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| 1 | LncRNA DPP10-AS1 promotes malignant processes through epigenetically activating its cognate gene DPP10 and predicts poor prognosis in lung cancer patients显示文摘Objective:The purpose of this study was to explore the function and gene expression regulation of the newly identified lnc RNA DPP10-AS1 in lung cancer,and its potential value as a prognostic biomarker.Methods:q RT-PCR and Western blot were conducted to detect the expression of DDP10-AS1 and DPP10 in lung cancer cell lines and tissues.The effects of DDP10-AS1 on DPP10 expression,cell growth,invasion,apoptosis,and in vivo tumor growth were investigated in lung cancer cells by Western blot,rescue experiments,colony formation,flow cytometry,and xenograft animal experiments.Results:The novel antisense lnc RNA DPP10-AS1 was found to be highly expressed in cancer tissues(P<0.0001),and its upregulation predicted poor prognosis in patients with lung cancer(P=0.0025).Notably,DPP10-AS1 promoted lung cancer cell growth,colony formation,and cell cycle progression,and repressed apoptosis in lung cancer cells by upregulating DPP10 expression.Additionally,DPP10-AS1 facilitated lung tumor growth via upregulation of DPP10 protein in a xenograft mouse model.Importantly,DPP10-AS1 positively regulated DPP10 gene expression,and both were coordinately upregulated in lung cancer tissues.Mechanically,DPP10-AS1 was found to associate with DPP10 m RNA but did not enhance DPP10 m RNA stability.Hypomethylation of DPP10-AS1 and DPP10 contributed to their coordinate upregulation in lung cancer.Conclusions:These findings indicated that the upregulation of the antisense lnc RNA DPP10-AS1 promotes lung cancer malignant processes and facilitates tumorigenesis by epigenetically regulating its cognate sense gene DPP10.DPP10-AS1 may serve as a candidate prognostic biomarker and a potential therapeutic target in lung cancer. | Haihua Tian Jinchang Pan Shuai Fang Chengwei Zhou Hui Tian Jinxian He Weiyu Shen Xiaodan Meng Xiaofeng Jin Zhaohui Gong | 2021 | Cancer Biology & Medicine2021，18，3： | 5 |
| 2 | Dieldrin and endrin removal from water by trioleinembedded adsorbent显示文摘A novel triolein-embedded adsorbent for re-moval of persistent organic pollutants (POPs) from water was developed. In this paper, taking dieldrin and endrin as the target pollutants, different factors (temperature, ion strength, pH, and concentration of humic acid) that affect the adsorption rate were investigated. Adsorption isotherms of these two pollutants fitted to Freundlich model well identi-fied the partition mechanism between the adsorbent and water. However, the equilibrium constant of dieldrin was larger than that of endrin due to larger octanol-water coeffi-cient of dieldrin. Adsorption rate of dieldrin increased with the increase of temperature, the decrease of ion strength, pH and concentration of humic acid, whereas adsorption rate of endrin decreased with the increase of temperature and pH. Humic acid firstly increased, and then decreased the adsorp-tion rate of endrin. Ion strength hardly affected the adsorp-tion rate of endrin. | HUO Jinxian LIU Huijuan QU Jiuhui RU Jia LIU Haining LI Guoting | 2005 | Chinese Science Bulletin2005，50，23： | 5 |
| 3 | Dynamical decoupling of electron spins in phosphorus-doped silicon显示文摘Quantum coherence is an important enabling feature underpinning quantum computation. However, because of couplings with its noisy surrounding environment, qubits suffer from the decoherence effects. The dynamical decoupling (DD) technique uses pulse-induced qubit flips to effectively mitigate couplings between qubits and environment. Optimal DD eliminates dephasing up to a given order with the minimum number of pulses. In this paper, we first introduce our recent work on prolonging electron spin coherence in γ-irradiated malonic acid crystals and analyze different decoherence mechanisms in this solid system. Then we focus on electron spin relaxation properties in another system, phosphorous-doped silicon (Si:P) crystals. These properties have been investigated by pulse electron paramagnetic resonance (EPR). We also investigate the performance of the dynamical decoupling technique on this system. Using 8-pulse periodic DD, the coherence time can be extended to 296 μs compared with 112 μs with one-pulse control. | RONG Xing WANG Ya YANG JiaHui ZHU JinXian XU WanJie FENG PengBo WEN XuJie SU JiHu DU JiangFeng | 2011 | Chinese Science Bulletin2011，56，7： | 4 |
