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| 1 | Biomarkers for Parkinson's Disease:Recent Advancement显示文摘As a multi-factorial degenerative disease,Parkinson's disease(PD) leads to tremor, gait rigidity,and hypokinesia, thus hampering normal living. As this disease is usually detected in the later stages when neurons have degenerated completely, cure is on hold, ultimately leading to death due to the lack of early diagnostic techniques. Thus, biomarkers are required to detect the disease in the early stages when prevention is possible.Various biomarkers providing early diagnosis of the disease include those of imaging, cerebrospinal fluid,oxidative stress, neuroprotection, and inflammation. Also,biomarkers, alone or in combination, are used in the diagnosis and evolution of PD. This review encompasses various biomarkers available for PD and discusses recent advances in their development. | Sharvari Lotankar Kedar S Prabhavalkar Lokesh K Bhatt | 2017 | Neuroscience Bulletin2017，33，5： | 41 |
| 2 | Incidence, risk factors and outcomes of de novo malignancies post liver transplantation显示文摘Liver transplantation(LT) is associated with a 2 to7 fold higher, age and gender adjusted, risk of de novo malignancy. The overall incidence of de novo malignancy post LT ranges from 2.2% to 26%, and 5 and 10 years incidence rates are estimated at 10% to 14.6% and 20% to 32%, respectively. The main risk factors for de novo malignancy include immunosuppression with impaired immunosurveillance, and a number of patient factors which include; age, latent oncogenic viral infections, tobacco and alcohol use history, and underlying liver disease. The most common cancers after LT are non-melanoma skin cancers, accounting for approximately 37% of de novo malignancies, with a noted increase in the ratio of squamous to basal cell cancers. While these types of skin cancer do not impact patient survival, post-transplant lymphoproliferative disorders and solid organ cancer, accounting for 25% and 48% of malignancies, are associated with increased mortality. Patients developing these types of cancer are diagnosed at more advanced stages, and their cancers behave more aggressively compared with the general population. Patients undergoing LT for primary sclerosing cholangitis(particularly with inflammatory bowel disease) and alcoholic liver disease have high rates of malignancies compared with patients undergoing LT for other indications. These populations are at particular risk for gastrointestinal and aerodigestive cancers respectively. Counseling smoking cessation, skin protection from sun exposure and routine clinical follow-up are the current approach in practice. There are no standardized surveillance protocol, but available data suggests that regimented surveillance strategies are needed and capable of yielding cancer diagnosis at earlier stages with better resulting survival. Evidence-based strategies are needed to guide optimal surveillance and safe minimization of immunosuppression. | Pavan Kedar Mukthinuthalapati Raghavender Gotur Marwan GhabrilMarwan Ghabril | 2016 | World Journal of Hepatology2016，8，12： | 7 |
| 3 | Two-step machine learning enables optimized nanoparticle synthesis显示文摘In materials science,the discovery of recipes that yield nanomaterials with defined optical properties is costly and time-consuming.In this study,we present a two-step framework for a machine learning-driven high-throughput microfluidic platform to rapidly produce silver nanoparticles with the desired absorbance spectrum.Combining a Gaussian process-based Bayesian optimization(BO)with a deep neural network(DNN),the algorithmic framework is able to converge towards the target spectrum after sampling 120 conditions.Once the dataset is large enough to train the DNN with sufficient accuracy in the region of the target spectrum,the DNN is used to predict the colour palette accessible with the reaction synthesis.While remaining interpretable by humans,the proposed framework efficiently optimizes the nanomaterial synthesis and can extract fundamental knowledge of the relationship between chemical composition and optical properties,such as the role of each reactant on the shape and amplitude of the absorbance spectrum. | Flore Mekki-Berrada Zekun Ren Tan Huang Wai Kuan Wong Fang Zheng Jiaxun Xie Isaac Parker Siyu Tian Senthilnath Jayavelu Zackaria Mahfoud Daniil Bash Kedar Hippalgaonkar Saif Khan Tonio Buonassisi Qianxiao Li Xiaonan Wang | 2021 | npj Computational Materials2021，，1： | 3 |
| 4 | Combined Thermo-Chemotherapy for Recurrent Bladder Cancer After Bacillus Calmette-Guerin显示文摘 | Ofer Nativ J. Alfred Witjes Kees Hendricksen Michael Cohen Daniel Kedar Ami Sidi Renzo Colombo Ilan Leibovitch | 2009 | The Journal of Urology2009，，4： | 2 |
| 5 | 理解并控制数字马达控制系统的量化误差显示文摘设计数字马达控制系统时需要考虑的主要问题是选择合适的处理器,同时,处理器字长也至关重要。设计人员需要关注定点处理器中因定点数表示法而引起的量化误差问题。这些误差将会降低控制系统的性能,使设计人员无法最大限度地发挥出高级算法的优势。 | Kedar Godbole | 2006 | 电子设计应用2006，，9： | 2 |
