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| 1 | Methylation-dependent loss of RIP3 expression in cancer represses programmed necrosis in response to chemotherapeutics显示文摘交往受体的蛋白质 kinase-3 (RIP3 或 RIPK3 ) 是执行 “ 的细胞的机械的必要部分; programmed”或 “ regulated”坏死。这里,我们证明那规划坏死响应许多化学疗法的代理人被激活并且贡献导致化疗的房间死亡。然而,我们证明那 RIP3 表情经常在化学疗法的死亡期间由于它的 transcriptional 开始地点, MLKL 的这样 RIP3 依赖的激活和下游地规划的坏死附近的 genomic methylation 是在癌症房间的 silenced 大部分被镇压。不过,有 hypomethylating 代理人的治疗恢复 RIP3 表示,并且从而以一种 RIP3 依赖的方式把敏感提升到 chemotherapeutics。RIP3 表示在 85% 乳癌病人与正常织物相比在肿瘤被减少,建议那 RIP3 缺乏断然在肿瘤生长 / 发展期间被选择。因为 hypomethylating 代理人在病人是相当容忍得好的,我们建议病人们可以从收到 hypomethylating 代理人与常规 chemotherapeutics 在治疗以前导致 RIP3 表示有益于的那 RIP3 缺乏的癌症。 | Gi-Bang Koo Michael J Morgan Da-Gyum Lee Woo-Jung Kim Jung-Ho Yoon Ja Seung Koo Seung I1 Kim Soo Jung Kim Mi Kwon Son Soon Still Hong Jean M Mulcahy Levy Daniel A Pollyea Craig T Jordan Pearlly Yan David Frankhouser Deedra Nicolet Kati Maharry Guido Marcucci Kyeong Sook Choi Hyeseong Cho ndrew Thorbum You-Sun Kim | 2015 | Cell Research2015，25，6： | 20 |
| 2 | 美国医学教育中的职业化问题:从证据到责任显示文摘职业化是维护公众对医学职业信任的核心要素,也是医患关系的本质所在。但有证据表明,公众对医学职业的信任日渐消失,医生也在维护医学职业价值观念时面临着各种挑战。本文在医学教育背景下界定“职业化”的定义和框架,描述了职业化面临的各种挑战,也详细论述了医学院校和教学医院在维护医学职业化过程中的角色和作用。此外,还评述了现行和试行中的评价职业化的工具、方法。最后,作者还提出一些建议供医学院校和教学医院参考。 | Jordan J Cohen 魏芬(编译) 梅人朗(审校) | 2007 | 复旦教育论坛2007，5，1： | 9 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | Effect of weekend admission on geriatric hip fractures显示文摘BACKGROUND The care discrepancy for patients presenting to a hospital on the weekend relative to the work week is well documented.With respect to hip fractures,however,there is no consensus about the presence of a so-called“weekend effect”.This study sought to determine the effects,if any,of weekend admission on care of geriatric hip fractures admitted to a large tertiary care hospital.It was hypothesized that geriatric hip fracture patients admitted on a weekend would have longer times to medical optimization and surgery and increased complication and mortality rates relative to those admitted on a weekday.AIM To determine if weekend admission of geriatric hip fractures is associated with poor outcome measures and surgical delay.METHODS A retrospective chart review of operative geriatric hip fractures treated from 2015-2017 at a large tertiary care hospital was conducted.Two cohorts were compared:patients who arrived at the emergency department on a weekend,and those that arrived at the emergency department on a weekday.Primary outcome measures included mortality rate,complication rate,transfusion rate,and length of stay.Secondary outcome measures included time from emergency department arrival to surgery,time from emergency department arrival to medical optimization,and time from medical optimization to surgery.RESULTS There were no statistically significant differences in length of stay(P=0.2734),transfusion rate(P=0.9325),or mortality rate(P=0.3460)between the weekend and weekday cohorts.Complication rate was higher in patients who presented on a weekend compared to patients who presented on a weekday(13.3%vs 8.3%;P=0.044).Time from emergency department arrival to medical optimization(22.7 h vs 20.0 h;P=0.0015),time from medical optimization to surgery(13.9 