|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Serum level of TSGF,CA242 and CA19-9 in pancreatic cancer显示文摘AIM: To establish a method to detect the expression of the tumor specific growth factor TSGF, CA242 and CA19-9 in serum and evaluate their value in diagnosis of pancreatic cancer. METHODS: ELISA and Biochemical colorimetric assay were used to detect the serum content of TSGF, CA242 and CA19-9 in 200 normal cases, 52 pancreatitis patients and 96 pancreatic cancer patients. RESULTS: The positive likelihood ratios of TSGF, CA242 and CA19-9 were 5.4, 12.6 and 6.3, respectively, and their negative likelihood ratios were 0.10, 0.19 and 0.17, respectively. With single tumor marker diagnosed pancreatic cancer, the highest sensitivity and specificity of TSGF were 91.6% and 93.5%. In combined test with 3 markers, when all of them were positive, the sensitivity changed to 77.0% and the specificity and the positive predictive value were 100%. The levels of TSGF and CA242 were significantly higher in the patients with pancreatic cancer of head than those in the patients with pancreatic cancer of body, tail and whole pancreas, but the expression of CA19-9 had no correlation with the positions of the pancreatic cancer. The sensitivity of TSGF, CA242 and CA19-9 was increased with the progress in stages of pancreatic cancer. In stage I, the sensitivity of TSGF was markedly higher than CA242 and CA19-9. CONCLUSION: The combined use of TSGF, CA242 and CA19-9 expressions can elevate the specificity for pancreatmc cancer diagnosis. And it shows that it plays an important role to differentiate positions and tissue typing. It is a forepart diagnosis for the pancreatic cancer by combination checking. There is very important correlation between the three markers and the pancreatic cancer. | Jing-TingJiang Chang-PingWu Hai-FengDeng Minq-YanqLu JunWu Hong-YuZhang Wen-HuiSun MeiJi | 2004 | World Journal of Gastroenterology2004，10，11： | 67 |
| 2 | 26mA cm^(-2) J_(sc) from organic solar cells with a low-bandgap nonfullerene acceptor显示文摘Nonfullerene-based organic solar cells(NFOSCs)have received great interest recently due to their higher performance and greater potential compared with fullerene-based solar cells[1].Power conversion efficiencies(PCEs)over 13% have been realized in single-junction NFOSCs[2].Compared with traditional fullerene acceptors,the greatest advantage of nonfullerene acceptors is their stronger light-harvesting capability in the visible and | Zuo Xiao Xue Jia Dan Li Shizhe Wang Xinjian Geng Feng Liu Junwu Chen Shangfeng Yang Thomas P.Russell Liming Ding | 2017 | Science Bulletin2017，62，22： | 28 |
| 3 | The culture and establishment of embryonic germ(EG)cell lines from Chinese mini swine显示文摘As a part of a basic research project on Xeno-transplantion, we have been engaged in the derivation ofembryonic stem cell lines from Chinese mini swine. Here, we reported for the first time the establishmentof two porcine EG cell lines (BPEG1 and BPEG2) from primordial germ cells of genital ridges of a 28 anda 27 d embryos respectively. Their pluripotent nature has been identified by colony morphology, markercharacterization as well as by in vitro and in vivo differentiation. These porcine EG cells are potentiallyuseful for further basic studies. | HSlAOCHIENTSUNG ZHONGWEIDU RONGRUI XIULANLI LINPINGBAO JUNWU SHIMINBAO ZHENYAO | 2003 | Cell Research2003，13，3： | 17 |
| 4 | Shake table tests of suspended ceilings to simulate the observed damage in the M_s 7.0 Lushan earthquake, China显示文摘Severe damage to suspended ceilings of metal grids and lay-in panels was observed in public buildings during the 2013 Ms7.0 Lushan earthquake in China. Over the past several years, suspended ceilings have been widely used practice in public buildings throughout China, including government offices, schools and hospitals. To investigate the damage mechanism of suspended ceilings, a series of three-dimensional shake table tests was conducted to reproduce the observed damage. A full-scale reinforced concrete frame was constructed as the testing frame for the ceiling, which was single-story and infilled with brick masonry walls to represent the local construction of low-rise buildings. In general, the ceiling in the tests exhibited similar damage phenomena as the field observations, such as higher vulnerability of perimeter elements and extensive damage to the cross runners. However, it exhibited lower fragility in terms of peak ground/roof accelerations at the initiation of damage. Further investigations are needed to clarify the reasons for this behavior. | Wang Duozhi Dai Junwu Qu Zhe Ning Xiaoqing | 2016 | Earthquake Engineering and Engineering Vibration2016，15，2： | 13 |
