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| 1 | Genotypic variations in the accumulation of Cd exhibited by different vegetables显示文摘It is an important approach to use the Cd-contaminated soils properly by growing low accumulator or excluder plants for Cd to produce safe foods. To find the suitable vegetable species for growing in Cd-contaminated soils, in the present study the variations in the Cd accumulation for twenty eight vegetable species and several cultivars of five common vegetables (cowpea, kidney pea, bitter gourd, cucumber and squash) were investigated in two soil Cd levels (1 and 2 mg/kg Cd). Experimental results showed that highly significant differences in Cd concentration were evident among 28 vegetables. For example, spinach Cd concentrations were 110-fold and 175-fold higher than that of sweet pea under the 1 and 2 mg/kg Cd exposures, respectively. For Cd accumulation, the order of vegetable species was: leafy vegetables > solanaceous vegetables > kale vegetables > root vegetables > allimus > melon vegetables > legumes. Distinctive differences were also identified when comparing different cultivars of the five common vegetables with an average range of 0.003–0.094 mg/kg Cd. Our results indicated that a large genotypic variation existed among vegetable species or cultivars when subjected to Cd exposure. Therefore, it is important and feasible to elect/breed vegetable species/cultivars with low accumulation of Cd, especially in mildly Cd-contaminated soils. | Junxing Yang Haitao Guo Yibing Ma Liqun Wang Dongpu Wei Luo Hua | 2010 | Journal of Environmental Sciences2010，22，8： | 16 |
| 2 | Cadmium accumulation and tolerance of two castor cultivars in relation to antioxidant systems显示文摘To investigate the effects of Cd on tolerance and antioxidant activities of castor, two different castor(Ricinus communis L.) cultivars(Zibo No. 5 and Zibo No. 8) were used for a hydroponic experiment(0, 1 and 2 mg/L Cd) and a pot experiment using Cd-contaminated soil(34 mg/kg) with the addition of ethylenedinitrilotetraacetic acid(EDTA). The results indicated that there were significant differences between the two cultivars with respect to Cd uptake in shoots(113–248 mg/kg for Zibo No. 5 and 130–288 mg/kg Zibo No. 8), biomass tolerance indexes(64.9%–74.6% for Zibo No. 5 and 80.1%–90.9% for Zibo No. 8) in the hydroponic experiment and survival rates(0% for Zibo No. 5 and 100% for Zibo No. 8)determined by the addition of EDTA in the pot experiment, suggesting that Zibo No. 8 has higher tolerance than Zibo No. 5. Moreover, the castor cultivars have low bioconcentration factors(4.80% for Zibo No. 5 and 5.43% for Zibo No. 8) and low translocation factors(<1%).Consequently, Zibo No. 8 can participate in Cd phytostabilization in highly Cd-polluted areas. The results indicated that glutathione(GSH) as a non-enzymatic antioxidant, and antioxidant enzymes including superoxide dismutase(SOD), catalase(CAT) and guaiacol peroxidase(GPX), were cultivar- and dose-dependent. The higher tolerance of Zibo No. 8compared with Zibo No. 5 can be attributed to the higher GSH levels in the root and higher GPX activity in the leaf. | Hanzhi Zhang Qingjun Guo Junxing Yang Tongbin Chen Guangxu Zhu Marc Peters Rongfei Wei Liyan Tian Chunyu Wang Deyun Tan Jie Ma Gangming Wang Yingxin Wan | 2014 | Journal of Environmental Sciences2014，26，10： | 15 |
| 3 | Heavy metal (Pb,Zn) uptake and chemical changes in rhizosphere soils of four wetland plants with different radial oxygen loss显示文摘Lead and Zn uptake and chemical changes in rhizosphere soils of four emergent-rooted wetland plants;Aneilema bracteatum,Cyperus alternifolius,Ludwigia hyssopifolia and Veronica serpyllifolia were investigated by two experiments:(1) rhizobag filled with 'clean' or metal-contaminated soil for analysis of Pb and Zn in plants and rhizosphere soils;and (2) applied deoxygenated solution for analyzing their rates of radial oxygen loss (ROL).The results showed that the wetland plants with different ROL rates had significant effects on the mobility and chemical forms of Pb and Zn in rhizosphere under flooded conditions.These