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117篇 您的检索式:作者名="Johnson CW"
    题名 作者 年代 出处 被引量
1Correlation and prognostic significance of beta-galactoside alpha-2,6-sialyltransferase and serum monosialylated alpha-fetoprotein in hepatocellular carcinoma显示文摘AIM: To investigate the correlation between tissue ST6Gal I and serum msAFP in HCC patients, and to investigate their prognostic significance.METHODS: Preoperative sera,paired tumorous and non-tumorous tissues were collected from 19 consecutive patients who had undergone surgical resection of HCC.ST6Gal T activities in the tissues were measured by an in vitro microsomal enzyme activity assay. The percentages of tumor-specific msAFP in the sera were also estimated by an isoelectric focusing-immunoblotting assay.RESULTS: The tumor ST6Gal I activity was negatively correlated with serum msAFP percentage (r = -0.53,P = 0.019). Both decreased tumor ST6Gal I activity andincreased serum msAFP percentage were associatedwith poor tumor cell differentiation. Univariate analyses showed that both decreased tumor ST6Gal T activity (P = 0.028), increased serum msAFP percentage (P = 0.034) and poor tumor cell differentiation (P = 0.031)were associated with shorter overall survival. Multivariate analysis using the Cox regression model showed that the preoperative serum msAFP percentage (P = 0.022)and tumor cell differentiation status (P = 0.048) were independent prognostic indicators for patient overall survival.CONCLUSION: Our results indicate that the presence of msAFP in blood circulation is associated with a decreased activity of ST6Gal I activity in HCC. Both tissue ST6Gal I and serum msAFP are potential prognostic markers for patients with operable HCC.Terence CW Poon Clarissa HS Chiu Paul BS Lai Tony SK Mok Benny Zee Anthony TC Chan Joseph JY Sung Philip J Johnson 2005World Journal of Gastroenterology2005,11,42:4
2Evidence for the shikimate pathway in apicomplexan parasites显示文摘Roberts F Roberts CW Johnson JJ 1998Nature1998,393,6699:1
3Genetic inactivation of IL- 1 signaling enhances atherosclerotic plaque instability and reduces outward vessel remodeling in advanced atherosclerosis in mice显示文摘Alexander MR Moehle CW Johnson JL 2012J Clin Invest2012,122,1:1
4E-volution in dalsage control for exsanguinating penetrating abdominal injury显示文摘Johnson JW Gracias VH Schwab CW 2001J rauma2001,51,2:1
5An in vitro study into the effect of a limited range of denture cleaners on surface roughness and removal of Candida albicans from conventional heat - cured acrylic resin denture base material显示文摘Harrison Z Johnson A Douglas CW 2004J Oral Rehabil2004,31,5:1
6Tubal sterilization:questioning the decision显示文摘Warren CW Monteith RS Johnson WT 1988Popul Stud (Camb)1988,42,3:1
7Trajectories of condylar points during nonworking side and protrusive movements of the mandible显示文摘Peck CC Murray GM Johnson CW 1999JProsthetDent1999,82,3:1
8Evolution in damage control for exsanguinating penetrating abdominal injury 显示文摘Johnson JW Gracias VH Schwab CW 2001J Trauma2001,51,:1
9Evolution in damage control for exsanguinating penetrating abdominal injury 显示文摘Johnson JW Gracias VH Schwab CW 2001JTrauma2001,51,2:1
10Surface analysis of porcelain fused to metal systems显示文摘Johnson T van Noort R Stokes CW 2006Dent Mater2006,22,4:1
11Evolution in damage control for exsanguinating penetrating ab- dominal injury显示文摘Johnson JW Gracias VH Schwab CW 2001J Trauma2001,51,2:1
12Towards a hybrid method to categorize interruptions and activities in healthcare显示文摘Brixey JJ Robinson CW Johnson TR 0,,11:1
13Salvage cryotherapy using an argon based system for locally recurrent prostate cancer after radiation therapy 显示文摘Ghafar MA Johnson CW De La Taille A 2001Uro12001,166,13:1
14Evolution in damage control for exsanguinating penetrating abdominal injury显示文摘Johnson JW Gracias VH Schwab CW 2001J Trauma2001,51,2:1
15Trajectories of condylar points during nonworking side and protrusive of the mandible显示文摘Peck CC murray GM Johnson CW 1999J Prostehet Dent1999,83,32:1
16Evolution in darnage control for exsanguinating penetratingal abdominal injury显示文摘Johnson JW Gracias VH Sehwab CW 2001J Trauma2001,51,2:1
17Interstitial fibrosis of unilateral ureteral obstruction is exacerbated in kidneys of mice lacking the gene for inducible nitric oxide synthase 显示文摘Hochberg D Johnson CW Chen J 2000Lab Invest2000,80,11:1
18Androgen receptor stabilization in recurrent prostate cancer is associated with hypersensitivity to low androgen 显示文摘 Johnson RT Mohler JL 2001Cancer Res2001,61,7:1
19Evolution in damage control for exsanguinating penetrating abdominal injury 显示文摘Johnson JW Gracias VH Schwab CW 2001J trau- ma2001,51,2:1
20Evolution in damage control for exsanguinating penetrating abdominal injury显示文摘Johnson JW Gracias VH Schwab CW 2001J Trauma2001,51,2:1
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