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| 1 | Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death显示文摘混合的系 kinase 像域的蛋白质(MLKL ) 被识别受体交往下游地工作蛋白质 3 (RIP3 ) 在肿瘤坏死 factor-α(TNF ) 导致了坏死(也叫的 necroptosis ) 。然而, MLKL 怎么工作调停 necroptosis 是未知的。由在 MLKL 大美人房间的 MLKL 功能的宪法,我们证明 MLKL 的 N 终点在 necroptosis 为它的功能被要求。在对待 TNF 的房间的 MLKL 的 oligomerization 为 necroptosis 是必要的,当人工地由使用荷尔蒙绑定领域一起强迫 MLKL (HBD*) 扳机 necroptosis。尤其是,一起强迫 N 终端领域(ND ) 然而并非 MLKL 的 C 终端 kinase 领域引起 necroptosis。进一步的删除分析证明 four-α MLKL (1-130 氨基酸) 的螺旋捆是足够的触发 necroptosis。两 HBD*调停并且 MLKL (ND ) 或 MLKL 的导致 TNF 的建筑群是到血浆膜的类脂化合物椽子的这些建筑群的 tetramers,和 translocation 先于房间死亡。homo-oligomerization 为 MLKL translocation 被要求,为血浆膜地点的信号顺序位于第一和第二 α 的连接; MLKL 的 -helices。MLKL 或 MLKL (ND ) 的血浆膜 translocation 导致钠流入,并且从房间文化媒介的钠的弄空禁止 necroptosis。上述所有现象没在 apoptosis 被看见。因此, MLKL oligomerization 导致 MLKL 的 translocation 到血浆膜,和血浆膜的类脂化合物椽子由自己或经由到增加的另外的蛋白质的 MLKL 复杂行为任何一个钠流入,增加渗透的压力,最后导致膜破裂。 | Xin Chen Wenjuan Li Junming Ren Deli Huang Wan-ting He Yunlong Song Chao Yang Wanyun Li Xinru Zheng PengdaChen Jiahuai Han | 2014 | Cell Research2014，24，1： | 67 |
| 2 | Impacts of thermodynamic processes over the Tibetan Plateau on the Northern Hemispheric climate显示文摘We here report our recent research results on the climatic features of Tibetan thermodynamic functions and their impacts on the regional climates of the Northern Hemisphere. The results show that the thermodynamic processes over the Tibetan Plateau not only strongly influence the Asian monsoon and precipitation, but also modulate the atmospheric circulation and climate over North America and Europe through stimulating the large-scale teleconnections such as the Asian-Pacific oscillation and affect the atmospheric circulation over the southern Indian Ocean. The Tibetan climate may be affected by sea surface temperatures over the tropical Pacific. On the other hand, the Tibetan climate also affects the atmosphere-ocean interactions in the tropics and mid-latitudes of the Pacific by the atmospheric circulation over the North Pacific. In spring and summer, the thermodynamic anomalies on the plateau affect the subtropical high pressure, the Hadley circulation, and the intertropical convergence zone over the Pacific, and then modulate the development of the El Ni-o/Southern Oscillation (ENSO). It is necessary to study the forecasting methods for the development of ENSO from the Tibetan climate anomaly. This result also embodies the essence of interactions among land, atmosphere, and ocean over the Northern Hemisphere. Since the previous studies focused on impacts of the plateau on climates in the Asian monsoon regions, it is essential to pay more attention to studying the roles of the plateau in the Northern Hemispheric and even global climates. | ZHOU XiuJi ZHAO Ping CHEN JunMing CHEN LongXun LI WeiLiang | 2009 | Science China Earth Sciences2009，52，11： | 42 |
| 3 | Development and Prospect of SiC Power Devices in Power Grid显示文摘碳化硅作为一种宽禁带材料,具有高击穿场强、高饱和电子漂移速率、高热导率等优点,可以实现高压、大功率、高频、高温应用的新型功率半导体器件。该文对碳化硅功率半导体器件的最新发展进行回顾,包括碳化硅功率二极管、MOSFET、IGBT和晶闸管,对其在电力系统的应用现状与前景进行展望。高压大容量碳化硅功率半导体器件的迅速发展,将对电力系统的发展带来深远的影响。 | SHENG Kuang GUO Qing ZHANG Junming QIAN Zhaoming | 2012 | 中国电机工程学报2012，32，30： | 42 |
| 4 | Mlkl knockout mice demonstrate the indispensable role of Mlkl in necroptosis显示文摘像域的蛋白质(Mlkl ) 最近被发现与受体交往交往的混合的系 kinase 蛋白质 3 (Rip3 ) 并且导致的坏死因素(TNF ) 在有教养的房间线规划了坏死(necroptosis ) 为肿瘤必要。我们由抄写产生了 Mlkl 缺乏的老鼠像使活跃之物的受动器核酸酶(TALEN ) 调停了基因混乱和发现 Mlkl 到为象有免疫力的房间开发一样的正常老鼠开发非必需。胚胎的成纤维细胞(MEF ) 和巨噬细胞两个都显示出的 Mlkl 缺乏的老鼠抵抗到坏死然而并非 apoptotic 刺激。Mlkl 缺乏的 MEF 和巨噬细胞与处于他们激活 NF-κ 的能力的野类型的房间难区分;响应 TNF 和 lipopolysaccharides (LPS ) 的 B,英皇家空军之阶级最低之兵, JNK,和 p38 分别地。一致地, Mlkl 缺乏的巨噬细胞和老鼠展出了正常 interleukin-1β(IL-1β) ,在 LPS 处理以后的 IL-6,和 TNF 生产。Mlkl 缺乏保护老鼠免受导致天蓝色的尖锐胰腺炎的伤害,坏死相关的疾病,但是没在 polymicrobial 上有效果腐败导致吃惊的动物死亡。我们的结果在 necroptosis 为 Mlkl 的角色提供基因证据。 | Jianfeng Wu Zhe Huang Junming Ren Zhirong Zhang Peng He Yangxin Li Jianhui Ma Wanze Chen Yingying Zhang Xiaojuan Zhou Zhentao Yang Su-Qin Wu Lanfen Chen Jiahuai Han | 2013 | Cell Research2013，23，8： | 35 |
