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| 1 | GABAergic Abnormalities Associated with Sensorimotor Corticostriatal Community Structural Deficits in ErbB4 Knockout Mice and First-Episode Treatment-Naive Patients with Schizophrenia显示文摘The current study was designed to explore how disruption of specific molecular circuits in the cerebral cortex may cause sensorimotor cortico-striatal community structure deficits in both a mouse model and patients with schizophrenia.We used prepulse inhibition(PPI)and brain structural and diffusion MRI scans in 23 mice with conditional ErbB4 knockout in parvalbumin interneurons and 27 matched controls.Quantitative real-time PCR was used to assess the differential levels of GABA-related transcripts in brain regions.Concurrently,we measured structural and diffusion MRI and the cumulative contribution of risk alleles in the GABA pathway genes in firstepisode treatment-naı¨ve schizophrenic patients(n=117)and in age-and sex-matched healthy controls(n=86).We present the first evidence of gray and white matter impairment of right sensorimotor cortico-striatal networks and reproduced the sensorimotor gating deficit in a mouse model of schizophrenia.Significant correlations between gray matter volumes(GMVs)in the somatosensory cortex and PPI as well as glutamate decarboxylase 1 mRNA expression were found in controls but not in knockout mice.Furthermore,these findings were confirmed in a human sample in which we found significantly decreased gray and white matter in sensorimotor cortico-striatal networks in schizophrenic patients.The psychiatric risk alleles of the GABA pathway also displayed a significant negative correlation with the GMVs of the somatosensory cortex in patients.Our study identified that ErbB4 ablation in parvalbumin interneurons induced GABAergic dysregulation,providing valuable mechanistic insights into the sensorimotor cortico-striatal community structure deficits associated with schizophrenia. | Chengcheng Zhang Peiyan Ni Yikang Liu Yang Tian Jinxue Wei Bo Xiang Liansheng Zhao Xiaojing Li Xiaohong Ma Wei Deng Wanjun Guo Rongjun Ni Yamin Zhang Qiang Wang Hailiang Huang Nanyin Zhang Tao Li | 2020 | Neuroscience Bulletin2020，36，2： | 9 |
| 2 | Interaction Between Variations in Dopamine D2 and Serotonin 2A Receptor is Associated with Short-Term Response to Antipsychotics in Schizophrenia显示文摘Dear Editor,Schizophrenia is a chronic and debilitating brain disorder,which has a strong genetic component with heritability ranging from 66%to 85%[1,2].Currently,antipsychotic drugs remain the most effective treatment for the psychotic symptoms of schizophrenia[3].Because of the severe sideeffects of first-generation antipsychotics(FGAs),secondgeneration antipsychotics(SGAs)have become more widely used in the treatment of schizophrenia. | Liansheng Zhao Huijuan Wang Yamin Zhang Jinxue Wei Peiyan Ni Hongyan Ren Gang Li Qiang Wang Gavin P Reynolds Weihua Yue Wei Deng Hao Yan Liwen Tan Qi Chen Guigang Yang Tianlan Lu Lifang Wang Fuquan Zhang Jianli Yang Keqing Li Luxian Lv Qingrong Tan Yinfei Li Hua Yu Hongyan Zhang Xin Ma Fude Yang Lingjiang Li Chuanyue Wang Huiyao Wang Xiaojing Li Wanjun Guo Xun Hu Yang Tian Xiaohong Ma Jeremy Coid Dai Zhang Chao Chen Tao Li Chinese Antipsychotics Pharmacogenomics Consortium | 2019 | Neuroscience Bulletin2019，35，6： | 3 |
| 3 | Glial U87 cells protect neuronal SH-SY5Y cells from indirect effect of radiation by reducing oxidative stress and apoptosis显示文摘最近的研究在 neurodegeneration 表明了放射的间接效果的角色。然而,在对放射的间接效果的 neuroprotection 的 glial 房间的角色仍然不是清楚的,尽管他们被知道在中央神经系统在压力条件下面保护神经原。我们的学习证明放射的那间接效果增加了进一步提高关键 apoptotic 蛋白质的表示并且导致 neuronal 房间死亡的氧化压力。我们也在一个 transwell 合作文化系统面对 glial 房间在 neuronal 房间上调查了放射的间接效果,当我们的分析集中于 neuronal 房间时。当间接放射和 neuroprotective 效果的来源被各种各样的端点分析,照耀的调节房间的中等 ICCM 被使用。导致 ICCM 的反应氧化种类水平显著地在与 glial U87 房间 co 有教养的 SH-SY5Y 房间被减少,这被观察,它可能帮助维持 mitochondrial 膜潜力的正直。抗氧化剂酶 superoxide dismutase 和抗氧化剂谷胱甘肽的增加的层次在与 glial U87 房间 co 有教养的 SH-SY5Y 房间被观察。而且,有 glial 房间的合作文化禁止导致 ICCM 的 apoptotic 蛋白质的表示,这也被观察,即在 SH-SY5Y 房间的 Bax,细胞色素 c,和 caspase-3。因此,在合作文化系统 glial,房间可以由减少导致 ICCM 的氧化压力和 apoptotic 死亡保护 neuronal SH-SY5Y 房间,这能被推测。 | Yasmeen Saeed Bingjie Xie JinXu Abdur Rehman Ma Hong Qing Hong Yulin Deng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 2 |
