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| 1 | 中国北方草原草畜代谢能平衡分析与对策研究显示文摘草畜平衡是天然草地可持续利用和放牧家畜高效生产的前提,草畜平衡评估技术是实现草原保护,提高草地畜牧业可持续发展的基础。本研究建立了以代谢能为指标的草畜平衡评价方法,2008年冬以甘肃肃南草原和典型牧户为研究对象,通过草畜代谢能平衡分析了草畜平衡现状,应用研究试验,验证了实现草畜平衡的优化途径和对策。草畜平衡分析结果表明,在牧草生长期(6月-10月)家畜获得的代谢能高于家畜的维持需要,因此,家畜体重增加,生长速度最快;在枯草期(11月-次年5月)代谢能摄入量低于维持需要量,家畜掉膘,体重下降,夏草场的载畜量最大。冬季暖棚舍饲养殖能够降低家畜的代谢能需要,有助于实现草畜平衡。与对照组相比,暖棚养殖绵羊平均产毛量显著提高(P<0.05),提高了0.73kg/只,冷季体重损失减少14.9%,纯收入增加126.25元/只。产羔时间对草畜平衡具显著的影响,适当推迟产羔时间能够有效的改善草畜平衡状况。分别测定了4月和5月所产羔羊的生长发育情况和母羊体况,5月羔羊平均初生重、1月龄、2月龄体重显著高于4月份羔羊(P<0.05),但由于生长期短,5月羔羊出栏重较4月低4~5kg。草畜代谢能平衡是分析研究草畜平衡的科学、合理和准确的方法和技术,草畜代谢能平衡分析模型的准确度高,适用性强,有利于草原管理,所提出的改善草畜平衡的途径和策略可行性高。 | 杨博 吴建平 杨联 David Kemp 宫旭胤 Taro Takahashi 冯明廷 | 2012 | 草业学报2012，21，2： | 37 |
| 2 | 重新认知青藏高原围栏禁牧的作用显示文摘围栏禁牧是中国政府为恢复青藏高原等地退化草地而采取的一项重要政策.然而,关于围栏对高寒草地生态系统功能和服务及其对牧民生计的影响,人们的认识还很有限.本研究荟萃分析和基于问卷的调查显示,围栏禁牧时间长达4年和8年的时间里可以有效地促进高寒草甸以及草原的地上植被生长,更长时间的围栏并没有带来任何生态和经济效益.研究还发现,围栏限制了野生动物的活动范围,增加了非围栏地区的放牧压力,降低了牧民的满意度,且给地区和国家政府带来了巨大的财政成本.因此,建议在适当的情况下,应鼓励传统的游牧方式来利用草地,在严重退化的草地上应采用短期围栏(4~8年),在重要的野生动物栖息地应避免使用围栏,特别是受保护的大型哺乳动物分布的区域.研究结果可为青藏高原草地可持续管理提供一定的参考. | 孙建 刘苗 傅伯杰 David Kemp 赵文武 刘国华 韩国栋 Andreas Wilkes 鲁旭阳 陈有超 程根伟 周天财 侯阁 詹天宇 彭飞 Hua Shang 徐明 石培礼 何永涛 李猛 王金牛 Atsushi Tsunekawa 周华坤 刘宇 李裕瑞 刘世梁 | 2020 | Science Bulletin2020，65，16： | 24 |
| 3 | 牧区绵羊精准管理技术体系建立与草畜平衡研究显示文摘选择肃南裕固族自治县3户典型牧户(分别代表低、中、高管理水平)进行甘肃高山细毛羊生产性能测定,结合经济效益数据,应用精准管理模型计算分析并对其中的低管理水平和高管理水平典型牧户实施精准管理技术,将经济效益不良绵羊的个体淘汰,存栏量分别下降了7%和26%,而未实施精准管理技术的中等管理水平典型牧户,存栏量上升了18%。结果表明:优化后低管理水平和高管理水平典型牧户的平均产毛量及总产毛量均有所提高,而中等管理水平的典型牧户虽然总产毛量提高,但平均每只产毛量下降了0.55kg。低管理水平和高管理水平典型牧户存栏母羊的体重较优化前均有提高,收入分别提高了11.39%和4.2%,而中等管理水平的典型牧户成年母羊体重下降,后备母羊体重增加不显著,同时收入降低了7.4%。因此,精准管理技术可有效的应用于指导实践。 | 杨博 吴建平 杨联 宫旭胤 David Kemp 冯明廷 孙亮 | 2012 | 草地学报2012，20，3： | 14 |
| 4 | Multiparametric analysis of colorectal cancer immune responses显示文摘Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC. | Julia KH Leman Sarah K Sandford Janet L Rhodes Roslyn A Kemp | 2018 | World Journal of Gastroenterology2018，24，27： | 12 |
| 5 | Autoantibodies against MMP-7 as a novel diagnostic biomarker in esophageal squamous cell carcinoma显示文摘AIM: To evaluate the diagnostic values of serum autoantibodies against matrix metalloproteinase-7 (MMP-7) in patients with esophageal squamous cell carcinoma (ESCC). METHODS: The MMP-7 cDNA was cloned from ESCC tissues, and MMP-7 was expressed and purified from a prokaryotic system. MMP-7 autoantibodies were then measured in sera from 50 patients with primary ESCC and 58 risk-matched controls, using a reverse capture enzyme-linked immunosorbent assay (ELISA) in which autoantibodies to MMP-7 bound to the purified MMP-7 proteins. In addition, MMP-7 autoantibody levels in sera from 38 gastric cancer patients and from control serum samples were also tested. RESULTS: The optimum conditions for recombinant MMP-7 protein expression were determined as 0.04 mmol/L Isopropyl-β-D-Thiogalactopyranoside (IPTG) induction at 37℃ for four hours. The levels of serum autoantibodies against MMP-7 were significantly higher in patients with ESCC than in the matched-control samples (OD450 = 1.69 ± 0.08 vs OD450 = 1.55 ± 0.10, P < 0.001). The area under the receiver operating characteristic (ROC) curve was 0.87. The sensitivity and specificity for detection of ESCC were 78.0% and 81.0%, respectively, when the OD450 value was greater than 1.65. Although the levels of autoantibodies against MMP-7 were also significantly higher in patients with gastric cancer compared to control samples (OD450 = 1.62 ± 0.06 vs OD450 = 1.55 ± 0.10, P < 0.001), the diagnostic accuracy was less significant than in ESCC patients. The area of ROC curve was 0.75, whereas the sensitivity and specificity were 60.5% and 71.7%, respectively, when the cut-off value of OD450 was set at 1.60. CONCLUSION: Serum autoantibody levels of MMP-7 may be a good diagnostic biomarker for esophageal squamous cell carcinoma. | Jing-Hua Zhou Bin Zhang Kemp H Kernstine Li Zhong | 2011 | World Journal of Gastroenterology2011，17，10： | 8 |
