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| 1 | Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c显示文摘AIM To determine whether successful treatment with direc-tacting antivirals(DAA) is associated with improvements in hemoglobin A1 c(HbA1 c) and if type 2 diabetes mellitus(T2 DM) or metabolic syndrome affects sustained virologic response(SVR).METHODS We performed a retrospective analysis of all hepatitis C virus(HCV) patients at the VA Greater Los Angeles Healthcare System treated with varying DAA therapy between 2014-2016. Separate multivariable logistic regression was performed to determine predictors of HbA1 c decrease ≥ 0.5 after DAA treatment and predictors of SVR 12-wk post treatment(SVR12).RESULTS A total of 1068 patients were treated with DAA therapy between 2014-2016. The presence of T2 DM or metabolic syndrome did not adversely affect SVR12. 106 patients had both HCV and T2 DM. Within that cohort,patients who achieved SVR12 had lower mean HbA1 c pre treatment(7.35 vs 8.60,P = 0.02),and lower mean HbA1 c post-treatment compared to non-responders(6.55 vs 8.61,P = 0.01). The mean reduction in HbA1 c after treatment was greater for those who achieved SVR12 than for non-responders(0.79 vs 0.01,P = 0.03). In adjusted models,patients that achieved SVR12 were more likely to have a HbA1 c decrease of ≥ 0.5 than those that did not achieve SVR12(adjusted OR = 7.24,95%CI: 1.22-42.94). CONCLUSION In HCV patients with T2 DM,successful treatment with DAA was associated with a significant reduction in HbA1 c suggesting that DAA may have a role in improving insulin sensitivity. Furthermore,the presence of T2 DM or metabolic syndrome does not adversely affect SVR12 rates in patients treated with DAA. | Tien S Dong Elizabeth S Aby Jihane N Benhammou Jenna Kawamoto Steven-Huy Han Folasade P May Joseph R Pisegna | 2018 | World Journal of Hepatology2018，10，9： | 4 |
| 2 | Effects of intraaortic balloon pumping on the angiographic no-reflow phenomenon after percutaneous coronary intervention in patients with anterior myocardial infarction显示文摘 | Maekawa K Kawamoto K Fuke S | 2006 | Circ J2006，70，1： | 1 |
| 3 | Reaction behavior of lignin in supercritical methanol as studied with lignin model compounds显示文摘 | Minami E Kawamoto H Saka S | 2003 | J Wood Sci2003，49，2： | 1 |
| 4 | An ex-ploratory analysis of relationships between socioeconom- ic, land use, activity participation variables and travel pat- terns 显示文摘 | PITOMBO C S KAWAMOTO E SOUSA A J | 2011 | Transport Policy2011，，18： | 1 |
| 5 | Synthesis and characterization of energetic thermoplastic elastomers for propellant formulations显示文摘 | Kawamoto A M Oliveira J I Dutra R S | 2009 | Journal of Aerospace Technology and Management2009，1，1： | 1 |
| 6 | Possible paracrine mechanism of insulin-like growth factor-2 in the development of liver metastases fi'om colorectal carcinoma显示文摘 | Kawamoto K Onodera H Kan S | 1999 | Cancer1999，85，1： | 1 |
| 7 | Improved turbulence models for estimation of wind loading显示文摘 | Kawamoto S | 1997 | Journal of Wind Engineering and Industrial Aerodynamics1997，6768，： | 1 |
| 8 | Hot extrusion of rapidly solidified Al-Si alloy powder by the rotation-water-atomization process显示文摘 | YAMAUCHI I OHNAKA I KAWAMOTO S FUKUSAKO T | 1986 | Transactions of the Japan Institute of Metals1986，27，3： | 1 |
| 9 | Preparation of partly hydrophobized, crosslinked polyacrylamide particles by terpolymerizafion of -lamide/styrene in inverse microemulsion显示文摘 | Barton J Kawamoto S Fujimoto K | 2000 | Polymerization International2000，49，： | 1 |
| 10 | 查看详情显示文摘 | Hosoya T Kawamoto H Saka S | | 0，，01： | 1 |
| 11 | Effectiveness of the Headshaking Method Combined with Cisternal Irrigation with Urokinase in Preventing Cerebral Vasospasm after Subarachnoid Hemorrhage显示文摘 | Kawamoto S Tsutsumi K | 2004 | J Neurosurg2004，100，： | 1 |
| 12 | A noval reporter mouse strain that expression enhanced green fluorescent protein upon Cre-mediated recomb ination显示文摘 | Kawamoto S Niwa H Tahiro F et a1 | 2000 | FEBS Lett2000，470，3： | 1 |
| 13 | Structures and sorption properties of ionic crystals of Macrocation-Dawson-type polyoxometalates with different charges显示文摘 | UCHIDA S KAWAMOTO R AKATSUKA T | 2005 | Chem Mater2005，17，6： | 1 |
| 14 | Protec- tion of chickens from fowl cholera by vaccination with recombi- nant adhesive protein of Pasteurella multocida 显示文摘 | STHITMATEE N NUMEE S KAWAMOTO E | 2008 | Vaccine2008，26，19： | 1 |
| 15 | Pyrolysis of melamine- formaldehyde and urea-formaldehyde resins 显示文摘 | HIRATA T KAWAMOTO S OKURO A | 1991 | Journal of Applied Polymer Science1991，42，12： | 1 |
| 16 | Contribution of bonemarrow-derived endothelial progenitor cells to neovascularization and astrogliosis following spinal cord injury显示文摘 | Kamei N Kwon S M Kawamoto A | 2012 | J Neurosci Res2012，90，12： | 1 |
| 17 | Hypoxia sensing in Cryptococcus neoformans: biofilm-like adaption for dormancy显示文摘 | Moranova Z Kawamoto S Raclavsky V | 2009 | Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub2009，153，3： | 1 |
| 18 | Production of γ-aminobutyric acid(GABA) by Lactobacillus paracasei isolated from traditional fermented foods 显示文摘 | Komatsuzaki N Shima J Kawamoto S | 2005 | Food Microbiol2005，22，6： | 1 |
| 19 | Control of epilepsy associated with cerebral arteriovenous malformations after radiosurgery 显示文摘 | Kawamoto S Suzuki I | 1998 | J Neurol Neurosurg Psychiatry1998，65，5： | 1 |
| 20 | Intraerythrocytic schizogony of Theileria sergenti in cattle显示文摘 | | 1990 | Nippon J uigaku Zasshi1990，52，6： | 1 |
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