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| 1 | Circulating inflammatory factors associated with worse long-term prognosis in colorectal cancer显示文摘AIM To investigate association of circulating inflammatory factors at the time of colorectal cancer(CRC) surgery with survival.METHODS Plasma levels from 174 CRC patients(69 females and 105 men), with median age 70 years(range 29-90), localized in the colon(n = 105) or rectum(n = 69), with stage Ⅰ(n = 24), stage Ⅱ(n = 54), stage Ⅲ(n = 67) and stage Ⅳ(n = 29) were measured using commercially available Bio-Plex Pro? Human Chemokine Panel 40-Plex, including 40 different chemokines, cytokines and interleukins. The prognostic association of each inflammatory factor was analysed as CRC-specific and total mortality.RESULTS Out of 174 patients, 66 died during the follow-up, 40 because of CRC specific mortality. High tertile levels of 8 factors were significantly associated with increased CRC-specific mortality, of which CCL1, CCL20, CCL24, CX3CL1, IL-4 and TNF-α remained significant in a multivariate Cox regression analysis. High tertile levels of 14 factors were associated with increased total mortality, of which CCL1, CCL15, CCL20, CX3CL1, CXCL13, IFN-γ, IL-2, IL-4 and IL-10 remained significant after adjustment for clinical covariates. For most of the inflammatory factors the association between higher tertile levels and an increased mortality in general appeared two years after surgery. High tertile levels of TNF-α and CCL24 were exclusively associated with CRC-specific mortality. The distribution of these factors were not associated with TNM stage with exception for CCL20.CONCLUSION High plasma levels of inflammatory factors are associated with increased risk of mortality among CRC patients and could be potential biomarkers for revealing prognosis. | Renate S Olsen Johnny Nijm Roland E Andersson Jan Dimberg Dick Wagsater | 2017 | World Journal of Gastroenterology2017，23，34： | 8 |
| 2 | Thermal Fatigue in Hot-Working Tools显示文摘 | Johnny S Jens B | 2005 | Scandinavian Journal of Metallurgy2005，34，4： | 1 |
| 3 | Optimization of the specific on-resistance of the COOLMOSTM 显示文摘 | CHEN X B JOHNNY K O S | 2001 | IEEE Transactions on Electron Devices2001，48，2： | 1 |
| 4 | Global warming and Western North Pacific typhoon activity from an observational perspective显示文摘 | CHAN JOHNNY C L LIU K S | 2004 | J Climate2004，17，23： | 1 |
| 5 | A framework for a world wide web based data mining system显示文摘 | Johnny S K Wong Rishi Nayar | 2000 | Journal at Network and Computer Applications2000，21，： | 1 |
| 6 | Integrated electro-hydraulic system modeling and analysis 显示文摘 | Fu S Johnny Liffring Mark Mehdi Ishaque S | 2002 | IEEE AESS Systems Magazine2002，，6： | 1 |
| 7 | Taylor-Kalman- Fourier filters for instantaneous oscillating phasor and harmonic estimates 显示文摘 | JOSE A D L O S JOHNNY R M | 2012 | IEEE Transactions on Instrumentation and Measurement2012，61，4： | 1 |
| 8 | Tropical cyclone intensity change from a simple ocean-atmosphere coupled model显示文摘 | Johnny C L Duan Y Lynn K S | 2001 | J Atmos Sci2001，58，： | 1 |
| 9 | Electrical and rheological percolation in poly(vinylidene fluoride)/multi-walled carbon nanotube nanocomposites显示文摘 | Johnny N Martins Taís S Bassani Guilherme MO Barra | 2011 | Polymer International2011，60，3： | 1 |
| 10 | Preventing ash agglomeration during gasification of high-sodium lignite显示文摘 | Robert S D Johnny R D Wan W P | 2009 | Energy&Fuels2009，23，： | 1 |
| 11 | A novel crosstalk isolation structure for bulk CMOS power IC's显示文摘 | Chan Wilson W T Sin Johnny K O Wong S Simon | 1998 | IEEE Trans on Electron Devices1998，45，7： | 1 |
| 12 | Design and Implementation of a Distributed Database System显示文摘 | Johnny S K Wong | 1996 | J SYSTEMS SOFTWARE1996，34，： | 1 |
| 13 | Internal boundary layer structure under sea-breeze conditions in Hongkong显示文摘 | Heping Liu Johnny C L Chan Andrew Y S Cheng | 2001 | Atmospheric Environment2001，，： | 1 |
| 14 | 瑞典森林可燃物变动与火行为显示文摘 | Johnny S | 1997 | Canadian Journal of Forestry Research1997，27，8： | 1 |
| 15 | Non-standard Work in Canada and the United Kingdom显示文摘 | FRANCIS G HARVEY K JOHNNY S | 1993 | International Journal of Manpower1993，，5： | 1 |
| 16 | Embolization of intra-axial hypervascular tumors with Onyx:report of three cases显示文摘 | Guilherme D Johnny P Gabriela S | 2013 | Journal of Neurointerventional Surgery2013，5，2： | 1 |
| 17 | Optimization of the specific on-resistance of the COOLMOSTM显示文摘 | CHEN X B JOHNNY K 0 S | 2001 | IEEE Transactions on Electrons Devices2001，48，2： | 1 |
| 18 | Intelligent Agents for Intrusion Detection 显示文摘 | HELMER G JOHNNY S K W HONAVAR V | 1998 | IEEE Information Technology Conference1998，，9： | 1 |
| 19 | Integrated electro-hydraulic system modeling and analysis显示文摘 | Mark L Mehdi I S Johnny F S | 2002 | IEEE Aerospace and Electronic Systems Magazine2002，17，7： | 1 |
| 20 | Tumour oxygenation assessed by 18 F-fluoromisonidazole PET and polarographic needle electrodes in human soft tissue tumours显示文摘 | Lise Bentzen Susanne Keiding Marianne Nordsmark Lise Falborg S?ren B Hansen Johnny Keller Ole S Nielsen Jens Overgaard | 2003 | Radiotherapy and Oncology2003，，3： | 1 |
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