| 5 | Preliminary investigation of seismic damage to two steel space structures during the 2013 Lushan earthquake显示文摘Severe damage to steel space structures is rarely reported when compared to other structural systems damaged during past major earthquakes around the world.Two gymnasiums of steel space structures in downtown Lushan County that were damaged during the 2013 M7.0 Lushan earthquake in China were investigated and the observations are summarized in this paper.Typical damage to these two steel space structures ranges from moderate to severe.Moderate damage includes global buckling and dislocation of bolted connections of truss members,and inelastic elongation of anchor bolts and sliding of pedestal plates of supports.Severe damage includes member fracture caused by local buckling,and fracture failure of anchor bolts and welds.The distribution of structural damage to these two structures is described in detail and future research opportunities are suggested. | Dai Junwu Qu Zhe Zhang Chenxiao Weng Xuran | 2013 | Earthquake Engineering and Engineering Vibration2013，12，3： | 11 |
| 6 | Effects of Zhaoyangwan on chronic hepatitis B and posthepatic cirrhosis显示文摘AIM:To study the therapeutic effects of zhaoyangwan (ZYW) on chronic hepatitis B and hepatic cirrhosis and the anti-virus, anti-fibrosis and immunoregulatory mechanisms of ZYW.METHODS: Fifty cases of chronic hepatitis B and posthepatic cirrhosis with positive serum HBsAg, HBeAg, anti-Hbc and HBV-DNA were divided randomly and single-blindly into the treatment group (treated with ZYW) and the control group (treated with interferon).After 3 month treatment,the effects of the treatment group and the control group were evaluated.RESULTS: The serum ALT normalization was 83.3%(30/36) in the treatment group and 85.7%(12/14) in the control group,with no significant difference (X^2=0.043, P>0.05).After the course, the negative expression rates of the serum HBV-DNA and HBeAg were 44.4%(16/36) and 50%(18/36) in the treatment group, and 50%(7/14) and 50%(7/14) in the control group, respectively,with no significant difference(X^2=0.125, X^2=0.00, both P>0.05). Negative HBsAg and positive HBsAb appeared in 4 cases of the treatment group and 1 case of the control group.Serum anti-HBc turned negative in 6 cases of the treatment group and 1 case of the control group, respectively. After the ZYW treatment,serum CD3^+, CD4^+, CD8^+, CD4^+/CD8^+ and NK cell activation were significantly increased. Only serum CD3^+ and NK cell activation were significantly increased in the control group with a significant difference between the two groups. The serum C4, C1q, C3, B and C9 were significantly in creased inthe treatment group. In the control group only the serum C4 was increased. The concentration of serum interferon had no change after treatment with ZYW, while it was significantly increased in the control group after treatment with interferon.The ultrastructure of the liver restored,which helped effectively to reduce the degeneration and necrosis of hepatic cells,infiltration of inflammatory cells and hepatic cirrhosis.CONCLUSION:ZYW is a pure Chinese herbal medicine. It can exert potent therapeutic effects on chronic hepatitis B and posthepatic cirrhosis.ZYW has similar therapeutic effects to those of interferon.It is cheap and easily administered with no obvious side-effects.It can be widely used in clinical practice. | Cui-PingZhang Zi-BinTian Xi-ShuangLiu Qing-xiZhao JunWu Yong-XinLiang | 2004 | World Journal of Gastroenterology2004，10，2： | 9 |