| 6 | The Muruntau gold deposit(Uzbekistan)--A unique ancient hydrothermal system in the southern Tien Shan显示文摘The Muruntau gold deposit in the Central Kyzylkum,Uzbekistan is one of the largest single gold deposits worldwide.Data available from the literature are reviewed with the aim to(1) integrate the present knowledge on this unique deposit from Russian and English literature;(2) show the considerable progress made in the understanding of the genesis of the Muruntau deposit during the last decades;and(3) point to problems still open for future research.Deposit formation occurred through a multi-stage process involving sedimentation,regional metamorphism including thrusting,magmatism with formation of hornfels aureoles and several stages of hydrothermal activity.According to recent knowledge,synsedimentary or pure metamorphic formation of gold mineralization seems unlikely.The role of granite magmatism occurring roughly within the same time interval as the main hydrothermal gold precipitation remains uncertain.There are no signs of interaction of matter between the magma(s) and the hydrothermal system(s).On the other hand,there was an intense,high-temperature(above 400 ℃)fluid- wall rock interaction resulting in the formation of gold-bearing,cone-like stockworks with veins,veinlets and gold-bearing metasomatites.Several chemical and isotope indicators hint at an involvement of lower-crustal or mantle-related sources as well as of surface waters in ore formation.Deposit formation through brecciation involving explosion,hydrothermal or tectonic breccias might explain these data.Further investigations on breccia formation as well as on the exact timing of relevant sedimentary,metamorphic,magmatic and hydrothermal events are recommended. | Ulf Kempe Torsten Graupner Reimar Seltmann Hugo de Boorder Alla Dolgopolova Maarten Zeylmans van Emmichoven | 2016 | Geoscience Frontiers2016，7，3： | 7 |
| 7 | 冬春季暖棚舍饲对母羊体重损失及产羔性能的影响显示文摘研究冬春季暖棚舍饲对母羊体重损失及产羔性能的影响。试验分别于2011、2012和2013年冬春季在内蒙古锡林郭勒盟太仆寺旗进行,在当地选用2户临近牧户,每户挑选120只母羊,随机分为2组,分别为传统棚+放牧组(TS,对照)、改造暖棚+舍饲组(WS)。参试母羊夏秋季白天自由放牧,晚上归牧后圈在传统棚内;到冬春季TS组饲养方式不变,WS组舍饲在简易改造暖棚。整个试验期间,2组母羊及其羔羊的补饲饲料组成及饲喂量相同。试验结果表明,WS组母羊体重较TS组高1.6kg(P=0.004),体重损失较之少22g/d(P=0.005);母羊体重损失在12-1月份最严重,但经第一年(2011)饲养损失程度显著缓解(P<0.001),体重损失随棚圈积温升高而减少。TS组的年均产羔数、羔羊体重及其日增重均显著低于WS组(P=0.020;P=0.0005;P=0.0001),初生重及日增重随着饲养年份的延后而增加(P<0.001);产羔率、羔羊存活率和双羔率随棚圈积温的升高而增大。以上结果表明,冬春季暖棚舍饲可显著减少母羊越冬体重损失,并提高产羔力,进而提高家庭牧场收入,保护退化草场。更重要的是,冷季舍饲有助于改变牧民的传统养殖观念,从'生存观'转向'生产观'。建议,西北牧区冷季绵羊圈舍适宜积温应高于-40℃·d或基本温度高于2℃。 | 张晓庆 KEMP David 马玉宝 姜超 | 2017 | 草业学报2017，26，6： | 6 |