effects were varied with different metal elements and metal concentrations in the soils.Lead mobility in rhizosphere of the four plants both in the 'clean' and contaminated soils was decreased,while Zn mobility was increased in the rhizosphere of the 'clean' soil,but decreased in the contaminated soil.Among the four plants,V.serpyllifolia,with the highest ROL,formed the highest degree of Fe plaque on the root surface,immobilized more Zn in Fe plaque,and has the highest effects on the changes of Zn form (EXC-Zn) in rhizosphere under both 'clean' and contaminated soil conditions.These results suggested that ROL of wetland plants could play an important role in Fe plaque formation and mobility and chemical changes of metals in rhizosphere soil under flood conditions. | Junxing Yang Zuoluo Ma Zhihong Ye Xueyan Guo Rongliang Qiu | 2010 | Journal of Environmental Sciences2010，22，5： | 11 |
| 4 | Irinotecan plus S-1 versus S-1 in patients with previously treated recurrent or metastatic esophageal cancer(ESWN 01):a prospective randomized,multicenter,open-labeled phase 3 trial显示文摘Background:The benefit of systemic treatments in esophageal squamous cell carcinoma(ESCC)which has pro-gressed after chemotherapy is still uncertain and optimal regimens based on randomized trials have not yet been established.We aimed to compare the efficacy of irinotecan plus S-1 with S-1 monotherapy in recurrent or metastatic ESCC patients who had resistance to platinum-or taxane-based chemotherapy.Methods:We conducted a prospective randomized,multicenter,open-label,phase 3 trial in 15 centers across China.Eligible patients were adults with histologically confirmed recurrent or metastatic ESCC,and were randomly assigned(ratio,1:1)to receive either irinotecan plus S-1(intravenous infusion of irinotecan[160 mg/m2]on day 1 and oral S-1[80-120 mg]on days 1-10,repeated every 14 days)or oral S-1 monotherapy(80-120 mg/day on days 1-14,repeated every 21 days)using a central computerized minimization procedure.The primary endpoint was progression-free survival(PFS).Results:Between December 23,2014 and July 25,2016,we screened 148 patients and randomly assigned 123 patients to receive either irinotecan plus S-1 regimen(n=61)or S-1 monotherapy(n=62).After a median follow-up of 29.2 months(95%confidence interval[CI]17.5-40.9 months),the median PFS was significantly longer in the irinotecan plus S-1 group than in the S-1 monotherapy group(3.8 months[95%CI 2.9-4.3 months]vs.1.7 months[95%CI 1.4-2.7 months],hazard ratio=0.58,95%CI 0.38-0.86,P=0.006).The objective response rates were 24.6%in the irinotecan plus S-1 group and 9.7%in the S-1 monotherapy group(P=0.002).The patients in the irinotecan plus S-1 group presented with increased rates of grade 3-4 leukopenia(16.4%vs.0%),neutropenia(14.8%vs.1.6%),and nausea(4.9%vs.0%).No significant difference in grade 3-4 diarrhea and no treatment-related deaths were observed in both groups.Conclusions: The combination of irinotecan with S-1 was similarly tolerable but significantly prolonged PFS compared to S-1 monotherapy as a second- or third-line treatment in patients with recurrent or metastatic ESCC. | Jing Huang Binghe Xu Ying Liu Junxing Huang Ping Lu Yi Ba Lin Wu Yuxian Bai Shu Zhang Jifeng Feng Ying Cheng Jie Li Lu Wen Xianglin Yuan Changwu Ma Chunhong Hu Qingxia Fan Xi Wang | 2019 | Cancer Communications2019，39，1： | 8 |
| 5 | Cloning and bioinformatics analysis of a full-length cDNA of porcine CRl-like gene显示文摘 | Jing Cheng Junbing Jiang Junxing Zhao Zhirui Wang Yaogui Sun Haili Ma Kuohai Fan Wei Yin Na Sun Zhiwei Wang Xin Zhao Hongquan Li | 2014 | Acta Biochimica et Biophysica Sinica2014，46，11： | 7 |
