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1Analysis and design for the second order nonlinear continuous extended states observer显示文摘The extended state observer (ESO) is a novel observer for a class of uncertain systems. Since ESO adopts the continuous non-smooth structure, the classical observer design theory is hard to use for ESO analysis. In this note, the self-stable region (SSR) approach, which is a nonlinear synthesis method for nonlinear uncertain systems, will be used for ESO design and its stability analysis. The advantages of the non-smooth structure in ESO for improving the convergence properties and the estimation precision will be shown.Yi Huang Jingqing Han 2000Chinese Science Bulletin2000,45,21:65
2Theranostic nanoparticles with tumor-specific enzyme-triggered size reduction and drug release to perform photothermal therapy for breast cancer treatment显示文摘Although progress has been indeed made by nanomedicines, their efficacies for cancer treatment remain low, consequently leading to failures in translation to clinic. To improve the drug delivery efficiency,nanoparticles need to change size so as to fully utilize the enhanced permeability and retention(EPR) effect of solid tumor, which is the golden principle of nanoparticles used for cancer treatment. Herein, we employed cationic small-sized red emission bovine serum albumin(BSA) protected gold nanocluster(Au NC@CBSA,21.06 nm) to both load indocyanine green(ICG) and act as imaging probe to realize theranostic. Then Au NC@CBSA-ICG was fabricated with negatively charged hyaluronic acid(HA) to form Au NC@CBSAICG@HA, which was about 200 nm to easily retain at tumor site and could be degraded by tumor-specific hyaluronidase into small nanoparticles for deep tumor penetration. The HA shell also endowed Au NC@CBSA-ICG@HA with actively targeting ability and hyaluronidase-dependent drug release. Furthermore, the quenching and recovery of fluorescence revealed the interaction between ICG and carrier, which was essential for the investigation of pharmacokinetic profiles. No matter in vitro or in vivo, Au NC@CBSAICG@HA showed markedly anti-tumor effect, and could suppress 95.0% of tumor growth on mice breast cancer model. All results demonstrated Au NC@CBSA-ICG@HA was potential for breast cancer therapy.Rui Liu Chuan Hu Yuanyuan Yang Jingqing Zhang Huile Gao 2019Acta Pharmaceutica Sinica B2019,9,2:24
3Does chemical index of alteration(CIA) reflect silicate weathering and monsoonal climate in the Changjiang River basin?显示文摘Chemical weathering of continental silicates significantly influences global climate change,earth surface processes,material cy-cling and oceanic chemical composition.How to quantitatively reconstruct chemical weathering history has become an important issue in global change research.Chemical index of alteration(CIA) has been widely used as a quantitative indicator for estimating the degree of silicate weathering.However,its method of calculation and the limitations of its application are not well understood.In this study,we calculated CIA values from suspended particulate matter collected from the mainstream and major tributaries of the Changjiang River.The values yielded considerable variations at different temporal and spatial scales.The average CIA values increased from the upper to middle-lower reaches,and were lower in the suspended samples taken during the flood than in the dry season.The spatial variation in the CIA is predominantly controlled by basinal monsoon climate.In contrast,the temporal varia-tion in the Changjiang River basin is controlled mainly by the changing provenance of suspended samples in relation to the shift of the precipitation zone.The CIA probably indicates the integrated weathering history in the river basin,and thus,cannot be used as a reliable proxy of instantaneous chemical weathering.Furthermore,the calculation method and hydrodynamic sorting also influence the CIA values.Therefore,caution should be taken when using the CIA as a proxy for studying chemical weathering from different regions.SHAO JingQing YANG ShouYe 2012Chinese Science Bulletin2012,57,10:22
