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| 1 | 帕博利珠单抗单用或与放疗联用治疗转移性非小细胞肺癌:两个随机试验的汇总分析显示文摘背景放疗可以提高整个机体对免疫治疗的应答。在Ⅱ期PEMBRO-RT研究和Ⅰ/Ⅱ期MDACC研究中,患有转移性非小细胞肺癌(NSCLC)的患者被随机分配入组,接受免疫治疗(帕博利珠单抗)+放疗联合疗法,或免疫治疗单一疗法。当上述2个研究单独分析时,联合疗法组显示出潜在获益。由于每个研究的样本量较小,缓解率和结局并未显示出统计学意义,然而却有显著的临床获益。因此,本研究进行汇总分析,来判断放疗是否会改善转移性NSCLC患者的免疫治疗应答。方法PEMBRO-RT和MDACC研究纳入标准:患者年龄≥18岁,患有转移性NSCLC,且有≥1处未经放疗照射的病灶,以便进行射野外应答监测。PEMBRO-RT研究纳入曾接受过化疗患者,MDACC研究纳入曾接受过治疗或新诊断患者。2个研究中的患者均未接受过免疫治疗。在PEMBRO-RT研究中患者被等比例随机分配入组,并根据吸烟状态进行分层(分为<10年组和≥10年组)。MDACC研究的患者根据放疗计划可行性被等比例随机分配入2个受试组。由于联合治疗组的干预本质,每个研究中的放疗均不适用盲法。在2个研究中,不论是否进行放疗,均静脉滴入帕博利珠单抗(每3周200 mg)。在PEMBRO-RT研究中,在放疗(24 Gy 3次分割照射)结束后1周给予第1剂帕博利珠单抗。在MDACC研究中,在第1次放疗(50 Gy 4次分割照射或45 Gy 15次分割照射)同时给予帕博利珠单抗。仅检测未经照射病灶的应答。本研究的终点为最佳射野外(远隔)应答率(ARR)、最佳射野外疾病控制率(ACR)、12周时ARR、12周时ACR、无进展生存期(PFS)和总生存期(OS)。2个研究的意向治疗(ITT)人群均纳入分析。PEMBRO-RT研究(NCT02492568)和MDACC研究(NCT02444741)均在ClinicalTrials.gov上注册。发现纳入148例患者,76例接受帕博利珠单抗治疗,72例接受帕博利珠单抗+放疗治疗。所有患者随访时间中位数为33个月[四分位距(IQR):32.4~33.6]。148例患者中124例(84%)组织学特征为非鳞癌,111例(75%)患者曾经接受过化疗。组间没有基线特征差异,包括PD-L1表达状态和转移灶体积。最常见的照射部位为肺转移灶(39%,28/72)、胸腔内淋巴结(21%,15/72)和非原发灶(17%,12/72)。帕博利珠单抗组和联合治疗组的最佳ARR分别为19.7%(15/76)和41.7%(30/72),OR=2.96,95%CI:1.42~6.20,P=0.0039;最佳ACR分别为43.4%(33/76)和65.3%(47/72),OR=2.51,95%CI:1.28~4.91,P=0.0071;PFS中位数分别为4.4(IQR:2.9~5.9)和9.0个月(IQR:6.8~11.2),HR=0.67,95%CI:0.45~0.99,P=0.045;OS中位数分别为8.7(IQR:6.4~11.0)和19.2个月(IQR:14.6~23.8),OR=0.67,95%CI:0.54~0.84,P=0.0004。在汇总分析中没有发现新的安全问题。解读帕博利珠单抗免疫疗法+放疗显著提高转移性NSCLC患者的应答和改善治疗结局。这些结果需要在三期临床试验中进行验证。 | 陈大卫(翻译) 于金明(校对) Willemijn S M E Theelen Vivek Verma Brian P Hobbs Heike M U Peulen Joachim G J V Aerts Idris Bahce Anna Larissa N Niemeijer Joe Y Chang Patricia M de Groot Quynh-Nhu Nguyen Nathan I Comeaux George R Simon Ferdinandos Skoulidis Steven H Lin Kewen He Roshal Patel John Heymach Paul Baas James W Welsh | 2021 | 中华肿瘤防治杂志2021，28，24： | 49 |
| 2 | An integrated thermo-mechanical-dynamic model to characterize motorized machine tool spindles during very high speed rotation显示文摘 | Chi-Wei Lin Jay F. Tu Joe Kamman | 2003 | International Journal of Machine Tools and Manufacture2003，，10： | 2 |
| 3 | Nucleation and growth mechanicsm of electroformation of polypyrrole on a heat-treated gold/highly oriented pyrolytic graphite 显示文摘 | HWANG BING JOE SANTHANAM RAMAN LIN YI LIANG | 2001 | Electrochimica Acta2001，46，： | 1 |
| 4 | On brain activity mapping: Insights and lessons from Brain Decoding Project to map memory patterns in the hippocampus显示文摘The BRAIN project recently announced by the president Obama is the reflection of unrelenting human quest for cracking the brain code, the patterns of neuronal activity that define who we are and what we are. While the Brain Activity Mapping proposal has rightly emphasized on the need to develop new technologies for measuring every spike from every neuron, it might be helpful to consider both the theoretical and experimental aspects that would accelerate our search for the organizing principles of the brain code. Here we share several insights and lessons from the similar proposal, namely, Brain Decoding Project that we initiated since 2007. We provide a specific example in our initial mapping of real-time memory traces from one part of the memory circuit, namely, the CA1 region of the mouse hippocampus. We show how innovative behavioral tasks and appropriate mathematical analyses of large datasets can play equally, if not more, important roles in uncovering the specific-to-general feature-coding cell assembly mechanism by which episodic memory, semantic knowledge, and imagination are generated and organized. Our own experiences suggest that the bottleneck of the Brain Project is not only at merely developing additional new technologies, but also the lack of efficient avenues to disseminate cutting edge platforms and decoding expertise to neuroscience community. Therefore, we propose that in order to harness unique insights and extensive knowledge from various investigators working in diverse neuroscience subfields, ranging from perception and emotion to memory and social behaviors, the BRAIN project should create a set of International and National Brain Decoding Centers at which cutting-edge recording technologies and expertise on analyzing large datasets analyses can be made readily available to the entire community of neuroscientists who can apply and schedule to perform cutting-edge research. | TSIEN Joe Z. LI Meng OSAN Remus CHEN GuiFen LIN LongNian WANG Phillip Lei FREY Sabine FREY Julietta ZHU DaJiang LIU TianMing ZHAO Fang KUANG Hui | 2013 | Science China(Life Sciences)2013，56，9： | 1 |
