|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Cancer Genetics and Epigenetics: Two Sides of the Same Coin?显示文摘 | Jueng Soo You Peter A. Jones | 2012 | Cancer Cell2012，，1： | 2 |
| 2 | Inhibition of BET selectively eliminates undifferentiated pluripotent stem cells显示文摘Embryonic stem cells(ESCs) maintain their cellular identity through the systematic regulation of master transcription factors and chromatin remodeling complexes. Recent work has shown that the unusually large-scale enhancers—namely super-enhancers(SEs), on which BRD4, a member of the bromodomain and extraterminal domain(BET) family is highly enriched—could regulate pluripotency-related transcription factors. Moreover, inhibition of BRD4 binding on SEs has been shown to induce the differentiation of ESCs. However, the underlying mechanism of BRD4 inhibition-mediated stem cell differentiation remains elusive. Here we show that both mouse and human ESCs lose their capacity for self-renewal upon treatment with JQ1, a selective inhibitor of BET family including BRD4, with rapid suppression of pluripotency-associated genes. Notably, a high concentration of JQ1 could selectively eliminate ESCs via apoptosis, without affecting the functionality of differentiated somatic cells from ESCs, suggesting that inhibition of BET may have a beneficial effect on the development of pluripotent stem cell-based cell therapy. | Jung Hyun Im Seon In Hwang Jong-Wan Kim soon-Jung Park Kyu-ree Kang Jueng Soo You Kee Pyo Kim Sung-Hwan Moon Hyuk-Jin Cha Hyung-Min Chung Hans R. Scholer Jung Keun Hyun DongWook Han | 2018 | Science Bulletin2018，63，8： | 2 |
| 3 | Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK26)that is expressed in Both oocytes and granulosa cells 显示文摘 | Wilson T Wu X Y Juenge I J | 2001 | Biol Reprod2001，64，： | 1 |
| 4 | The role of transforming growth factor-beta (TGF beta) during o varian follicular development in sheep 显示文摘 | Juenge JL Bibby AH Reader KL | 2004 | Reproduc tive Biology and Endocrinology2004，2，： | 1 |
| 5 | Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of Bone morphogenetic protein IB receptor (ALK-6) that is expressed in Both ooeytes and granulosa cells显示文摘 | Wilson T Wu X Y Juenge I J | 2001 | Biolo Reprod2001，64，： | 1 |
| 6 | Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor(ALK-6)that is expressed in both oocytes and granulosa cells 显示文摘 | WILSON T WU X Y JUENGE I J | 2001 | Biology of Reproduction2001，64，： | 1 |
| 7 | Reconstruction a diagnostic method in oral and maxillofacial surgery 显示文摘 | Sehimming R Juenging FD Siegmund C | 2000 | Mund kiefer Gesiehtsehir2000，4，1： | 1 |
| 8 | Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor (ALK ~ 6) that is expressed inboth oocytes and granulosa cells显示文摘 | WILSON T WU X Y JUENGE I J | 2001 | Biology of Reproduction2001，，64： | 1 |
| 9 | The physical and chemical characteristics of the shell of air-entrained bubbles in cement paste显示文摘 | Ley M T Chancey R Juenge M C G Folliard K J | 2009 | Cement and Concrete Research2009，，39： | 1 |
| 10 | Endoscopicsubmucosal dissection for sessile,nonampullary duode-nal adenomas显示文摘 | JUENG J H CHOI K D AHN J Y | 2013 | Endoscopy2013，45，： | 1 |
| 11 | Cancer Genetics and Epigenetics: Two Sides of the Same Coin?显示文摘 | Jueng Soo You Peter A. Jones | 2012 | Cancer Cell2012，，1： | 1 |
| 12 | Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of Bone morphogenetic protein IB receptor(ALK-6) that is expressed in Both oocytes and granulosa cells显示文摘 | Wilson T Wu X Y Juenge l J | 2001 | Biology of Reproduction2001，64，： | 1 |
| 13 | MUTYH hotspot mutations in unselected colonoscopy patients 显示文摘 | Casper M Plotz G Jueng!ing B | 2012 | Colorectal Dis2012，14，5： | 1 |
| 14 | Nifedipine GITS and hydrochlorothiazide in essential hypertension 显示文摘 | Halperin AK Hashimoto F | 1987 | J Clin Hypertens1987，3，4： | 1 |
| 15 | Vinyl isocyanurates:Preparation of alkenyl isocyanurates by trimerization or cotrimerization of isocyanates显示文摘 | ERIC C Juenge FRANCIS Wm C | 1961 | Journal of OrganicChemistry1961，26，： | 1 |
| 16 | Liquid chromatographic separation and detection of epinephrine and its oxidation products,adrenochrome and adrenolutin显示文摘 | Juenge E C Flinn P E Furman W B | | 0，，02： | 1 |
| 17 | DNA methylation and cellular re- programming显示文摘 | Daniel D Jueng S Y Peter A J | 2014 | Cell Press2014，20，10： | 1 |
| 18 | Highly prolific Booroola sheep have a mutation in the intracellular kinase domain of bone morphogenetic protein IB receptor(ALK26)that is expressed in both oocytes and granulosa cells显示文摘 | Wilson T Wu X Y Juenge I J | | 0，，： | 1 |
| 19 | DNA methylation and cellular reprogramming显示文摘 | Daniel D. De Carvalho Jueng Soo You Peter A. Jones | 2010 | Trends in Cell Biology2010，，10： | 1 |
| 20 | Overview of genetic signaling pathway interactions within cutaneous malignancies显示文摘Melanoma and non-melanoma cutaneous malignancies are some of the leading causes of cancer-related death in the United States.Though melanoma is more known to have a high mortality rate,the total mortality per year is nearly equal for between melanoma and non-melanoma skin cancer.Moreover,the non-melanoma types of cutaneous malignancies have potential to become locally invasive and even metastasize with very little to no treatment options when advanced.The development of these malignancies involves various genetic pathways through the four hallmarks of cancer development:malignant cell growth,apoptosis evasion,the use of supporting stroma and vascularization,and modulating and promoting an inadequate immune response.The genetic signaling pathways of basal cell carcinoma,squamous cell carcinoma,verrucous carcinoma,basosquamous cell carcinoma,melanoma,and cutaneous T-cell lymphoma interact with each other through genetic predisposition as well as with environmental exposures.Furthermore,solar ultraviolet radiation and chronic inflammatory states are found to initiate the progression of many of these cutaneous malignancies.This paper includes validated models of genetic pathways,emerging pathways,and crosstalk between genetic pathways through the four hallmarks of cancer development.Moreover,unlike most reviews addressing oncogenetics of the well-recognized,as well as newly discovered,genetic pathway mutations,this review stresses that these pathways are not fixed but rather exist in dynamic,interrelated,interactive,complex,and adaptive flux states. | Brittany S.Maner Leonie Dupuis Ashley Su Jeremy J Jueng Tanner P.Harding John Meisenheimer Ⅶ Fahad S.Siddiqui Mia R.Hardack Savina Aneja James A.Solomon | 2020 | Journal of Cancer Metastasis and Treatment2020，6，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员