2006 | Stroke2006，37，10： | 1 |
| 20 | Hemodynamics of the central nervous system arteriovenous malformation nidus during particulate embolization显示文摘 | S. T. Hecht J. A. Horton C. W. Kerber | 1991 | Neuroradiology1991，，1： | 1 |
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