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| 1 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 2 | Origin of the threshold voltage instability in SiO2/HfO2 dual layer gate dielectrics 显示文摘 | KERBER A CARTIER E PANTISANO L | 2003 | IEEE EDL2003，24，2： | 1 |
| 3 | Defective human T - cell lympho- tropic virus type I (HTLV -I) provirus in 10 Chilean seronegative pa- tients with tropical spastic paraphrases or HTLV - I - associated myelop- athy 显示文摘 | Ramirez E Cartier L Rios M | 1998 | American Society for Microbiology1998，36，6： | 1 |
| 4 | Passivation and interface state density of SiO/HfO-based/polycrystalline-Si gate stacks 显示文摘 | Carter R J Cartier E Kerber A | 2003 | Applied Physics Letters2003，，： | 1 |
| 5 | The herpes simplex virus-1 Us3 protein kinase blocks CD8T cell lysis by preventing the cleavage of Bid by granzyme B 显示文摘 | Cartier A Broberg E Komai T | 2003 | Cell Death Differ2003，10，12： | 1 |
| 6 | Impact ionization and positive charge formation in silicon dioxide films on silicon 显示文摘 | Arnold D Cartier E | 1992 | Appl Phy Lett1992，60，： | 1 |
| 7 | Determinants of potency on alpha-conotoxin MII,a peptide antagonist of neuronal nicotinic receptors显示文摘 | Everhart D Cartier G E Malhotra A | 2004 | Biochemistry2004，43，10： | 1 |
| 8 | 显示文摘 | Gusev E P Copel M Cartier E | 2000 | Appl Phys Lett2000，76，： | 1 |
| 9 | Single-residue al- teration in alpha-conotoxin PnlA switches its nAChR sub- type selectivity 显示文摘 | Luo S Nguyen T A Cartier G E | 1999 | Biochem1999，38，14： | 1 |
| 10 | Ef- fective electron mobility in Si inversion layers in metal-oxide semiconductor systems with a high-k insulator: the role o{ re mote phonon scattering 显示文摘 | FISCHETTI M V NEUMAYER D A CARTIER E A | 2001 | Journal of Applied Physics2001，90，9： | 1 |
| 11 | High-resolution depth profiling in ultrathin Al2 O3 films on Si 显示文摘 | Gusev E P Copel M Cartier E | 2000 | Appl Phys Lett2000，76，2： | 1 |
| 12 | Relative enzymatic ac- tivity, protein stability, and tissue distribution of human steroid - metabolizing UGT2B subfamily members 显示文摘 | Turgeon D Cartier JS Lvesque E | 2001 | Endocrinology2001，142，2： | 1 |
| 13 | Single-residue alteration in α-conotoxin PnIA switches its nAChR subtype selec tivity显示文摘 | Luo S Nguyen T A Cartier G E | 1999 | Biochemistry1999，38，14： | 1 |
| 14 | A pathologic cascade leading to synaptic dysfunction in alpha-synuclein-induced neurodegeneration显示文摘 | Scott D A Tabarean I Tang Y Cartier A Masliah E Roy S | 2010 | J Neurosci2010，30，： | 1 |
| 15 | 显示文摘 | Copel M Cartier E | 2000 | Appl Phys Lett2000，76，2： | 1 |
| 16 | Effective electron mobility in Si inversion layers in metaloxide-semiconductor systems with a high-insulator:The role of remote phonon scattering显示文摘 | Fischetti M V Neumayer D A Cartier E A | 2001 | J Appl Phys2001，90，9： | 1 |
| 17 | Simulation of breast cancer screening:quality assessment of two protocols显示文摘 | CARTIER K J CASTRO F KESSIER E | 2004 | Health Qual2004，26，6： | 1 |
| 18 | Long - term al- terations of colonic nerve - mast cell interactions induced by neonatal maternal deprivation in rats 显示文摘 | B~reau F Salvador - Cartier C Houdeau E | 2009 | Gut2009，57，5： | 1 |
| 19 | Impact of anesthesia technique on the incidence of major complications after open aortic abdominal surgery:a cohort study显示文摘 | Licker M Christoph E Cartier V | 2013 | J Clin Anesth2013，25，4： | 1 |
| 20 | alpba-conotoxin AuIB selectively blocks alpha3 beta4 nicotinic acetylcholine receptors and nicotine-evoked norepinephrine release 显示文摘 | Luo S Kulak J M Cartier G E | 1998 | J Neurosci1998，18，： | 1 |
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