| 6 | Effect of Laser Remelting on the Microstructure and Corrosion Resistance of Plasma Sprayed Fe-based Coating显示文摘Fe-based amorphous and nanocrystalline coatings were fabricated by air plasma spraying. The coatings were further treated by laser remelting process to improve their microstructure and properties. The corrosion resistance of the as-sprayed and laser-remelted coatings in 3.5wt% Na Cl and 1 mol/L HCl solutions was evaluated by electrochemical polarization analysis. It was found that laser-remelted coating appeared much denser than the as-sprayed coating. However, laser-remelted coating contains much more nanocrystalline grains than the as-sprayed coatings, resulting from the lower cooling rate in laser remelting process compared with plasma spraying process. Electrochemical polarization results indicated that the laser-remelted coating has great corrosion resistance than the as-sprayed coating because of its dense structure. | 姜超平 WANG Junxing HAN Jianjun LU Yuan XING Yazhe CHEN Yongnan SONG Xuding | 2015 | Journal of Wuhan University of Technology(Materials Science)2015，30，4： | 6 |
| 7 | Recent Advances in Single-Atom Electrocatalysts for Oxygen Reduction Reaction显示文摘Oxygen reduction reaction(ORR)plays significant roles in electrochemical energy storage and conversion systems as well as clean synthesis of fine chemicals.However,the ORR process shows sluggish kinetics and requires platinum-group noble metal catalysts to accelerate the reaction.The high cost,rare reservation,and unsatisfied durability significantly impede large-scale commercialization of platinum-based catalysts.Single-atom electrocatalysts(SAECs)featuring with well-defined structure,high intrinsic activity,and maximum atom efficiency have emerged as a novel field in electrocatalytic science since it is promising to substitute expensive platinum-group noble metal catalysts.However,finely fabricating SAECs with uniform and highly dense active sites,fully maximizing the utilization efficiency of active sites,and maintaining the atomically isolated sites as single-atom centers under harsh electrocatalytic conditions remain urgent challenges.In this review,we summarized recent advances of SAECs in synthesis,characterization,oxygen reduction reaction(ORR)performance,and applications in ORR-related H_(2)O_(2)production,metal-air batteries,and low-temperature fuel cells.Relevant progress on tailoring the coordination structure of isolated metal centers by doping other metals or ligands,enriching the concentration of single-atom sites by increasing metal loadings,and engineering the porosity and electronic structure of the support by optimizing the mass and electron transport are also reviewed.Moreover,general strategies to synthesize SAECs with high metal loadings on practical scale are highlighted,the deep learning algorithm for rational design of SAECs is introduced,and theoretical understanding of active-site structures of SAECs is discussed as well.Perspectives on future directions and remaining challenges of SAECs are presented. | Junxing Han Juanjuan Bian Chunwen Sun | 2020 | Research2020，，1： | 6 |
| 8 | Multi-scale modeling of liquid-metal cooling directional solidification and solidification behavior of nickel-based superalloy casting显示文摘Liquid-metal cooling(LMC)process can offer refinement of microstructure and reduce defects due to the increased cooling rate from enhanced heat extraction,and thus an understanding of solidification behavior in nickel-based superalloy casting during LMC process is essential for improving mechanical performance of single crystal(SC)castings.In this effort,an integrated heat transfer model coupling meso grain structure and micro dendrite is developed to predict the temperature distribution and microstructure evolution in LMC process.An interpolation algorithm is used to deal with the macro-micro grids coupling issues.The algorithm of cells capture is also modified,and a deterministic cellular automaton(DCA)model is proposed to describe neighborhood cell tracking.In addition,solute distribution is also considered to describe the dendrite growth.Temperature measuring,EBSD,OM and SEM experiments are implemented to verify the proposed model,and the experiment results agree well with the simulation results.Several simulations are performed with a range of withdrawal rates,and the results indicate that 12 mm·min^(-1)is suitable for LMC process in this work,which can result in a fairly narrow and flat mushy zone and correspondingly exhibited fairly straight grains.The mushy zone length is about 4.8 mm in the steady state and the average deviation angle of grains is about 13.9°at the height 90 mm from the casting base under 12 mm·min^(-1)withdrawal process.The competitive phenomenon of dendrites at different withdrawal rates is also observed,which has a great relevant to the temperature fluctuation. | Xuewei Yan Qjngyan Xu Guoqiang Tian Quanwei Liu Junxing Hou Baicheng Liu | 2021 | Journal of Materials Science & Technology2021，，8： | 4 |
