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| 1 | Heparin resistance in severe thermal injury:a prospective cohort study显示文摘Background:Low molecular-weight heparin(LMWH)is routinely administered to burn patients for thromboprophylaxis.Some studies have reported heparin resistance,yet the mechanism(s)and prevalence have not been systematically studied.We hypothesized that nucleosomes,composed of histone structures with associated DNA released from injured tissue and activated immune cells in the form of neutrophil extracellular traps(NETs or NETosis),neutralize LMWH resulting in suboptimal anticoagulation,assessed by reduction in anti-factor Xa activity.Methods:Blood was sampled from>15%total body surface area(TBSA)burn patients receiving LMWH on days 5,10 and 14.Peak anti-factor Xa(AFXa)activity,anti-thrombin(ATIII)activity,cellfree DNA(cfDNA)levels and nucleosome levels were measured.Mixed effects regression was adjusted for multiple confounders,including injury severity and ATIII activity,and was used to test the association between nucleosomes and AFXa.Results:A total of 30 patients with severe burns were included.Mean TBSA 43%(SD 17).Twentythree(77%)patients were affected by heparin resistance(defined by AFXa activity<0.2 IU/mL).Mean peak AFXa activity across samples was 0.18 IU/mL(SD 0.11).Mean ATIII was 81.9%activity(SD 20.4).Samples taken at higher LWMH doses were found to have significantly increased AFXa activity,though the effect was not observed at all doses,at 8000 IU no samples were heparin resistant.Nucleosome levels were negatively correlated with AFXa(r=−0.29,p=0.050)consistent with the hypothesis.The final model,with peak AFXa as the response variable,was adjusted for nucleosome levels(p=0.0453),ATIII activity(p=0.0053),LMWH dose pre-sample(p=0.0049),drug given(enoxaparin or tinzaparin)(p=0.03),and other confounders including severity of injury,age,gender,time point of sample.Conclusions:Heparin resistance is a prevalent issue in severe burns.Nucleosome levels were increased post-burn,and showed an inverse association with AFXa consistent with the hypothesis that they may interfere with the anticoagulant effect of heparin in vivo and contribute to heparin resistance.Accurate monitoring of AFXa activity with appropriate therapy escalation plans are recommended with dose adjustment following severe burn injury. | Liam D Cato Benjamin Bailiff Joshua Price Christos Ermogeneous Jon Hazeldine William Lester Gillian Lowe Christopher Wearn Jonathan RB Bishop Janet M Lord Naiem Moiemen Paul Harrison | 2021 | Burns & Trauma2021，9，1： | 3 |
| 2 | Sorafenib for non-selected patient population with advanced hepatocellular carcinoma: efficacy and safety data according to liver function显示文摘 | Jon Zugazagoitia Aránzazu Manzano Javier Sastre Jose María Ladero Javier Puente Eduardo Díaz-Rubio | 2013 | Clinical and Translational Oncology2013，，2： | 2 |
| 3 | Cancellation of GLONASS signals from radio astronomy da- ta 显示文摘 | ELLINGSON Steven W BUNTON John D BELL Jon F | 2009 | The Smithsonian/NASA Astrophysics Data System2009，4015，： | 1 |
| 4 | Two-stage and multi-splitting methods for the parallel solution of lienar system显示文摘 | SZYLD D B JONS M T | 1992 | SIAM J Matrix Annl Appl1992，13，2： | 1 |
| 5 | Alginate hydrogels as synthetic extraeellular matrix materials 显示文摘 | Jon A R Gerard M Mooney D J | 1999 | Biomaterials1999，20，： | 1 |
| 6 | Methyl bromide recovery on activated carbon with repeated adsorption and electrothermal regeneration显示文摘 | Jon D Snyder James G Leeseh | 2001 | Ind Eng Chem Res2001，，40： | 1 |
| 7 | A drug-loaded aptamer gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer显示文摘 | Kim D Jeong Y Y Jon S | 2010 | ACS Nano2010，4，7： | 1 |
| 8 | Coping style use predicts posttraumatic stress and complicated grief symptom severity among college students reporting a traumatic loss显示文摘 | Kimberly R S Jon D E Matt J G | 2007 | Journal of Counseling Psychology2007，54，3： | 1 |
| 9 | Peppetti, JAGC, USN, Building the global maritime security network: A multinational legal structure to combat transnational threats 显示文摘 | LCDR Jon D | 2008 | Naval law Review2008，，： | 1 |
| 10 | Carbon sequestration in Mrica :the land tenure problem 显示文摘 | JON D U | 2008 | Global Environmental Change2008，，18： | 1 |
| 11 | What diagnostic tests are useful for low back pain显示文摘 | Jon D Lurle | 2005 | Best Practice & Research Clinical Rheumatology2005，19，4： | 1 |
| 12 | A drug-loaded aptamer-gold nanoparticle bioconjugate for combined CT imaging and therapy of prostate cancer显示文摘 | Kim D Jeong YY Jon S | | 0，，07： | 1 |
| 13 | Surgical Versus Nonoperative Treatment for Lumbar Disc Herniation: Four year Results for the gpine Patient Outcomes Research Trial (SPORT)显示文摘 | James N W Jon D L Tor DT etal | 2008 | Spine2008，33，25： | 1 |
| 14 | Fractal behavior in space and time in a simplified model of fluvial landform evolution显示文摘 | Jon D Pelletier | 2007 | Geomorphology2007，91，34： | 1 |
| 15 | Characterization of the ovarian transcriptome through the use of differential analysis of gene expression methodologies 显示文摘 | Jon D Hennebold | 2004 | Hum Reprod2004，5，10： | 1 |
| 16 | Shelf life testing显示文摘 | MARK S JON D | 2003 | Analytical Progress2003，21，1： | 1 |
| 17 | The marine planning framework for South Australia:a new ecosystem-based zoning policy for marine management显示文摘 | Val D Rosemary P Jon E | 2008 | Marine Policy2008，32，： | 1 |
| 18 | A drug-loaded aptamer gold nanop- article bioconjugate for combined CT imaging and therapy of prostatecancer显示文摘 | Kim D Jeong YY Jon S | 2010 | AcsNano2010，4，7： | 1 |
| 19 | Surgical Versus Non-Operative Treatment for Lumbar Disc Herniation:Eight-Year Results for the Spine Patient Outcomes Research Trial(SPORT)显示文摘 | Lurie Jon D Tosteson Tor D Tosteson Anna N A | 2014 | Spine2014，39，1： | 1 |
| 20 | Behavioral responses of hatchling painted turtles (Chrysemys picta) and snapping turtles (Chelydra serpenlina) at subzero temperatures显示文摘 | Jon P Costanzo Jacqueline D Litzgus Richard E LeeJr | 1999 | Journal of Thermal Biology1999，24，3： | 1 |
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