| 7 | Experimental and analytical studies on multiple tuned mass dampers for seismic protection of porcelain electrical equipment显示文摘Porcelain electrical equipment(PEE),such as current transformers,is critical to power supply systems,but its seismic performance during past earthquakes has not been satisfactory.This paper studies the seismic performance of two typical types of PEE and proposes a damping method for PEE based on multiple tuned mass dampers(MTMD).An MTMD damping device involving three mass units,named a triple tuned mass damper(TTMD),is designed and manufactured.Through shake table tests and finite element analysis,the dynamic characteristics of the PEE are studied and the effectiveness of the MTMD damping method is verified.The adverse influence of MTMD redundant mass to damping efficiency is studied and relevant equations are derived.MTMD robustness is verified through adjusting TTMD control frequencies.The damping effectiveness of TTMD,when the peak ground acceleration far exceeds the design value,is studied.Both shake table tests and finite element analysis indicate that MTMD is effective and robust in attenuating PEE seismic responses.TTMD remains effective when the PGA far exceeds the design value and when control deviations are considered. | Bai Wen Dai Junwu Zhou Huimeng Yang Yongqiang Ning Xiaoqing | 2017 | Earthquake Engineering and Engineering Vibration2017，16，4： | 8 |
| 8 | The RNA-binding protein QKI5 regulates primary miR-124-1 processing via a distal RNA motif during erythropoiesis显示文摘 | Fang Wang Wei Song Hongmei Zhao Yanni Ma Yuxia Li Di Zhai Jingnan Pi Yanmin Si Jiayue Xu Lei Dong Rui Su Mengmeng Zhang Yong Zhu Xiaoxia Ren Fei Miao Wenjie Liu Feng Li Junwu Zhang Aibin He Ge Shan Jingyi Hui Linfang Wang Jia Yu | 2017 | Cell Research2017，27，3： | 7 |
| 9 | Non-limit passive soil pressure on rigid retaining walls显示文摘This paper aims to reveal the depth distribution law of non-limit passive soil pressure on rigid retaining wall that rotates about the top of the wall(rotation around the top(RT) model). Based on Coulomb theory, the disturbance degree theory, as well as the spring-element model, by setting the rotation angle of the wall as the disturbance parameter, we establish both a depth distribution function for sand and a nonlinear depth distribution calculation method for the non-limit passive soil pressure on a rigid retaining wall under the RT model, which is then compared with experiment. The results suggest that under the RT model: the non-limit soil pressure has a nonlinear distribution; the backfill disturbance degree and the lateral soil pressure increase with an increase in the wall rotation angle; and, the points where the resultant lateral soil pressure acts on the retaining wall are less than 2/3 of the height of the wall. The soil pressure predicted by the theoretical calculation put forward in this paper are quite similar to those obtained by the model experiment, which verifies the theoretical value, and the engineering guidance provided by the calculations are of significance. | Dou Guotao Xia Junwu YU Wenjie Yuan Fang Bai Weigang | 2017 | International Journal of Mining Science and Technology2017，27，3： | 7 |
| 10 | Sedimentary Evolution and Transgressions of the Western Subei Basin in Eastern China since the Late Pliocene显示文摘Sedimentary sequences in the Subei Basin are complex and have been affected by interactions between the ocean and rivers since the Late Pliocene, including the Yellow River, Huaihe River, and the Yangtze River. This sedimentary evolution, in particular the timing of Pleistocene transgressions, has long been a matter of controversy owing to the lack of precise chronological evidence. The aim of this study is to explore the evolution of the sedimentary environment throughout the past 3.00 Ma in this region on the basis of a comprehensive analysis of particle size and foraminifera and ostracods collected in the TZK9 core from the Subei Basin combined with geochronological studies of magnetostratigraphy, AMS^(14)C and optically stimulated luminescence(OSL). The results show that fluvial facies in the sedimentary environment from 3.00 to 1.01 Ma. There were fluvial facies and reflects six sea-level high stands from 1.01 to 0.25 Ma. The study area was affected by four large-scale transgressions since 0.25 Ma. The four marine sedimentary layers known as DU7(buried at 48–52 m), DU5(buried at 35–41 m), DU3(buried at 16–23 m), and DU1(buried at 2–4 m) are recorded in the MIS7(210–250 ka), MIS5, MIS3, and Holocene, respectively. The magnitude of the DU5 transgression was identical to that of the DU3 transgression, both were