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	题名	作者	年代	出处	被引量
1	Murine hepatocellular carcinoma derived stem cells reveal epithelial-to-mesenchymal plasticity显示文摘AIM To establish a model to enrich and characterize stemlike cells from murine normal liver and hepatocellular carcinoma(HCC) cell lines and to further investigate stem-like cell association with epithelial-to-mesenchymal transition(EMT).METHODS In this study,we utilized a stem cell conditioned serumfree medium to enrich stem-like cells from mouse HCC and normal liver cell lines,Hepa 1-6 and AML12,respectively.We isolated the 3-dimensional spheres and assessed their stemness characteristics by evaluating theRNA levels of stemness genes and a cell surface stem cell marker by quantitative reverse transcriptase-PCR(q RTPCR).Next,we examined the relationship between stem cells and EMT using q RT-PCR.RESULTS Three-dimensional spheres were enriched by culturing murine HCC and normal hepatocyte cell lines in stem cell conditioned serum-free medium supplemented with epidermal growth factor,basic fibroblast growth factor and heparin sulfate.The 3-dimensional spheres had enhanced stemness markers such as Klf4 and Bmi1 and hepatic cancer stem cell(CSC) marker Cd44 compared to parental cells grown as adherent cultures.We report that epithelial markers E-cadherin and ZO-1 were downregulated,while mesenchymal markers Vimentin and Fibronectin were upregulated in 3-dimensional spheres.The 3-dimensional spheres also exhibited changes in expression of Snai,Zeb and Twist family of EMT transcription factors.CONCLUSION Our novel method successfully enriched stem-like cells which possessed an EMT phenotype.The isolation and characterization of murine hepatic CSCs could establish a precise target for the development of more effective therapies for HCC.	Aparna Jayachandran Ritu Shrestha Bijay Dhungel I-Tao Huang Marianna Yumi Kawashima Vasconcelos Brian J Morrison Charmaine A Ramlogan-Steel Jason C Steel	2017	World Journal of Stem Cells2017，9，9：	4
2	Postcarotid endarterectomy cerebral hyperperfusion can be prevented by minimizing intraoperative cerebral ischemia and strict postoperative blood pressure control under continuous sedation 显示文摘	Kawamata T Okada Y Kawashima A	2009	Neurosurgery2009，64，3：	1
3	Imaging of nontraumatic hemorrhage of the adrenal gland显示文摘	Kawashima A Sandler C M Ernst R D	1999	Radiographics1999，19，：	1
4	DDB accumulates at DNA damage sites immediately after UV irradiation and directly stimulates nucleotide excision repair显示文摘	WAKASUGI M KAWASHIMA A MORIOKA H		0，，277：	1
5	Adaptation of HIV-1to human leukocyte antigen class I显示文摘	Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P	2009	Nature2009，458，7238：	1
6	Role of the CXCL12/CXCR4 axis inperitoneal carcinomatosis of gastric cancer显示文摘	YASUMOTO K KOIZUMI K KAWASHIMA A	2006	Cancer Res2006，66，4：	1
7	Role of the CXCL12/ CXCR4 axis in peritoneal carcinomatosis of gastric cancer显示文摘	Yasumoto K Koizumi K Kawashima A	2006	Cancer Res2006，66，4：	1
8	Relative displacement response spectra with pounding effect显示文摘	Ruangrassamee A Kawashima K	2001	Earthquake Engineering and Structural Dynamics2001，30，10：	1
9	Prevalence of dry eye disease and its risk factors in visual display terminal users:the osaka study显示文摘	Uchino M Yokoi N Uchino Y Dogru M Kawashima M Komuro A		0，，04：	1
10	Imaging of the seminal vesicle and vas deferens 显示文摘	Kim B Kawashima A Ryu J A	2009	Radiographics2009，29，4：	1
11	Incidence and predictive factors of cerebral hyperperfusion after extracranial-intracranial bypass for occlusive cerebrovascular diseases显示文摘	Yamaguchi K Kawamata T Kawashima A	2010	Neurosurgery2010，67，6：	1
12	Highly corrosion-resistant Ni-based bulk amorphous alloys显示文摘	KAWASHIMA A HABAZAKI H HASHIMOTO K	2001	Ma- terials Science and Engineering A2001，，：	1
13	Role of the CXCL12/CXCR4 axis in peritoneal carcinomatosis of gastric cancer 显示文摘	Yasumoto K Koizumi K Kawashima A	2006	Cancer Res2006，66，：	1
14	CTofrenal inflammatory disease显示文摘	Kawashima A SandierCM GoldmanSM el al	1997	Radiographics1997，17，4：	1
15	Vascular endothelial growth factor increases endothelin - converting enzyme expression in vascular endothelial cells 显示文摘	Matsuura A Kawashima S Yamochi W	1997	Biochem Biophys Res Commun1997，235，3：	1
16	Prevention of cerebral vasospasm by nicardipine prolonged-release implants in dogs 显示文摘	Kawashima A Kasuya H Sasahara A	2000	Neurol Res2000，22，6：	1
17	Post - earthquake residual displacements of bilinear oscillators 显示文摘	Macrae G A Kawashima K	1997	Earthquake Engineering & Structural Dynamics1997，26，7：	1
18	Imaging of renal trauma :a comprehensive review 显示文摘	Kawashima A Sandier CM Corl FM	2001	Radiographics2001，21，3：	1
19	Removal of H2S from hot gas in the presence of Cu-containing sorbents 显示文摘	Kyotani T Kawashima H Tomita A	1989	Fuel1989，68，1：	1
20	The efficacy of superficial temporal artery-middle cerebral artery anastomosis in patients with moyamoya disease complaining of severe headache 显示文摘	OKADA Y KAWAMATA T KAWASHIMA A	2012	J Neurosurg2012，116，3：	1

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