| 8 | Understanding the health and social care needs of people living with IBD: A meta-synthesis of the evidence显示文摘AIM:To undertake a metasynthesis of qualitative studies to understand the health and social needs of people living with inflammatory bowel disease (IBD). METHODS:A systematic search strategy identified qualitative studies exploring the phenomenon of living with inflammatory bowel disease. Databases included MEDLINE, PsychInfo, EMBASE, CINAHL and the British Nursing Index via the OVID platform. Qualitative search filters were adapted from Hedges database (http://gffzzb46bbb8efc364c51hpukv9qwv5obq69bu.ffgz.tsg.suse.edu.cn/hslt/miner/ digital_library/tip_sheets/Cinahl_eb_filters.pdf). Qualitative empirical studies exploring the health and social needs of people living with inflammatory bowel disease were selected. Study eligibility and data extraction were independently completed using the Critical Appraisal Skills Programme for qualitative studies. The studies were analysed and synthesised using metasynthesis methodology. The themes from the studies allowed for common translations into a new interpretation of the impact of living with inflammatory bowel disease. RESULTS:Of 1395 studies, six published studies and one unpublished thesis fulfilled the inclusion criteria. First iteration of synthesis identified 16 themes, 2nd iteration synthesised these into three main 2nd order constructs:'detained by the disease'; 'living in a world of disease' and 'wrestling with life'. 'Detained by the disease' is the fear of incontinence, the behaviour the patients display due to the fear, and the impact this has on the individual, such as social isolation and missing out on life events. All of these serve to 'pull' the patient back from normal living. 'Living in a world of disease' is the long term effects of living with a long term condition and the fear of these effects. 'Wrestling with life' is the continued fight to thrive, the 'push' to continue normal living. CONCLUSION:The metasynthesis provides a comprehensive representation of living with IBD. The unmistakeable burden of incontinence is exposed and its ongoing effects are demonstrated. The combined overall impact of living with IBD is the tension these patients live with:'Pushed and pulled:a compromised life', people living with IBD experience a constant conflict throughout their lives, they push to be normal but IBD pulls them back. The impact of the fear of incontinence and behaviour of the individual as a result, requires further qualitative enquiry. | Karen Kemp Jane Griffiths Karina Lovell | 2012 | World Journal of Gastroenterology2012，18，43： | 5 |
| 9 | The P132H mutation in the main protease of Omicron SARSCoV-2 decreases thermal stability without compromising catalysis or small-molecule drug inhibition显示文摘Dear Editor,The ongoing SARS-CoV-2 pandemic continues to be a significant threat to global health.First reported in November 2021,the Omicron variant(B.1.1.529)is more transmissible and can evade immunity better than previous SARS-CoV-2 variants,fueling an unprecedented surge in cases.To produce functional proteins from its polyprotein,SARS-CoV-2 relies on the cysteine proteases Nsp3/papain-like protease(PLpro)and Nsp5/main protease(Mpro)/3C-like protease to cleave at three and more than 11 sites,respectively.1 Therefore,Mpro and PLpro inhibitors are considered to be one of the most promising SARS-CoV-2 antivirals.On December 22,2021,the Food and Drug Administration(FDA)issued an Emergency Use Authorization(EUA)for PAXLOVID,a ritonavir-boosted formulation of nirmatrelvir.Nirmatrelvir is a first-in-class orally bioavailable SARSCoV-2 Mpro inhibitor.2 Thus,the scientific community must vigilantly monitor potential mechanisms of drug resistance,especially because SARS-CoV-2 is naïve to Mpro inhibitors.Mutations have been well identified in variants to this point.3 Notably,Omicron Mpro(OMpro)harbors a single mutation—P132H.In this study,we characterized the enzymatic activity,drug inhibition,and structure of OMpro while evaluating the past and future implications of Mpro mutations. | Michael Dominic Sacco Yanmei Hu Maura Verenice Gongora Flora Meilleur Michael Trent Kemp Xiujun Zhang Jun Wang Yu Chen | 2022 | Cell Research2022，32，5： | 3 |
