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| 1 | Modulation of autophagy for neuroprotection and functional recovery in traumatic spinal cord injury显示文摘Spinal cord injury(SCI) is a serious central nervous system trauma that leads to loss of motor and sensory functions in the SCI patients. One of the cell death mechanisms is autophagy, which is ‘self-eating' of the damaged and misfolded proteins and nucleic acids, damaged mitochondria, and other impaired organelles for recycling of cellular building blocks. Autophagy is different from all other cell death mechanisms in one important aspect that it gives the cells an opportunity to survive or demise depending on the circumstances. Autophagy is a therapeutic target for alleviation of pathogenesis in traumatic SCI. However, functions of autophagy in traumatic SCI remain controversial. Spatial and temporal patterns of activation of autophagy after traumatic SCI have been reported to be contradictory. Formation of autophagosomes following therapeutic activation or inhibition of autophagy flux is ambiguous in traumatic SCI studies. Both beneficial and harmful outcomes due to enhancement autophagy have been reported in traumatic SCI studies in preclinical models. Only further studies will make it clear whether therapeutic activation or inhibition of autophagy is beneficial in overall outcomes in preclinical models of traumatic SCI. Therapeutic enhancement of autophagy flux may digest the damaged components of the central nervous system cells for recycling and thereby facilitating functional recovery. Many studies demonstrated activation of autophagy flux and inhibition of apoptosis for neuroprotective effects in traumatic SCI. Therapeutic induction of autophagy in traumatic SCI promotes axonal regeneration, supporting another beneficial role of autophagy in traumatic SCI. In contrast, some other studies demonstrated that disruption of autophagy flux in traumatic SCI strongly correlated with neuronal death at remote location and impaired functional recovery. This article describes our current understanding of roles of autophagy in acute and chronic traumatic SCI, crosstalk between autophagy and apoptosis, therapeutic activation or inhibition of autophagy for promoting functional recovery, and future of autophagy in traumatic SCI. | Swapan K.Ray | 2020 | Neural Regeneration Research2020，15，9： | 9 |
| 2 | A Power Management Scheme for Grid-connected PV Integrated with Hybrid Energy Storage System显示文摘The penetration of renewable energy sources(RESs)in the distribution system becomes a challenge for the reliable and safe operation of the existing power system.The sporadic characteristics of sustainable energy sources along with the random load variations greatly affect the power quality and stability of the system.Hence,it requires storage systems with both high energy and high power handling capacity to coexist in microgrids.An efficient energy management structure is designed in this paper for a grid-connected PV system combined with hybrid storage of supercapacitor and battery.The combined supercapacitor and battery storage system grips the average and transient power changes,which provides a quick control for the DC-link voltage,i.e.,it stabilizes the system and helps achieve the PV power smoothing.The average power distribution between the power grid and battery is done by checking the state of charge(SOC)of a battery,and an effective and efficient energy management scheme is proposed.Additionally,the use of a supercapacitor lessens the current stress on the battery system during unexpected disparity in the generated power and load requirement.The performance and efficacy of the proposed energy management scheme are justified by simulation studies. | Anindya Bharatee Pravat K.Ray Arnab Ghosh | 2022 | Journal of Modern Power Systems and Clean Energy2022，10，4： | 2 |
| 3 | Design of high-strength refractory complex solid-solution alloys显示文摘Nickel-based superalloys and near-equiatomic high-entropy alloys containing molybdenum are known for higher temperature strength and corrosion resistance.Yet,complex solid-solution alloys offer a huge design space to tune for optimal properties at slightly reduced entropy.For refractory Mo-W-Ta-Ti-Zr,we showcase KKR electronic structure methods via the coherent-potential approximation to identify alloys over five-dimensional design space with improved mechanical properties and necessary global(formation enthalpy)and local(short-range order)stability.Deformation is modeled with classical molecular dynamic simulations,validated from our first-principle data.We predict complex solid-solution alloys of improved stability with greatly enhanced modulus of elasticity(3×at 300 K)over near-equiatomic cases,as validated experimentally,and with higher moduli above 500 K over commercial alloys(2.3×at 2000 K).We also show that optimal complex solid-solution alloys are not described well by classical potentials due to critical electronic effects. | Prashant Singh Aayush Sharma A.V.Smirnov Mouhamad S.Diallo Pratik K.Ray Ganesh Balasubramanian Duane D.Johnson | 2018 | npj Computational Materials2018，，1： | 2 |
