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| 1 | Plant-derived phosphocholine facilitates cellular uptake of anti-pulmonary fibrotic HJT-sRNA-m7显示文摘Pulmonary fibrosis, a progressive chronic disease with a high mortality rate, has limited treatment options. Currently, lung transplantation remains the only effective treatment. Here we report that a small RNA, HJT-sRNA-m7, from a Chinese herbal medicine Hong Jing Tian(HJT, RHODIOHAE CRENULATAE RADIX ET RHIZOMA, Rhodiola crenulata) can effectively reduce the expressions of fibrotic hallmark genes and proteins both in alveolar in vitro and in mouse lung tissues in vivo. We also discovered over one hundred oil-soluble chemicals from HJT decoctions, most of which are found in lipid extracts from other Chinese herbals decoctions, including Pu Gong Ying(PGY, TARAXACI HERBA, Taraxacum mongolicum), Chuan Xin Lian(CXL, changed to 'ANDROGRAPHIS HERBA, Andrographis paniculata'), and Jin Yin Hua(JYH, lonicera japonica or Honeysuckle). We identified the active component in these decoctions as two forms of phosphocholines, PC(18:0/18:2) and PC(16:0/18:2). These PCs potentially could form liposomes with small RNAs to enter human alveolar and gastric cells. Our experimental results suggest an unprecendent lipid complex route through which botanic small RNA can enter human bodies.Our results provide an innovative treatment strategy for oral delivery of siRNAs as therapeutic medication. | Jianchao Du Zhu Liang Jiantao Xu Yan Zhao Xiaoyun Li Yanli Zhang DANDan Zhao Ruxuan Chen Yang Liu Trupti Joshi Jiahui Chang Zhiqing Wang Yanxu Zhang Jindong Zhu Qiang Liu Dong Xu Chengyu Jiang | 2019 | Science China(Life Sciences)2019，62，3： | 21 |
| 2 | Mnk kinase pathway: Cellular functions and biological outcomes显示文摘The mitogen-activated protein kinase(MAPK) interacting protein kinases 1 and 2(Mnk1 and Mnk2) play important roles in controlling signals involved in mRNA translation. In addition to the MAPKs(p38 or Erk), multiple studies suggest that the Mnk kinases can be regulated by other known kinases such as Pak2 and/or other unidentified kinases by phosphorylation of residues distinct from the sites phosphorylated by the MAPKs. Several studies have established multiple Mnk protein targets, including PSF, heterogenous nuclear ribonucleoprotein A1, Sprouty 2 and have lead to the identification of distinct biological functions and substrate specificity for the Mnk kinases. In this review we discuss the pathways regulating the Mnk kinases, their known substrates as well as the functional consequences of engagement of pathways controlled by Mnk kinases. These kinases play an important role in mRNA translation via their regulation of eukaryotic initiation factor 4E(eIF4E) and their functions have important implications in tumor biology as well as the regulation of drug resistance to anti-oncogenic therapies. Other studies have identified a role for the Mnk kinases in cap-independent mRNA translation, suggesting that the Mnk kinases can exert important functional effects independently of the phosphorylation of eIF4 E. The role of Mnk kinases in inflammation and inflammationinduced malignancies is also discussed. | Sonali Joshi Leonidas C Platanias | 2014 | World Journal of Biological Chemistry2014，5，3： | 16 |
| 3 | MicroRNAs in lung cancer显示文摘Micro RNAs have become recognized as key players in the development of cancer. They are a family of small non-coding RNAs that can negatively regulate the expression of cancer-related genes by sequenceselective targeting of m RNAs, leading to either m RNA degradation or translational repression. Lung cancer is the leading cause of cancer-related death worldwide with a substantially low survival rate. Micro RNAs have been confirmed to play roles in lung cancer development, epithelial-mesenchymal transition and response to therapy. They are also being studied for their future use as diagnostic and prognostic biomarkers and as potential therapeutic targets. In this review we focus on the role of dysregulated micro RNA expression in lung tumorigenesis. We also discuss the role of micro RNAs in therapeutic resistance and as biomarkers. We further look into the progress made and challenges remaining in using micro RNAs for therapy in lung cancer. | Pooja Joshi Justin Middleton Young-Jun Jeon Michela Garofalo | 2014 | World Journal of Methodology2014，4，2： | 13 |