| 10 | Sustainable management of Chinese grasslands—issues and knowledge显示文摘China has almost 400 Mhm^2 of grasslands,90% of which is considered degraded to varying degrees,on which 16 million herders depend for their livelihoods and many more indirectly, along the value-adding chain.Since 1950, average stocking rates across China have increased 4-fold. National policies have focused over recent decades on finding ways to rehabilitate the degraded grasslands, to sustain livestock production from them, and to improve the livelihoods of herder households, who are among the poorest people in China. A large collaborative program commenced in the early 2000 s to help find solutions to the sustainable management of grasslands.This paper summarizes key findings of many research projects, identifies where knowledge is weak and argues that the successful rehabilitation of grasslands will also require policies that provide incentives and support for herders as they move from a focus on survival to a focus on production of higher quality products, for which consumers are increasingly willing to pay. A key focus is to emphasize the improvement of animal production per head. When this is done, it naturally leads to lower stocking rates, which in turn provides the opportunities for grasslands to recover. Across a range of experiments, farm demonstrations and analyses using models, in Inner Mongolia and Gansu, a consistent result has been that a 50% reduction in stocking rates, improves net household income and starts the process of grassland rehabilitation.Rather than focusing on stocking rates, better management of grasslands could be achieved by maintaining the grasslands above critical values for herbage mass, values that help optimize botanical composition, reduce soil erosion, optimize animal growth rates and aid ecosystem functions. Managing to critical values for herbage mass is likely to be more effective than efforts to calculate sustainable stocking rates. An early summer rest is valuable for aiding grassland rehabilitation and summer productivity, but a total grazing ban(typically for 5 years)may not achieve its aims as evidence shows it may take 10–15 years to achieve a better grassland state. Lessdesirable plant species often increase in degraded grasslands that are rested and grazing can help manage those species. Surveys of herders indicate they have very mixed views on the benefits of total grazing bans that are unlikely to rehabilitate grasslands to an ideal botanical composition.The current objective is to work with grasslands that herders now have and optimize the existing composition.Grazing grasslands in winter results primarily in weight loss by animals and there is now evidence of how winter grazing reduces grassland growth in the next summer. It is better to keep animals in well-built sheds and feed them better, improved feeding through the cold months is required. In addition to the application of results from national programs designed to improve grasslands, it will be important to train herders as they move from survival to production, to foster the development of better markets for their livestock products, to devise better financial support for herder businesses and to revise land tenure arrangements so that herders can expand the area of land they graze on better terms than apply at present. | David KEMP Guodong HAN Fujiang HOU Xiangyang HOU Zhiguo LI Yi SUN Zhongwu WANG Jianping WU Xiaoqing ZHANG Yingjun ZHANG Xuyin GONG | 2018 | Frontiers of Agricultural Science and Engineering2018，5，1： | 3 |