| 4 | Flavonoids activated caspases for apoptosis in human glioblastoma T98G and U87MG cells but not in human normal astrocytes显示文摘 | ArabindaDas Naren L.Banik Swapan K.Ray | 2010 | Cancer2010，，1： | 2 |
| 5 | Neuroprotective role of Noggin in spinal cord injury显示文摘Spinal cord injury is one of the leading causes of morbidity and mortality among young adults in many countries including the United States.Difficulty in the regeneration of neurons is one of the main obstacles that leave spinal cord injury patients with permanent paralysis in most instances.Recent research has found that preventing acute and subacute secondary cellular damages to the neurons and supporting glial cells can help slow the progression of spinal cord injury pathogenesis,in part by reactivating endogenous regenerative proteins including Noggin that are normally present during spinal cord development.Noggin is a complex protein and natural inhibitor of the multifunctional bone morphogenetic proteins,and its expression is high during spinal cord development and after induction of spinal cord injury.In this review article,we first discuss the change in expression of Noggin during pathogenesis in spinal cord injury.Second,we discuss the current research knowledge about the neuroprotective role of Noggin in preclinical models of spinal cord injury.Lastly,we explain the gap in the knowledge for the use of Noggin in the treatment of spinal cord injury.The results from extensive in vitro and in vivo research have revealed that the therapeutic efficacy of Noggin treatment remains debatable due to its neuroprotective effects observed only in early phases of spinal cord injury but little to no effect on altering pathogenesis and functional recovery observed in the chronic phase of spinal cord injury.Furthermore,clinical information regarding the role of Noggin in the alleviation of progression of pathogenesis,its therapeutic efficacy,bioavailability,and safety in human spinal cord injury is still lacking and therefore needs further investigation. | Nadia Al-Sammarraie Mohammed Mahmood Swapan K.Ray | 2023 | Neural Regeneration Research2023，18，3： | 2 |
| 6 | Melatonin attenuates calpain upregulation, axonal damage and neuronal death in spinal cord injury in rats显示文摘 | SupritiSamantaray Eric A.Sribnick ArabindaDas Varduhi H.Knaryan D. DeniseMatzelle Anil V.Yallapragada Russel J.Reiter Swapan K.Ray Naren L.Banik | 2007 | Journal of Pineal Research2007，，4： | 1 |
| 7 | Early induction of secondary injury factors causing activation of calpain and mitochondria‐mediated neuronal apoptosis following spinal cord injury in rats显示文摘 | J. MichaelWingrave Kurt E.Schaecher Eric A.Sribnick Gloria G.Wilford Swapan K.Ray Debra J.Hazen‐Martin Edward L.Hogan Naren L.Banik | 2003 | J Neurosci Res2003，，1： | 1 |
| 8 | Early induction of secondary injury factors causing activation of calpain and mitochondria‐mediated neuronal apoptosis following spinal cord injury in rats显示文摘 | J. MichaelWingrave Kurt E.Schaecher Eric A.Sribnick Gloria G.Wilford Swapan K.Ray Debra J.Hazen‐Martin Edward L.Hogan Naren L.Banik | 2003 | J Neurosci Res2003，，1： | 1 |
| 9 | Recent patterns of crop yield growth and stagnation显示文摘 | Deepak K.Ray Navin Ramankutty Nathaniel D.Mueller Paul C.West & Jonathan A.Foley | | 0，，： | 1 |
| 10 | Rotational asymmetry of reactant concentration and its evolution in a circulating fluidized bed riser显示文摘Rotational asymmetric distribution of reactant (ozone) concentration and its evolution along with the gas-solid reactive flow were studied in a 76 mm i.d., 10.2 m high circulating fluidized bed (CFB) riser reactor. The superficial gas velocity ranged from 3 to 5 m/s and the solids circulation rates were 50 and 100 kg/(m2 s). Experimental results show that the asymmetry of reactant distribution can extend to a height close to the length of flow developing zone of the CFB riser reactor and then disappears. Based on the hydrodynamics of the gas and solid phases in the solids entrance region, this asymmetry can be attributed to the effect of the solids entrance structure. | Ajay K.Ray Madhumita B.Ray Jesse Zhu | 2012 | Particuology2012，10，5： | 1 |