| 4 | Recent Progress in Deciphering the Biosynthesis of Aspartate-Derived Amino Acids in Plants显示文摘植物直接或间接地是大多数在动物食谱的必要氨基酸的来源。都经由一条很好学习的生合成小径从 aspartate 生产的四这些必要氨基的 acidsmethionine, threonine,异白氨酸,和 lysineare。在必要氨基酸给营养的兴趣,导出 aspartate 的氨基酸小径是广泛的研究的题目。另外,因为为经济地重要的除草剂的目标,和一些下游的产品是为象乙烯和 S-adenosylmethionine 那样的另外的必要植物代谢物的 biosynthetic 先锋,几小径酶服务。关于氨基酸的导出 aspartate 的家庭的最近、进行中的研究识别了新酶活动,规章的机制,并且在 vivo 新陈代谢的功能。一起,这些发现将为植物开创新可能性新陈代谢的工程。 | Georg Jander Vijay Joshi | 2010 | Molecular Plant2010，3，1： | 12 |
| 5 | Extra-articular distal tibial fractures, is interlocking nailing an option? A prospective study of 147 cases显示文摘Purpose:Distal tibia fractures comprise about 7%-10% of lower extremity trauma.Because of the peculiarity of the soft tissue and subcutaneous location of the bone there are many controversies in the ideal treatment of distal tibia fractures especially extra articular pilon fractures.Plating is fraught with complications of wound dehiscence and infection.There are limited studies which document outcomes in such cases using intramedullary interlocking nail.We intend to study the outcome and complications of extra articular distal tibial fractures treated with interlocking nailing.Methods:This is a prospective study conducted in a tertiary care orthopaedic hospital in southern India.There are 147 patients of distal tibia extra-articular fractures managed by IM nailing with follow up of more than one year were included in this study.Only cases with fresh injury (less than 1 week),fracture below the isthmus,closed and open Gustilo Anderson type 1 and 2 fractures were included in the study.Patients were reviewed at 3,6,12 and 24 weeks after surgery and thereafter at one year and were assessed for clinical and radiological signs of healing,any complications,time to union and functional outcome.Results:There were 102 males and 45 females (male/female ratio is 2.3∶1) with a mean age of 38.96 (range 23-65) years.According to AO classification,there were 78 cases (53.06%) of 43-A1,39 cases (26.53%) of 43-A2 and 30 cases of 43-A3 constituting 20.40%.The fracture united in all the patients at an average of 18 weeks (range 16-22 weeks),none of the patient in our series had a delayed or non-union.Two patients (1.47%) had the fracture united in mild valgus but it was well within the acceptable limits (<5°).The functional outcome was assessed in all the patients at final follow up using Olerud and Molander score all the patients fared an excellent to good score,there were no cases with poor score.Conclusion:Intramedullary nailing is a viable option to treat distal tibial fractures with excellent outcome.Wound complications related to plating can be avoided but meticulous surgical technique is key to avoid malunion. | PNVSV Prasad Amit Nemade Rashid Anjum Nilesh Joshi | 2019 | Chinese Journal of Traumatology2019，22，2： | 11 |
| 6 | Association between obesity-related adipokines and colorectal cancer:A case-control study and meta-analysis显示文摘AIM:To examine the association between obesityrelated adipokines(adiponectin,leptin,resistin,interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)and colorectal cancer(CRC)risk.METHODS:Serum levels of adipokines were measured in 100 CRC patients and age-and sex-matched controls for the data analysis.Unconditional logistic regression models were used for estimating ORs and95%CIs related to each adipokine.For the metaanalysis,studies published before July 2013 available on Medline/PubMed and EMBASE were retrieved.The analysis included a total of 17 relevant studies(including the present case-control study):nine studies on adiponectin and eight on leptin.The effect sizes of ORs and 95%CIs were estimated using RevMan 5.1.Heterogeneity was evaluated using Cochran’s Q-test and I2 statistics.RESULTS:Among the five adipokines,only resistin levels were significantly higher in cases than in controls(P<0.001).The case-control study results showed no association between adiponectin and CRC and a negative association between leptin and CRC.However,the