larger than the DU7 transgression, and the DU1 transgression was the weakest. The variation of transgression strength reflects the influence of global changes in sea level, tectonic subsidence, shell ridges, and sand dams. In the TZK9 core, we found evidence of seven sea-level high stands from the Early–Middle Pleistocene, and the first one caused by regional rapid subsidence and could be traced back to 0.83-0.84 Ma. The sea-level high stands and the age of the first one recorded above was different from other cores in eastern China, this was caused by the lack of absolute age control and the differences in paleotopography during this period. This study reconstructs sedimentary evolution, determines the transgression and its age, establishes the chronology since the Late Pliocene, and provides a scientific framework for further paleoenvironmental and tectonic studies. The results of this study highlight the important role that local tectonics and global sea level play in the sedimentary evolution and transgressions that have occurred in the western Subei Basin. | CHENG Yu LI Xiangqian SHU Junwu BAI Shibiao ZHAO Zengyu ZHANG Xiangyun GUO Gang ZHANG Ping LIN Jingxing | 2019 | Acta Geologica Sinica(English Edition)2019，93，1： | 7 |
| 11 | Assembling of a novel 3D Ag(Ⅰ)-MOFs with mixed ligands tactics:Syntheses, crystal structure and catalytic degradation of nitrophenol显示文摘A silver-based metal-organic framework(Ag-MOFs), [Ag2(H3 ddcba)(dpp)2](1)(H5 ddcba = 3,5-(di(2',5'-dicarboxylphenyl)benozoic acid, dpp = 1,3-di(4-pyridyl)propane), was successfully constructed via hydrothermal assembly of a pentacaboxylate ligand, a N-donor ligand and Ag(I) ions, which possesses a pcu topology and exhibits excellent catalytic properties in aqueous solution for the degradation of onitrophenol(2-NP), m-nitrophenol(3-NP) and p-nitrophenol(4-NP). Related kinetics of such catalytic reactions, photoluminescent and thermal stability of compound 1 were also investigated. | Dandan Huang Xueqian Wua Junwu Tian Xiaokun Wang Zhihang Zhou Dongsheng Li | 2018 | Chinese Chemical Letters2018，29，6： | 7 |
| 12 | Flow structures inside a large-scale turbulent fluidized bed of FCC particles:Eulerian simulation with an EMMS-based sub-grid scale model显示文摘Turbulent fluidized bed reactors are widely used in industry. However, CFD simulations of the hydrodynamic characteristics of these reactors are relatively sparse, despite the urgent demand from industry. To address this problem, Eulerian simulations with an EMMS-based sub-grid scale model, accounting for the effect of sub-grid scale structures on the inter-phase friction, are performed to study the hydrodynamics inside a large-scale turbulent fluidized bed of FCC particles. It is shown that the simulated axial and radial solid concentration profiles, entrained solid fluxes and standard deviation of the solid concentration fluc- tuation agreed well with experimental data available in the literature. In-depth analysis of time-averaged particle velocity and solid concentration shows that a dense-suspension upflow regime coexists with fast fluidization regime in this bed, which is reminiscent of the hydrodynamic characteristics in high-density circulating fluidized bed (CFB) risers, even though they are operated in different fluidization regimes. The Reynolds stresses in turbulent fluidized beds are anisotropic, but the degree of anisotropy is far less pronounced than the reported values in CFB risers. It was also found that the solid concentration fluctuation and axial particle velocity fluctuation are strongly correlated. | Junwu Wang | 2010 | Particuology2010，8，2： | 6 |
| 13 | A novel key pre-distribution scheme for wireless distributed sensor networks显示文摘A novel key pre-distribution scheme for sensor networks is proposed, which enables sensor nodes to communicate securely with each other using cryptographic techniques. The approach uses the rational normal curves in the projective space with the dimension n over the finite field F q . Both secure connectivity and resilience of the resulting sensor networks are analyzed. By choosing the parameters q and n properly, this key pre-distribution scheme has some advantages over the previous known schemes. In addition, if the number of the rational normal curves in the scheme becomes too large for an application, the size may be reduced by choosing a part of the curves randomly. This reduction has, shown by our experiments, only minimal impact on secure connectivity and resilience of the resulting sensor network. | PEI DingYi DONG JunWu RONG ChunMing | 2010 | Science China(Information Sciences)2010，53，2： | 6 |