| 11 | Author Correction:Design of high-strength refractory complex solid-solution alloys显示文摘Correction to:npj Computational Materials http://gffzzd3cc09b8251d45dfsqxvufo9uk9p6605v.ffgz.tsg.suse.edu.cn/10.1038/s41524-018-0072-0,Published online 28 March 2018 The caption of Fig.6 and the main text contained an error in the chemical formula of the“(Mo_(z)W_(1−z))_(0.85)Ta_(0.10)(TiZr)_(0.05)”alloy;it has now been corrected to“(Mo_(1−z)W_(z))_(0.85)Ta_(0.10)(TiZr)_(0.05)”.Figure 5 also contained an erroneous text box,which has now been removed.This has now been corrected in both the PDF and HTML version of this article. | Prashant Singh Aayush Sharma A.V.Smirnov Mouhamad S.Diallo Pratik K.Ray Ganesh Balasubramanian Duane D.Johnson | 2018 | npj Computational Materials2018，，1： | 0 |
| 12 | Human-like stereo sensors using plasmonic antenna embedded MZI with space–time modulation control[Invited]显示文摘A micro stereo sensor system is proposed for human sensors,where eyes,ears,tongue,nose,body,and brain are applied by six panda rings embedded in a Mach–Zehnder interferometer(MZI).The input power is applied to the upper branch of MZI and propagates within the system.The six antennas(sensors)are formed by the whispering gallery modes of the panda rings.The space–time modulation signal is applied to the MZI lower branch.The modulated stereo signals can be configured as the plasmon(electron)spin orientations,which can be identified and applied for quantum codes and quantum consciousness. | A.Garhwal A.E.Arumona P.Youplao K.Ray I.S.Amiri P.Yupapin | 2021 | Chinese Optics Letters2021，19，10： | 0 |
| 13 | 油气微渗漏及相关近地表蚀变模型显示文摘尽管在地表和近地表地球化学勘探方面取得了一些进展,但还有必要对这一与油气藏有关的学科进行进一步的了解。在博览了与我们过去使用的方法有关的文献后,将这些信息与我们大约100人年的经历综合之后形成了此文。事实表明,来自油气藏的微渗漏极有可能包含上浮的胶粒大小的轻烃(主要是从甲烷到丁烷)微气泡,这些气泡通过充满水的裂隙、节理和岩层面网络相对较快地上升这些烃经细菌的消耗能产生CO_2和H_2S,它们能改变沉积物,从而在地形、地震剖面、航磁和放射性特征等方面产生可探测到的变化。我们已将航空微波遥感和土壤烃气实验室分析与浅源航磁和土壤磁性测量、航空和地表放射性测量以及地貌学结合起来用于发现油气藏,结果表明,使用这些方法能大大增加野猫井的成功率,并在精选的地质环境中降低发现成本。然而,这些方法不能提供有关深度、大小、储层质量以及油气藏是否具有开发价值这类信息。 | Donald F.Saunders K.Ray Burson 王桂宏 张友焱 李永铁 夏响华 | 1999 | 国外油气勘探1999，11，6： | 0 |
| 14 | Why do‘OFF’periods still occur during continuous drug delivery in Parkinson’s disease?显示文摘Continuous drug delivery(CDD)is used in moderately advanced and late-stage Parkinson’s disease(PD)to control motor and non-motor fluctuations(‘OFF’periods).Transdermal rotigotine is indicated for early fluctuations,while subcutaneous apomorphine infusion and levodopa-carbidopa intestinal gel are utilised in advanced PD.All three strategies are considered examples of continuous dopaminergic stimulation achieved through CDD.A central premise of the CDD is to achieve stable control of the parkinsonian motor and non-motor states and avoid emergence of‘OFF’periods.However,data suggest that despite their efficacy in reducing the number and duration of‘OFF’periods,these strategies still do not prevent‘OFF’periods in the middle to late stages of PD,thus contradicting the widely held concepts of continuous drug delivery and continuous dopaminergic stimulation.Why these emergent‘OFF’periods still occur is unknown.In this review,we analyse the potential reasons for their persistence.The contribution of drug-and device-related involvement,and the problems related to site-specific drug delivery are analysed.We propose that changes in dopaminergic and non-dopaminergic mechanisms in the basal ganglia might render these persistent‘OFF’periods unresponsive to dopaminergic therapy delivered via CDD. | Silvia Rota Daniele Urso Daniel J.van Wamelen Valentina Leta Iro Boura Per Odin Alberto J.Espay Peter Jenner K.Ray Chaudhuri | 2022 | Translational Neurodegeneration2022，11，1： | 0 |
| 15 | ANTIMICROBIAL ACTIVITY OF COPOLYMERS OF 2,4-DICHLOROPHENYL ACRYLATE WITH STYRENE:SYNTHESIS,CHARACTERIZATION AND REACTIVITY RATIOS显示文摘Some copolymers of 2,4-dichlorophenyl acrylate (2,4-DCPA) with styrene (St) of different teed compositions were prepared by tree radical polymerization technique using 2,2′-azobisisobutyronitrile (AIBN) as an initiator,and the copolymers were characterized by IR spectroscopy.The copolymer composition obtained by UV-spectra led to determination of reactivity ratio by employing Fineman-Ross (F-R) and Kelen-Tudos (K-T) methods.Average molecular weight,as well as intrinsic viscosity,was obtained by vapor pre... | Hetal J.Patel Mitesh G.Patel Kirit H.Patel Arabinda K.Ray Rajni M.Patel | 2009 | Chinese Journal of Polymer Science2009，27，1： | 0 |
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