results of the meta-analysis showed a significant inverse association between adiponectin and CRC(OR=0.91,95%CI:0.83-1.00,P=0.04)and no association between CRC and leptin.After stratification by study design,an inverse association between adiponectin and CRC was observed in prospective studies only(OR=0.90,95%CI:0.82-0.99,P=0.03),whereas the association between leptin and CRC was inconsistent(prospective studies:OR=1.14,95%CI:1.02-1.27,P=0.02 and retrospective studies:OR=0.47,95%CI:0.29-0.74,P=0.001).The associations of resistin and TNF-αwith CRC risk were positive,but no association was observed for IL-6.CONCLUSION:Our results suggest a negative association of leptin,positive associations of resistin and TNF-α,and null associations of adiponectin and IL-6with CRC.However,further studies with larger number of prospective approaches are needed. | Rakhi Kumari Joshi Woo Jin Kim Sang-Ah Lee | 2014 | World Journal of Gastroenterology2014，20，24： | 11 |
| 7 | Laser-Assisted Reduction of Highly Conductive Circuits Based on Copper Nitrate for Flexible Printed Sensors显示文摘Stretchable electronic sensing devices are defining the path toward wearable electronics. High-performance flexible strain sensors attached on clothing or human skin are required for potential applications in the entertainment,health monitoring, and medical care sectors. In this work,conducting copper electrodes were fabricated onpolydimethylsiloxane as sensitive stretchable microsensors by integrating laser direct writing and transfer printing approaches. The copper electrode was reduced from copper salt using laser writing rather than the general approach of printing with pre-synthesized copper or copper oxide nanoparticles. An electrical resistivity of 96 l X cm was achieved on 40-lm-thick Cu electrodes on flexible substrates. The motion sensing functionality successfully demonstrated a high sensitivity and mechanical robustness.This in situ fabrication method leads to a path toward electronic devices on flexible substrates. | Shi Bai Shigang Zhang Weiping Zhou Delong Ma Ying Ma Pooran Joshi Anming Hu | 2017 | Nano-Micro Letters2017，9，4： | 10 |
| 8 | Primary duodenal neoplasms:A retrospective clinico-pathological analysis显示文摘AIM: To analyze the clinico-pathological spectrum of primary duodenal neoplasms. METHODS: A total of 55 primary duodenal neoplasms reported in the last 10 years after excluding ampullary and periampullary tumors were included in the study. Clinical details were noted and routine hematoxylin and eosin stained paraffin sections were studied for histological subtyping of the tumors. RESULTS: On histopathological examination primary duodenal neoplasms were categorized as: epithelial tumor in 27 cases (49.0%) including 10 cases of adenoma, 15 cases of adenocarcinoma, and 2 cases of Brunner gland adenoma; mesenchymal tumor in 9 cases (16.3%) consisting of 4 cases of gastrointestinal stromal tumor, 4 cases of smooth muscle tumor and I case of neurofibroma; lymphoproliferative tumor in 12 cases (21.8%), and neuroendocrine tumor in 7 cases (12.7%). CONCLUSION: Although non-ampullary/periampullary duodenal adenocarcinomas are rare, they constitute the largest group. Histopathological examination of primary duodenal tumors is important for correct histological subtyping. | Amanjit Bal Kusum Joshi Kim Vaiphei JD Wig | 2007 | World Journal of Gastroenterology2007，13，7： | 10 |
| 9 | Species diversity, regeneration and dominance as influenced by canopy gaps and their characteristics in tropical evergreen forests of Western Ghats, India显示文摘Canopy gaps play a significant role in maintaining structure and composition of tropical forests. This study was carried out in tropical evergreen forests of central Western Ghats in India to understand the influence of canopy gap size and the relationship of gap regime attributes to diversity measures and regeneration. The average gap size in the study area was found to be 396 m2 and around half of gaps were 4–8 years old. Gaps created by natural single tree fall were smaller in size but significantly higher in number. Diversity and regeneration of woody species were compared with canopy gaps and intact vegetation. Species richness and