| 11 | Fen1 mutations that specifically disrupt its interaction ~vith PCNA cause aneuploidy-associated cancer显示文摘 | Li Zheng Huifang Dai Muralidhar L Hegde Mian Zhou Zhigang Guo Xiwei Wu Jun Wu Lei Su Xueyan Zhong Sankar Mitra Qin Huang Kemp H Kernstine Gerd P Pfeifer Binghui Shen | 2011 | Cell Research2011，21，7： | 3 |
| 12 | Different options of endosonography-guided biliary drainage after endoscopic retrograde cholangiopancreatography failure显示文摘AIM To investigate the success rates of endosonography(EUS)-guided biliary drainage(EUS-BD) techniques after endoscopic retrograde cholangiopancreatography(ERCP) failure for management of biliary obstruction.METHODS From Feb/2010 to Dec/2016, ERCP was performed in 3538 patients, 24 of whom(0.68%) suffered failure to cannulate the biliary tree. All of these patients were initially submitted to EUS-guided rendez-vous(EUS-RV) by means of a transhepatic approach. In case of failure, the next approach was an EUS-guided anterograde stent insertion(EUS-ASI) or an EUS-guided hepaticogastrostomy(EUS-HG). If a transhepatic approach was not possible or a guidewire could not be passed through the papilla, EUS-guided choledochoduodenostomy(EUS-CD) was performed.RESULTS Patients were submitted to EUS-RV(7), EUS-ASI(5), EUS-HG(6), and EUS-CD(6). Success rates did not differ among the various EUS-BD techniques. Overall,technical and clinical success rates were 83.3% and 75%, respectively. Technical success for each technique was, 71.4%, 100%, 83.3%, and 83.3%, respectively(P = 0.81). Complications occurred in 3(12.5%) patients. All of these cases were managed conservatively, but one patient died after rescue percutaneous transhepatic biliary drainage(PTBD).CONCLUSION The choice of a particular EUS-BD technique should be based on patient's anatomy and on whether the guidewire could be passed through the duodenal papilla. | JoséCelso Ardengh César Vivian Lopes Rafael Kemp Jose Sebastiao dos Santos | 2018 | World Journal of Gastrointestinal Endoscopy2018，10，5： | 3 |
| 13 | Introduction to the Varenius Project显示文摘 | GOODCHILD M F EGENHOFER M J KEMP K K | 1999 | Geographic Information Science1999，13，8： | 2 |
| 14 | Polyclonal and allergen-induced cytokine responses in adults with asthma: Resolution of asthma is associated with normalization of IFN-γ responses显示文摘 | Joanne M. Smart Elisabeth Horak Andrew S. Kemp Colin F. Robertson Mimi L.K. Tang | 2002 | The Journal of Allergy and Clinical Immunology2002，，3： | 2 |
| 15 | Conservative management of cholestasis with and without fever in acute biliary pancreatitis显示文摘The presence of cholestasis in both mild and severe forms of acute biliary pancreatitis(ABP)does not justify,of itself,early endoscopic retrograde cholangiography(ERC)or endoscopic sphincterotomy(ES).Clinical support treatment of acute pancreatitis for one to two weeks is usually accompanied by regression of pancreatic edema,of cholestasis and by stone migration to the duodenum in 60%-88%of cases.On the other hand,in cases with both cholestasis and fever,a condition usually