h vs 10.8 h;P=0.0172),and time from emergency department arrival to surgery(42.7 h vs 32.5 h;P<0.0001)were all significantly longer in patients who presented to the hospital on a weekend compared to patients who presented to the hospital on a weekday.CONCLUSION This study provided insight into the“weekend effect”for geriatric hip fractures and found that day of presentation has a clinically significant impact on delivered care. | Jordan B Pasternack Matthew L Ciminero Michael Silver Joseph Chang Ronald J Simon Kevin K Kang | 2020 | World Journal of Orthopedics2020，11，9： | 2 |
| 5 | Assessing your company's knowledge management style 显示文摘 | Jordan J Jones P | 1997 | Long Range Planning1997，30，3： | 1 |
| 6 | Immolocalization of basic fibroblast growth factor (bFGF) in human periodontal ligament (PDL) tissue显示文摘 | Jordan TW Cutress TW | 1996 | J Periodontal Res1996，31，4： | 1 |
| 7 | Neurologic disease in wapiti naturally infected with meningeal worm显示文摘 | Carpenter J W Jordan H E Ward B C | 1973 | J Wildl Dis1973，9，： | 1 |
| 8 | Categorizing the severity of neck pain: establishment of cut- points for use in clinical and epidemiological re- search显示文摘 | Fejer R Jordan A Hartvigsen J | 2005 | Pain2005，119，： | 1 |
| 9 | Weight neutrality with the DPP-4 inhibitor, vildagliptin: mechanistic basis and clinical experience显示文摘 | Foley JE Jordan J | 2010 | Vasc Health Risk Manag2010，6，3： | 1 |
| 10 | Changes in anorectal morphologic and functional parameters after fistula-in-ano surgery显示文摘 | Roig JV Jordan J Garcia-Armengol J | | 0，，08： | 1 |
| 11 | The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells显示文摘 | Jordan CT Upchurch D Szilvassy S J | 2000 | Leukemia2000，14，10： | 1 |
| 12 | Inhibition of self-incompatible pollen in Papaver rhoeas involves a complex series of cellular events显示文摘 | JORDAN N D RIDE J P RUDD J J | 2000 | Annals of Botany2000，85，： | 1 |
| 13 | Sympathetic genes, baroreflexes, and hypertension 显示文摘 | Jordan J | 2004 | Clin Auton Res2004，14，6： | 1 |
| 14 | Potential of selective estrogen receptor modulators as treatments and preventives of breast cancer显示文摘 | Peng J Sengupta S Jordan VC | 2009 | Anticaneer Agents Med Chem2009，9，5： | 1 |
| 15 | The Development and future of reconstructive and microvascular surgery of the hand显示文摘 | Marco Malahias Daniel J Jordan Sandip Hindocha | 2014 | Open Orthop J2014，8，8： | 1 |
| 16 | Deaeration and pasteurization effects on the orange juice aromatic fraction显示文摘 | JORDAN M J GOODNER K L LAENCINA J | 2003 | J Lebensm Wiss Technol2003，36，： | 1 |
| 17 | Effect of organic sulfonic acids as catalysts during phenol liquefaction of Pinus radiata bark显示文摘 | MUN S P GILMOUR I A JORDAN P J | 2006 | Journal of Industrial and Engineering Chemistry2006，12，5： | 1 |
| 18 | Vacancy formation and effects in FeAl显示文摘 | Jordan J L Deevi S C | 2003 | Intermetallics2003，11，： | 1 |
| 19 | Deaeration andpasteurization effects on the orange juice aromatic fraction显示文摘 | JORDAN M J GOODNER K L LAENCINA J | 2003 | LWT-Food Science and Technology2003，36，4： | 1 |
| 20 | Es- timating costs of pressure ulcer care in one Irish hospital 显示文摘 | Gethin G Jordan -0' Brien J Moore Z | 2005 | J Wound Care2005，14，4： | 1 |
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