diversity was higher in gaps than in intact vegetation. Macaranga peltata, a shade intolerant species dominated gaps while intact vegetation was dominated by shade tolerant Kingiodendron pinnatum.Gap size significantly influenced species diversity and regeneration. Gap area and age were significantly and negatively correlated with diversity measures but positively correlated with regeneration. Among all the attributes of gaps, regeneration was significantly positively correlated with light intensity. Gaps maintained species diversity and favored regeneration of woody species. In addition to gap size and age, other gap ecological attributes also affected species diversity and regeneration. | Guddappa Mahalingappa Devagiri Anil Kumar Khaple Siddagangaiah Mohan Puttanaik Venkateshamurthy Sanjay Tomar Arkalgud Nagaraja Arunkumar Geeta Joshi | 2016 | Journal of Forestry Research2016，27，4： | 9 |
| 10 | Alcohol dehydrogenase: A potential new marker for diagnosis of intestinal ischemia using rat as a model显示文摘AIM: Intestinal ischemia (Ii) is an abdominal emergency due to blockade of the superior mesenteric artery resulting in 60-100% mortality if diagnosed late. Changes in several biochemical parameters such as D (-)-lactate, Creatinine kinase isoenzymes and lactate dehydrogenase suggested for early diagnosis, lack specificity and sensitivity. Therefore a biochemical parameter with greater sensitivity needs to be identified.METHODS: Wistar male rats were randomly assigned into two groups; control sham operated (n = 24) and ischemic test (n = 24) group. Superior mesenteric arterial occlusion was performed in the ischemic test group for 1 h. Alcohol dehydrogenase (ADH) was estimated in blood from portal vein, right ventricle of heart, dorsal aorta (DA) and inferior vena cava (IVC). The Serum glutamic acid pyruvate transaminase (SGPT) was also estimated in blood from portal vein and right ventricle of heart.RESULTS: A significant increase (P<0.001) in the levels of ADH in both portal blood as well as heart blood of the test group (232.72±99.45 EU and 250.85±95.14 EU, respectively)as compared to the control group (46.39±21.69 EU and 65.38±30.55 EU, respectively) were observed. Similarly,increased levels of ADH were observed in blood samples withdrawn from DA and IVC in test animals (319.52±80.14EU and 363.90±120.68 EU, respectively) as compared to the control group (67.68±63.22 EU and 72.50±58.45 EU,respectively). However, in test animals there was significant increase in SGPT in portal blood (P = 0.054) without much increase in heart blood.CONCLUSION: Significant increase in the levels of ADH in portal and heart blood within 1 h of SMA occlusion without increase in SGPT in heart blood, suggests that the origin of ADH is from ischemic intestine and not from liver. Similarly, raised ADH levels were found in DA and IVC as well. IVC blood does represent peripheral blood sample. A raised level of ADH in test animals confirms it to be a potential marker in the early diagnosis of Ii. | Upendra R Gumaste Mukund M Joshi Devendra T Mourya Pradip V Barde Ghanshyam K Shrivastav Vikram S Ghole | 2005 | World Journal of Gastroenterology2005，11，6： | 9 |
| 11 | Comparison of split-dosing vs non-split(morning) dosing regimen for assessment of quality of bowel preparation for colonoscopy显示文摘AIM: To compare(using the Ottawa Bowel Preparation Scale) the efficacy of split-dose vs morning administration of polyethylene glycol solution for colon cleansing in patients undergoing colonoscopy, and to assess the optimal preparation-to-colonoscopy interval.METHODS: Single-centre, prospective, randomized, investigator-blind stud in an academic tertiarycare centre. Two hundred patients requiring elective colonoscopy were assigned to receive one of the two preparation regimens(split vs morning) prior to colonoscopy. Main outcome measurements were bowel preparation quality and patient tolerability.RESULTS: Split-dose regimen resulted in better bowel preparation compared to morning regimen [Ottawascore mean 5.52(SD 1.23) vs 6.02(1.34); P = 0.017]. On subgroup analysis, for afternoon procedures, both the preparations were equally effective(P = 0.756). There was no difference in tolerability and compliance between the two regimens.CONCLUSION: Overall, previous evening- same morning split-dosing regimen results in better bowel cleansing for colonoscopy compared to morning preparation. For afternoon procedures, both schedules are equally effective; morning preparation may be more convenient to the patient. | Hardik Shah Devendra Desai Hrishikesh Samant Sandeep Davavala Anand Joshi Tarun Gupta Philip Abraham | 2014 | World Journal of Gastrointestinal Endoscopy2014，6，12： | 8 |