| 4 | Failure behavior of interfacial domain in SiC-matrix based composites显示文摘In this work,the microstructure,failure behavior and interfacial properties with respective to the interfacial domain in SiCf/BN/SiC and C_(f)/PyC/SiC composites were studied via the fiber push-in test.The differences in the mechanical response of the interfacial domain were observed.During the fiber push-in test for SiCf/BN/SiC,the interface debonding accompanied with interphase fracture occurred,resulting in an obvious sign of the onset of debonding on loading-displacement(P-u)curves.While the good continuity of P-u curves can be observed for Cf/PyC/SiC,which is due to that the failure is in the form of interface debonding along with interphase lateral slipping caused by the extension of buckled carbon fiber,without any interphase fracture.The interfacial properties calculated from the fiber push-in test show that Cf/PyC/SiC possesses a weaker interfacial domain compared with SiC_(f)/BN/SiC.The interfacial shear stress of SiCf/BN/SiC and C_(f)/PyC/SiC composites amounts 94.2 and 48.1 MPa,respectively. | Jinxue Ding Xiaokang Ma Xiaomeng Fan Jimei Xue Fang Ye Laifei Cheng | 2021 | Journal of Materials Science & Technology2021，，29： | 1 |
| 5 | Apparent Kinetics of 1-Decene Polymerization Catalyzed Using the Ionic Liquid[Bmim]_(x)[C_(2)H_(5)NH_(3)]_(1-x)[Al_(2)Cl_(7)]显示文摘Poly-α-olefin(PAO)synthetic oil,a regular long-chain alkane produced from the catalytic polymerization ofα-olefin,is a high-quality lubricating base oil with huge market potential.In this study,PAO synthesis based on the catalytic polymerization of 1-decene using the ionic liquid(IL)[Bmim]_(x)[C_(2)H_(5)NH_(3)]_(1-x)[Al_(2)Cl_(7)]as the catalyst was studied.Compared with the conventional catalyst[Bmim][Al_(2)Cl_(7)],the obtained PAO product incorporates more trimers and tetramers of 1-decene and contains few double-bond end groups,demonstrating a better catalytic system for PAO-10 production.The apparent polymerization kinetics of 1-decene in this catalytic system were studied based on the 1-decene concentration,catalyst concentration,and reaction temperature.An apparent kinetic equation for PAO formation was determined,providing a promising strategy for PAO production using 1-decene polymerization. | Chen Yingze He Jinxue Wang Ben Pan Shiguang Zhang Di Bai Zhongxiang An Liangcheng Liu Dan Ma Aijing Li Hu Gui Jianzhou | 2023 | China Petroleum Processing & Petrochemical Technology2023，25，4： | 0 |
| 6 | Microstructure and mechanical properties of Zr_(3)Al_(3)C_(5)-based ceramics synthesized by Al-Si melt infiltration显示文摘In this work,bulk Zr_(3)Al_(3)C_(5)-based ceramics were synthesized by the infiltration of A1-Si melt into zirconium carbide (ZrC) perform.The phase composition,microstructure,and mechanical properties of as-fabricated ceramics were studied.The results demonstrate that Si is more effective to reduce the twin boundary energy of ZrC than A1,and thus promotes the decrease of formation temperature of Zr_(3)Al_(3)C_(5).With the infiltration temperatures increasing from 1200 to 1500 ℃,the Zr_(3)Al_(3)C_(5) content increases from 10 to 49 vol%,which is contributed to the increase of flexural strength from 62±9 to 222±10 MPa,and fracture toughness (KIC) from 2.8+0.2 to 4.1±0.3 MPa.m^(1/2).The decrease of mechanical properties for the samples fabricated at 1600 ℃ is ascribed to the abnormal growth of Zr_(3)Al_(3)C_(5) grains. | Xiaomeng FAN Yuzhao MA Yangfang DENG Jinxue DING Laifei CHENG | 2021 | Journal of Advanced Ceramics2021，10，3： | 0 |
| 7 | Ca^2+ doping effects in(K,Na,Li)(Nb0.8Ta0.2)O3 lead-free piezoelectric ceramics显示文摘Lead-free(K0.5-x/2Na0.5-x/2Lix)(Nb0.8Ta0.2)O3(KNLNT)and(K0.49-x/2Na0.49-x/2-LixCa0.01)(Nb0.8Ta0.2)O3(KNLNT-Ca)ceramics were prepared by a conventional ceramic processing.Structural analysis shows that the Ca^2+ doping takes the A site of ABO3 perovskite and decreases the phase transition temperature.Property measurements reveal that as a donor dopant,the Ca^2+ doping results in higher room-temperature dielectric constant,lower dielectric loss,and lower mechanical quality factor.In addition,the Ca^2+ doping does not change the positive piezoelectric coefficient d33,but increases the converse piezoelectric coefficient d 33*significantly.This is likely due to the increase in the relaxation,as well as the appearance of(CaNa/K·-VNa/K’)defect dipoles. | Lei TANG Tengfei LIU Jinxu MA Xiaowen ZHANG Linan AN Kepi CHEN | 2019 | Frontiers of Materials Science2019，13，4： | 0 |
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