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| 1 | Metabolic syndrome does not affect sustained virologic response of direct-acting antivirals while hepatitis C clearance improves hemoglobin A1c显示文摘AIM To determine whether successful treatment with direc-tacting antivirals(DAA) is associated with improvements in hemoglobin A1 c(HbA1 c) and if type 2 diabetes mellitus(T2 DM) or metabolic syndrome affects sustained virologic response(SVR).METHODS We performed a retrospective analysis of all hepatitis C virus(HCV) patients at the VA Greater Los Angeles Healthcare System treated with varying DAA therapy between 2014-2016. Separate multivariable logistic regression was performed to determine predictors of HbA1 c decrease ≥ 0.5 after DAA treatment and predictors of SVR 12-wk post treatment(SVR12).RESULTS A total of 1068 patients were treated with DAA therapy between 2014-2016. The presence of T2 DM or metabolic syndrome did not adversely affect SVR12. 106 patients had both HCV and T2 DM. Within that cohort,patients who achieved SVR12 had lower mean HbA1 c pre treatment(7.35 vs 8.60,P = 0.02),and lower mean HbA1 c post-treatment compared to non-responders(6.55 vs 8.61,P = 0.01). The mean reduction in HbA1 c after treatment was greater for those who achieved SVR12 than for non-responders(0.79 vs 0.01,P = 0.03). In adjusted models,patients that achieved SVR12 were more likely to have a HbA1 c decrease of ≥ 0.5 than those that did not achieve SVR12(adjusted OR = 7.24,95%CI: 1.22-42.94). CONCLUSION In HCV patients with T2 DM,successful treatment with DAA was associated with a significant reduction in HbA1 c suggesting that DAA may have a role in improving insulin sensitivity. Furthermore,the presence of T2 DM or metabolic syndrome does not adversely affect SVR12 rates in patients treated with DAA. | Tien S Dong Elizabeth S Aby Jihane N Benhammou Jenna Kawamoto Steven-Huy Han Folasade P May Joseph R Pisegna | 2018 | World Journal of Hepatology2018，10，9： | 4 |
| 2 | Relationship Between Non-stoichiometry and Physical Properties in LiNiO2 显示文摘 | HIRANO A KANNO R KAWAMOTO Y | 1995 | Solid State Ionics1995，78，： | 1 |
| 3 | Three tenets for staged eorreetion of Kleehlattsehidelor cloverleaf skull deformity 显示文摘 | Jarrahy R Kawamoto HK Keagle J | 2009 | Plast Reeonstr Surg2009，123，： | 1 |
| 4 | An association between decreased estimated glomerular filtration rate and arterial stiffness显示文摘 | Kawamoto R Kohara K Tabara Y | 2008 | Intern Med2008，47，7： | 1 |
| 5 | Synthesis and characterization of energetic thermoplastic elastomers for propellant formulations显示文摘 | Kawamoto A M Oliveira J I Dutra R S | 2009 | Journal of Aerospace Technology and Management2009，1，1： | 1 |
| 6 | Therapeutic potential ofvasculogenesis and osteogenesis promoted by peripheral blood CD34-positive cells for functional bone healing显示文摘 | Matsumoto T Kawamoto A Kuroda R | 2006 | Am J Pathol2006，169，： | 1 |
| 7 | Phase relationship and lithium deintercalation in lithium nickel oxide显示文摘 | Kanno R Kubo H Kawamoto Y | 1994 | J Solid State Chem1994，110，2： | 1 |
| 8 | Role of Hand1/eHAND in the dorso-ventral patterning and interventricular septum formation in the embryonic heart显示文摘 | Togi K Kawamoto T Yamauchi R | 2004 | Mol Cell Biol2004，24，11： | 1 |
| 9 | Plasma resistin, associated with single nucleotide polymorphism-420, is correlated with insulin resistance, lower HDL cholesterol, and hlgh-sensitivity C-reactive protein in the Japanese general population 显示文摘 | OSAWA H TABARA Y KAWAMOTO R | 2007 | Diabetes Care2007，30，： | 1 |
| 10 | A longitudinal study of gender differences in quality of life among Japanese patients with lower rectal cancer treated with sphincter-saving surgery: a l-year follow-up显示文摘 | Kinoshita Y Chishaki A Kawamoto R | 2015 | World JSurgOncol2015，13，： | 1 |
| 11 | Significance of serum circulating hepatocyte growth factor in the development of carotid atherosclerosis显示文摘 | Kawamoto R Oka Y Yoshida O | 2003 | J Atheroscler Thromb2003，10，3： | 1 |
| 12 | High-sensitivity C-reactive protein and gamma-glutamyl transferase levels are synergistically associated with metabolic syndrome in community-dwelling persons 显示文摘 | Kawamoto R Tabara Y Kohara K | 2010 | Cardiovasc Diabetol2010，9，： | 1 |
| 13 | Structures and sorption properties of ionic crystals of Macrocation-Dawson-type polyoxometalates with different charges显示文摘 | UCHIDA S KAWAMOTO R AKATSUKA T | 2005 | Chem Mater2005，17，6： | 1 |
| 14 | Significance of Serum Circulating Hepatocyte Growth Factor in the Development of Carotid Atherosclerosis显示文摘 | KAWAMOTO R OKA Y YOSHIDA O | 2003 | J Atheroscler Thromb(S1340- 3478)2003，10，3： | 1 |
| 15 | An association of 5, 10-Methylenete-trahydro- folate Reductase (MTHFR) gene polymorphism and ischemic stroke显示文摘 | Kawamoto R Kohara K Oka Y | 2005 | J Stroke Cerebrovasc Dis2005，14，2： | 1 |
| 16 | Serum high molecular weight adiponectin correlates with arterial stiffness in community- dwelling persons 显示文摘 | Kawamoto R Tabara Y Kohara K | 2011 | Endoer Res2011，36，2： | 1 |
| 17 | High prevalence of prehypertension is associated with the increased body mass index in community-dwelling Japanese显示文摘 | Kawamoto R Kohara K Tabara Y | 2008 | The Tohoku Journal of Experimental Medicine2008，216，： | 1 |
| 18 | Different inflammatory response and oxidative stress in neointimal hyperplasia after balloon angioplasty and stent implantation in cholesterol-fed rabbits显示文摘 | Kawamoto R Yamashita A Nishihira K | 2006 | Pathol Res Pract2006，202，6： | 1 |
| 19 | Channel-selective independent sorption and collection of hydrophilic and hydrophobic molecules by Csz 2 ionic crystal 显示文摘 | Jiang C Lesbani A Kawamoto R | 2006 | J Am Chem Soc2006，128，14： | 1 |
| 20 | Postoperative hemor- rhage after major pancreatobiliary surgery:an update显示文摘 | Jagad R B Koshariya M Kawamoto J | 2008 | Hepato- gastroenterology2008，55，： | 1 |
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