| 12 | Interactive Effects of Elevated CO_2 and Growth Temperature on the Tolerance of Photosynthesis to Acute Heat Stress in C_3 and C_4 Species显示文摘Determining effects of elevated CO2 on the tolerance of photosynthesis to acute heat-stress (heat wave) is necessary for predicting plant responses to global warming,as photosynthesis is thermolabile and acute heat-stress and atmospheric CO2 will increase in the future.Few studies have examined this,and past results are variable,which may be due to methodological variation.To address this,we grew two C3 and two C4 species at current or elevated CO2 and three different growth temperatures (GT).We assessed photosynthetic thermotolerance in both unacclimated (basal tolerance) and preheat-stressed (preHS=acclimated) plants.In C3 species,basal thermotolerance of net photosynthesis (Pn) was increased in high CO2,but in C4 species,Pn thermotlerance was decreased by high CO2 (except Zea mays at low GT); CO2 effects in preHS plants were mostly small or absent,though high CO2 was detrimental in one C3 and one C4 species at warmer GT.Though high CO2 generally decreased stomatal conductance,decreases in Pn during heat stress were mostly due to non-stomatal effects.Photosystem Ⅱ (PSⅡ efficiency was often decreased by high CO2 during heat stress,especially at high GT; CO2 effects on post-PSII electron transport were variable.Thus,high CO2 often affected photosynthetic theromotolerance,and the effects varied with photosynthetic pathway,growth temperature,and acclimation state.Most importantly,in heat-stressed plants at normal or warmer growth temperatures,high CO2 may often decrease,or not benefit as expected,tolerance of photosynthesis to acute heat stress.Therefore,interactive effects of elevated CO2 and warmer growth temperatures on acute heat tolerance may contribute to future changes in plant productivity,distribution,and diversity. | E. William Hamilton III Scott A. Heckathorn Puneet Joshi Dan Wang Deepak Barua | 2008 | Journal of Integrative Plant Biology2008，50，11： | 8 |
| 13 | Synaptic electronics and neuromorphic computing显示文摘In order to map the computing architecture and intelligent functions of the human brain on hardware, we need electronic devices that can emulate biological synapses and even neurons, preferably at the physical level. Beginning with the history of neuromorphic computation, in this article, we will briefly review the architecture of the brain and the learning mechanisms responsible for its plasticity. We will also introduce several memristive devices that have been used to implement electronic synapses, presenting some important milestones in this area of research and discussing their advantages, disadvantages, and future prospects. | Navnidhi K.UPADHYAY Saumil JOSHI J.Joshua YANG | 2016 | Science China(Information Sciences)2016，59，6： | 8 |
| 14 | Blumgart's technique of pancreaticojejunostomy: Analysis of safety and outcomes显示文摘Background: Blumgart's pancreaticojejunostomy(PJ) has been described with low pancreatic leak rates. This study aimed to evaluate our experience with this technique regarding the pancreatic leak and other perioperative outcomes. Methods: We performed a single-center retrospective analysis of a cohort of 81 patients who underwent pancreaticoduodenectomy in our department from January 2011 to February 2018. The primary endpoint was the occurrence of a clinically relevant postoperative pancreatic fistula(CR-POPF) and analysis of its risk factors. Results: The CR-POPF rate was 12.3%. Fistula risk score(FRS) was the only significant risk factor for the occurrence of overall POPF in multivariate analysis. However, none of the other factors including FRS was found to be significantly