| 9 | Fluid migration paths in the marine strata of typical structures in the western Hubei-eastern Chongqing area,China显示文摘The western Hubei-eastern Chongqing area is an important prospective zone for oil and gas exploration in the central Yangtze area. Three representative structures, the Xinchang structure, Longjuba gas-bearing structure and the Jiannan gas field, were selected to analyze biomarker parameters in marine strata and to examine various types of natural gas and hydrocarbon sources. Fluid inclusions; carbon, oxygen, and strontium isotopic characteristics; organic geochemical analysis and simulation of hydrocarbon generation and expulsion history of source rocks were used for tracing fluid migration paths in marine strata of the study area. The Carboniferous-Triassic reservoirs in three typical structures all experienced at least two stages of fluid accumulation. All marine strata above the early Permian were shown to have fluids originating in the Permian rocks, which differed from the late stage fluids. The fluids accumulated in the late Permian reservoirs of the Xinchang structure were Cambrian fluids, while those in the late Carboniferous reservoirs were sourced from a combination of Silurian and Cambrian fluids. A long-distance and large-scale cross-formational flow of fluids destroyed the preservation conditions of earlier accumulated hydrocarbons. A short-distance cross-formational accumulation of Silurian fluids was shown in the late Permian reservoirs of the Longjuba structure with favorable hydrocarbon preservation conditions. The fluid accumulation in the Carboniferous reservoirs of the Jiannan structure mainly originated from neighboring Silurian strata with a small amount from the Cambrian strata. As a result, the Jiannan structure was determined to have the best preservation conditions of the three. Comparative analysis of fluid migration paths in the three structures revealed that the zone with a weaker late tectonism and no superimposition and modification of the Upper and Lower Paleozoic fluids or the Upper Paleozoic zone with the fluid charging from the Lower Paleozoic in the western Hubei-eastern Chongqing area are important target areas for future exploration. | Xu Guosheng Liang Jiaju Gong Deyu Wang Guozhi Yuan Haifeng Cao Junxing Zhang Chengfu | 2013 | Petroleum Science2013，10，1： | 3 |
| 10 | Molecular phylogenetic evidence that the Chinese viviparid genus Margarya(Gastropoda:Viviparidae) is polyphyletic显示文摘We investigated the phylogeny of the viviparid genus Margarya,endemic to Yunnan,China,using two mitochondrial gene fragments(COI and 16S rRNA).The molecular phylogeny based on the combined dataset indicates that Margarya is polyphyletic,as two of the three well-supported clades containing species of Margarya also comprise species from other viviparid genera.In one clade,sequences of four species of Margarya even cluster indiscriminately with those of two species of Cipangopaludina,indicating that the current state of Asian viviparid taxonomy needs to be revised.Additionally,these data suggest that shell evolution in viviparids is complex,as even the large and strongly sculptured shells of Margarya,which are outstanding among Asian viviparids,can apparently be easily converted to simple smooth shells.The molecular data also indicate that the species status of the six extant species of Margarya should be re-assessed. | DU LiNa YANG JunXing RINTELEN Thomas von CHEN XiaoYong ALDRIDGE David | 2013 | Chinese Science Bulletin2013，58，17： | 3 |
