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| 1 | The culture and establishment of embryonic germ(EG)cell lines from Chinese mini swine显示文摘As a part of a basic research project on Xeno-transplantion, we have been engaged in the derivation ofembryonic stem cell lines from Chinese mini swine. Here, we reported for the first time the establishmentof two porcine EG cell lines (BPEG1 and BPEG2) from primordial germ cells of genital ridges of a 28 anda 27 d embryos respectively. Their pluripotent nature has been identified by colony morphology, markercharacterization as well as by in vitro and in vivo differentiation. These porcine EG cells are potentiallyuseful for further basic studies. | HSlAOCHIENTSUNG ZHONGWEIDU RONGRUI XIULANLI LINPINGBAO JUNWU SHIMINBAO ZHENYAO | 2003 | Cell Research2003，13，3： | 17 |
| 2 | A novel method for extracting vanadium by low temperature sodium roasting from converter vanadium slag显示文摘Long-term high temperature in conventional vanadium extraction process would cause particles to be sintered and wrapped, thus reducing extraction efficiency of vanadium. Based on the purpose of directional conversion and process intensification, this work proposed a combination of low temperature sodium roasting and high efficiency selective oxidation leaching in vanadium extraction. The investigation of the reaction mechanism suggested that the structure of vanadium slag was changed by roasting, which also caused the fracture of spinel.The addition of MnO2 promoted the directional oxidation of low-valent vanadium into high valence. It also found that Na2S2O8 could oxidize low-valent vanadium effectively in leaching. The leaching efficiency of vanadium reached 87.74% under the optimum conditions, including a roasting temperature of 650 ℃, a roasting time of 2.0 h, a molar ratio of sodium-to-vanadium of 0.6, a MnO2(roasting additive) dosage of 5 wt% and a Na2S2O8(leaching oxidant) dosage of 5 wt%. This percentage is 7.18% higher than that of direct roasting-andleaching under the same conditions. | Rongrui Deng Hao Xiao Zhaoming Xie Zuohua Liu Qiang Yu Geng Chen Changyuan Tao | 2020 | Chinese Journal of Chemical Engineering2020，28，8： | 4 |
| 3 | PhaseⅠdose-escalation and expansion study of PARP inhibitor,fluzoparib(SHR3162),in patients with advanced solid tumors显示文摘Objective:Fluzoparib(SHR3162)is a novel,potent poly(ADP-ribose)polymerases(PARP)1,2 inhibitor that showed anti-tumor activity in xenograft models.We conducted a phaseⅠ,first-in-human,dose-escalation and expansion(D-Esc and D-Ex)trial in patients with advanced solid cancer.Methods:This was a 3+3 phaseⅠD-Esc trial with a 3-level D-Ex at 5 hospitals in China.Eligible patients for DEsc had advanced solid tumors refractory to standard therapies,and D-Ex enrolled patients with ovarian cancer(OC).Fluzoparib was administered orally once or twice daily(bid)at 11 dose levels from 10 to 400 mg/d.Endpoints included dose-finding,safety,pharmacokinetics,and antitumor activity.Results:Seventy-nine patients were enrolled from March,2015 to January,2018[OC(47,59.5%);breast cancer(BC)(16,20.3%);colorectal cancer(8,10.1%),other tumors(8,10.1%)];48 patients were treated in the D-Esc arm and 31 in the D-Ex arm.The maximum tolerated dose(MTD)was 150 mg bid,with a half-life of 9.14 h.Grade 3/4 adverse events included anemia(7.6%)and neutropenia(5.1%).The objective response rate(ORR)was 30%(3/10)in patients with platinum-sensitive OC and 7.7%(1/13)in patients with BC.Among patients treated with fluzoparib≥120 mg/d,median progression-free survival(m PFS)was 7.2[95%confidence interval(95%CI),1.8-9.3]months in OC,9.3(95%CI,7.2-9.3)months in platinum-sensitive OC,and 3.5(range,2.0-28.0)months in BC.In patients with germline BC susceptibility gene mutation(g BRCAMut)(11/43 OC;2/16 BC),m PFS was 8.9 months for OC(range,1.0-23.2;95%CI,1.0-16.8)and 14 and 28 months for BC(those two patients both also had somatic BRCAMut).Conclusions:The MTD of fluzoparib was 150 mg bid in advanced solid malignancies.Fluzoparib demonstrated single-agent antitumor activity in BC and OC,particularly in BRCAMut and platinum-sensitive OC. | Huiping Li Rongrui Liu Bin Shao Ran Ran Guohong Song Ke Wang Yehui Shi Jihong Liu Wenjing Hu Fu Chen Xiaoran Liu Gairong Zhang Chuanhua Zhao Ru Jia Quanren Wang Hope S.Rugo Yifan Zhang Guangze Li Jianming Xu | 2020 | Chinese Journal of Cancer Research2020，32，3： | 4 |
