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| 1 | Spatial Variability of Nutrient Properties in Black Soil of Northeast China显示文摘A total of 1400 soil samples from the plow layer (0-20 cm) at an approximate interval of 5 km were collected in the autumn of 2002 over the entire black soil arable crops region to determine the spatial variability of seven variables, such as total organic matter content (OMC), total N, total P, total K, alkali-dissolvable N (AN), available P (AP) and available K (AK), with classical statistics and geostatistical analysis across the entire black soil area in Northeast China. In nonsampled areas ordinary kriging was utilized for interpolation of estimated nutrient determinations. Classical statistics revealed highly significant (P≤0.01) correlations with all seven of the soil properties, except for OMC with AP and total K with AK. In addition, using coefficients of variation, all soil properties, except for total K, were moderately variable. A geostatistical analysis indicated that structural factors, such as parent material, terrain, and water table, were the main causes of the spatial correlations. Strong spatial correlations were noted with OMC, total N, total P, AN, and AP, while they were moderate for total K and AK. The effective spatial autocorrelation of OMC, total N, total P, and AN ranged from 1 037 to 1 353 km, whereas the ranges of total K, AP, and AK were only from 6 to 138 km. The fit of the experimental semi-variograms to the theoretical models indicated that except for AN, kriging could successfully interpolate other six variables. Thus, the geostatistical method used on a large scale could accurately evaluate the spatial variability of most black soil nutrient properties in Northeast China. | ZHANG Xing-Yi SUI Yue-Yu ZHANG Xu-Dong MENG Kai S. J. HERBERT | 2007 | Pedosphere2007，17，1： | 118 |
| 2 | Prevalence of Nontraumatic Osteonecrosis of the Femoral Head and its Associated Risk Factors in the Chinese Population: Results from a Nationally Representative Survey显示文摘 | De-Wei Zhao Mang Yu Kai Hu Wei Wang Lei Yang Ben-Jie Wang Xiao-Hong Gao Yong-Ming Guo Yong-Qing Xu Yu-Shan Wei Si-Miao Tian Fan Yang Nan Wang Shi-Bo Huang Hui Xie Xiao-Wei Wei Hai-Shen Jiang Yu-Qiang Zang Jun Ai Yuan-Liang Chen Guang-Hua Lei Yu-Jin Li Geng Tia Zong-Sheng Li Yong Cao Li Ma | 2015 | Chinese Medical Journal2015，，21： | 151 |
| 3 | Two Faces of One Seed: Hormonal Regulation of Dormancy and Germination显示文摘种子植物演变维持刚成熟的种子的休眠直到萌芽的适当时间。种子休眠和萌芽是不同生理的过程,并且到萌芽的从休眠的转变是在植物的生命周期的关键发展的步,但是为农业生产也是重要的不仅。这些过程被多样的内长的荷尔蒙和环境暗示精确调整。尽管骆驼毛的织物(abscisic 酸) 和气体(赤霉素) 被知道是反对地调整种子休眠的主要植物激素,最近的调查结果表明那另外一个植物激素,植物生长素,为导致并且维持也是批评的播种休眠,可能因此充当种子休眠的一个关键保护者。在这评论,我们总结我们在调整种子休眠和萌芽包含植物激素的关键角色的复杂分子的网络的当前的理解,在里面它 AP2-domain-containing 抄写因素 playkey 角色。我们也在种子休眠和萌芽讨论多样的神经质的信号的相互作用(串音) ,集中于组成中央节点的 ABA/GA 平衡。 | Kai Shu Xiao-dong Liu Qi Xie Zu-hua He | 2016 | Molecular Plant2016，9，1： | 95 |
| 4 | Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis显示文摘Necroptosis 和 pyroptosis 是有血浆膜破裂的一个普通特征的规划房间死亡的二种形式。这里,我们与 necroptosis 比较学习了 pyroptosis 的形态学和机制。与 necroptosis 不同, pyroptosis 经历膜 blebbing 并且生产 apoptotic 在血浆膜以前的像身体的房间伸出(称为的 pyroptotic 身体) 破裂。在 necroptosis 的破裂是像爆炸的,而在 pyroptosis 它导致房间变平。necroptosis 的实行被混合的系 kinase 调停,这被知道像域(MLKL ) 在血浆膜的 oligomers,而 gasdermin-D (GSDMD ) 调停在它由 caspase-1 或 caspase-11 的劈开以后的 pyroptosis。我们显示出那 N 终端碎片 caspase 劈开产生的 GSDMD (GSDMD-N ) 也形成 oligomer 并且移居到血浆膜杀死房间。MLKL 和 GSDMD-N 是脂性的,两蛋白质的 N 终端序列为他们的 oligomerization 和血浆膜 translocation 是重要的。不同于在血浆膜上形成隧道的 MLKL,那导致渗透地胀大的选择离子的流入冲破的房间, GSDMD-N 形成非选择的毛孔并且不依靠增加的 osmolarity 破坏房间。我们的学习表明 GSDMD 的形成毛孔的活动和 MLKL 的形成隧道的活动在 pyroptosis 和 necroptosis 决定血浆膜破裂的不同方法。 | Xin Chen Wan-ting He Lichen Hu Jingxian Li Yuan Fang Xin Wang Xiaozheng Xu Zhuo Wang Kai Huang Jiahuai Han | 2016 | Cell Research2016，26，9： | 110 |