| 11 | Light-driven artificial muscles based on electrospun microfiber yarns显示文摘Artificial muscles are widely potential in diverse fields including medical treatment, humanoid robotics and industrial automation. Soft materials due to bio-friendly interaction are suitable for those applications. Planar and fiber shape based artificial muscles that use the polymer as substrate materials can be triggered by various stimuli like electric, moisture and heat. Here,artificial muscles based on electrospun microfiber yarns are demonstrated, which can be remotely controlled. The carbon nanotubes embedded in polyurethane microfibers enable the yarns to efficiently absorb near-infrared light and radiate heat,which induces the fast temperature change that leads to the contraction/expansion motions along the axial direction. Microfiber mats are collected by a rotating cylinder that results in highly oriented alignment. The yarns from microfiber mats are highly twisted into the coiled structure, which generates maximum contractive actuation of 6.7% at 70°C. 1000 cycles were demonstrated without an obvious decline of actuating performances. The light-driven artificial muscles can be potentially applied in wireless control, bio-medical devices and so on. | MENG JunXing HOU ChengYi ZHANG QingHong LI YaoGang WANG HongZhi | 2019 | Science China(Technological Sciences)2019，62，6： | 3 |
| 12 | AMPKα1 regulates Idh2 transcription through H2B O-GlcNAcylation during brown adipogenesis显示文摘AMP-activated protein kinase (AMPK) is indispensable for the development and maintenance of brown adipose tissue (BAT), and its activity is inhibited due to obesity. The isocitrate dehydrogenase 2 (IDH2) is a mitochondrial enzyme responsible for the production of α-ketoglutarate, a key intermediate metabolite integrating multiple metabolic processes. We previously found that AMPKα1 ablation reduced cellular α-ketoglutarate concentration during brown adipocyte differentiation, but the effect of AMPKα1 on Idh2 expression remains undefined. In the present study, mouse C3H10T1/2 cells were transfected with Idh2-CRISPR/Cas9, and induced to brown adipogenesis. Our data suggested that brown adipogenesis was compromised due to IDH2 deficiency in vitro, which was accompanied by down-regulation of PR-domain containing 16. Importantly, the IDH2 content was reduced in brown stromal vascular cells (BSVs) separated from AMPKα1 knockout (KO) BAT, which was associated with lower contents of histone 2B (H2B) O-GlcNAcylation and monoubiquitination. Furthermore, both GlcNAcylated-H2B (S112) and ubiquityl-histone 2B (K120) contents in the Idh2 promoter were decreased in AMPKα1 KO BSVs. Meanwhile, ectopic O-linked N-acetylglucosamine transferase (OGT) expression was positively correlated with Idh2 expression, while OGT (T444A) mutation abolished the regulatory effect of AMPKα1 on Idh2. In vivo, reduced AMPKα1 activity and lower IDH2 abundance were observed in BAT of obese mice when compared with those in control mice. Taken together, our data demonstrated that IDH2 is necessary for brown adipogenesis and that AMPKα1 deficiency attenuates Idh2 expression, which might be by suppressing H2B O-GlcNAcylation modification. | Yuxin Cao Xiangdong Liu Junxing Zhao Min Du | 2021 | Acta Biochimica et Biophysica Sinica2021，53，1： | 3 |
| 13 | Effect of poly(ethylene oxide) with different molecular weights on the electrospinnability of sodium alginate显示文摘 | Huarong Nie Aihua He Wanling Wu Jianfen Zheng Shanshan Xu Junxing Li Charles C. Han | 2009 | Polymer2009，，20： | 2 |
| 14 | RETROPERITONEAL LAPAROSCOPIC SURGERY FOR ADRENAL DISEASES (REPORT OF 136 CASES)显示文摘Objective:To summarize experiences in 136 cases of retroperitoneal laparoscopic surgery.Methods: From April 1997 to May 2002, retroperitoneal laparoscopic surgery were performed for 136 cases of adrenal diseases. There were 63 aldosterone-producing adenoma, 22 adrenalcortical adenoma, 39 nonfunctional adrenal tumor, 7 adrenal cyst and 5 phenochromocytoma.Results:Except for one case converts to open surgery, success has been achieved in all cases without major complications. Intraoperative blood loss was 76±32ml without blood transfusion. Postoperative hospital stay was 6±3 days. There were statistical differences among these indices when comparing to those of open surgery for 126 cases with adrenal diseases( P <0.05).But operative time was little longer in laparoscopic group than in group of open surgery( P <0.05),whereas it has been changed to similar in those recent cases.Conclusion:Retroperitoneal laparoscopic surgery was less traumatic to the patients, with less postoperative discomfort and quicker recovery and should be considered the first choice of therapy for adrenal disorders. | Qiu Shaopeng, Tang Min, Chen Junxing, et al. Urology Department, The First Affiliated Hospital, Sun Yat-sen University of Medical Sciences,Guangzhou 510080 | 2003 | 中国内镜杂志2003，9，1： | 2 |