| 5 | Visual performance and fatigue in reading vibrating numeric displays显示文摘 | Chiuhsiang Joe Lin Yao-Hung Hsieh Hsiao-Ching Chen | 2008 | Displays2008，29，4： | 1 |
| 6 | An Integrated Thermo- mechanical-dynamic Model to Characterize Motor- ized Machine Tool Spindles During Very High Speed Rotation显示文摘 | Lin Chiwei Tu J F Joe K | 2003 | International Journal of Machine Tool & Manufacture2003，43，： | 1 |
| 7 | An integrated thermo-meehanical-dynamic model to characterize motorized machine tool spindles during very high speed rotation显示文摘 | LIN Chi-wei TU Jay F KAMMAN Joe | 2003 | International Journal of Machine Tools and Manufacture2003，43，10： | 1 |
| 8 | An integrated thermal- mechanical- dynamic model to characterize motorized machine tool spindles during very high speed rotation 显示文摘 | Lin C W Jay F T Joe K | 2003 | International Journal of Machine Tools & Manufacture2003，43，10： | 1 |
| 9 | An Integrated Thermo- Mechanical- Dynamic Model to Characterize Motorized Machine Tool Spindles During Very High Speed Rotation 显示文摘 | Lin Chiwei Jay F T Joe Kaman | 2003 | International Journal of Machine Tools & Manufacture2003，，43： | 1 |
| 10 | Learning Online Community Citizenship Behavior: A Socio-Cognitive Model显示文摘 | JOE S W LIN C P | 2008 | CyberPsychology & Behavior2008，11，3： | 1 |
| 11 | Modeling perceived job productivity and its antecedents considering gender as a moderator显示文摘 | Chieh-Peng Lin Chou-Kang Chiu Sheng-Wuu Joe | 2009 | The Social Science Journal2009，46，： | 1 |
| 12 | An integrated thermo- mechanical-dynamic model to characterize motorized machine tool spindles during very high speed rotation 显示文摘 | Chi-Wei Lin Jay F Tu Joe Kamman | 2003 | International Journal of Machine Tools & Manufacture2003，43，： | 1 |
| 13 | Transient three- dimensional side-load analysis of out-of-round film- cooled nozzles 显示文摘 | WANG Ten-See LIN Jeff RUF Joe | 2011 | Journal of Propulsion and Power2011，27，4： | 1 |
| 14 | The implementation of a human factors engineering checklist for human-system interfaces upgrade in nuclear power plants显示文摘 | Jou Yung-Tsan Lin Chiuhsiang Joe Yenn Tzu-Chung | 2009 | Safety Science2009，47，7： | 1 |
| 15 | An integrated thermo-mechanical-dynamic model to characterize motorized machine tool spindles during very high speed rotation显示文摘 | Chi-Wei Lin Jay F. Tu Joe Kamman | 2003 | International Journal of Machine Tools and Manufacture2003，，10： | 1 |
| 16 | Identification of network-level coding units for real-time representation of episodic experiences in the hippocampus显示文摘 | Longnian Lin Remus Osaa Joe Z Tsien | 2005 | PNAS2005，102，17： | 1 |
| 17 | An integrated thermal-mechanical-dynamic model to characterize motorized machine tool spindles during very high speed rotation显示文摘 | Lin Chi-Wei Tu Jay F Kamman Joe | 2003 | International Journal of Machine Tools & Manufacture2003，43，5： | 1 |
| 18 | Using Workflow Technology to Manage Flexible e-Learning Serviees显示文摘 | Joe Lin Charley Ho | 2002 | Edueational Technology & Society2002，5，4： | 1 |
| 19 | An integrated thermo-mechanical-dynamic model to characterize motorized machine tool spindies during very high speed rotation显示文摘 | Lin Chi-Wei Jay F Tu Joe Kamman | 2003 | Machine Tools & Manufacture2003，43，： | 1 |
| 20 | Severe thunderstorm internal structure from Daul-Doppler radar measurements显示文摘 | Joe R Eagleman Wen C Lin | 1977 | J Appl Meteor1977，16，10： | 1 |
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