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| 1 | Long-term prognosis in patients with severe late radiation enteropathy:A prospective cohort study显示文摘AIM: To assess persistent symptoms and mortality in a cohort of patients with severe (grade 3-4) radiation enteropathy,59 patients were followed up after 15-18 years. METHODS: Fifty-nine patients were prospectively enrolled by twelve surgical departments. Primary malignant disease,radiation therapy and surgical management were recorded at inclusion. The cause of death or persistence of symptoms was examined in public death records or by interview of survivors. RESULTS: Thirty-nine patients had received radiation therapy for gynaecological cancers,twelve for urological cancers,four for gastrointestinal cancers and four for other malignancies. Forty-five patients (76%) required surgical intervention. Complications occurred in 11 (25%) operated patients. Forty-seven patients had died at the time of follow-up,seven (12%) died as a direct result of radiation enteropathy,while radiation enteropathy contributed to death in an additional seven patients. Four of the twelve surviving patients suffered from chronic debilitating symptoms of radiation enteropathy,while three had moderate symptoms. CONCLUSION: Patients with severe delayed radiation enteropathy have a high risk of persistence of symptoms after surgery. At least one in ten patients dies from radiation-induced bowel injury. | Annette Larsen Jon B Reitan Steinar T Aase Martin Hauer-Jensen | 2007 | World Journal of Gastroenterology2007，13，26： | 4 |
| 2 | Functions and Clinical Implications of Autocrine VEGF Signaling in Colorectal Cancer显示文摘 | Annette K. Larsen Aimery Gramont Virginie Poindessous Ana?s Bouygues Mériam Ayadi Paul Mésange | 2013 | Current Colorectal Cancer Reports2013，，3： | 1 |
| 3 | Quality of sour cream packaged in cups with different light barrier properties measured by fluorescence spectroscopy and sensory analysis显示文摘 | Hanne Larsen Siri Birgitte Geiner Tellefsen Annette Veberg Dahl | | 0，，17： | 1 |
| 4 | FOLFIRI3-aflibercept in previously treated patients with metastatic colorectal cancer显示文摘AIM To evaluate the efficacy and safety of the modified FOLFIRI3-aflibercept as second-line therapy in patients with metastatic colorectal cancer.METHODS This is a retrospective multicenter cohort, evaluating the efficacy and safety of the association of aflibercept with FOLFIRI3(day 1: aflibercept 4 mg/kg, folinic acid 400 mg/m^2, irinotecan 90 mg/m^2, 5-fluorouracil infusion 2400 mg/m^2 per 46 h; day 3: irinotecan 90 mg/m^2) in patients with previously treated metastatic colorectal cancer. The primary endpoint was overall response rate(ORR). Secondary endpoints were disease control rate(DCR), progression-free survival(PFS), overall survival(OS), and safety.RESULTS Among 74 patients treated in four French centers, nine were excluded due to prior use of aflibercept(n = 3), more than one prior treatment line in irinotecanna?ve patients(n = 3), and inadequate liver function(n = 3). In the 'irinotecan-na?ve' patients(n = 30), ORR was 43.3% and DCR was 76.7%. Median PFS and OS were 11.3 mo(95%CI: 6.1-29.0) and 17.0 mo(95%CI: 13.0-17.3), respectively. The most common(> 5%) grade 3-4 adverse events were diarrhea(37.9%), neutropenia(14.3%), stomatitis and anemia(10.4%), and hypertension(6.7%). In the 'pre-exposed irinotecan' patients(n = 35), 20(57.1%) received ≥ 2 prior lines of treatment. ORR was 34.3% and DCR was 60.0%. Median PFS and OS were 5.7 mo(95%CI: 3.9-10.4) and 14.3 mo(95%CI: 12.8-19.5), respectively.CONCLUSION Minimally modified FOLFIRI has improvement dramatically the FOLFIRI3-aflibercept efficacy, whatever prior use of irinotecan. A prospective randomized trial is warranted to compare FOLFIRI-aflibercept to FOLFIRI3-aflibercept. | CANDice Carola Fran?ois Ghiringhelli Stefano Kim Thierry ANDré Juliette Barlet Le?la Bengrine-Lefevre Hélène Marijon Marie-Line Garcia-Larnicol Christophe Borg Linda Dainese Nils Steuer Hubert Richa Magdalena Benetkiewicz Annette K Larsen Aimery de Gramont Benoist Chibaudel | 2018 | World Journal of Clinical Oncology2018，9，5： | 1 |
| 5 | Regeneration of protoplast-derived green plants of Kentucky blue grass (Poa pratensis L.)显示文摘 | Kirsten Annette Nielsen Else Larsen Elisabeth Knudsen | 1993 | Plant Cell Reports1993，，10： | 1 |
| 6 | Regeneration of protoplast-derived green plants o{ Ken- tucky Bluegrass (Poa pratensis L)显示文摘 | Kirsten Annette Nielsen Else Larsen Elisabeth Knudsen | 1993 | Plant Cell Report1993，，12： | 1 |
| 7 | Quality of sour cream packaged in cups with different light barrier properties measured by fluorescence spectroscopy and sensory analysis显示文摘 | Hanne Larsen Siri Birgitte Geiner Tellefsen Annette Veberg Dahl | 2009 | Journal of food science2009，8，17： | 1 |
| 8 | Bioremediation of reject water from anaerobically digested waste water sludge with macroalgae ( Ulva lactuca , Chlorophyta)显示文摘 | Sidsel Sode Annette Bruhn Thorsten J.S. Balsby Martin M?rk Larsen Annemarie Gotfredsen Michael Bo Rasmussen | 2013 | Bioresource Technology2013，，： | 1 |
| 9 | From Chemotherapy to Targeted Therapy in Adjuvant Treatment for Stage III Colon Cancer显示文摘 | Aimery de Gramont Armand de Gramont Benoist Chibaudel Jean-Baptiste Bachet Annette K. Larsen Christophe Tournigand Christophe Louvet Thierry André | 2011 | Seminars in Oncology2011，，： | 1 |
| 10 | Targeting EGFR and VEGF(R) pathway cross-talk in tumor survival and angiogenesis显示文摘 | Annette K. Larsen Djamila Ouaret Karima El Ouadrani Amélie Petitprez | 2011 | Pharmacology and Therapeutics2011，，1： | 1 |
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