| 5 | Linking atmospheric pollution to cryospheric change in the Third Pole region: current progress and future prospects显示文摘The Tibetan Plateau and its surroundings are known as the Third Pole(TP). This region is noted for its high rates of glacier melt and the associated hydrological shifts that affect water supplies in Asia. Atmospheric pollutants contribute to climatic and cryospheric changes through their effects on solar radiation and the albedos of snow and ice surfaces; moreover, the behavior and fates within the cryosphere and environmental impacts of environmental pollutants are topics of increasing concern. In this review, we introduce a coordinated monitoring and research framework and network to link atmospheric pollution and cryospheric changes(APCC) within the TP region. We then provide an up-to-date summary of progress and achievements related to the APCC research framework, including aspects of atmospheric pollution’s composition and concentration, spatial and temporal variations, trans-boundary transport pathways and mechanisms, and effects on the warming of atmosphere and changing in Indian monsoon, as well as melting of glacier and snow cover. We highlight that exogenous air pollutants can enter into the TP’s environments and cause great impacts on regional climatic and environmental changes. At last, we propose future research priorities and map out an extended program at the global scale. The ongoing monitoring activities and research facilitate comprehensive studies of atmosphere–cryosphere interactions, represent one of China’s key research expeditions to the TP and the polar regions and contribute to the global perspective of earth system science. | Shichang Kang Qianggong Zhang Yun Qian Zhenming Ji Chaoliu Li Zhiyuan Cong Yulan Zhang Junming Guo Wentao Du Jie Huang Qinglong You Arnico K.Panday Maheswar Rupakheti Deliang Chen Orjan Gustafsson Mark H.Thiemens Dahe Qin | 2019 | National Science Review2019，6，4： | 35 |
| 6 | Single Current Feedback Control Strategy for Grid-connected Inverters With LCL Filters显示文摘LCL滤波器广泛应用于并网逆变器系统中,其对高次谐波具有良好的衰减作用;但LCL滤波器为低阻尼三阶系统,容易发生谐振。传统的有源阻尼方法,通过对电容电流进行采样并反馈,能够抑制系统振荡,但增加了传感器数量。提出一种单电流反馈控制策略,其采用入网电流两次微分的反馈方法,增加了系统阻尼,从而有效地抑制LCL滤波器的谐振尖峰,保证系统的稳定性;同时其对系统参数不敏感,并且不增加额外的传感器,是一种低成本高可靠性的控制策略。文中推导该控制策略下的系统传递函数,并分析系统的稳定性。最后,通过仿真和实验,验证提出的控制策略的可行性与有效性。 | CHEN Dong ZHANG Junming QIAN Zhaoming | 2013 | 中国电机工程学报2013，33，9： | 33 |
| 7 | Re-Os isotope dating of molybdenites in the Huang-shaping Pb-Zn-W-Mo polymetallic deposit, Hunan Province, South China and its geological significance显示文摘The large-scale Huangshaping Pb-Zn-W-Mo polymetallic deposit is located in the central Nanling min- eralization zone, South China. Six molybdenite samples from the Huangshaping deposit were selected for Re-Os isotope measurement in order to define the mineralization age of the deposit. It yields a Re-Os isochron age of 154.8±1.9 Ma (2σ ), which is in accordance with the Re-Os model ages of 150.9― 156.9 Ma. This age is about 7 Ma younger than their host granite porphyry, which was dated as 161.6±1.1 Ma by zircon U-Pb method using LA-ICPMS. All these ages demonstrate that the Huang- shaping granite and related Pb-Zn-W-Mo deposit occurred in the middle Yanshanian period, when many other granitoid and related ore deposits emplaced and formed, e.g. the Qitianling granite and Furong tin deposit, the Qianlishan granite and giant Shizhuyuan W-Sn-Mo-Bi deposit and Jinchuantang Sn-Bi deposit in the nearby area. They constitute the main part of the magmatic-metallogenic belt of southern Hunan, and represent the large-scale metallogeny in middle Yanshanian in the area. The lower rhenium content in molybdenite of Huangshaping deposit suggests that the ore-forming material was mainly of crust origin. | YAO JunMing HUA RenMin QU WenJun QI HuaWen LIN JinFu DU AnDao | 2007 | Science China Earth Sciences2007，50，4： | 29 |