| 14 | Infective viruses produced from full-length complementary DNA of swine vesicular disease viruses HK/70 strain显示文摘The full-length cDNA clone of swine vesicular disease virus HK/70 strain named pSVOK12 was constructed in order to study the antigenicity, replication, maturation and pathogenicity of swine vesicular disease virus. In vitro transcription RNA from pSVOK12 transfected IBRS-2 cells and the re- covered virus RNA were isolated and sequenced, then indirect hemagglutination test, indirect im- munofluorescence assays, eleectron microscope test, 50% tissue culture infecting dose (TCID50) assays and mouse virulence studies were performed to study the antigenicity and virulence of the recovered virus. The result showed that the infectious clones we ob- tained and the virus derived from pSVOK12 had the same biological properties as the parental strain HK/70. The full-length infectious cDNA clone, pSVOK12, will be very useful in studies of the anti- genicity, virulence, pathogenesis, maturation and replication of SVDV. | ZHENG Haixue LIU Xiangtao SHANG Youiun WU Jinyan BAI Xingwen JIN Ye SUN Shiqi GUO Huichen TIAN Hong FENG Xia YIN Shuanghui GUO Jianhong CONG Guozheng LIU Zaixin CHANG Huiyun MA Junwu XIE Qingge | 2006 | Chinese Science Bulletin2006，51，17： | 6 |
| 15 | Midterm results of diagnostic treatment and repair strategy in older patients presenting with nonrestrictive ventricular septal defect and severe pulmonary artery hypertension显示文摘 | Liu Aijun Li Zhiqiang Li Xiaofeng Fan Xiangming Su Junwu Zhang Jing He Yan Liu Yinglong | 2014 | Chinese Medical Journal2014，，5： | 6 |
| 16 | Small molecular non-fullerene electron acceptors for P3HT-based bulk-heterojunction solar cells显示文摘Three small molecules with the same arms and different cores of perylene diimide(PDI)or indaceno[2,1-b:6,5-b']dithiophene(IDT)were designed and synthesized as the acceptor materials for P3HT-based bulk-heterojunction(BHJ)solar cells.The impacts of the different cores on the optical absorption,electrochemical properties,electron mobility,film morphology,photoluminescene characteristics,and solar cell performance were thoroughly studied.The three compounds possess a broad absorption covering the wavelength range of 400–700 nm and relatively low lowest unoccupied molecular orbital(LUMO)energy levels of?3.86,?3.81 and?3.99 eV.The highest power conversion efficiency of 0.82%was achieved for the BHJ solar cells based on SM3 as the acceptor material,the compound with a PDI core. | LIU Xin CAI Ping CHEN DongChen CHEN JunWu SU ShiJian CAO Yong | 2014 | Science China Chemistry2014，57，7： | 5 |
| 17 | Subcutaneous and intramuscular fat transcriptomes show large differences in network organization and associations with adipose traits in pigs显示文摘Subcutaneous fat(SCF)and intramuscular fat(IMF)deposition is relevant to health in humans,as well as meat production and quality in pigs.In this study,we generated RNA sequence data for 122 SCF,120 IMF,and 87 longissimus dorsi muscle(LDM)samples using 155 F6 pigs from a specially designed heterogeneous population generated by intercrossing four highly selected European commercial breeds and four indigenous Chinese pig breeds.The phenotypes including waist back fat thickness and intramuscular fat content were also measured in the 155 F6 pigs.We found that the genes in SCF and IMF differed largely in both expression levels and network connectivity,and highlighted network modules that exhibited strongest gain of connectivity in SCF and IMF,containing genes that were associated with the immune process and DNA double-strand repair,respectively.We identified 215 SCF genes related to kinase inhibitor activity,mitochondrial fission,and angiogenesis,and 90 IMF genes related to lipolysis and fat cell differentiation,displayed a tissue-specific association with back fat thickness and IMF content,respectively.We found that cis-expression QTL for trait-associated genes in the two adipose tissues tended to have