4Efficacy of Add-on Montelukast in Nonasthmatic Eosinophilic Bronchitis: The Additive Effect on Airway Inflammation, Cough and Life Quality显示文摘Wuping Bao Ping Liu Zhongmin Qiu Li Yu Jingqing Hang Xiaohua Gao Xin Zhou 2015Chinese Medical Journal2015,,1:19
5Multiple Cropping Intensity in China Derived from Agro-meteorological Observations and MODIS Data显示文摘Double-and triple-cropping in a year have played a very important role in meeting the rising need for food in China.However,the intensified agricultural practices have significantly altered biogeochemical cycles and soil quality.Understanding and mapping cropping intensity in China′s agricultural systems are therefore necessary to better estimate carbon,nitrogen and water fluxes within agro-ecosystems on the national scale.In this study,we investigated the spatial pattern of crop calendar and multiple cropping rotations in China using phenological records from 394 agro-meteorological stations(AMSs)across China.The results from the analysis of in situ field observations were used to develop a new algorithm that identifies the spatial distribution of multiple cropping in China from moderate resolution imaging spectroradiometer(MODIS)time series data with a 500 m spatial resolution and an 8-day temporal resolution.According to the MODIS-derived multiple cropping distribution in 2002,the proportion of cropland cultivated with multiple crops reached 34%in China.Double-cropping accounted for approximately 94.6%and triple-cropping for 5.4%.The results demonstrat that MODIS EVI(Enhanced Vegetation Index)time series data have the capability and potential to delineate the dynamics of double-and triple-cropping practices.The resultant multiple cropping map could be used to evaluate the impacts of agricultural intensification on biogeochemical cycles.YAN Huimin XIAO Xiangming HUANG Heqing LIU Jiyuan CHEN Jingqing BAI Xuehong 2014Chinese Geographical Science2014,24,2:11
6Impacts of ecological restoration projects on agricultural productivity in China显示文摘在农田数量和质量的变化由于陆地使用是国家食物安全的批评担心,特别地为中国。尽管有重要生态的效果,生态的恢复节目(ERP ) ,从 1999 开始了,显然改变了瓷器农田和农业生产率的空间模式。从 2000 ~ 2008 把动态数据基于农田首先与主要生产率建模的 30-m 分辨率和基于卫星的网源于卫星图象,我们在 ERP 引起的农业生产率上识别了影响,包括为格林的谷物,节目(GFGP ) 和到湖(RCTL ) 的回收农田编程序。我们的结果显示农业生产率与 132.67lis 的率输了。在 R 的射击的 Pb 的累积。pseudoacacia 比另外的种类显著地高。在学习区域的土壤的 Pb 的数量是 s 吗??QIN Yuanwei YAN Huimin LIU Jiyuan DONG Jinwei CHEN Jingqing XIAO Xiangming 2013Journal of Geographical Sciences2013,23,3:8
7A SYNTHESIS METHOD FOR TWO-ORDER UNCERTAIN SYSTEMS: AUTO-STABLE REGIONAPPROACH显示文摘In this paper, the variable structure control method is improved. Based on the existence and the reaching conditions for the auto-stable region of two-order systems, a new synthesis method, auto-stable region approach is presented to construct a global stabilizing feedback law by using a positive definite function and a properly selected saturated function. This new approach is robust with respect to the bounded model uncertainties and is convenient for both analysis and engineering implemelltation.HAN Jingqing WANG Wei HUANG Yi (Institute of Systems Science, Academia Sinica, Beijing 100080, China) 1997Systems Science and Mathematical Sciences1997,10,2:7