| 8 | Metallogenesis related to Mesozoic Granitoids in the Nanling Range, South China and Their Geodynamic Settings显示文摘Affected by the compressive stress from the South-Central (Indo-China) Peninsula, the Indosinianorogenesis, characterized by collision, thrust and uplifting, took place inside the South China Plate during 250?230 Ma.The ages of the Indosinian granitoids in the Nanling Range and vicinity areas are mostly 240?205 Ma, indicating that theywere emplaced in both late collision and post-collision geodynamic environments. No important granite-relatedmetallogenesis occurred in this duration. A post-orogenic setting started at the beginning of the Yanshanian Period, whichcontrolled large-scale granitic magmatism and related metallogenesis. This paper makes the first attempt to divide theYanshanian Period into three sub-periods, i.e. the early, middle and late Yanshanian Periods, based mainly on the featuresof magmatism, especially granitoids and related metallogenesis and their geodynamic environments. The magmaticassociation of the Early Yanshanian (about 185?170 Ma) comprises four categories of magmatism, i.e. basalt, bimodalvolcanics, A-type granite and intraplate high-K calc-alkaline (HKCA) magmatism, which indicates an extension-thinningof lithosphere and upwelling of mantle material to a relative small and local extent. Pb-Zn, Cu and Au mineralizationsassociated with HKCA magmatism represents the first high tide of Mesozoic metallogenesis in the Nanling Range area.During the middle Yanshanian, the lithosphere was subjected to more extensive and intensive extending and thinning, andhence mantle upwelling and basaltic magma underplating caused a great amount of crust remelting granitoids. This periodcan be further divided into two stages. The first stage (170?150 Ma) is represented by large-scale emplacement of crustremelting granites with local tungsten mineralization at its end. The second stage (150?140 Ma) is the most important timeof large-scale mineralizations of non-ferrous and rare metals, e.g. W, Sn, Nb-Ta, Bi, Mo, Be, in the Nanling Range area.The late Yanshanian (140?65 Ma) was generally characterized by full extension and breakup of the lithosphere of SouthChina. However, owing to the influence of the Pacific Plate movement, the eastern part of South China was predominatedby subduction-related compression, which resulted in magmatism of calc-alkaline and shoshonite series and relatedmetallogeneses of Au, Ag, Pb-Zn, Cu and (Mo, Sn), followed by extension in its late stage. In the Nanling Range area, thelate Yanshanian magmatism was represented by granitic volcanic-intrusive complexes and mafic dikes, which aregenetically related to volcanic-type uranium and porphyry tin deposits, and the mobilization-mineralization of uraniumfrom pre-existing Indosinian granites. | HUA Renmin CHEN Peirong ZHANG Wenlan YAO Junming LIN Jinfu ZHANG Zhanshi GU Shengyan LIU Xiaodong QI Huawen | 2005 | Acta Geologica Sinica(English Edition)2005，79，6： | 22 |
| 9 | An investigation of surface deformation after fully mechanized,solid back fill mining显示文摘The surface deformation after fully mechanized back filling mining was analyzed.The surface deformation for different backfill materials was predicted by an equivalent mining height model and numerical simulations.The results suggest that:(1) As the elastic modulus,E,of the backfill material increases the surface subsidence decreases.The rate of subsidence decrease drops after E is larger than 5 GPa;(2) Fully mechanized back fill mining technology can effectively control surface deformation.The resulting surface deformation is within the specification grade I,which means surface maintenance is not needed.A site survey showed that the equivalent mining height model is capable of predicting and analyzing surface deformation and that the model is conservative enough for engineering safety.Finally,the significance of establishing a complete error correction system based on error analysis and correction is discussed. | Li Jian Zhang Jixiong Huang Yanli Zhang Qiang Xu Junming | 2012 | International Journal of Mining Science and Technology2012，22，4： | 23 |