| 4 | Carbon and hydrogen isotopic compositions and their evolutions of gases generated by herbaceous swamp peat at different thermal maturity stages显示文摘Coalbed methane (CBM) accumulation models include continuous gas accumulation and staged gas accumulation.However,studied on the geochemical characteristics and indices to evaluate staged accumulation CBM are lacking.This study for the first time obtained the carbon and hydrogen isotopic compositions of methane and ethane generated at different evolution stages using thermal simulation of samples prepared by treating an herbaceous swamp peat at different temperatures.The results showed that the carbon isotopic compositions of methane and ethane were obviously affected by the thermal evolution level of the starting sample,while the hydrogen isotopic compositions were closely related to the maturity of gases.The carbon and hydrogen isotopic compositions of gases generated by coal-forming organic matter with Ro values from 1.2%,1.7%,2.4%,3.2% and 3.7% to 5.2% were determinated.The relationship between Ro values and the carbon and hydrogen isotopic compositions of gases generated by coal-forming organic matter at different evolution stages as well as the carbon or hydrogen isotopic relationships between methane and ethane were established.The results provide a scientific basis for studying the genesis of CBM generated at different maturity intervals and understanding the geochemical characteristics of staged accumulation CBM.These results were applied to a case study on CBM from the southern Qinshui basin,and it was found that the CBM accumulated after the Middle Jurassic and was characteristic of staged gas accumulation.This is consistent with the result of geological studies,and further showed that the results of thermal simulation experiments are very important for evaluating the genesis of natural CBM. | DUAN Yi ZHANG XiaoLi SUN Tao WU BaoXiang HE JinXian XU Li | 2011 | Chinese Science Bulletin2011，56，13： | 3 |
| 5 | Photooxidation of hydrochlorofluocarbons and hydrofluorocarbons initiated by OH radicals显示文摘PhotooxidationofhydrochlorofluocarbonsandhydrofluorocarbonsinitiatedbyOHradicals￥ZhongJinxian;MuYujing;YangWenxiang(ResearchC... | Zhong Jinxian Mu Yujing Yang Wenxiang(Research Center for Eco-Environmental Sciences Chinese Academy of Sciences, Beijing 100085, China)Chen Dazhou(Chinese Center for Certified Reference Materials, Beijing 100013, China) | 1996 | Journal of Environmental Sciences1996，8，2： | 2 |
| 6 | An improved cellular automata model for heterogeneous work zone traffic显示文摘 | Qiang Meng Jinxian Weng | 2011 | Transportation Research Part C2011，，6： | 2 |
| 7 | Targeted delivery of a STING agonist to brain tumors using bioengineered protein nanoparticles for enhanced immunotherapy显示文摘Immunotherapy is emerging as a powerful tool for combating many human diseases.However,the application of this life-saving treatment in serious brain diseases,including glioma,is greatly restricted.The major obstacle is the lack of effective technologies for transporting therapeutic agents across the blood-brain barrier(BBB)and achieving targeted delivery to specific cells once across the BBB.Ferritin,an iron storage protein,traverses the BBB via receptor-mediated transcytosis by binding to transferrin receptor 1(TfR1)overexpressed on BBB endothelial cells.Here,we developed bioengineered ferritin nanoparticles as drug delivery carriers that enable the targeted delivery of a small-molecule immunomodulator to achieve enhanced immunotherapeutic efficacy in an orthotopic