8THE TYPHOON DISASTERS AND RELATED EFFECTS IN CHINA显示文摘China is one of the countries which were affected very seriously by tropical cyclones. In this paper, the active features of tropical cyclones which affected and landfell over China, the distinguishing characteristics of typhoon disasters and related formation laws have been studied, and the impact of trphoon disasters on China’s socio-economic development have been discussed. The study reveals that typhoon disasters which affected China are characterized by high freqency in occurrence, violent in sudden occurrence, remarkable effects in China,widescope in impact and severe intensities in disasters, and this type of disaster was caused by huge gales, rainstorms, storm surges and reatal chain-disasters.Typhoon disasters have not only caused great casualties but also exerted severe effects on every economic departments in China. There is an annual increasing tendency in direct economic loss caused by taphoon disasters and since 1990, the annual average economic loss has totalled up to over lo billion RMB yuan.Liang Biqi Wen Zhiqing Liang Jingqing (Department of Atmospheric Science, Zhongshan University, Guanghou 510275People’s Republic of China) 1996Journal of Geographical Sciences1996,6,1:7
9Influencing factors on efficacy of summer acupoint application treatment for allergic rhinitis:a retrospective study显示文摘OBJECTIVE:Allergic rhinitis(AR) is a common health problem.Summer acupoint application treatment(SAAT) is reported to effectively treat and prevent AR from seasonal onset.In the present study,we aimed to evaluate its effects,especially on the course of AR,through a retrospective study.METHOD:A cross-sectional multicenter study was performed based on patients treated between 2008 and 2009 in 13 clinical centers in China.A total of 1058 outpatients aged ≥2 years with documented AR and ≥1 year SAAT were eligible for enrollment.A case report form(CRF) was completed by both patient and doctor.The CRF was designed to collect data on the patient's history of SAAT,AR condition,and self-reported health condition.The outcomes(dependent variables) were incidence and intensity of AR and concomitant medications used.Data were analyzed with ordinal logistic regression(OLR).RESULTS:Treatment course and seasonal pattern of AR were related to all dependent variables positively.After controlling for sample bias and confounding factors,the findings suggested that a 3-year treatment course had better efficacy(OR/incidence of AR:2.57,95%CI:1.76-3.76;OR/intensity of AR:2.17,95%CI:1.50-3.17;OR/concomitant medications:2.20,95% CI:1.50-3.23) compared with a 2-year or less treatment course.CONCLUSION:The results showed that:1)the length of treatment course was positively associated with the efficacy of SAAT(the longer the treatment course,the better the efficacy);and 2)SAAT was more efficacious in treating seasonal AR than non-seasonal AR.Jin Peng Xiaqiu Wu Jingqing Hu Yigong Fang Mingjie Zi Baoyan Liu 2012Journal of Traditional Chinese Medicine2012,32,3:7
10Clinical phenotype network: the underlying mechanism for perso- nalized diagnosis and treatment of traditional Chinese medicine显示文摘繁体中文药(TCM ) 在个性化的药的一个典型纲要调查临床的诊断和治疗整齐,它意味着有一样的疾病的个性化的病人将从不同 TCM 医生获得不同诊断和最佳的治疗。这个原则被 TCM 临床的专业人员认出并且粘住几千年了。然而,个性化的药不是的 TCM 的内在的机制到目前为止充分调查了并且仍然保持未知。这份报纸讨论 TCM 的框架在经典文学并且在真实世界的临床的背景的个性化的药,并且调查 TCM 的内在的机制从网络药的观点的个性化的药。在失眠上基于 246 个设计得好的门诊病人记录,由评估表明观察的个人偏爱和植物药方的偏爱,我们注意了每张植物药方的重要类似和每相遇的症状类似。为了调查 TCM 的内在的机制,个性化药,我们构造了一个临床的显型网络(CPN ) ,在哪个临床的显型实体喜欢症状并且诊断作为连接表现为在这些实体之间的节点和关联。这 CPN 被用来调查症候群和症状的同现的混杂的边界。小世界的拓扑的特征与高聚类结构在 CPN 被注意,它在 TCM 的合理性上提供卓见个性化的诊断和处理。这个网络上的调查将帮助我们在 TCM 的内在的机制上获得理解个性化的药并且将为 TCM 的精炼建议一个新观点个性化的临床的技巧。Xuezhong Zhou Yubing Li Yonghong Peng Jingqing HU Runshun Zhang Liyun He Yinghui Wang Lijie Jiang Shiyan Yan Peng Li Qi Xie Baoyan Liu 2014Frontiers of Medicine2014,8,3:7
