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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Repair of anterior hypospadias with transurethral vesical catheter:comparison of ambulatory surgery with the 'between 2 diapers' catheter and traditional hospitalization显示文摘 | Mondet F Johanet S Larroquet M | 1999 | Prog Urol1999，9，1： | 1 |
| 3 | Induction and recovery characteristics and hemodynamie responses to sevoflurane and halothane in children显示文摘 | Piat V Dubois MC Johanet S | 1994 | Anesth Analg1994，79，： | 1 |
| 4 | Induction and recovery characteristics and hemodynamic responses to sevoflurance and halothane in children 显示文摘 | Piat V Dubois MC Johanet S | 1994 | Anesth Anallg1994，79，5： | 1 |
| 5 | Induction and recovery characteris- tics responses to sevltluranc and halothane in children 显示文摘 | Plat V Dubis MC Johanet S | 1994 | Anesth Analg1994，79，200723： | 1 |
| 6 | Repair of anterior hypospadias with transurethral vesical catheter:Comparison of ambulatory surgery with the ''between 2 diapers'' catheter and traditional hospitalization显示文摘 | Mondet F Johanet S Larroquet M | 1999 | Prog Urol1999，9，1： | 1 |
| 7 | Induction and recovery characteristics and hemodynamic response to sevoflurane and halothane in children 显示文摘 | Piat V Cubois MC Johanet S | 1994 | Anesth Analg1994，79，5： | 1 |
| 8 | Antimitochondrial antibodies in patients with chronic hepatitis C显示文摘 | Grimbert S Johanet C Bendjaballah F | | Liver0，，： | 1 |
| 9 | The risk of wound infection after inguinal incision in pediatric outpatient surgery 显示文摘 | Audry G Johanet S Achrafi H | 1994 | Eur J Pediatr Surg1994，4，2： | 1 |
| 10 | The risk of wound infection after inguinal incision in pediatric outpatient surgery 显示文摘 | Audry G Johanet S Achraft H | 1994 | Eur J Pediatr Surg1994，4，2： | 1 |
| 11 | Antimitochondrial antibodiesin patients with chronic hepatitis C 显示文摘 | Grimbert S Johanet C Bendjaballah F | 1996 | Liver1996，16，3： | 1 |
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