| 5 | Ameliorating effects of traditional Chinese medicine preparation, Chinese materia medica and active compounds on ischemia/reperfusion-induced cerebral microcirculatory disturbances and neuron damage显示文摘Ischemic stroke and ischemia/reperfusion(I/R) injury induced by thrombolytic therapy are conditions with high mortality and serious long-term physical and cognitive disabilities. They have a major impact on global public health. These disorders are associated with multiple insults to the cerebral microcirculation, including reactive oxygen species(ROS) overproduction, leukocyte adhesion and infiltration, brain blood barrier(BBB) disruption, and capillary hypoperfusion, ultimately resulting in tissue edema, hemorrhage, brain injury and delayed neuron damage. Traditional Chinese medicine(TCM)has been used in China, Korea, Japan and other Asian countries for treatment of a wide range of diseases.In China, the usage of compound TCM preparation to treat cerebrovascular diseases dates back to the Han Dynasty. Even thousands of years earlier, the medical formulary recorded many classical prescriptions for treating cerebral I/R-related diseases. This review summarizes current information and underlying mechanisms regarding the ameliorating effects of compound TCM preparation, Chinese materia medica,and active components on I/R-induced cerebral microcirculatory disturbances, brain injury and neuron damage. | Kai Sun Jingyu Fan Jingyan Han | 2015 | Acta Pharmaceutica Sinica B2015，5，1： | 85 |
| 6 | Mettl3-mediated m ^6A regulates spermatogonial differentia- tion and meiosis initiation显示文摘METTL3 催化 N 6-methyl-adenosine 的形成(m 6 一) 它在调整各种各样的生物过程有重要角色。然而,在里面 Mettl3 的 vivo 功能在哺乳动物仍然保持大部分未知。这里,我们产生了细菌房间特定的 Mettl3 猛烈老鼠并且证明 Mettl3 为男富饶和精子发生是必要的。在细菌房间的 Mettl3 的脱离严重地禁止了 spermatogonial 区别并且堵住了成熟分裂的开始。Transcriptome 和 m 6 介绍分析表明在精子发生工作的基因改变了表示并且其他的拼接的侧面。我们的调查结果提供新奇卓见进功能和调停 Mettl3 的 m 6 在精子发生的修正和在哺乳动物的复制。 | Kai Xu Ying- Yang Gui-Hai Feng Bao-Fa Sun Jun-Qing Chen Yu-Fei Li Yu-Sheng Chen Xin-Xin Zhang Chen-Xin Wang Li-Yuan Jiang Chao Liu Ze-Yu Zhang Xiu-Jie Wang Qi Zhou Yun-Gui Yang Wei Li | 2017 | Cell Research2017，27，9： | 53 |
| 7 | Precise A. T to G-C Base Editing in the RiceGenome显示文摘 | Kai Hua Xiaoping Tao Fengtong Yuan Dong Wang Jian-Kang Zhu | 2018 | Molecular Plant2018，11，4： | 60 |
| 8 | An insoluble polysaccharide from the sclerotium of Poria cocos improves hyperglycemia, hyperlipidemia and hepatic steatosis in ob/ob mice via modulation of gut microbiota显示文摘Metabolic syndrome characterized by obesity, hyperglycemia and liver steatosis is becoming prevalent all over the world. Herein, a water insoluble polysaccharide(WIP) was isolated and identified from the sclerotium of Poria cocos, a widely used Traditional Chinese Medicine. WIP was confirmed to be a(1-3)-β-D-glucan with an average Mw of 4.486 × 10~6 Da by NMR and SEC-RI-MALLS analyses. Furthermore, oral treatment with WIP from P. cocos significantly improved glucose and lipid metabolism and alleviated hepatic steatosis in ob/ob mice. 16 S DNA sequencing analysis of cecum content from WIP-treated mice indicated the increase of butyrate-producing bacteria Lachnospiracea, Clostridium. It