glioma-bearing mouse model.We fused different glioma-targeting moieties on self-assembled ferritin nanoparticles via genetic engineering,and RGE fusion protein nanoparticles(RGE-HFn NPs)were identified as the best candidate.Furthermore,RGE-HFn NPs encapsulating a stimulator of interferon genes(STING)agonist(SR717@RGE-HFn NPs)maintained stable self-assembled structure and targeting properties even after traversing the BBB.In the glioma-bearing mouse model,SR717@RGE-HFn NPs elicited a potent local innate immune response in the tumor microenvironment,resulting in significant tumor growth inhibition and prolonged survival.Overall,this biomimetic brain delivery platform offers new opportunities to overcome the BBB and provides a promising approach for brain drug delivery and immunotherapy in patients with glioma. | Bin Wang Maoping Tang Ziwei Yuan Zhongyu Li Bin Hu Xin Bai Jinxian Chu Xiaoyang Xu Xue-Qing Zhang | 2022 | Bioactive Materials2022，7，10： | 2 |
| 8 | Summarization on variable liquid thrust rocket engines显示文摘The technology actuality and development trend of variable thrust rocket engines at home and abroad are summarized. Key technologies of developing variable thrust rocket engines are analyzed. Development advices on developing variable thrust rocket engines that are adapted to the situation of our country are brought forward. | YUE ChunGuo LI JinXian HOU Xiao FENG XiPing YANG ShuJun | 2009 | Science China(Technological Sciences)2009，52，10： | 2 |
| 9 | Skeletal Microstructures of the Chiton Ischnochiton hakodadensis and a Comparison with the Cambrian Halkieria显示文摘Halkieria 是一个早寒武纪的石块类,建议种系发生的亲密关系从茎组 lophotrochozoan 到茎组 aculiferan。骨胳的类似经常在对 Halkieria 和相关寒武纪的石块的软体动物解释的支持作为证据被引用。polyplacophoran 软体动物(一种衬衣) 的骨胳的微观结构 Ischnochiton hakodadensis,它忍受类似于 halkieriids 和另外的 coeloscleritophoran 的 sclerites 的 perinotum 元素小壳的石块(SSF ) ,被学习评估解释。一种衬衣有类似和差别骨胳的结构和 halkieriid sclerites:1 ) 头阀门我。hakodadensis 和 Halkieria evangelista 的背面的壳分享背面的壳缺乏的好同心生长线,而是 halkieriid 的一个类似的模式另外的 polyplacophoran 阀门特征包括塑造 V 的缩进,散发肋骨;2 ) 安排我。在三个地区的 hakodadensis perinotum 元素有点类似于 halkieriid sclerites 的安排模式;3 ) 内部 perinotum 规模我。hakodadensis (在直径的 ∼200 μm ) 有一个底和片,在到 halkieriid 的形态学显著地类似掌状的 sclerites (在直径的 ∼400 μm ) 。然而,我。而 halkieriid sclerites 是空的, hakodadensis perinotum 规模是将近稳固的。这些观察把一种微结构尺寸加到在软体动物和 halkeriids 之间的骨胳的比较,并且可以证明在解决 Halkieria 和 Halwaxiidae 的种系发生的亲密关系有用。 | ZHANG Xiaochuan YAO Jinxian | 2014 | Acta Geologica Sinica(English Edition)2014，88，5： | 2 |
| 10 | Study on north boundary of subtropical zone in Funiu Mountain according to soil geochemistry显示文摘The boundary between subtropical zone and temperate zone is not only important in physical geography, but also attractive in agricultural production. Seven soil profiles studied in this paper are placed along the southern slope of Funiu Mountain at different heights above sea level. Many compositions and properties of these soils have been determined in laboratory. In this paper, the laws of migration and accumulation of soil materials on the southern slope of Funiu Mountain are discussed first, then the division of the boundary between subtropical zone and temperate zone in this area according to soil geochemistry is discussed with qualitative methods and mathematical classification method in which twelve selected indexes such as K m , Saf, Ba, β, Feo/Fet, Mno/Mnt and so on are used. The result indicates that the boundary between subtropical zone and temperate zone on the southern slope of Funiu Mountain is about 950 m above sea level. | MA Jianhua,XU Shuming,HAN Jinxian,ZHU Lianqi,ZHAO Qingliang(College of Environment and Planning, Henan University, Kaifeng 475001, China) | 2003 | Journal of Geographical Sciences2003，13，3： | 1 |
| 11 | Development of a General and Practical Iron Nitrate/TEMPO Catalyzed Aer- obic Oxidation of Alcohols to Aldehydes/Ketones: Catalysis with Table Salt显示文摘 | Ma Shengming Liu Jinxian Li Suhua | 2011 | Adv Synth Catal2011，353，6： | 1 |
| 12 | Iron-Catalyzed Aerobic Oxida- tion of Allylic Alcohols: The Issue of C==C Bond Isomeriza- tion显示文摘 | Liu Jinxian Ma Shengming | 2013 | OrgLett2013，15，20： | 1 |
