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| 1 | Distr ibution, risk and bioavailability of metals in sediments of Lake Yamdrok Basin on the Tibetan Plateau, China显示文摘Total contents of metals in soil and sediments on the Tibetan Plateau of China have been widely analyzed,but existing information is insufficient to effectively evaluate metal ecological risk because of a lack of metal bioavailability data.In this study,distribution,potential risk,mobility and bioavailability of metals in sediments of Lake Yamdrok Basin in Tibet of China were explored by combined use of total digestion,sequential extraction and the diffusive gradient in thin-films(DGT).Average concentrations of Cr,Ni,Cu,Zn,As,Cd and Pb in surface sediments were 31.25,30.31,22.00,45.04,31.32,0.13 and 13.39 mg/kg,respectively.Higher levels of metals were found near the inflowing rivers.Residual form was dominant in Cr,Ni,Zn,Cd and Pb,and reducible form was dominant in As and Cd.Metals in surface sediments showed a low enrichment degree overall,but Cd and As had higher ecological risk levels than the other metals.Furthermore,there was a larger average proportion of exchangeable form of As(20.4%)and Cd(9.0%)than the other metals(1.7%-3.3%),implying their higher mobility and release risk.Average DGT-labile concentrations of Cr,Ni,Cu,Zn,As,Cd and Pb were 0.5,4.5,0.7,25.1,60.0,0.22 and 1.0μg/L,respectively.The DGT-labile As was significantly correlated with extractable As forms(p<0.01),suggesting that extractable As in sediments acts as a'mobile pool'for bioavailable As.These results suggest potential risks of As and Cd,especially As,deserve further attention in Lake Yamdrok Basin. | Feifei Che Junyi Chen Bo Zhang Xia Jiang Shuhang Wang | 2020 | Journal of Environmental Sciences2020，32，11： | 4 |
| 2 | Stem cell niche-inspired microcarriers with ADSCs encapsulation for diabetic wound treatment显示文摘Stem cell therapies have made great progress in the treatment of diabetic wounds during recent decades,while their short in vivo residence,alloimmune reactions,undesired behaviors,and dramatic losses of cell functions still hinder the translation of them into clinic.Here,inspired by the natural components of stem cell niches,we presented novel microfluidic hydrogel microcarriers with extracellular matrix(ECM)-like composition and adipose-derived stem cells(ADSCs)encapsulation for diabetic wound healing.As the hydrogel was synthesized by conjugating hyaluronic acid methacryloyl(HAMA)onto the Fibronectin(FN)molecule chain(FN-HAMA),the laden ADSCs in the microcarriers showed improved bioactivities and pro-regenerative capabilities.Based on these features,we have demonstrated that these ADSCs microcarriers exhibited significant promotion of neovascularization,follicular rejuvenation,and collagen deposition in a mouse diabetic wound model.These results indicated that the stem cell niche-inspired FN-HAMA microcarriers with ADSCs encapsulation have great clinical potential for diabetic wound treatment. | Xiangyi Wu Haofang Zhu Junyi Che Ye Xu Qian Tan Yuanjin Zhao | 2023 | Bioactive Materials2023，，8： | 1 |
| 3 | Treatment of Alzheimer’s disease by microcapsule regulates neurotransmitter release via microfluidic technology显示文摘Alzheimer’s disease(AD)is a progressive neurodegenerative disease with a complex etiology.The main neu-ropathological feature is the accumulation of amyloid-beta(Aβ),and the dysregulation of the cholinergic system is well associated with its mechanism of occurrence,for which no effective treatment is yet available.Daily oral administration remains the mainstay of treatment with AD,and how to improve the efficacy,prolong adsorp-tion and medication compliance is still the focus of the current solution.We proposed a microcapsule based on microfluidic electrospray to form an intestinal epithelial lining for AD treatment,reducing the frequency of administration.Microfluidic electrospray technology was recruited to overcome the limitations associated with the variability in the microencapsulation production process and to produce functional microcapsules with finely adapted chemical composition,capsule thickness and encapsulant volume ratio.These microcapsules could slowly release drugs after adhering to the intestine,and their effectiveness and safety were further evaluated using cell culture studies and animal model studies.The results from the in vivo and in vitro experiments showed a significant reduction in administration frequency(i.e.,from daily medication to once every five days),superior therapeutic efficacy and sufficient safety of these microcapsules in cell culture and APP/PS1 mice.These features make the microcapsules an excellent drug delivery system and represent great potential for clinical applications in AD. | Weina Yao Junyi Che Cheng Zhao Xiao Zhang Huijuan Zhou Feng Bai | 2023 | Engineered Regeneration2023，4，2： | 0 |
| 4 | Wearable microneedle-integrated sensors for household health monitoring显示文摘Wearable biosensors,which aim at providing continuous,real-time physiological information via monitoring and screening biomarkers in human body,are receiving increasing attention among various fields including dis-ease treatment,diagnosis and self-health management.The ongoing development in this realm starves for the exploration of fully-integrated,non-invasive devices.In this paper,we review the latest achievements with break-through significance on the wearable biosensors.We start with the classification of different types of wearable electronic devices and analyze their characteristics and application values.Subsequently,we introduce a fully-integrated microneedle-based sensor and provide an in-depth look at its structure,subcomponents and in vivo performances.Finally,we put forward critical commentaries and clarify the direction of future researches. | Zezun Xie Xiaoxuan Zhang Guopu Chen Junyi Che Dagan Zhang | 2022 | Engineered Regeneration2022，3，4： | 0 |
| 5 | Microfluidic electrospray photo-crosslinkable κ-Carrageenan microparticles for wound healing显示文摘When organs,especially external organs are injured,pathogens and excessive water loss can threaten the wound healing process and cause local irreversible tissue damage.Here,novel natural κ-Carrageenan microparticles(MPs)able to deliver bioactive proteins and small molecules to the wound surface for promoted regeneration were developed using microfluidic electrospray.The side chains of κ-Carrageenan were modified with methacrylate pendant groups to make the monomer photonic cross-linkable.By changing the concentration of methacrylated-κ-Carrageenan,different porosities of MPs with controllable drug loading were achieved.The size of the MPs can also be tailored by adjusting the voltage of the applied electric field.Vascular endothelial growth factor(VEGF)and antimicrobial peptides Eumenitin were co-loaded into the microparticles(VEGF-Eumenitin-MPs)and released sustainedly in phosphate-buffered saline.The VEGF-Eumenitin-MPs had high biocompatibility and intensive antibacterial activities for bacteria.Furthermore,the antibacterial and angiogenetic properties of the VEGF-Eumenitin-MPs were demonstrated in a infectious wound model and the chronic wound healing process was significantly enhanced in vivo.Therefore,the developed porous MPs with sustained drug release properties have the potential to serve as a platform to deliver bioactive proteins and small molecules to the wound surface for promoted regeneration. | Zhiqiang Luo Junyi Che Lingyu Sun Lei Yang Yan Zu Huan Wang Yuanjin Zhao | 2021 | Engineered Regeneration2021，2，1： | 0 |
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