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| 1 | 视网膜微血管异常的5年发病率及其与高血压的相关性显示文摘目的描述“北京眼病研究”人群从2001年至2006年5年随访问非糖尿病老年人中视网膜微血管异常的累积发病率,并分析其与高血压的相关性。设计人群为基础的队列研究。研究对象“北京眼病研究”基线人群中参加2006年随访调查者3251人。方法对每位受检者在基线调查和随访调查时均进行了问卷调查和全面的眼科检查,其中包括散瞳后彩色眼底照相。每位受检者随机选一眼进行眼底照片中视网膜血管异常的评价。评价指标包括局限性视网膜动脉缩窄(FN)、动静脉交叉压迫征(AVN)和视网膜病变,评价采用半定量的方法进行。问卷调查以了解一般情况、眼部及全身疾病史、治疗史和吸烟饮酒史。随访调查时进行了身高、体重和血压测量,并收集空腹血液标本检测血糖、血脂。考虑的危险因素包括:年龄、性别、城乡、人均收入、教育程度、高血压、高血脂、冠心病病史、脑卒中病史、糖尿病、体重指数(BMI)、吸烟饮酒、眼局部可能相关疾病(青光眼、老年性黄斑变性和中央份支视网膜静脉阻塞等)和屈光状态等。通过对比基线和5年随访时受检者视网膜微血管的变化,确定视网膜微血管异常的5年发病率和改变情况(进展或消退)。根据治疗情况,将高血压患者分为血压控制的治疗组、未控制的治疗组和未治疗组。比较血压正常者与高血压病患者、不同高血压治疗情况组问视网膜微血管异常的发病率、进展率和好转率的差异。主要指标视网膜微血管异常的发病率、进展率和好转率。结果排除患有糖尿病或任何视网膜视神经疾病等眼局部病变的患者后,2058例受检者纳入本研究,其中女性1409例(68.5%)。平均年龄(53.8+9.5)岁。FN、AVN和视网膜病变的5年累积发病率分别为4.1%,1.4%和3.3%。高血压患者中FN、AVN和视网膜病变的5年发病率明显高于血压正常者(P均〈0.01)。对年龄、性别和居住地区进行调整后,平均动脉压每增加10mmHg,FN、AVN和视网膜病变的5年发病率分别增加1.58倍(95%CI:1.24—2.00;P〈0.001),1.55倍(95%CI:1.04。2.32;P=O.03),1.46倍(95%CI:1.12~1.91;P=0.005)。对年龄、性别和居住地区进行调整后,高血压分级每增加1级,FN好转率减少28%。相应的,血压控制组的FN的好转率(44.4%)明显高于未控制组(22.6%)和未治疗组(11.5%)(P=-O.01)。结论在非糖尿病患者中,高血压与视网膜微血管异常的发病率和进展变化具有强相关性。血压控制理想者的视网膜微血管异常发病率较低,局限性动脉缩窄消退率较高。这表明如果高血压控制良好,作为视网膜微血管异常的早期表现,局限性视网膜动脉缩窄是可逆的。 | 王爽 徐亮 Jons Jost B 王亚星 游启生 王云松 杨桦 周金琼 刘雪 | 2013 | 眼科2013,22,6: | 9 |
| 2 | 温度限制串联相关神经网络及其在细菌辨识中的应用显示文摘蛋白质在微生物研究中可用作生物标记物, 故在生物技术中其表征工作很重要. 各种质谱技术已被用于细菌的表征[1~3]. 1994年, Cain等[4]首先报道了将色谱和基体辅助激光解离/电离飞行时间质谱(MALDI-TOF-MS)用于细菌的辨识. Holland等[5]采用高质量离子MALDI-TOF-MS对细菌全细胞进行辨识. 最近, Lay[6]对该技术的细菌辨识做了综述. MALDI-TOF-MS是目前对细菌全细胞分析的最佳手段. | 张卓勇 Aaron Urbas Peter de B Harrington Kent J.Voorhees Jon Rees | 2002 | 高等学校化学学报2002,23,4: | 4 |
| 3 | Long-term prognosis in patients with severe late radiation enteropathy:A prospective cohort study显示文摘AIM: To assess persistent symptoms and mortality in a cohort of patients with severe (grade 3-4) radiation enteropathy,59 patients were followed up after 15-18 years. METHODS: Fifty-nine patients were prospectively enrolled by twelve surgical departments. Primary malignant disease,radiation therapy and surgical management were recorded at inclusion. The cause of death or persistence of symptoms was examined in public death records or by interview of survivors. RESULTS: Thirty-nine patients had received radiation therapy for gynaecological cancers,twelve for urological cancers,four for gastrointestinal cancers and four for other malignancies. Forty-five patients (76%) required surgical intervention. Complications occurred in 11 (25%) operated patients. Forty-seven patients had died at the time of follow-up,seven (12%) died as a direct result of radiation enteropathy,while radiation enteropathy contributed to death in an additional seven patients. Four of the twelve surviving patients suffered from chronic debilitating symptoms of radiation enteropathy,while three had moderate symptoms. CONCLUSION: Patients with severe delayed radiation enteropathy have a high risk of persistence of symptoms after surgery. At least one in ten patients dies from radiation-induced bowel injury. | Annette Larsen Jon B Reitan Steinar T Aase Martin Hauer-Jensen | 2007 | World Journal of Gastroenterology2007,13,26: | 4 |