| 10 | The porosity origin of dolostone reservoirs in the Tarim, Sichuan and Ordos basins and its implication to reservoir prediction显示文摘Origin of dolostone remained a controversial subject, although numerous dolomitization models had been proposed to date. Because of the dolomitization's potential to be hydrocarbon reservoirs, one debatable issue was the role of dolomitization in porosity construction or destruction. Based upon case studies of dolostone reservoirs in various geological settings such as evaporative tidal flat(Ordos Basin, NW China), evaporative platform(Sichuan Basin, SW China), and burial and hydrothermal diagenesis(Tarim Basin, NW China), here we systematically discuss the origin of porosity in dolostone reservoirs. Contrary to traditional concepts, which regarded dolomitization as a significant mechanism for porosity creation, we found two dominant factors controlling reservoir development in dolostones, i.e., porosity inherited from precursor carbonates and porosity resulted from post-dolomitization dissolution. Actually, dolomitization rarely had a notable effect on porosity creation but rather in many cases destroyed pre-existing porosity such as saddle dolostone precipitation in vugs and fractures. Porosity in dolostones associated with evaporative tidal flat or evaporative platform was generally created by subaerial dissolution of evaporites and/or undolomitized components. Porosity in burial dolostones was inherited mostly from precursor carbonates, which could be enlarged due to subsequent dissolution. Intercrystalline porosity in hydrothermal dolostones was either formed during dolomitization or inherited from precursor carbonates, whereas dissolution-enlarged intercrystalline pores and/or vugs were usually interpreted to be the result of hydrothermal alteration. These understandings on dolostone porosity shed light on reservoir prediction. Dolostone reservoirs associated with evaporative tidal flat were laterally distributed as banded or quasi-stratified shapes in evaporite-bearing dolostones, and vertically presented as multi-interval patterns on tops of shallowing-upward cycles. Dolostone reservoirs associated with evaporative platform commonly occurred along epiplatforms or beneath evaporite beds, and vertically presented as multi-interval patterns in dolostones and/or evaporite-bearing dolostones of reef/shoal facies. Constrained by primary sedimentary facies, burial dolostone reservoirs were distributed in dolomitized, porous sediments of reef/shoal facies, and occurred vertically as multi-interval patterns in crystalline dolostones on tops of shallowing-upward cycles. Hydrothermal dolomitization was obviously controlled by conduits(e.g., faults, unconformities), along which lenticular reservoirs could develop. | ZHAO WenZhi SHEN AnJiang ZHENG JianFeng QIAO ZhanFeng WANG XiaoFang LU JunMing | 2014 | Science China Earth Sciences2014，57，10： | 23 |
