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| 1 | Maytenus erythroxylon Reissek(Celastraceae) ethanol extract presents antidiarrheal activity via antimotility and antisecretory mechanisms显示文摘AIM To investigate the acute toxicity,phytochemical profile,antidiarrheal activity and mechanisms of action of Maytenus erythroxylon(M.erythroxylon)ethanol extract.METHODS A castor oil-induced diarrhea model was used to evaluate antidiarrheal activity.Intestinal transit and gastric emptying protocols were used to evaluate a possible antimotility effect.KATP channels,nitric oxide,presynapticα2-adrenergic and tissue adrenergic receptors were investigated to uncover antimotility mechanisms of action and castor oil-induced enteropooling to elucidate antisecretory mechanisms.RESULTS All tested doses of the extract(62.5,125,250 and 500 mg/kg)possessed antidiarrheal activity,with a significant decrease of the evacuation index.This activity is possibly related to a reduced gastric emptying(125,250 and 500 mg/kg)and to a decreased percentage of intestinal transit for all tested doses.That last effect seems to be modulated by nitric oxide,KATP channels and tissue adrenergic receptors.Besides,the extract also presented antisecretory effect due to a decrease of intestinal fluid accumulation.CONCLUSION The antidiarrheal effect of M.erythroxylon found in this study involves antimotility and antisecretory mechanisms that may be attributed to the chemical compounds found in this species:saponins,flavonoids,tannins,triterpenes and steroids. | Rodrigo de Oliveira Formiga Zelma Glebya Maciel Quirino Margareth de Fátima Formiga Melo Diniz Alexsandro Fernandes Marinho Josean Fechine Tavares Leonia Maria Batista | 2017 | World Journal of Gastroenterology2017，23，24： | 1 |
| 2 | Poly(ester urethane) s with polycaprolactone soft segments:a morphological study显示文摘 | Juliana Kloss M M Gabriel Pinto de Souza Joseane Valentc Gulmine | 2002 | Journal of Polymer Science : Part A: Polymer Chemistry2002，40，： | 1 |
| 3 | Neuroendocrine control of body fluid metabolism显示文摘 | Josean tunes-Rodriguet Castro MD Elias LLK | 2004 | Physiol Rev2004，84，： | 1 |
| 4 | Candida?albicans and Candida?tropicalis in Oral Candidosis: Quantitative Analysis, Exoenzyme Activity, and Antifungal Drug Sensitivity显示文摘 | Karen Regina Carim da Costa Joseane Cristina Ferreira Marilena Chinali Komesu Regina Celia Candido | 2009 | Mycopathologia2009，，2： | 1 |
| 5 | Prospective evaluation of HSV , Candida spp., and oral bacteria on the severity of oral mucositis in pediatric acute lymphoblastic leukemia显示文摘 | Regina Maria Holanda Mendon?a Marcela Araújo Carlos Emilio Levy Joseane Morari Rosangela A. Silva José Andres Yunes Silvia Regina Brandalise | 2012 | Supportive Care in Cancer2012，，5： | 1 |
| 6 | The use of reverse transcription-polymerase chain reaction (RT-PCR) for the rapid detection and identification of dengue virus in an endemic region: a validation study显示文摘 | Sérgio Oliveira De Paula Roberto J. Pires^Neto Joseane A.C. Tocantins Corrêa Silvia R. Assump??o Márcia L.S. Costa Danielle Malta Lima Benedito Ant?nio Lopes Fonseca | 2002 | Transactions of the Royal Society of Tropical Medicine and Hygiene2002，，3： | 1 |
| 7 | Anti-inflammatory intestinal activity of Combretum duarteanum Cambess. in trinitrobenzene sulfonic acid colitis model显示文摘AIM To evaluate the anti-inflammatory intestinal effect of the ethanolic extract(EtO HE) and hexane phase(HexP) obtained from the leaves of Combretum duarteanum(Cd).METHODS Inflammatory bowel disease was induced using trinitrobenzenesulfonic acid in acute and relapsed ulcerative colitis in rat models. Damage scores, and biochemical, histological and immunohistochemical parameters were evaluated. RESULTS Both Cd-Et OHE and Cd-Hex P caused significant reductions in macroscopic lesion scores and ulcerative l e sionareas. The vegetable samples inhibited myeloperoxidase increase, as well as pro-inflammatory cytokines TNF-α and IL-1β. Anti-inflammatory cytokine IL-10 also increased in animals treated with the tested plant samples. The anti-inflammatory intestinal effect is related to decreased expression of cyclooxygenase-2, proliferating cell nuclear antigen, and an increase in superoxide dismutase. CONCLUSION The data indicate anti-inflammatory intestinal activity. The effects may also involve participation of the antioxidant system and principal cytokines relating to inflammatory bowel disease. | Gedson Rodrigues de Morais Lima Flavia Danniele Frota MachadoLarissa Lucena Périco Felipe Meira de Faria Anderson Luiz-Ferreira Alba Regina Monteiro Souza Brito Cláudia Helena Pellizzon Clélia Akiko Hiruma-Lima Josean Fechine Tavares JoséMaria Barbosa Filho LeOnia Maria Batista | 2017 | World Journal of Gastroenterology2017，23，8： | 1 |
| 8 | The effect of accelerated aging on the surface mechanical properties of polyethylene显示文摘 | ANDREIA C T JOSEANE GULMINE V | 2003 | Polymer Degradation and Stability2003，，81： | 1 |
| 9 | Interleukin-10 is a protective factor against diet-induced insulin resistance in liver显示文摘 | Dennys E. Cintra José R. Pauli Eliana P. Araújo Juliana C. Moraes Cláudio T. de Souza Marciane Milanski Joseane Morari Alessandra Gambero Mário J. Saad Licio A. Velloso | 2008 | Journal of Hepatology2008，，4： | 1 |
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