11Synthesis and biological activities of thio-triazole derivatives as novel potential antibacterial and antifungal agents显示文摘A series of novel thio-triazole derivatives including thiols, thioethers and thiones as well as some corresponding triazolium compounds were conveniently and efficiently synthesized from commercially available halobenzyl halides and thiosemicarbazide. All the new compounds were characterized by 1 H NMR, 13 C NMR, FTIR, MS and HRMS spectra. Their antibacterial and antifungal activities in vitro were evaluated against four Gram-positive bacteria, four Gram-negative bacteria and two fungi by two-fold serial dilution technique. The preliminary bioassay indicated that some prepared triazoles exhibited effective antibacterial and antifungal activities. Especially, 3,4-dichlorobenzyl triazolethione and its triazolium derivatives displayed the most potent activities against all the tested strains.WANG QingPeng ZHANG JingQing DAMU Guri L.V. WAN Kun ZHANG HuiZhen ZHOU ChengHe 2012Science China Chemistry2012,55,10:7
12Dominant Gene cplsr1 Corresponding to Premature Leaf Senescence Resistance in Cotton (Gossypium hirsutum L.)显示文摘Cotton (Gossypium hirsutum L.) premature leaf senescence-resistant inbred XLZ33 and senescence-susceptible inbred lines XLZ13 were selected and crossed to produce F1, F1-reciprocal, F2 and BC1 generations for evaluation of leaf senescence process and inheritance. The results showed that leaf senescence processes for XLZ13 and XLZ33 were obviously different and leaf senescence traits could be distinguished between the two parents at particular periods of cotton growth. Inheritance anlysis for the cotton premature leaf senescence resistant trait further showed that the segregation in the F2 fit a 3:1 ratio inheritance pattern, with resistance being dominant. The backcross of F1 to the susceptible parent produced a 1:1 ratio, confirming that cotton premature leaf senescence resistant trait was from a single gene. The single dominant gene controlling cotton premature leaf senescence resistance in XLZ33 was named as cotton premature leaf senescence resistance 1, with the symbol cplsr1.Jingqing Zhao Tengfei Jiang Zhi Liu Wenwei Zhang Guiliang Jian Fanfljun Qi 2012Journal of Integrative Plant Biology2012,54,8:6
13Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention.Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng 2021Cellular & Molecular Immunology2021,18,4:5
14Downregulation of KCTD12 contributes to melanoma stemness by modulating CD271显示文摘Objective: Cancer metastasis remains the primary cause of cancer-related death worldwide.In a previous study, we found that levels of BTB/POZ domain-containing protein KCTD12 are lower in metastatic melanoma cells than in parental melanoma cells.The purpose of this study was to identify the roles of KCTD12 in cancer metastasis.Methods: The Cancer Genome Atlas(TCGA) datasets were used to evaluate the relationship between KCTD12 and skin cutaneous melanoma(SKCM) prognosis.The effects of endogenous KCTD12 on biological behaviors were examined using the MTT assay.The impacts of KCTD12 on melanoma stemness were explored using spheroid formation assay.KCTD12 knockout A375 cells were generated to confirm the inhibitory effect of KCTD12 on CD271, and a mouse metastatic model was used to determine the impact of KCTD12 on melanoma metastasis in vivo.Results: KCTD12 levels were lower in lung metastatic cells than in paired parental melanoma cells, and low KCTD12 expression indicated a poor prognosis in SKCM.Cancer metastasis-related capacities were higher in lung metastatic cells than in parental melanoma cells.Moreover, KCTD12 knockdown enhanced tumor growth and metastasis both in vitro and in vivo.Mechanistically, the interaction between KCTD12 and CD271 might be responsible for the stemness transformation after KCTD12 knockdown.Conclusions: This study identifies for the first time the role of the interaction between KCTD12 and CD271 in inducing melanoma cell stemness transformation.Moreover, KCTD12 repression enhances melanoma cell growth, adhesion, migration and invasion.Weiyu Shen Yumei Li Bifei Li Liping Zheng Xiaodong Xie Jingqing Le Yusheng Lu Tao Li Fan Chen Lee Jia 2019Cancer Biology & Medicine2019,16,3:4