tissuedependent predictability for the two adipose traits.Alternative splicing of genes was also found to be associated with SCF or IMF deposition,but the association was much less extensive than that based on expression levels.This study provides a better understanding of SCF and IMF gene transcription and network organization and identified critical genes and network modules that displayed tissue-specific associations with subcutaneous and intramuscular fat deposition.These features are helpful for designing breeding programs to genetically improve the two adipose traits in a balanced way. | Yifeng Zhang Yingchun Sun Zhongzi Wu Xinwei Xiong Junjie Zhang Junwu Ma Shijun Xiao Lusheng Huang Bin Yang | 2021 | Science China(Life Sciences)2021，64，10： | 5 |
| 18 | Duration of hypertension is associated with cognitive function: a cross-sectional study in Chinese adults显示文摘 | Li Tuo Bai Yu Xiang Junwu Wang Rui Bai Jie Tuo Xiping Zhao Zhongxin | 2014 | Chinese Medical Journal2014，，11： | 5 |
| 19 | Coupling control on pillar stress concentration and surface cracks in shallow multi-seam mining显示文摘In order to ensure safe mining and reduce surface damage in shallow multi-seam mining,the failure characteristics of interburden strata with different coal pillars offset distances between pillars in the upper and lower seams,the distribution characteristics of stress concentration in coal pillars,and the development characteristics of stratum cracks and subsidence were investigated by physical and UDEC2D simulation.Meanwhile,the effect of different coal pillar offset distances on stress concentration of coal pillar and development of stratum cracks were studied.Based on those results,a formula for safe mining and reducing surface damage was established,which provided a theoretical basis for safe and environmentally friendly mining in shallow multi-seam.According to the results,the optimal coal pillar offset distance(the side to side horizontal distance of the upper and lower coal pillars)between the upper and lower coal seams was developed to reduce the stress concentration of coal pillars and surface damage.The results of this study have been applied in Ningtiaota coal mine and have achieved good results in safe and environmentally friendly mining. | Qingxiang Huang Junwu Du Jie Chen Yanpeng He | 2021 | International Journal of Mining Science and Technology2021，31，1： | 4 |
| 20 | LncDACH1 promotes mitochondrial oxidative stress of cardiomyocytes by interacting with sirtuin3 and aggravates diabetic cardiomyopathy显示文摘Diabetic cardiomyopathy(DCM)is a common complication in diabetic patients.The molecular mechanisms of DCM remain to be fully elucidated.The intronic long noncoding RNA of DACH1(lnc DACH1)has been demonstrated to be closely associated with heart failure and cardiac regeneration.In this study,we investigated the role of lnc DACH1 in DCM and the underlying molecular mechanisms.The expression of lnc DACH1 was increased in DCM hearts and in high glucose-treated cardiomyocytes.Knockout of lnc DACH1 reduced mitochondrial oxidative stress,cell apoptosis,cardiac fibrosis and hypertrophy,and improved cardiac function in DCM mice.Overexpression of lnc DACH1 exacerbated mitochondria-derived reactive oxygen species(ROS)level and apoptosis,decreased activity of manganese superoxide dismutase(Mn-SOD);while silencing of lnc DACH1 attenuated ROS production,mitochondrial dysfunction,cell apoptosis,and increased the activity of Mn-SOD in cardiomyocytes treated with high glucose.Lnc DACH1 directly bound to sirtuin3(SIRT3)and facilitated its degradation by ubiquitination,therefore promoting mitochondrial oxidative injury and cell apoptosis in mouse hearts.In addition,SIRT3 silencing abrogated the protective effects of lnc DACH1 deficiency in cardiomyocytes.In summary,lnc DACH1 aggravates DCM by promoting mitochondrial oxidative stress and cell apoptosis via increasing ubiquitination-mediated SIRT3 degradation in mouse hearts.Inhibition of lnc DACH1 represents a novel therapeutic strategy for the intervention of diabetic cardiomyopathy. | Qi Zhang Danyang Li Xue Dong Xiaowen Zhang Junwu Liu Lili Peng Bo Meng Qi Hua Xinyu Pei Lu Zhao Xiaoxi Hu Yang Zhang Zhenwei Pan Yanjie Lu Baofeng Yang | 2022 | Science China(Life Sciences)2022，65，6： | 4 |
您所在的机构暂未开通此部分的功能，请联系管理员