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| 1 | Roles of CREB-binding protein (CBP)/p300 in respiratory epithelium tumorigenesis显示文摘CREB 有约束力的蛋白质(CBP ) 和它的相当或相同事物 p300 是涉及细胞的活动的一个宽数组的各种各样的顺序特定的抄写因素的 transcriptionalco 使活跃之物,例如脱氧核糖核酸修理,房间生长,区别和 apoptosis。Severalstudies 建议了 CBP 和 p300 可能被看作瘤压制 ors,与他们是的突出的角色响应各种各样的刺激的不同基因表示模式的跨 coupling。他们主要经由乙酰化施加行动嘘和另外的规章的蛋白质(例如 p53 ) 。在 CBP/p300 功能的主要悖论是他们似乎能够贡献各种各样的反对细胞的进程。呼吸上皮 tumorigenesis 代表一个范围的多步累积的一个复杂过程基因并且 epigenetic 错误。通过激活和压抑的建筑群的交替的形成的 Transcriptionmodulation 是这些精神错乱的最终的收敛点,并且 CBP/p300 在这相互影响代表关键参加者。因此,他们的分子的行动和相互作用的照明能在呼吸上皮 carcinogenesis 为药理学干预揭示新潜在的目标。 | Michalis V Karamouzis Panagiotis A Konstantinopoulos Athanasios G Papavassiliou | 2007 | Cell Research2007，17，4： | 5 |
| 2 | Pancreatic ductal adenocarcinoma: Treatment hurdles, tumor microenvironment and immunotherapy显示文摘Pancreatic ductal adenocarcinoma(PDAC)is one of the most lethal diseases,with an average 5-year survival rate of less than 10%.Unfortunately,the majority of patients have unresectable,locally advanced,or metastatic disease at the time of diagnosis.Moreover,traditional treatments such as chemotherapy,surgery,and radiation have not been shown to significantly improve survival.Recently,there has been a swift increase in cancer treatments that incorporate immunotherapybased strategies to target all the stepwise events required for tumor initiation and progression.The results in melanoma,non-small-cell lung cancer and renal cell carcinoma are very encouraging.Unfortunately,the application of checkpoint inhibitors,including anti-CTLA4,anti-PD-1,and anti-PD-L1 antibodies,in pancreatic cancer has been disappointing.Many studies have revealed that the PDAC microenvironment supports tumor growth,promotes metastasis and consists of a physical barrier to drug delivery.Combination therapies hold great promise for enhancing immune responses to achieve a better therapeutic effect.In this review,we provide an outline of why pancreatic cancer is so lethal and of the treatment hurdles that exist.Particular emphasis is given to the role of the tumor microenvironment,and some of the latest and most promising studies on immunotherapy in PDAC are also presented. | Panagiotis Sarantis Evangelos Koustas Adriana Papadimitropoulou Athanasios G Papavassiliou Michalis V Karamouzis | 2020 | World Journal of Gastrointestinal Oncology2020，12，2： | 4 |
| 3 | Upgraded role of autophagy in colorectal carcinomas显示文摘Autophagy is a basic catabolic process closely asso-ciated with degradation of cellular components. The role of autophagy in colorectal cancer(CRC) remains controversial. The mechanism of autophagy has been identified as protecting mechanism against tumorige-nesis by isolation of damaged organelles or as cytopro-tective provides energy in hypoxic regions of CRC tumors. Mutations in proto-oncogenes, such as RAS and BRAF, have been associated with autophagy initiation through signaling pathways of BRAF/MEK/ERK and PI3 K/AKT/m TOR. A combination therapy of chemotherapeutic agents and autophagy inhibitors such as hydroxychloroquine or immunotherapy might represent a major step that could be evaluated as a putative novel therapeutic strategy in CRC patients. | Evangelos Koustas Panagiotis Sarantis Athanassios G Papavassiliou Michalis V Karamouzis | 2018 | World Journal of Gastrointestinal Oncology2018，10，11： | 3 |