| 13 | Decomposing income polarization and tax-benefit changes across 31 European countries and Europe-wide, 2004 - 2012 显示文摘 | JinXian Wan Koen Caminada Kees Goudswaard and Chen Wang | 2015 | Department of Economics Research Memorandum2015，，3： | 1 |
| 14 | Aerobic Oxidation of Indole Carbinols Using Fe (NO3) 3 9HO/TEMPO/NaC1 as Catalysts 显示文摘 | Liu Jinxian Ma Shengming | 2013 | OrgBiomolChem2013，11，25： | 1 |
| 15 | 显示文摘 | Dong Xiangting Wang Jinxian Cui Qizheng | 2009 | Mod Ap- pl Sei2009，3，1： | 1 |
| 16 | Adjusting principle of gas jet controlling inlet and numerical verification显示文摘To improve the inlet performance of a ramjet working under variable conditions,a design is proposed by controlling the inlet with jet controlling,which combines the method of reducing the sealing Mach number of the external waves and the technique of controlling inlet by jet controlling.Three inlets were designed to analyze the feasibility and a numerical simulation method was used to simulate the three inlet flow fields.The adjustment mechanism of the design was studied through analysis of the simulation results.The design was verified by comparing the performances of the three inlets.The study showed that the method of reducing the sealing Mach number of the external wave system can improve the flow coefficient when the inlet works at low Mach numbers.The technique of controlling inlet by jet controlling can homogenize inlet flow fields at high Mach numbers,reduce effective throat area and increase the total pressure recovery(TPR).Adjustable inlets controlled by jet controlling demonstrate good performance at certain working ranges. | FENG XiPing LIN ZhiYuan ZHENG Ya LI JinXian CAO Qi | 2011 | Science China(Technological Sciences)2011，54，11： | 1 |
| 17 | Hydro- thermal synthesis of spherical and hollow Gd2 03:Eu3+ phosphors 显示文摘 | Liu Guixia Hong Guangyan Wang Jinxian | 2007 | J Alloy Comp2007，432，： | 1 |
| 18 | Decorating rare-earth fluoride upconversion nanoparticles on AuNRs@Ag core-shell structure for NIR light-mediated photothermal therapy and bioimaging显示文摘Photothermal therapy(PTT)has presented its inherent application value in cancer treatment.Nevertheless,single-functional photothermal materials cannot meet the precise diagnosis and treatment of cance r.Therefo re,it is important to design a nanocomposite that has both high therapeutic efficiency and multimodal imaging capabilities.In our work,a new nanostructure of gold nanorods(AuNRs)with silver shells decorated by BaGdF5:Yb^(3+),Er^(3+)nanoparticle was synthesized by a simple way.The biostability of AuNRs is increased by coating with silver shells,and the AuNR@Ag nanoparticles can be used as excellent surface enhanced Raman scattering(SERS)probe.Moreover,the modification of BaGdF5:Yb^(3+),Er^(3+)nanoparticles provides the possibility of real-time optical imaging of the tumor area.Under the irradiation of NIR laser,the AuNR@Ag/BaGdF5:Yb^(3+),Er^(3+)nanocomposites(NCs)have strong upconversion emission and excellent photothermal conversion efficiency.Meanwhile,the NCs show low cytotoxicity and good biocompatibility in MTT cytotoxicity test.Moreover,the NCs are also exceptional contrast agents for CT imaging.For in vitro photothermal therapy test,NCs show excellent killing efficiency on tumor cells.Therefore,the multifaceted research of AuNR@Ag/BaGdF5:Yb^(3+),Er^(3+)multifunctional nanomaterials provides a break for high-efficiency tumor photothermal therapy and multimodal imaging. | Jingzhi Dou Bei Chen Guixia Liu Xiangting Dong Wensheng Yu Jinxian Wang Yunxiao Zhang Zhanguo Li Jiang Zhu | 2022 | Journal of Rare Earths2022，40，2： | 1 |
| 19 | Nodal solutions for m-point boundary value problems using bifurcation methods显示文摘 | SUN Jinxian XU Xian ORegan D | | 0，，10： | 1 |
| 20 | Positive solutions of m-point boundary value problems显示文摘 | Zhang Guowei Sun Jinxian | 2004 | J Math Anal Appl2004，，291： | 1 |
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