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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Regulation of inter-feron signaling by the C and V proteins from attenuated and wild-type strains of measles virus 显示文摘 | Judith M F Bettina B William J B | 2008 | Virology2008，374，： | 1 |
| 3 | Electrophysiological properties of human mesenchymal stem cells 显示文摘 | Heubach J F Graf E M Judith Leutheuser | 2003 | J Physiol2003，554，： | 1 |
| 4 | Receptor Model andEmissions Inventory Source Apportionments of NonmethaneOrganic Gases in California,San Joaquin Valley and SanFrancisco Bay Area显示文摘 | ERIC M F JOHN G W JUDITH C H | 1995 | Atmospheric Enuironment1995，29，21： | 1 |
| 5 | The Ectomyeorrhizal Fungus Laeearia bicalor Stimulates Lateral Root Formation in Poplar and Arabidopsis through Auxin Transport and Signaling 显示文摘 | Judith F Annegret K Emmanuelle M | 2009 | Plant Physiology2009，151，： | 1 |
| 6 | Study d anionic and nomonic silicone latlices by si NMR Si pectroscopy 显示文摘 | JUDITH S TRACEY M L JOANN F S | 1993 | Journal of Applied Polymer Science1993，47，： | 1 |
| 7 | Immune response to a carcinoembryonic antigen polynucleotide vaccine 显示文摘 | Robert M Conry Albert F LoBuglio Judith Kantor | 1994 | Cancer Res1994，54，： | 1 |
| 8 | Effects of diet,bacitracin,and body weight restrictions on the intestine of broiler chicks显示文摘 | Stutz M W Johnson S L Judith F R | 1983 | Poultry science1983，62，8： | 1 |
| 9 | In vitro and in vivo evaluartions of the antibioticefrotomycin 显示文摘 | Stutz M W Johnson S L Judith F R | 1983 | Poultry Science1983，62，： | 1 |
| 10 | Examining supply chain relationships:Do buyer and supplier perspectives on collaborative relationships differ显示文摘 | GILBERT N NYAGA JUDITH M WHIPPLE DANIEL F LYNCH | 2010 | Journal of operations management2010，28，2： | 1 |
| 11 | A buyer's perspective on collaborative versus transactional relationships 显示文摘 | Judith M Whipple Daniel F Lynch Gilbert N Nyaga | 2010 | Industrial Marketing Management2010，，39： | 1 |
| 12 | Factors associ- ated with non-completion in a double-blind randomized controlled trial of olanzapine plus sertraline versus olanzapine plus placebo for psychotic depression 显示文摘 | Judith W Alastair F Barnett M | 2012 | Psychiatry Research2012，197，3： | 1 |
| 13 | Mwticenter co uabo-- rative randomized parallel gyoup compative studg显示文摘 | Gilbert N Nyaga Judith M Whipple Daniel F Lynch | 2010 | Journal of Operations Management2010，28，： | 1 |
| 14 | Clinical Applications of Biofeedback Systems in Hemodialysis显示文摘 | Judith J Casper F M | 2013 | Studies in Computational Intelligence2013，405，： | 1 |
| 15 | Electrophysiological properties of human mesenchymal stem cells 显示文摘 | Jurgen F Eva M Judith L | 2004 | J Physiol2004，554，3： | 1 |
| 16 | Long-term protective immune re,sponse elicited by vaccination with an expression genomic library of Toxoplasma gondii显示文摘 | Alberto F Alexandro R Judith M | 2003 | lnfect Immun2003，71，9： | 1 |
| 17 | In Vivo Imaging of Endogenous Pancreatic [Beta]-Cell Mass in Healthy and Type 1 Diabetic Subjects Using ^sup 18^F-Fluoropropyl-Dihydrotetrabenazine and PET显示文摘 | Normandin Marc D Petersen Kitt F Ding Yu-Shin Lin Shu-Fei Naik Sarita Fowles Krista Skovronsky Daniel M Herold Kevan C McCarthy Timothy J Calle Roberto A Carson Richard E Treadway Judith L Cline Gary W | 2012 | EN2012，，6： | 1 |
| 18 | CTGF Expression is Induced by TGF- β in Cardiac Fibroblasts and Cardiac Myocytes: a Potential Role in Heart Fibrosis显示文摘 | Michelle M Chen Andrew Lam Judith A Abraham George F Schreiner Alison H Joly | 2000 | Journal of Molecular and Cellular Cardiology2000，，10： | 1 |
| 19 | An efficient method for the preparation of N,N-disubstituted 1,2-diamines显示文摘 | Judith M M Nathaniel S F | 2000 | Tetra- hedron Lett2000，41，44： | 1 |
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