| 4 | Non -palpable breast carcinomas:correlation of mammographically detected malignant-appearing microcalcifications and molecular prognostic factors显示文摘 | Karamouzis MV Likaki -Karatza E Ravazoula P | 2002 | Int J Cancer2002，，1： | 1 |
| 5 | Molecular networks in respiratory epithelium carcinomas 显示文摘 | Pallis A G Karamouzis M V Konstantinopoulos P A | 2010 | Cancer Lett2010，295，1： | 1 |
| 6 | Hepatocellular carcinoma metastasis in the pituitary gland:case report and review of the literature显示文摘 | MV Karamouzis M Melachrinou M Fratzoglou | 2003 | J Neure - Oneol2003，63，： | 1 |
| 7 | Effects of cetrorelix, a GnRH-receptor antagonist, on gonadal axis in women with functional hypothalamic amenorrhea显示文摘 | Berardelli R Gianotti L Karamouzis I | 2011 | Gynecol Endocrinol2011，27，10： | 1 |
| 8 | Non-palpable breast car- cinomas: correlation of mammographically detected malignant-appearing microcalcifications and molecular prognostic factors 显示文摘 | Karamouzis MV Karatza EL Ravagiota P | 2002 | Int J Cancer2002，102，1： | 1 |
| 9 | Targeting MET as a strategy to overcome crosstalk-related resistance to EGFR inhibitors显示文摘 | Karamouzis MV Konstantinopoulos PA Papavassiliou AG | 2009 | Lancet Oncol2009，10，7： | 1 |
| 10 | The effects of mara- thon swimming on serum leptin and plasma neuropeptide Y levels 显示文摘 | I Karamouzis M Karamouzis IS Vrabas et al | 2002 | Clin Chein Lab Med2002，，2： | 1 |
| 11 | Evidence for in vivo synergism between docetaxel and gemcitabine in patients with metastatic breast cancer 显示文摘 | Alexopoulos A Tryfonopoulos D Karamouzis MV | 2004 | Ann Oncol2004，15，： | 1 |
| 12 | Head and neck cancer显示文摘 | Argiris A Karamouzis MV Raben D | 2008 | Lancet2008，371，9625： | 1 |
| 13 | Effect of sympathetic and plasma renin activity on hemodialysis hypertension 显示文摘 | Grekas D Kalevrosoglou I Karamouzis M | 2001 | Clin Nephrol2001，55，2： | 1 |
| 14 | The power and promise of 'rewiring' the mitogen-activated protein kinase network in prostate cancer therapeutics 显示文摘 | Papatsoris AG Karamouzis MV Papavassiliou AG | 2007 | Mol Cancer Ther2007，6，： | 1 |
| 15 | Phase Ⅱ trial of pemetrexed and bevacizumab in patients with recurrent or metastatic head and neck cancer显示文摘 | ARGIRIS A KARAMOUZIS M V GOODING W E | | 0，，09： | 1 |
| 16 | Effect of sympathetic and plasma renin activity on hemodialysis hypertension显示文摘 | Grekas D Kalevrosoglou I Karamouzis M | 2001 | Clin Nephrol2001，55，2： | 1 |
| 17 | Phase II trial of pemetrexed(P)and bevacizumab(B)in patients(pts)with recurrent or metastatic head and neck squamous cell carcinoma(HNSCC):an interim analysis显示文摘 | Karamouzis M Friedland D Johnson R | 2007 | J Clin Oncol2007，25，18： | 1 |
| 18 | Investigational agents for treatment of AIDS-related Kaposi′s sarcoma显示文摘 | Konstantinopoulos PA Sullivan RJ Karamouzis MV | | 0，，： | 1 |
| 19 | The effects of marathon swimming on serum leptin and plasma neuropeptide Y levels 显示文摘 | I Karamouzis M Karamouzis IS Vrabas et al | 2002 | Clin Chem Lab Med2002，，2： | 1 |
| 20 | Non-palpable breast carcinomas:correlation of mammographically detected malignant-appearing microcalcifications and molecular prognostic factors显示文摘 | Karamouzis MV Likaki-Karatza E Ravazoula P | 2002 | Int J Cancer2002，102，： | 1 |
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