associated with CR-POPF risk. A strong positive correlation was found between the CR-POPF and the incidence of delayed gastric emptying, post-pancreatectomy hemorrhage and increased length of hospital stay. Conclusion: Blumgart's technique is a safe technique of pancreatico-enteric anastomosis with low rates of CR-POPF. CR-POPF with this technique is independent of most of the preoperative and intraoperative factors. Therefore, this technique can be used for all types of the pancreas with consistently good results. | Vishal Gupta Saket Kumar Vivek Gupta Pradeep Joshi Rahul Rahul Rakesh Kumar Yadav Amit Dangi Abhijit Chandra | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，2： | 8 |
| 15 | The effect of laser surface texturing on the tribological performance of different Sialon ceramic phases显示文摘A tribological performance was carried out on different types of hot press Sialon ceramics regarding the phases, i.e., the α-Sialon phase, the β-Sialon phase, and the α/β-Sialon composite phase. The different phases of Sialon ceramics were analyzed by XRD patterns. For the tribological performance, the Sialon ceramics were laser textured and the starved lubrication method was applied with different dimple pitches under a load of 10 N at room temperature. The material having a dimple pitch of 200 mm shows the lowest coefficient of friction. The α/β-Sialon composite phase shows the least coefficient of friction i.e. 0.04 and 0.1 for the textured and polished(without being textured) samples, respectively. The Sialon ceramics show mild wear and therefore, the wear rate of the steel ball(mating partner) was taken into account for the wear analysis. The α-Sialon phase having a higher hardness shows the least wear in comparison to the α/β-Sialon composite phase and the β-Sialon phase. | Bhupendra Joshi Khagendra Tripathi Gobinda Gyawali Soo Wohn Lee | 2016 | Progress in Natural Science:Materials International2016，26，4： | 8 |
| 16 | Comparative prospective study between medial and lateral distal tibial locking compression plates for distal third tibial fractures显示文摘 | Sandeep Garg Vikram Khanna Mahaveer Prashad Goyal Narendra Joshi Amrut Borade Ishan Ghuse | 2017 | Chinese Journal of Traumatology2017，20，3： | 8 |
| 17 | Contrast induced neurotoxicity following coronary angiogram with Iohexol in an end stage renal disease patient显示文摘Neurotoxicity is an infrequent adverse reaction to iodinated contrast agents. Contrast induced neurotoxicity following coronary angiogram is very rare. Renal disease is a risk factor for contrast induced neurotoxicity. We report a case of contrast induced neurotoxicity following coronary angiogram and intervention using Iohexol(Omnipaque 350) in an end stage renal disease patient on peritoneal dialysis who had prior exposure to iodinated contrast without any adverse reaction. Hemodialysis had to be initiated for rapid removal of the contrast agent with subsequent complete resolution of neurological deficits. This case highlights the need for interventionalists to be aware of an important adverse reaction to iodinated contrast agents, especially in individuals with renal dysfunction, and that neurotoxicity is a possibility even with prior uneventful exposures. The role and timing of hemodialysis in contrast induced neurotoxicity in patients with chronic kidney disease and in those without chronic kidney disease needs further deliberation. | Narasimha Swamy Gollol Raju Deepak Joshi Ramesh Daggubati Assad Movahed | 2015 | World Journal of Clinical Cases2015，3，11： | 8 |
| 18 | Molecular analysis of long-term biofilm formation on PVC and cast iron surfaces in drinking water distribution system显示文摘To understand the impacts of different plumbing materials on long-term biofilm formation in water supply system, we analyzed microbial community compositions in the bulk water and biofilms on faucets with two different materials-polyvinyl chloride(PVC) and cast iron, which have been frequently used for more than10 years. Pyrosequencing was employed to describe both bacterial and eukaryotic microbial compositions. Bacterial communities in the bulk water and biofilm samples were significantly different from each other. Specific bacterial