| 11 | Isolation,characterization,and phylogenic analysis of three new severe fever with thrombocytopenia syndrome bunyavirus strains derived from Hubei Province,China显示文摘Hubei Province is a major epidemic area of severe fever with thrombocytopenia syndrome bunyavirus(SFTSV) in China. However, to date, a few SFTSV strains have been isolated from Hubei Province, preventing effective studies of epidemic outbreaks. Here, we report three confirmed patients(2015–2016) with typical symptoms of severe fever with thrombocytopenia syndrome disease(SFTS) who were farmers resident in different regions in Hubei Province. Three new SFTSV strains were isolated from the serum samples of each patient. Characterization of viral growth properties showed that there were no significant differences in virus production. All strains were completely sequenced, and phylogenetic analysis showed that unlike the other strains from Hubei province, which belonged to the SFTSV C3 genotype, one of the three strains belonged to the SFTSV C2 genotype. These results suggested that multiple SFTSV genotypes have been circulating in Hubei Province, providing insights into SFTSV evolution and improving our understanding of SFTSV prevalence in Hubei Province. | Yanfang Zhang Shu Shen Junming Shi Zhengyuan Su Mingyue Li Wenjing Zhang Mengmeng Li Zhihong Hu Cheng Peng Xin Zheng Fei Deng | 2017 | Virologica Sinica2017，32，1： | 21 |
| 12 | Mechanism-based anti-anxiety effects of polysaccharides extracted from Shudihuang (Radix Rehmanniae Preparata) by two-dimensional electrophoresis analysis in rat hippocampus proteins显示文摘OBJECTIVE: To investigate mechanism-based anti-anxiety effects of Shudihuang (Radix Rehmanniae Preparata) polysaccharides (RRPPs) through two-dimensional electrophoresis (2-DE) analysis with mass spectrometry (MS) of hippocampus proteins in rats treated with monosodium L-glutamate (MSG).METHODS: MSG (4 g/kg) or normal saline (NS) was injected subcutaneously into infant male rats on days 2, 4, 6, 8, 10 after birth. MSG-treated rats at 8 weeks old were given NS, diazepam, or RRPPs daily for seven consecutive days by intragastric administration, while NS-treated rats given the same volume of NS. Elevated plus maze (EPM) and light/ dark transition (LDT) tests were used to observe anti-anxiety effects of RRPPs at 1 h after the last administration. After EPM and LDT tests, hippocampus tissues were excised on ice rapidly from the brains of rats. Thereafter, 2-DE and matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF/MS) were used for detecting differential proteins in hippocampus of rats so as to explore the potential mechanisms. RESULTS: RRPPs (200, 400 mg/kg) could significantly inhibit MSG-induced decrease of time and entries percentages in open zones in EPM test and numbers of light-dark transition in LDT test. Further analysis of 2-DE and MALDI-TOF/MS indicated that β-synuclein, protein DJ-1, peroxiredoxin-2, peroxiredoxin-6, dimethylarginine dimethylaminohydrolase 1 (DDAH-1) and iron-sulfur proteins were all found to be down-regulated significantly in MSG-treated rats, while such down-regulation was significantly inhibited after treatment with RRPPs. CONCLUSION: RRPPs showed anti-anxiety effects and potential mechanisms might be related to inhibiting MSG-induced down-regulation of β-synuclein, DJ-1, peroxiredoxin-2, peroxiredoxin-6, DDAH-1 and iron-sulfur proteins in hippocampus of rats. | Ying Cui Chunlei Rong Junming Wang Can Cui Li Wang Zhiyi Feng Jing Feng Bing Niu | 2013 | Journal of Traditional Chinese Medicine2013，33，4： | 19 |
| 13 | Effects of dietary arginine levels on growth performance,body composition, serum biochemical indices and resistance ability against ammonia-nitrogen stress in juvenile yellow catfish(Pelteobagrus fulvidraco)显示文摘This experiment was conducted to investigate the effects of dietary arginine levels on growth performance, body composition, serum biochemical indices and resistance ability against ammonia-nitrogen stress in juvenile yellow catfish(Pelteobagrus fulvidraco). Five isonitrogenous and isolipidic diets(42%protein and 9% lipid) were formulated to contain graded levels of arginine(2.44%, 2.64%, 2.81%, 3.01% and3.23% of diet), by supplementing L-Arginine HCI. Seven