| 2 | MOCS2 links nucleotide metabolism to nucleoli function显示文摘Dear Editor,Three polyamines,putrescine,spermidine,and spermine,are tightly regulated and are synthesized from arginine,ornithine,and methionine(Miller-Fleming et al.,2015;Figure 1A).Polyamine levels are increased in the red blood cells of amyotrophic lateral sclerosis and Parkinson’s disease(PD)patients(Miller-Fleming et al.,2015).Sulfur amino acid catabolism regulated by the molybdopterin synthase associating complex prevents onset of early events in PD and Alzheimer’s disease(Suganuma et al.,2018).MPT synthase,a heterodimer of MOCS2A and MOCS2B encoded by MOCS2,is essential for the biosynthesis of molybdenum cofactor(Moco). | Tamaki Suganuma Selene K.Swanson Madelaine Gogol Timothy J.Garrett Laurence Florens Jerry L.Workman | 2021 | Journal of Molecular Cell Biology2021，13，11： | 0 |
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