| 15 | Paleogeomorphy evolution of the Ordovician weathering crust and its implication for reservoir development,eastern Ordos Basin显示文摘Gas reservoir development of the Ordovician weathering crust in the Ordos Basin is closely controlled by the pre-Carboniferous paleogeomorphy.Previous studies show that the paleogeomorphy is high in the west and low in the east,and the karst highland,karst slope and karst basin are developed from west to east.With further exploration in recent years,many karst breccia that represent strong karstification,are found in the east area which previously is considered to be the Ordovician karst basin.Thus,it is necessary to revaluate controlling factors of karst paleogeomorphy development from a viewpoint of the dynamic paleogeomorphy evolution,to investigate the paleogeomorphy evolution of the Ordovician weathering crust in geological history and guide further research and prediction of development law of reservoir spaces.In order to reconstruct the paleogeomorphy of the weathering crust in the top of Ordovician in the east Ordos Basin,paleogeography,thickness of residual strata and paleokarst characteristics are well studied.The result shows that a wide range of paleokarst highland occurred in the central to east part of Ordos Basin in the early period,and the karst reservoir spaces were formed;but in the late period,the east part of the basin gradually evolved into the paleokarst basin,the current pre-Carboniferous paleogeomorphy was thus formed,and the dissolution reservoir spaces formed in the early period were mostly filled,accordingly the reservoirs were tight.However fracture networks formed by cave collapse connect intercrystalline pores of dolomite,therefore,the reservoirs can still be well preserved locally and are worthy targets for hydrocarbon exploration. | Xinshan Wei Junfeng Ren Junxing Zhao Daofeng Zhang Shunshe Luo Liubin Wei Juanping Chen | 2018 | Petroleum Research2018，3，1： | 2 |
| 16 | A high-quality sponge gourd(Luffa cylindrica)genome显示文摘Sponge gourd(Luffa cylindrica)is an important cultivated vegetable and medicinal plant in the family Cucurbitaceae.In this study,a draft genome sequence of the sponge gourd inbred line P93075 was analyzed.Using Illumina,PacBio,and 10×Genomics sequencing techniques as well as new assembly techniques such as FALCON and chromatin interaction mapping(Hi-C),a chromosome-scale genome of approximately 656.19 Mb,with an N50 scaffold length of 48.76 Mb,was generated.From this assembly,25,508 protein-coding gene loci were identified,and 63.81%of the whole-genome consisted of transposable elements,which are major contributors to the expansion of the sponge gourd genome.According to a phylogenetic analysis of conserved genes,the sponge gourd lineage diverged from the bitter gourd lineage approximately 41.6 million years ago.Additionally,many genes that respond to biotic and abiotic stresses were found to be lineage specific or expanded in the sponge gourd genome,as demonstrated by the presence of 462 NBS-LRR genes,a much greater number than are found in the genomes of other cucurbit species;these results are consistent with the high stress resistance of sponge gourd.Collectively,our study provides insights into genome evolution and serves as a valuable reference for the genetic improvement of sponge gourd. | Haibin Wu Gangjun Zhao Hao Gong Junxing Li Caixia Luo Xiaoli He Shaobo Luo Xiaoming Zheng Xiaoxi Liu Jinju Guo Junqiu Chen Jianning Luo | 2020 | Horticulture Research2020，7，1： | 2 |