was also observed that WIP treatment elevated the level of butyrate in gut, improved the gut mucosal integrity and activated the intestinal PPAR-γ pathway. Fecal transplantation experiments definitely confirmed the causative role of gut microbiota in mediating the benefits of WIP. It is the first report that the water insoluble polysaccharide from the sclerotium of P. cocos modulates gut microbiota to improve hyperglycemia and hyperlipidemia. Thereby, WIP from P. cocos, as a prebiotic, has the potential for the prevention or cure of metabolic diseases and may elucidate new mechanism for the efficacies of this traditional herbal medicine on the regulation of lipid and glucose metabolism. | SUN Shan-Shan WANG Kai MA Ke BAO Li LIU Hong-Wei | 2019 | Chinese Journal of Natural Medicines2019，17，1： | 60 |
| 9 | Water-Saving and High-Yielding Irrigation for Lowland Rice by Controlling Limiting Values of Soil Water Potential显示文摘现在的学习调查了一个灌溉系统是否能被建立节省水和增加谷物产量在灌溉低地大米(Oryza sativa L.) 在领域水平由合适的用水管理提高水生产率。用二地成年的米饭栽培变种,二个灌溉系统;常规灌溉和节省水的灌溉,被进行。在节省水的灌溉系统,限制与特定的生长阶段有关的土壤水潜力的价值作为灌溉索引被建议。与排水在在哪儿的常规灌溉相比在另外的时间,增加的谷物在 7.4% ~ 11.3% 产出的节省水的灌溉,在 24.5% ~ 29.2% 的减少的灌溉用水,和增加的水生产率中间季节、充满(谷物每灌溉用水的立方的米让步) 在 43.1% ~ 50.3% 。节省水的灌溉显著地增加了产量指数,改进 milling 和外观质量,在根流血提高了玉米素 + 玉米素核糖甙集中并且提高了在谷物的蔗糖 synthase,腺苷 diphosphateglucose pyrophosphorylase,淀粉 synthase 和淀粉分叉酶的活动。我们的结果由控制限制根和谷物,还原剂水输入,和增加谷物的生理的活动产出的与阶段能提高的特定的生长有关的土壤水潜力的价值显示那节省水的灌溉。 | Jianchang Yang Kai Liu Zhiqin Wang Yong Du Jianhua Zhang | 2007 | Journal of Integrative Plant Biology2007，49，10： | 46 |
| 10 | Spatio-temporal framework of tectonic uplift stages of the Tibetan Plateau in Cenozoic显示文摘Four intensive uplift periods, i.e., 60–35, 25–17 and 12–8 Ma (but 18–13 Ma in the Himalayas of the southern Tibet), and since about 5 Ma, can be determined on the Tibetan Plateau by synthetical analysis of low-temperature thermo-chronology data, sedimentary deposit records, and structural deformation records of different areas. The strong tectonic uplift periods in different areas on the Tibetan Plateau are penecontemporaneous, except for the Himalayan area of the southern Tibet, where a rapid uplift and exhumation period, controlled by the activity of the South Tibetan Detachment System faults, occurred during 18–13 Ma. These strong uplift and exhumation periods correspond well to intensive deformation activity periods, suggesting tectonically-controlled uplift and exhumation. The deposit records, such as the distribution of coarse clastic sediments, the distribution of tectonically-controlled basins, stratigraphic discontinuousness or unconformity, and fault-controlled geomorphologic evolution, also match well with the strong uplift and exhumation periods. Expanding processes of the plateau are also discussed. | WANG GuoCan CAO Kai ZHANG KeXin WANG An LIU Chao MENG YanNing XU YaDong | 2011 | Science China Earth Sciences2011，54，1： | 49 |
| 11 | Characteristics of hydrocarbon accumulation and exploration potential of the northern South China Sea deepwater basins显示文摘Although the huge potential of the northern South China Sea deepwater basins has been proven by a series of discoveries that followed the exploration breakthrough of well LW 3-1-1, recent drilling and other studies have demonstrated the uniqueness and complicated nature of hydrocarbon accumulations of the deepwater basins there. Based on a review of previous work and the latest exploration activities and studies, the purpose of this paper is to discuss the critical