hundred juvenile yellow catfish with an initial average body weight of 1.13 ± 0.02 g were randomly divided into 5 groups with 4 replicates of 35 fish each and each group was fed one of the diets. After 56 d feeding, fish were exposed to 100 mg/L of ammonia-nitrogen for 72 h. The results showed that weight gain(WG) and specific growth rate(SGR) in2.64% and 2.81% groups were significantly higher than those in 3.23% group(P < 0.05). The feed conversation ratio(FCR) in 2,64%, 2,81% and 3.01% groups was significantly decreased when compared with3,23% group. The protein efficiency ratio(PER) in 2.64% group was significantly higher than that in 2.44%and 3.23% groups(P < 0.05). The condition factor(CF) of fish was significantly higher in 2.81% group than that in 2,44% group(P < 0.05). Dietary arginine levels had no significant effect on hepatosomatic index(HSI), viscerosomatic index(VSI), and whole-body dry matter, crude protein, crude lipid, ash contents, as well as serum total protein(TP), triglyceride(TG), glucose(GLU), urea nitrogen(UN) contents and aspartate aminotransferase(AST), alanine aminotransferase(ALT) activities(P> 0.05). After the fish were challenged to ammonia-nitrogen for 72 h, their cumulative mortality rate in 2.81% group was significantly lower than that in 2.44% group(P < 0.05). The results suggested that dietary arginine level at 2.81%could optimize anti-ammonia-nitrogen stress ability of juvenile yellow catfish and a level of 3.23%arginine seemed to depress the growth performance of fish and decreased their tolerance to the ammonia-nitrogen stress under current study. A quadratic regression analysis based on WG indicated that the optimal dietary arginine requirement of juvenile yellow catfish was estimated to be 2.74% of the diet(6.45% of dietary protein) under current culture conditions. | Qiming Chen Hongxia Zhao Yanhua Huang Junming Cao Guoxia Wang Yuping Sun Yongjuan Li | 2016 | Animal Nutrition2016，，3： | 19 |
| 14 | Impact of mechanical circulatory support and immunomodulation therapy on outcome of patients with fulminant myocarditis: Chinese registry of fulminant myocarditis显示文摘Dear Editor,Patients presenting with acute myocarditis and sudden hemodynamic instability (termed fulminant myocarditis [FM]) still have a high mortality and need for heart transplantation, up to 28% at 60 days.1,2,3 Recent scientific statements and expert opinion consensus suggests early use of temporary mechanical circulatory supports (t-MCS).3,4 Specifically, Chinese scientific statement proposed an extensive use of t-MCS combined with immunoregulatory therapy (IT),4 although formal trials are lacking. We present a multicenter, retrospective study to compare the outcome of patients who were treated with t-MCS and IT vs. patients who didn’t receive these treatments. We included patients with the diagnosis of FM based on the presence of viral prodromal signs/symptoms followed by acute onset of severe heart failure (HF) without other relevant differential diagnosis or pre-existing cardiac disorders. Patients who received both t-MCS and IT during hospitalization were classified as t-MCS+IT group. | Ning Zhou Yuhua Zhao Jiangang Jiang Lan Shen Junming Li Jing Wan Xueping Ma Jing Zhang Enrico Ammirati Dao Wen Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，11： | 14 |
