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| 1 | p53-mediated transcriptional regulation and activation of the actin cytoskeleton regulatory RhoC to LIMK2 signaling pathway promotes cell survival显示文摘响应 DNA 损坏的房间命运的中央仲裁人是 p53,它调整涉及房间周期拘捕,幸存和 apoptosis 的基因的表示。尽管 DNA 损坏开始的许多回答被描绘了,肌动朊细胞骨架管理者的角色大部分是未知的。我们现在显示出那 RhoC 和秘鲁利玛机场之代号 kinase (LIMK2 ) 2 是 genotoxic 代理人导致的直接 p53 目标基因。尽管 RhoC 和 LIMK2 在肌动朊细胞骨架规定有生长得很好的角色,我们的结果显示 LIMK2 的激活也有支持幸存的功能追随者 DNA 损坏。由调停 siRNA 的击倒或选择的药理学封锁的 LIMK 抑制敏化房间到无线电 -- 或化疗,以便当与 LIMK 抑制结合了时,当单身地管理了时,是尚不致命的治疗导致了房间死亡。我们的调查结果建议把 LIMK 禁止者与 genotoxic 治疗相结合能比单个代理人的管理更有效,并且加亮在肌动朊细胞骨架管理者和 DNA 之间的一个新奇连接导致损坏的房间幸存机制。 | Daniel R Croft Diane Crighton Michael S Samuel Filipe C Lourenco June Munro Jenifer Wood Karim Bensaad Karen H Vousden Owen J Sansom Kevin M Ryan Michael F Olson | 2011 | Cell Research2011，21，4： | 3 |
| 2 | Costimulatory approaches to adoptive immunotherapy显示文摘 | Lee K June C | 1998 | Curr Opin Oncol1998，10，： | 1 |
| 3 | Thompson CB: The B7 and CD28 receptor families显示文摘 | June C H Bluestone J A Nadler L M | 1994 | Immunol Today1994，15，7： | 1 |
| 4 | Phase Ⅱ study of intraperitoneal recombinant interleukin-12 (rhlL-12) in patients with peritoneal carcinomatosis (residual disease < 1 cm) associated with ovarian cancer or primary peritoneal carcinoma显示文摘 | Lenzi R Edwards R June C | 2007 | J Transl Med2007，5，： | 1 |
| 5 | Predicting Registered Nurse Job Satisfaction and Intent to Leave显示文摘 | June H. Larrabee Michelle A. Janney C Lynne Ostrow Mary Lynne Withrow Gerald R. Hobbs Christopher Burant | 2003 | JONA: The Journal of Nursing Administration2003，，5： | 1 |
| 6 | Considerations for the clinical applicationof chimeric antigen receptor T cells: observations froma recombinant DNA Advisory Committee Symposiumheld June 15,2010 显示文摘 | Ertl H C Zaia J? Rosenberg S A June C H Dotti G Kahn J | 2011 | Cancer Res2011，71，： | 1 |
| 7 | Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology显示文摘 | Kalos M June C H | 2013 | Immunity2013，39，1： | 1 |
| 8 | Blockade of CD28 during in vitro activation of encephalitogenic T cells or after disease onset ameliorates experimental autoimmune encephalomyelitis 显示文摘 | Perrin P June C Maldonado J | 1999 | J Immunol1999，163，17： | 1 |
| 9 | Chemokine receptor 5 knockout strategies显示文摘 | Cannon P June C | 2011 | Curr Opin HIV AIDS2011，6，1： | 1 |
| 10 | CT healthcare failure mode effect analy- sis(HFMEA) :The misadministration of IV contrast in outpatients 显示文摘 | Kathy OP Ben A June C | 2007 | Radiology Management2007，29，1： | 1 |
| 11 | Engineering lympho- cyte subsets: tools, trials and tribulations显示文摘 | June C H Blazar B R Riley J L | 2009 | Nature Re- views Immunology2009，9，10： | 1 |
| 12 | Clinical perspec- tives for regulatory T cells in transplantation tolerance 显示文摘 | HIPPEN K L RILEY J L JUNE C H | 2011 | Semin Immunol2011，23，6： | 1 |
| 13 | The reprofessionalisation of community pharmacy An exploration of attitudes to extended roles for community pharmacists amongst pharmacists and general practioners in the United Kingdom显示文摘 | JUNE E MICHAEL W C | 2001 | Soc Sci Med2001，11，53： | 1 |
| 14 | Satellite observations of the microwave emissivity of a semi-arid land surface显示文摘 | June C Morland David I F Grimes T J Hewison | 2001 | Remote Sensing of Environment2001，77，1： | 1 |
| 15 | The Estimation of Land Surface Emissivities at 24GHz to 157GHz Using Remotely Sensed Aircraft Data显示文摘 | June C Morland David I F Grimes George Dugdale | 2000 | Remote Sensing of Environment2000，73，2： | 1 |
| 16 | An anisotropic theory of elasticity for continuum damagemechanics显示文摘 | CHOW C L WANG June | 1987 | Int J Fract1987，33，1： | 1 |
| 17 | CCR5 knockout strategies显示文摘 | Cannon P June C | 2011 | Curr Opin HIV AIDS2011，6，1： | 1 |
| 18 | Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology 显示文摘 | Kalos M June C H | 2013 | Immunity2013，39，1： | 1 |
| 19 | Clinical application of expanded CD4 + 25 + cells显示文摘 | June C H Blazar B R | 2006 | Semi Immunol2006，18，2： | 1 |
| 20 | Preneoplastic lesions and gallbladder cancer: an estimate of the period require for progression显示文摘 | Ivan Roa June C Araya Miguel Villaseca | 1996 | Gastroenterology1996，111，： | 1 |
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