controls for hydrocarbon accumulations in the deepwater basins of the northern South China Sea. A terrestrial-marine transitional coal-bearing source rock is proposed to be the primary source rock for the deepwater basins. A marine source rock, which was first identified as contributing to hydro-carbon generation in this region, probably plays a significant role in the deep-and ultra-deep water basins south to the Pearl River Mouth and Qingdongnan basins. The shelf margin delta depositional systems in the Baiyun Sag, sourced from the Pearl River, are currently primary exploration targets in the deepwater part of the Pearl River Mouth Basin, whereas the western Red River delta-ic-submarine fan depositional systems, initially proven by drilling, are the possible major exploration reservoirs in the Qing-dongnan deepwater areas. Current deepwater exploration targets at the large-sized structural traps and deep and ultra-deep areas in the south of the Pearl River Mouth and Qingdongnan basins will be the future exploration focus. Deepwater exploration activities and relevant fundamental studies, supporting and promoting each other, are of great importance to the national energy supply of China, the basic regional studies of the South China Sea, advancements in technology, and development of related deepwater industries, and will safeguard national sovereignty and territorial integrity. | ZHU WeiLin ZHONG Kai LI YouChuan XU Qiang FANG DianYong | 2012 | Chinese Science Bulletin2012，57，24： | 48 |
| 12 | Crustal deformation on the Chinese mainland during 1998—2004 based on GPS data显示文摘This study focuses on resolving moderate amounts of crustal motion at the continental scale based on a large volume of global positioning system(GPS) data during 1998e2014. A state-of-the-art GPS processing strategy was used to resolve position time series and velocities from carrier beat phases for all available data. Position time series were closely analyzed to estimate linear constant, coseismic displacements, postseismic motions, and other parameters. We present coseismic offsets inferred from the GPS data for the 2010 Yushu and 2014 Yutian earthquakes, and also illustrate transient postseismic motions following the 2001 Kokoxili, 2008 Wenchuan, and 2011 Tohoku-Oki earthquakes. Since not all GPS position time series dominated by postseismic motions can be modeled and corrected reasonably, we present contemporary horizontal velocities from 2009 to 2014 for campaign stations and from 1998 to 2014 for continuous stations, irrespective of postseismic deformations. Our study concludes that we need to accumulate observations over a greater duration and apply accurate postseismic modeling to correct for transient displacement in order to resolve reasonable interseismic velocity. | Zhao Bin Huang Yong Zhang Caihong Wang Wei Tan Kai Du Rinlin | 2015 | Geodesy and Geodynamics2015，6，1： | 50 |
| 13 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 14 | Soil microbial biomass carbon and nitrogen in forest ecosystems of Northeast China:a comparison between natural secondary forest and larch plantation显示文摘Aims Natural secondary forest(NSF)and larch plantation are two of the predominant forest types in Northeast China.However,how the two types of forests compare in sustaining soil quality is not well understood.This study was conducted to determine how natural secondary forest and larch plantation would differ in soil microbial biomass and soil organic matter quality.Methods