| 6 | A unique deubiquitinase that deconjugates phosphoribosyl-linked protein ubiquitination显示文摘Ubiquitination 调整主人免疫的许多方面并且因此是为传染代理人的一个普通目标。最近的研究表明了细菌的病原体 Legionella pneumophila 的方面受动器家庭的成员攻击不要求主人 ubiquitination 机械的 E1 和 E2 酶的新奇 ubiquitination 机制与 endoplasmic 蜂窝胃联系的几小 GTPases。在这种情况中, ubiquitin 被一项 mono-ADP-ribosyltransferase 活动被 ADP-ribosylation 首先在 Arg 42 激活;中介然后被也住在 SdeA 以内的一项 phosphodiesterase 活动劈开,有到经由一个 phosphoribosyl 连接器的底层蛋白质的丝氨酸残余的 ubiquitin 的附件的伴随物。这里,我们证明方面的效果被 SidJ 反对,一个受动器由位于为方面家庭(SdeC, SdeB 和 SdeA ) 的三个成员编码的地点的基因编码了。SidJ 由劈开连接 phosphoribosylated ubiquitin 到蛋白质底层的 phosphodiester 契约颠倒修改方面的底层的 ubiquitination。SidJ 也显示古典 deubiquitinase 活动但是不要求催化半胱氨酸残余。进一步, SidJ 的这些 deubiquitinase 活动为它在 L 的角色是必要的。pneumophila 感染。最后, SidJ 的活动为高效地在细菌的举起以后在一些小时以内在感染的房间减少许多 ubiquitinated Rab33b 被要求。我们的结果作为工作在方面受动器的活动强加时间的规定的 ubiquitin-deconjugating 酶建立 SidJ。SidJ 可能在表明串联的未来研究是重要的由这唯一的 ubiquitination 调停了,潜在地也在真核细胞的房间调整细胞的过程的。 | Jiazhang Qiu Kaiwen Yu Xiaowen Fei Yao Liu Emesto S Nakayasu Paul D Piehowski Jared B Shaw Kedar Puva Chittaranjan Das Xiaoyun Liu Zhao-Qing Luo | 2017 | Cell Research2017，27，7： | 2 |
| 7 | Benchmarking the performance of Bayesian optimization across multiple experimental materials science domains显示文摘Bayesian optimization(BO)has been leveraged for guiding autonomous and high-throughput experiments in materials science.However,few have evaluated the efficiency of BO across a broad range of experimental materials domains.In this work,we quantify the performance of BO with a collection of surrogate model and acquisition function pairs across five diverse experimental materials systems.By defining acceleration and enhancement metrics for materials optimization objectives,we find that surrogate models such as Gaussian Process(GP)with anisotropic kernels and Random Forest(RF)have comparable performance in BO,and both outperform the commonly used GP with isotropic kernels.GP with anisotropic kernels has demonstrated the most robustness,yet RF is a close alternative and warrants more consideration because it is free from distribution assumptions,has smaller time complexity,and requires less effort in initial hyperparameter selection.We also raise awareness about the benefits of using GP with anisotropic kernels in future materials optimization campaigns. | Qiaohao Liang Aldair E.Gongora Zekun Ren Armi Tiihonen Zhe Liu Shijing Sun James R.Deneault Daniil Bash Flore Mekki-Berrada Saif A.Khan Kedar Hippalgaonkar Benji Maruyama Keith A.Brown John Fisher III Tonio Buonassisi | 2021 | npj Computational Materials2021，，1： | 2 |
| 8 | MR Evaluation of Rectal Cancer: Current Concepts显示文摘 | Claire Beaumont Tarun Pandey R. Gaines Fricke Jonathan Laryea Kedar Jambhekar | 2013 | Current Problems in Diagnostic Radiology2013，，3： | 2 |
| 9 | Homonymous Hemianopia in Stroke显示文摘 | Zhang X Kedar S Lynn MJ | 2006 | J Neuro Ophthalmol2006，26，3： | 1 |
| 10 | Differential expression of progre- ssion-related genes in the evolution of superficial to invasive transitional cell carcinoma of the bladder显示文摘 | Izawa JI Slaton JW Kedar D | 2001 | Oncol Rep2001，8，1： | 1 |
| 11 | Evaluation of subjective and objective cyclodeviation following oblique muscle weakening procedures显示文摘 | Sharma P Thanikachalam S Kedar S | 2008 | Indian J Ophthalmol2008，56，1： | 1 |
| 12 | Non-line-of-sight optical wireless sensor network operating in multiscattering channel 显示文摘 | Debbie Kedar Shlomi Arnon | 2006 | Applied Optics2006，45，33： | 1 |
| 13 | Advances in polymeric micelles for drug delivery and tumor targeting显示文摘 | Kedar U Phutane P Shidhaye S | | 0，，06： | 1 |
| 14 | Survival of solenopsis mealybug, Phenacoccus solenopsis Tinsley (Hemiptera: Pseudococcidae) on cotton in relationto abotic and biotic factors显示文摘 | Kedar S C Saini R K Ram P | 2012 | International Journal of Plant Protection2012，5，2： | 1 |
| 15 | Management of benign ureteral strictures following radical cystectomy and urinary diversion for bladder cancer显示文摘 | Tal R Sivan B Kedar D | 2007 | J Urol2007，178，： | 1 |
| 16 | Experimental investigations on single stage modified Savonius rotor 显示文摘 | Kamoji M A Kedare S B Prabhu S V | 2009 | Applied Energy2009，86，78： | 1 |
| 17 | Natural history of homonymous hemianopsia显示文摘 | Zhang X Kedar S Lynn M J | 2006 | Neurology2006，66，6： | 1 |
| 18 | Experimental inves- tigations on single stage, two stages and three stage conven- tional Svonius rotor显示文摘 | Kamoji M A Kedare S B Prabhu S V | 2008 | International Journal of Energy Re- search2008，，32： | 1 |
| 19 | Neonatal anemia显示文摘 | Sanjay Aher Kedar Malwatka Sandeep Kadam | 2008 | Seminars in Fetal&Neonatal Medicine2008，13，4： | 1 |
| 20 | 去除水中的氟化物 使用载铝螯合树脂选择性去除废水和饮用水中的氟化物显示文摘使用一种基于可再生载铝螯合树脂的新吸附方法可以很容易地实现水中氟化物的浓度低于1mg/L的目标。本文介绍的案例说明了其实施的可行性,实验室数据则给出了关于工艺设计重要参数的更多技术背景。 | Kedar Oke Stefan Neumann Beryn Adams | 2011 | 流程工业2011，，15： | 1 |
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