| 4 | Epigenetic Mechanism Involved in the HBV/HCV-Related Hepatocellular Carcinoma Tumorigenesis显示文摘 | Liang Rongrui Huang Na Li Zongfang Ji Fanpu Jiang Shiwen | 2014 | Current Pharmaceutical Design2014，，11： | 2 |
| 5 | A high-efficiency grating coupler between single-mode fiber and silicon-on-insulator waveguide显示文摘We present the design of a diffractive grating structure and get the optimal parameters which can achieve more than 75%coupling efficiency(CE) between single-mode fiber and silicon-on-insulator(SOI) waveguide through 2D finite-different time-domain(FDTD) simulation.The proposed architecture has a uniform structure with no bottom reflection element or silicon overlay.The structure,including grating couplers,adiabatic tapers and interconnection waveguides can be fabricated on the SOI waveguide with only a single electron-beam lithography(ICP) step,which is CMOS-compatible.A relatively high coupling efficiency of 47.2%was obtained at a wavelength of 1562 nm. | Rongrui Liu Yubing Wang Dongdong Yin Han Ye Xiaohong Yang Qin Han | 2017 | Journal of Semiconductors2017，38，5： | 1 |
| 6 | Single-Crystal Gallium Nitride Nanotubes显示文摘 | Joshua Goldberger Rongrui He Yanfeng Zhang | 2003 | Nature2003，422，： | 1 |
| 7 | Single-crystal gallium nitride nanotubes显示文摘 | Joshua Goldberger Rongrui He Yanfeng Zhang | 2003 | Nature2003，422，： | 1 |
| 8 | A Localized Algorithm for Finding Disjoint Paths in Wireless Sensor Networks显示文摘 | Hou Rongrui Shi Haoshan | 2006 | IEEE Communications Letters2006，10，12： | 1 |
| 9 | Single-crystal gallium nitride nanotubes显示文摘 | Joshua Goldberger Rongrui He Yanfeng Zhang | 2003 | Nature2003，422，： | 1 |
| 10 | 显示文摘 | Yan Haoquan He Rongrui | 2003 | Adv Mater2003，155，： | 1 |
| 11 | 显示文摘 | Yingjiu Z Jun L Rongrui H | 2001 | Chem Mater2001，13，： | 1 |
| 12 | 靶向表观遗传相互作用为EZH2异常的实体瘤群体提供精准治疗策略显示文摘文章简介表观遗传调控异常与肿瘤发生发展密切相关,其中组蛋白甲基转移酶EZH2因在肿瘤中广泛突变和过表达,成为备受关注肿瘤治疗靶点,多个抑制剂处于临床研究。然而,目前EZH2抑制剂仅对少量血液系统肿瘤有效,对实体瘤治疗基本无效,极大限制了其临床应用空间。 | Xun Huang Juan Yan Min Zhang Yafang Wang Yi Chen Xuhong Fu Rongrui Wei Xing-ling Zheng Zhiwei Liu Xiong Zhang Hong Yang Bingbing Hao Yan-yan Shen Yi Su Xiaoji Cong Min Huang 谭敏佳 丁健 耿美玉 | 2019 | 科学新闻2019，0，2： | 1 |
| 13 | Effects of cryopreservation on the developmental competence, ultrastructure and cytoskeletal structure of porcine oocytes显示文摘 | CaihongWu RongRui JianjunDai ChunyanZhang ShiqiangJu BingXie XiaoLu XiaofengZheng | 2006 | Mol Reprod Dev2006，，11： | 1 |
| 14 | Single-crystal gallium nitride nanotubes 显示文摘 | Joshua Goldberger Rongrui He Yanfeng Zhang | 2003 | Nature2003，422，： | 1 |
| 15 | Single-crystal gallium nitride nanotubes显示文摘 | Goldberger Joshua He Rongrui Zhang Yanfeng | 2003 | Nature2003，422，： | 1 |
| 16 | Self- organized GaN quantum wire UV lasers 显示文摘 | Choi Heon-Jin Johnson J C He Rongrui | 2003 | Journal of Physics and Chemistry B2003，107，34： | 1 |
| 17 | Effects of follicular size and FSH on granulosa cell apoptosis and atresia in porcine antral follicles显示文摘 | PengfeiLin RongRui | 2010 | Mol Reprod Dev2010，，8： | 1 |
| 18 | Single-crystal gallium nitride nanotubes显示文摘 | Goldberger J He Rongrui Zhang Yanfeng | 2003 | Nature2003，422，6932： | 1 |
| 19 | Applica- tion of ionic liquids basedmicrowave-assisted simulta- neous extraction of earnosic acid, rosmarinic acid and essential oil from Rosma-rinus officinalis显示文摘 | Tingting Liul Xiaoyu Suil Rongrui Zhang | 2011 | Journal of Chromatography A2011，1218，： | 1 |
| 20 | Morphologenesis of One dimensional ZnO Nano and Microcrystals显示文摘 | Haoquan Yan Rongrui He Johnny Pham | 2003 | J Adv Mater2003，15，5： | 1 |
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