characterized as ABP associated with cholangitis,early ES is normally indicated.However,in daily clinical practice,it is practically impossible to guarantee the coexistence of cholangitis and mild or severe acute pancreatitis.Pain,fever and cholestasis,as well as mental confusion and hypotension,may be attributed to inflammatory and necrotic events related to ABP. Under these circumstances,evaluation of the bile duct by endo-ultrasonography(EUS)or magnetic resonance cholangiography(MRC)before performing ERC and ES seems reasonable.Thus,it is necessary to assess the effects of the association between early and opportune access to the treatment of local and systemic inflammatory/infectious effects of ABP with cholestasis and fever, and to characterize the possible scenarios and the subsequent approaches to the common bile duct,directed by less invasive examinations such as MRC or EUS. | JoséSebastio Santos Rafael Kemp JoséCelso Ardengh Jorge Elias Jr | 2012 | World Journal of Gastrointestinal Surgery2012，4，3： | 2 |
| 16 | Hematopoietic AMPK [Beta]1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity显示文摘 | Galic Sandra Fullerton Morgan D Schertzer Jonathan D Sikkema Sarah Marcinko Katarina Walkley Carl R Izon David Honeyman Jane Chen Zhi-Ping van Denderen Bryce J Kemp Bruce E Steinberg Gregory R | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 17 | Effect of Cardiac Resynchronization on Myocardial Efficiency and Regional Oxidative Metabolism显示文摘 | Heikki Ukkonen Rob S.B. Beanlands Ian G. Burwash Robert A. de Kemp Claude Nahmias Ernest Fallen Michael R.S. Hill Anthony S.L. Tang | 2003 | Circulation: Journal of the American Heart Association2003，，1： | 2 |
| 18 | Choreography of AMPK activation显示文摘 | Christopher G Langendorf Bruce E Kemp | 2015 | Cell Research2015，25，1： | 2 |
| 19 | Designing for duetility显示文摘 | KEMP A R | 2003 | Structural Engineer2003，81，6： | 2 |
| 20 | Machine learning for detecting mesial temporal lobe epilepsy by structural and functional neuroimaging显示文摘Mesial temporal lobe epilepsy(mTLE),the most common type of focal epilepsy,is associated with functional and structural brain alterations.Machine learning(ML)techniques have been successfully used in discriminating mTLE from healthy controls.However,either functional or structural neuroimaging data are mostly used separately as input,and the opportunity to combine both has not been exploited yet.We conducted a multimodal ML study based on functional and structural neuroimaging measures.We enrolled 37 patients with left mTLE,37 patients with right mTLE,and 74 healthy controls and trained a support vector ML model to distinguish them by using each measure and the combinations of the measures.For each single measure,we obtained a mean accuracy of 74%and 69%for discriminating left mTLE and right mTLE from controls,respectively,and 64%when all patients were combined.We achieved an accuracy of 78%by integrating functional data and 79%by integrating structural data for left mTLE,and the highest accuracy of 84%was obtained when all functional and structural measures were combined.These findings suggest that combining multimodal measures within a single model is a promising direction for improving the classification of individual patients with mTLE. | Baiwan Zhou Dongmei An Fenglai Xiao Running Niu Wenbin Li Wei Li Xin Tong Graham J Kemp Dong Zhou Qiyong Gong Du Lei | 2020 | Frontiers of Medicine2020，14，5： | 2 |
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