| 15 | Predicting the onset temperature(Tg) of GexSe1-x glass transition: a feature selection based two-stage support vector regression method显示文摘Despite the usage of both experimental and topological methods, realizing a rapid and accurate measurement of the onset temperature(Tg ) of GexSe1-xglass transition remains an open challenge. In this paper, a predictive model for the Tg in GexSe1-xglass system is presented by a machine learning method named feature selection based two-stage support vector regression(FSTS-SVR). Firstly, Pearson correlation coefficient(PCC) is used to select features highly correlated with Tg from the candidate features of GexSe1-x glass system. Secondly, in order to simulate the two-stage characteristic of Tg which is caused by structural variation with a turning point at x = 0.33 via the structural analysis, SVR is utilized to build predictive models for two stages separately and then the two achieved models are synthesized using a minimum error based model for Tg prediction. Compared with the topological and other methods based on SVR, the FSTS-SVR gives the highest predictive accuracy with the root mean square error(RMSE) and mean absolute percentage error(MAPE) of 10.64 K and 2.38%, respectively. This method is also expected to be more efficient for the prediction of Tg of other glass systems with the multi-stage characteristic. | Yue Liu Junming Wu Guang Yang Tianlu Zhao Siqi Shi | 2019 | Science Bulletin2019，64，16： | 12 |
| 16 | Distribution and transportation of mercury from glacier to lake in the Qiangyong Glacier Basin, southern Tibetan Plateau, China显示文摘The Tibetan Plateau is home to the largest aggregate of glaciers outside the Polar Regions and is a source of fresh water to 1.4 billion people. Yet little is known about the transportation and cycling of Hg in high-elevation glacier basins on Tibetan Plateau. In this study, surface snow,glacier melting stream water and lake water samples were collected from the Qiangyong Glacier Basin. The spatiotemporal distribution and transportation of Hg from glacier to lake were investigated. Significant diurnal variations of dissolved Hg(DHg) concentrations were observed in the river water, with low concentrations in the morning(8:00 am–14:00 pm) and high concentrations in the afternoon(16:00 pm–20:00 pm). The DHg concentrations were exponentially correlated with runoff, which indicated that runoff was the dominant factor affecting DHg concentrations in the river water. Moreover, significant decreases of Hg were observed during transportation from glacier to lake. DHg adsorption onto particulates followed by the sedimentation of particulate-bound Hg(PHg) could be possible as an important Hg removal mechanism during the transportation process. Significant decreases in Hg concentrations were observed downstream of Xiao Qiangyong Lake, which indicated that the high-elevation lake system could significantly affect the distribution and transportation of Hg in the Qiangyong Glacier Basin. | Shiwei Sun | 2016 | Journal of Environmental Sciences2016，28，6： | 10 |
| 17 | Tick-Borne Viruses显示文摘Ticks are important vectors for the transmission of pathogens including viruses.The viruses carried by ticks also known as tick-borne viruses(TBVs),contain a large group of viruses with diverse genetic properties and are concluded in two orders,nine families,and at least 12 genera.Some members of the TBVs are notorious agents causing severe diseases with high mortality rates in humans and livestock,while some others may pose risks to public health that are still unclear to us.Herein,we review the current knowledge of TBVs with emphases on the history of virus isolation and identification,tick vectors,and potential pathogenicity to humans and animals,including assigned species as well as the recently discovered and unassigned species.All these will promote our understanding of the diversity of TBVs,and will facilitate the further investigation of TBVs in association with both ticks and vertebrate hosts. | Junming Shi Zhihong Hu Fei Deng Shu Shen | 2018 | Virologica Sinica2018，33，1： | 10 |