Microbial biomass carbon(MBC),microbial biomass nitrogen(MBN),soil organic carbon(SOC)and total nitrogen(TN)in the 0-to 15-cm and 15-to 30-cm soil layers were investigated by making chemical and biological measurements in the montane region of eastern Liaoning Province,Northeast China,during the growing season of 2008 in stands of NSF and Larix olgensis plantation(LOP).Important Findings We found that soil MBC and MBN were significantly lower in the LOP than in the NSF.Both MBC and MBN declined significantly with increasing soil depth in the two types of stands.The ratios of MBC to SOC(MBC/SOC)and MBN to TN(MBN/TN)were also significantly lower in the LOP than in the NSF.Moreover,the values of MBC,MBC/SOC,and MBN/TN significantly varied with time and followed a similar pattern during the growing season,all with an apparent peak in summer.Our results indicate that NSF is better in sustaining soil microbial biomass and nutrients than larch plantation in the temperate Northeast China.This calls for cautions in large-scale conversions of the native forests to coniferous plantations as a forest management practice on concerns of sustaining soil productivity. | Kai Yang Jiaojun Zhu Min Zhang Qiaoling Yan Osbert Jianxin Sun | 2010 | Journal of Plant Ecology2010，3，3： | 44 |
| 15 | PPAR gamma inhibits growth of rat hepatic stellate cells and TGF beta-induced connective tissue growth factor expression显示文摘瞄准:调查 peroxisome 的效果激活 proliferator 的受体鲸鱼群妈(PPAR 鲸鱼群妈) 肝的星形细胞(HSC ) 和转变生长因素贝它(TGF 贝它) 导致了的老鼠的生长上的激活结缔组织生长因素(CTGF ) 表示。方法:在与 PPAR 鲸鱼群妈天赋 ligand 15-deoxy-delta12,14-prostaglandin J (2 )(15-d-PGJ (2 )) 或合成 ligand GW7845 的各种各样的数量被对待以后, HSC 增长和 apoptosis 的地位被 MTT 试金和流动血细胞计数检测。而且, HSC 与 PPAR 鲸鱼群妈一起被对待在 15-d-PG J (2 ) 或 GW7845 的增加以前的特定的对手 GW9662 并且随后与 TGF- beta1 被刺激。CTGF 表示的 mRNA 和蛋白质层次被半量的 RT-PCR 和西方的弄污分析检测。在 HSC 的词法变化被电子显微镜学观察。结果:15-d-PGJ (2 ) 和 GW7845 显著地禁止了 HSC 增长并且以一种剂量依赖者方式导致了房间 apoptosis。而且, PPAR 鲸鱼群妈 ligands 显著地压制了 TGF-beta1-induced CTGF 表示(在 transcriptional 和 post-transcriptional 层次) 在 HSC,和禁止的效果是戏剧性地,如果不完全,与 GW9662 由预告的处理废除了,建议抑制是确实由 PPAR 鲸鱼群调停了妈。而且,词法观察揭示了激活引起了 HSC 的明显的变化从的那个 PPAR 鲸鱼群妈激活到静止显型。结论:PPAR 鲸鱼群妈 ligand 有一个有势力禁止在 HSC 和 TGF-beta1-induced CTGF 表示的生长上完成,它为肝的纤维变性的处理和预防使它成为一个潜在的 antifibrotic 候选人。 | Kai SUN Qian WANG Xiao-hui HUANG | 2006 | Acta Pharmacologica Sinica2006，27，6： | 35 |
| 16 | Reactivation of the insulin-like growth factor-Ⅱsignaling pathway in human hepatocellular carcinoma显示文摘Constitutive activation of the insulin-like growth factor (IGF)-signaling axis is frequently observed in human hepatocellular carcinoma(HCC).Especially the over- expression of the fetal growth factor IGF-Ⅱ,IGF-Ⅰ receptor(IGF-IR),and cytoplasmic downstream effectors such as insulin-receptor substrates(IRS)contribute to proliferation,anti-apoptosis,and invasive behavior. This review focuses on the relevant alterations in this signaling pathway and independent in vivo models that support the central role IGF-Ⅱsignaling during HCC development and progression.Since this pathway has become the center of interest as a target for potential anti-cancer therapy in many types of malignancies,various experimental strategies have been developed,including neutralizing antibodies and selective receptor kinase inhibitors,with respect to the specific and efficient reduction of oncogenic IGF-Ⅱ/IGF-IR-signaling. | Kai Breuhahn Peter Schirmacher | 2008 | World Journal of Gastroenterology2008，14，11： | 40 |