| 4 | Methods for the development and assessment of atrial fibrillation and heart failure dog models显示文摘与动物的发展报导 Medtronic 经验的目的用为 AF 模型,的为 CHF.Methods 的为 AF 和 microemboli 的高率的踱步为 atrial 纤维性颤动( AF )和长期的心失败( CHF )当模特儿一根 atrial 皮带被纳入 Medtronic 协同作用 neurostimulator ,它被规划在开关责任 cycle.Atrial natnuretic 肽( ANP )在 50 Hz 刺激,大脑 natriuretic 肽( BNP )和N终端职业人员大脑 natriuretic 肽( NT-proBNP )皮脂腺囊瘤;在精选时间 points.For CHF 模型,的 assayed 在 62,400 beads/mL 的 90 m 聚苯乙烯 microspheres 的连续注射( Polybead , Polysciences 公司)被执行导致全球局部缺血,有每周监视的任何一个和 embolization 时间表(集团 1 , n = 25 )或与监视的双周刊和 emboliation 时间表(集团 2 , n36 ) .Echocardiograms 每周与 ventriculograms 和磁性的回声成像扫描一起被使用估计心脏的功能和 ANP , BNP 和 NT-proBNP 是为 AF 模型的 monitored.Results ,为 CHF 模型,遇见 CHF 端点的日子在集团 2 .For 在集团 1 和 89 是 116 AF 和 CHF 模型, NT-proBNP 与在为动物的搜索的研究人员为估计基于设备的治疗的安全和功效建模的我们为 AF 和 CHF 狗模型的发展和评价的经验可以帮助的疾病 states.Conclusion 的发展相关很好。 | Jon F Urban Renee L Gerhart Jason R Krzeszak Corey R Leet Linnea R Lentz Carolyn B McClay | 2011 | Journal of Geriatric Cardiology2011,8,3: | 3 |
| 5 | Ankle Fractures in the Elderly: What You Get Depends on Where You Live and Who You See显示文摘 | Kenneth J Koval Jon Lurie Weiping Zhou Michael B Sparks Robert V Cantu Scott M Sporer James Weinstein | 2005 | Journal of Orthopaedic Trauma2005,,9: | 2 |
| 6 | Gene expression proling of renal cell carcinoma:a DNA macroarray analysis显示文摘 | Jon AJ Lovisol O Casati B | 2006 | BJU Iint2006,98,1: | 1 |
| 7 | Two-stage and multi-splitting methods for the parallel solution of lienar system显示文摘 | SZYLD D B JONS M T | 1992 | SIAM J Matrix Annl Appl1992,13,2: | 1 |
| 8 | Narrative review: Aspirin resistance and its clinical implications显示文摘 | Simon S Jon E Trevor B | 2005 | Annals of Internal Medicine2005,142,5: | 1 |
| 9 | Application oftransient infrared and near infrared spectroscopy totransition metal complex excited states and inter-mediates显示文摘 | Jennifer M B Michael W G Jon R S | 2007 | Coord Chem Rev2007,251,: | 1 |
| 10 | Assessing watershed: Scale, long-term hydrologic impacts of land-use change using a GIS-NPS model显示文摘 | Budhendra B Jon H Bemie E | 2003 | Environmental Management2003,26,6: | 1 |
| 11 | Frontier estimation and firm-specific ineffi- ciency measures in the presence of heteroscedasticity显示文摘 | Steven B Caudill Jon M Ford and Daniel M Groppe | 1995 | Journal of Business and Economic Statistics1995,13,1: | 1 |
| 12 | The role of the thi- oredoxin and glutaredoxin pathways in reducing pro- teindisulfide bonds in the Escherichia coli cytoplasm 显示文摘 | WILLIAM A P ARNE H JON B | 1997 | J Biol Chem1997,272,15: | 1 |
| 13 | Localization of a susceptibilitylocus for schizophrenia on chromosome 5显示文摘 | Robin S Jon B Hannes P | 2008 | Nature2008,336,10: | 1 |
| 14 | Vector for Pop-In/Pop-Out Gene Replacement in Pichia pastoris 显示文摘 | JON S BROOKE J B BENJAMIN S G | 2001 | BioTechniques2001,31,: | 1 |
| 15 | How Does Charitable Giving Respond to Incentives And Income? New Estimates from Panel Date显示文摘 | Bakija Jon Heim B T | 2011 | National Tax Journal2011,,64: | 1 |
| 16 | Recent advance in techniques for hyperspectral image processing显示文摘 | Antonio P Jon A B Joseph W B Jason B Lorenzo B Gustavo C V Jocelyn C Mathieu F Paolo G Anthony G Mattia M James C T Giovanna T | 2009 | Remote Sensing of Environment2009,113,: | 1 |
| 17 | From 4PL to managed supplychain operations显示文摘 | Jon B Kempton C | 2002 | Logistics & Transport Focus2002,1,4: | 1 |
| 18 | Contributions to Wavelength shifts of DFB fiber lasers used as acoustic sensors in air显示文摘 | Sigurd W L Kjell B Jon T K | 1998 | SPIE1998,3484,: | 1 |
| 19 | Comparison of differnt transition P from human显示文摘 | Sidenius U Farver O Jons O metal Ions atography of selenoprotein Chromatography B 1999 735: 85-91 | 1999 | Journal of1999,,: | 1 |
| 20 | Narrative review:Aspirin resistance and its clinical implications显示文摘 | Simon S Jon E Trevor B | 2005 | Annals of Internal Medicine2005,142,5: | 1 |