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| 1 | Update on Anti-Saccharomyces cerevisiae antibodies, anti-nuclear associated anti-neutrophil antibodies and antibodies to exocrine pancreas detected by indirect immunofluorescence as biomarkers in chronic inflammatory bowel diseases: Results of a multicent显示文摘AIM: Anti-Saccharomyces cerevisiae antibodies (ASCA), anti-nuclear associated anti-neutrophil antibodies (NANA) and antibodies to exocrine pancreas (PAB), are serological tools for discriminating Crohn’s disease (CrD) and ulcerative colitis (UC). Like CrD, coeliac disease (CoD) is an inflammatory bowel disease (IBD) associated with (auto) antibodies. Performing a multicenter study we primarily aimed to determine the performance of ASCA, NANA and PAB tests for IBD diagnosis in children and adults, and secondarily to evaluate the prevalence of these markers in CoD. METHODS: Sera of 109 patients with CrD, 78 with UC, 45 with CoD and 50 healthy blood donors were retrospectively included. ASCA, NANA and PAB were detected by indirect immunofluorescence (IIF). RESULTS: ASCA+/NANA- profile displayed a positive predictive value of 94.2% for CrD. Detection of ASCA was correlated with a more severe clinical profile of CrD and treatment of the disease did not influence their serum levels. ASCA positivity was found in 37.9% of active CoD.PAB were found in 36.7% CrD and 13.3% CoD patients and were not correlated with clinical features of CrD, except with an early onset of the disease. Fifteen CrD patients were ASCA negative and PAB positive. CONCLUSION: ASCA and PAB detected by IIF are specific markers for CrD although their presence does not rule out a possible active CoD. The combination of ASCA, NANA and PAB tests improves the sensitivity of immunological markers for CrD. Repeating ASCA, NANA, and PAB testing during the course of CrD has no clinical value. | S Desplat-Jégo C Johanet A Escande J Goetz N Fabien N Olsson E Ballot J Sarles JJ Baudon JC Grimaud M Veyrac P Chamouard RL Humbel | 2007 | World Journal of Gastroenterology2007，13，16： | 24 |
| 2 | Auto-antibodies in autoimmune hep- atitis: anti-smooth muscle antibodies (ASMA)显示文摘 | JOHANET C BALLOT E | 2012 | Clin Res Hepatol Gastroenterol2012，36，2： | 1 |
| 3 | Features and outcome of autoimmune hepatitis type 2 presenting with isolated positivity for anti-liver cytosol antibody显示文摘 | Bridoux-Henno L Maggiore G Johanet C | 2004 | Clin Gastroenterol Hepatol2004，2，9： | 1 |
| 4 | Antibodies to soluble liver antigen: an additional marker in type 1 autoimmune hepatitis显示文摘 | Ballot E Homberg JC Johanet C | 2000 | J Hepatol2000，33，2： | 1 |
| 5 | Signification clinique des anticorps antiri bosomes显示文摘 | Johanet C André C Sibilia J | 2000 | Rev Méd Interne2000，21，： | 1 |
| 6 | Habitual abortions in 678 healthy patients: investigation and prevention显示文摘 | Reznikoff-Etievant MF Cayol V Zou GM Abuaf N Robert A Johanet C Milliez J | 1999 | Human Reproduction1999，14，8： | 1 |
| 7 | Auto-antibodies in autoimmune hepatitis:antismooth muscle antibodies (ASMA)显示文摘 | Johanet C Ballot E | | 0，，： | 1 |
| 8 | Prevalence of serum antibodies to hepatitis C virus is not increased in patient with multiple sclerosis显示文摘 | Heinzlef O Roullet E Johanet C el al | 1996 | J Neurosurg Psychiatry1996，61，6： | 1 |
| 9 | Antimitochondrial antibodies in patients with chronic hepatitis C显示文摘 | Grimbert S Johanet C Bendjaballah F | | Liver0，，： | 1 |
| 10 | Detection of autoantibodies to Sm antigen in systemic lupus rythematosus by immunodiffusion,ELISA and immunoblotting:variability of incidence related to assays and ethnic origin of patients显示文摘 | Abuaf N Johanet C Chretien P | 1990 | Eur J Clin Invest1990，20，4： | 1 |
| 11 | Antimitochondrial antibodiesin patients with chronic hepatitis C 显示文摘 | Grimbert S Johanet C Bendjaballah F | 1996 | Liver1996，16，3： | 1 |
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