| 17 | Identifying factors that influence soil heavy metals by using categorical regression analysis:A case study in Beijing,China显示文摘Identifying the factors that influence the heavy metal contents of soil could reveal the sources of soil heavy metal pollution.In this study,a categorical regression was used to identify the factors that influence soil heavy metals.First,environmental factors were associated with soil heavy metal data,and then,the degree of influence of different factors on the soil heavy metal contents in Beijing was analyzed using a categorical regression.The results showed that the soil parent material,soil type,land use type,and industrial activity were the main influencing factors,which suggested that these four factors were important sources of soil heavy metals in Beijing.In addition,population density had a certain influence on the soil Pb and Zn contents.The distribution of soil As,Cd,Pb,and Zn was markedly influenced by interactions,such as traffic activity and land use type,industrial activity and population density.The spatial distribution of soil heavy metal hotspots corresponded well with the influencing factors,such as industrial activity,population density,and soil parent material.In this study,the main factors affecting soil heavy metals were identified,and the degree of their influence was ranked.A categorical regression represents a suitable method for identifying the factors that influence soil heavy metal contents and could be used to study the genetic process of regional soil heavy metal pollution. | Jun Yang Jingyun Wang Pengwei Qiao Yuanming Zheng Junxing Yang Tongbin Chen Mei Lei Xiaoming Wan Xiaoyong Zhou | 2020 | Frontiers of Environmental Science & Engineering2020，14，3： | 1 |
| 18 | Astragalus polysaccharide regulates brown adipogenic differentiation through miR-1258-5p-modulated cut-like homeobox 1 expression显示文摘Astragalus polysaccharide(APS)is the major natural active component of Astragalus membranaceus,which has been recognized as one of the most popular herbal medicines worldwide.Enhancing the formation and function of brown adipose tissue increases energy expenditure and hence may potentially be used against obesity and type 2 diabetes.The aim of the present study was to explore the effect and mechanism of APS on brown adipocyte formation.Mouse C3H10T 1/2 cells were subject to APS,and both proliferation and brown adipogenic differentiation were determined.The results showed that APS exhibits a decreased proliferation ability,which is accompanied by downregulated proliferating cell nuclear antigen,cyclin D1,and cyclin-dependent kinase 4.APS promotes the differentiation of C3H10T 1/2 cells into brown adipocytes and induces the expressions of key brown adipogenic transcriptional factors,including CCAAT/enhancer-binding proteinβ,uncoupling protein 1,and PR domain-containing 16.Importantly,APS enables insulin sensitization in brown adipocytes,which may proceed through activation of the canonical phosphatidylinositol-3-kinase(PI3K)/protein kinase B(AKT)signaling pathway and AMP-activated protein kinase(AMPK).Furthermore,the level of cut-like homeobox 1(CUX1)is positively related to brown adipogenic differentiation,while APS regulates Cux1 expression through interaction with miR-1258-5p.Notably,the promotional effect of APS on brown adipogenic differentiation was abolished by Cux1 knockout.Collectively,our results suggest that APS enhances the differentiation of C3H10T 1/2 cells into brown adipocytes through regulating Cux1 via miR-1258-5p. | Yuxin Cao Buhao Deng Shihe Zhang Hongmei Gao Pengkang Song Jianxin Zhang Junxing Zhao | 2021 | Acta Biochimica et Biophysica Sinica2021，53，12： | 1 |
| 19 | A study of the construction and application of a Daubechies wavelet-based beam element显示文摘 | Junxing Ma Jijun Xue Shengjun Yang Zhengjia He | 2003 | Finite Elements in Analysis and Design2003，39，1： | 1 |
| 20 | A study of the construction and application of a Daubechies wavelet-based beam element 显示文摘 | Junxing Ma Jijun Xue Shengjun Yang Zhengjia He | 2003 | Finite Elements in Analysis and Design2003，39，10： | 1 |
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