| 17 | 蜜瓜和西瓜果汁的射频介电特性及其与糖度的关系显示文摘为了解果汁的介电特性与其主要内部品质——糖度之间的关系,该文利用末端开路的同轴探头和阻抗分析仪测量了10 MHz~1.8 GHz的频率范围内不同成熟度的3个品种密瓜汁和4个品种西瓜汁的介电特性,同时测量了反映果汁糖度的可溶性固形物含量和果肉的含水率,分析了介电特性和糖度间的关系。结果显示:密瓜和西瓜果汁的相对介电常数和介质损耗因数皆随频率的增大单调减小,品种间的差异对介电特性有影响;1.8 GHz下密瓜汁的损耗角正切与糖度有较好的线性关系,其决定系数为0.784,但西瓜汁的介电特性与糖度的相关性较差;密瓜和西瓜果汁的糖度与果肉的含水率有很好的线性相关性,其决定系数分别为0.973和0.906。该研究将为基于介电特性的果汁糖度检测仪的开发提供了研究基础。 | 郭文川 Smart O. Nelson Samir Trabelsi Stanley J. Kays | 2008 | 农业工程学报2008，24，5： | 38 |
| 18 | The edaravone and 3-n-butylphthalide ring-opening derivative lob effectively attenuates cerebral ischemia injury in rats显示文摘目的: 复合 10b 是 edaravone 和 3-n-butylphthalide (NBP ) 的戒指洞衍生物的一个混合分子。这研究的目的是在焦点的服的局部缺血以后在老鼠在大脑损坏上检验复合 10b 的效果。 | Kai HUA Xiao SHENG Ting-ting LI Lin-na WANG Yi-hua ZHANG Zhang-jian HUANG Hui JI | 2015 | Acta Pharmacologica Sinica2015，36，8： | 35 |
| 19 | The role of the gut microbiome and its metabolites in metabolic diseases显示文摘It is well known that an unhealthy lifestyle is a major risk factor for metabolic diseases,while in recent years,accumulating evidence has demonstrated that the gut microbiome and its metabolites also play a crucial role in the onset and development of many metabolic diseases,including obesity,type 2 diabetes,nonalcoholic fatty liver disease,cardiovascular disease and so on.Numerous microorganisms dwell in the gastrointestinal tract,which is a key interface for energy acquisition and can metabolize dietary nutrients into many bioactive substances,thus acting as a link between the gut microbiome and its host.The gut microbiome is shaped by host genetics,immune responses and dietary factors.The metabolic and immune potential of the gut microbiome determines its significance in host health and diseases.Therefore,targeting the gut microbiome and relevant metabolic pathways would be effective therapeutic treatments for many metabolic diseases in the near future.This review will summarize information about the role of the gut microbiome in organism metabolism and the relationship between gut microbiome-derived metabolites and the pathogenesis of many metabolic diseases.Furthermore,recent advances in improving metabolic diseases by regulating the gut microbiome will be discussed. | Jiayu Wu Kai Wang Xuemei Wang Yanli Pang Changtao Jiang | 2021 | Protein & Cell2021，12，5： | 40 |
| 20 | SQUAMOSA Promoter-Binding Protein-Like Transcription Factors:Star Players for Plant Growth and Development显示文摘SQUAMOSA Promoter-Binding Protein-Like (SPL) genes encode plantspecific transcription factors that play important roles in plant phase transition,flower and fruit development,plant architecture,gibberellins signaling,sporogenesis,and response to copper and fungal toxins.In Arabidopsis,many SPL genes are post-transcriptionally regulated by the microRNA (miRNA) miR156,among which AtSPL9 in turn positively regulates the expression of the second miRNA miR172.This miR156AtSPL9-miR172 regulatory pathway plays critical roles during juvenile to adult leaf development and the miR156-SPLs feedback interaction persists all through the plant development,which may be conserved in other plants.In the present paper,we provide a concise review on the most recent progress in the regulatory mechanisms associated with plant SPL transcription factors,especially in relation to miRNAs.The potential application of these discoveries in agriculture is briefly discussed. | Xiaobo Chen Zenglin Zhang Danmei Liu Kai Zhang Aili Li Long Mao | 2010 | Journal of Integrative Plant Biology2010，52，11： | 31 |
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