| 18 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 19 | White Matter Abnormalities in Major Depression Biotypes Identified by Diffusion Tensor Imaging显示文摘Identifying data-driven biotypes of major depressive disorder(MDD) has promise for the clarification of diagnostic heterogeneity. However, few studies have focused on white-matter abnormalities for MDD subtyping. This study included 116 patients with MDD and118 demographically-matched healthy controls assessed by diffusion tensor imaging and neurocognitive evaluation.Hierarchical clustering was applied to the major fiber tracts, in conjunction with tract-based spatial statistics, to reveal white-matter alterations associated with MDD.Clinical and neurocognitive differences were compared between identified subgroups and healthy controls. With fractional anisotropy extracted from 20 fiber tracts, cluster analysis revealed 3 subgroups based on the patterns of abnormalities. Patients in each subgroup versus healthy controls showed a stepwise pattern of white-matter alterations as follows: subgroup 1(25.9% of patient sample),widespread white-matter disruption;subgroup 2(43.1% of patient sample), intermediate and more localized abnormalities in aspects of the corpus callosum and left cingulate;and subgroup 3(31.0% of patient sample),possible mild alterations, but no statistically significant tract disruption after controlling for family-wise error. The neurocognitive impairment in each subgroup accompanied the white-matter alterations: subgroup 1, deficits in sustained attention and delayed memory;subgroup 2, dysfunction in delayed memory;and subgroup 3, no significant deficits. Three subtypes of white-matter abnormality exist in individuals with major depression, those having widespread abnormalities suffering more neurocognitive impairments, which may provide evidence for parsing the heterogeneity of the disorder and help optimize typespecific treatment approaches. | Sugai Liang Qiang Wang Xiangzhen Kong Wei Deng Xiao Yang Xiaojing Li Zhong Zhang Jian Zhang Chengcheng Zhang Xin-min Li Xiaohong Ma Junming Shao Andrew J. Greenshaw Tao Li | 2019 | Neuroscience Bulletin2019，35，5： | 9 |
| 20 | Insights into mercury in glacier snow and its incorporation into meltwater runoff based on observations in the southern Tibetan Plateau显示文摘The Tibetan Plateau(TP) is recognized as 'Water Tower of Asia'. Yet our understanding of mechanisms influencing incorporation of mercury(Hg) into freshwater in mountain glaciers on the TP remains quite limited. Extensive sampling of environmental matrices(e.g., snow/ice)were conducted on the East Rongbuk glacier on Mt. Everest and Zhadang glacier on Mt.Nyainqentanglha for Hg speciation analysis. Speciated Hg behaved quite different during snowmelt: a preferential early release of DHg(dissolved Hg) was observed at the onset of snowmelt, whereas PHg(particulate-bound Hg) and THg(total Hg) become relatively enriched in snow and released later. Small fraction of Hg in snow was lost during a snowmelt day(18.9%–34.7%) with a large proportion(58.1%–87.3%) contributed by PHg decrease, indicating that the deposited Hg is most likely retained in glacier snow/ice. Furthermore, THg were positively correlated with PHg and crustal major ions(e.g., Ca^(2+), Mg^(2+)) during snowmelt, indicating that Hg is mainly migrated with particulates. The main pathway of Hg loss during snowmelt was most probably associated with release of PHg with meltwater, which was greatly influenced by ablation intensity of snow/ice. This should be paid particular concern as Hg preserved in mountain glaciers will mostly enter aquatic ecosystem as climate warms, impacting on downstream ecosystems adversely. Obvious decrease of THg during the downstream transport from glacier was observed with a large proportion contributed by PHg decrease. The main removal mechanism of Hg was associated with sedimentation of PHg during the transport process. | Shiwei Sun Shichang Kang Junming Guo Qianggong Zhang Rukumesh Paudyal Xuejun Sun Dahe Qin | 2018 | Journal of Environmental Sciences2018，30，6： | 9 |
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