populations colonized on the surface of different materials. Hyphomicrobia and corrosion associated bacteria, such as Acidithiobacillus spp., Aquabacterium spp., Limnobacter thiooxidans, and Thiocapsa spp., were the most dominant bacteria identified in the PVC and cast iron biofilms, respectively, suggesting that bacterial colonization on the material surfaces was selective. Mycobacteria and Legionella spp. were common potential pathogenic bacteria occurred in the biofilm samples, but their abundance was different in the two biofilm bacterial communities. In contrast, the biofilm samples showed more similar eukaryotic communities than the bulk water. Notably, potential pathogenic fungi, i.e., Aspergillus spp. and Candida parapsilosis, occurred in similar abundance in both biofilms. These results indicated that microbial community, especially bacterial composition was remarkably affected by the different pipe materials(PVC and cast iron). | Ruyin Liu Junge Zhu Zhisheng Yu DevRaj Joshi Hongxun Zhang Wenfang Lin Min Yang | 2014 | Journal of Environmental Sciences2014，26，4： | 8 |
| 19 | Colorectal cancers in ulcerative colitis from a low-prevalence area for colon cancer显示文摘AIM: To determine the incidence and risk factors for colorectal cancer(CRC) in patients with ulcerative colitis from a low prevalence region for CRC.METHODS: Our prospective database yielded a cohort of 430 patients [age: 44 ± 14.6 years; 248 men(57.7%)] with ulcerative colitis(median disease duration 6, range: 1-39 years) for analysis. Of these, 131(30.5%) had left-sided colitis and 159(37%) extensive colitis. Patients with histologically confirmed CRC within the segment with colitis were compared with those without CRC, to determine the risk factors for the development of CRC.RESULTS: Twelve patients(2.8%) developed CRC. The overall incidence density was 3.56/1000 patient-years of disease- 3/1000 in the first 10 years, 3.3/1000 at 10 to 20 years, and 7/1000 at > 20 years. Three of our 12 patients developed CRC within 8 years of disease onset. On univariate analysis, extensive colitis, longer duration of disease, and poor control of disease were associated with development of CRC. On multivariate analysis, duration of disease and extent of colitis remained significant.CONCLUSION: CRC occurred in 2.8% of patients with ulcerative colitis in our population- an incidence density similar to that in Western countries in spite of a low overall prevalence of colon cancer in our population.The risk increased with extent and duration of disease. | Devendra Desai Sudeep Shah Abhijit Deshmukh Philip Abraham Anand Joshi Tarun Gupta Ramesh Deshpande Varun Khandagale Siji George | 2015 | World Journal of Gastroenterology2015，21，12： | 7 |
| 20 | Forest fire risk assessment in parts of Northeast India using geospatial tools显示文摘Forest fire is a major cause of changes in forest structure and function. Among various floristic regions, the northeast region of India suffers maximum from the fires due to age-old practice of shifting culti- vation and spread of fires from jhum fields. For proper mitigation and management, an early warning of forest fires through risk modeling is required. The study results demonstrate the potential use of remote sens- ing and Geographic Information System (GIS) in identifying forest fire prone areas in Manipur, southeastern part of Northeast India. Land use land cover (LULC), vegetation type, Digital elevation model (DEM), slope, aspect and proximity to roads and settlements, factors that influ- ence the behavior of fire, were used to model the forest fire risk zones. Each class of the layers was given weight according to their fire inducing capability and their sensitivity to fire. Weighted sum modeling and ISODATA clustering was used to classify the fire zones. To validate the results, Along Track Scanning Radiometer (ATSR), the historical fire hotspots data was used to check the occurrence points and modeled forest fire locations. The forest risk zone map has 55 63% of agreement with ATSR dataset. | Kanchan Puri G. Areendran Krishna Raj Sraboni Mazumdar P.K. Joshi | 2011 | Journal of Forestry Research2011，22，4： | 7 |
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