15Relationship between miRNA-338-3p expression and progression and prognosis of human colorectal carcinoma显示文摘Sun Kai Su Guiyuan Deng Haijun Dong Jingqing Lei Shangtong Li Guoxin 2014Chinese Medical Journal2014,,10:4
16SINS model in the management of biosafety level 2 laboratories: exploration and practice显示文摘A significant number of biosafety level 2(BSL-2)laboratories have been established in many countries for studies of various types of pathogenic agents and other infectious biological materials.The harmonized management of biological risks in such diverse laboratories thus appears as a real challenge.Zhejiang Province in China has taken the initiative to establish a comprehensively integrated laboratory biosafety management system called SINS(Standardization,Informatization,Normalization and Systematization).The SINS model system has been introduced and adopted in 1,721 BSL-2 laboratories in Zhejiang Province,and thus lead to an increase in the number of biosafety committees from 20%to more than 95%from 2007 to 2018,and the number of biosafety laboratory managers who knows biosafety-related laws and regulations increase from 52.7%to 83.7%from 2009 to 2017.Such achievements indicate that the successful implementation of SINS model has increased the effective control of biological risks in BSL-2 laboratories of the Zhejiang Province.SINS model and its main effects on leading the improvement of laboratory biosafety management was presented in this review.The SINS model helps to strengthen laboratory biosafety and thus effectively reduces occurrence of biosafety-related incidences.This model can potentially be used by other regions or countries where harmonized biosafety management system is still under-developing.Xiaoxia Qiu Jingqing Weng Zhenggang Jiang Congcong Yan Hua Gu 2019Biosafety and Health2019,1,3:3
17基于景观营建视角的草原游荡型河流保护实践——以海拉尔河湿地公园为例显示文摘文章以海拉尔河湿地公园景观规划设计为例,分析了景观规划设计师在面对区域特色景观的保护和营构时,运用城市规划、区域规划设计为媒介,以保护和尊重区域特色生态基底为原则,为特色景观生态修复和人类使用间的平衡提出差异化、渐进式的针对性策略,最终达到区域环境优化、区域特色景观营构和城市现代化建设共生共美的目标,并引起大众对于区域风景营建和保护的思考和应用。Jingqing Lu 冯杰 余畅 2020园林2020,,7:3
18Dietary L-arginine supplementation reduces lipid accretion by regulating fatty acid metabolism in Nile tilapia(Oreochromis niloticus)显示文摘Background: Excessive white fat accumulation in humans and other animals is associated with the development of multiple metabolic diseases. It is unknown whether dietary L-arginine supplementation reduces lipid deposition in high fat diet-fed Nile tilapia(Oreochromis niloticus).Results: In the present study, we found that dietary supplementation with 1% or 2% arginine decreased the deposition and concentration of fats in the liver;the concentrations of triglycerides, low-density lipoprotein, total cholesterol, and high-density lipoprotein in the serum;and the diameter of adipocytes in intraperitoneal adipose tissue. Compared with the un-supplementation control group, the hepatic activities of alanine aminotransferase,aspartate aminotransferase, and lactate dehydrogenase, and hepatic concentration of malondialdehyde were reduced but these for catalase and superoxide dismutase were enhanced by dietary supplementation with 2% arginine. Arginine supplementation reduced the total amounts of monounsaturated fatty acids, while increasing the total amounts of n-3 and n-6 polyunsaturated fatty acids in the liver. These effects of arginine were associated with reductions in mRNA levels for genes related to lipogenesis(sterol regulatory element-binding protein-1, acetyl-CoA carboxylase α, stearoyl-CoA desaturase, and fatty acid synthase) but increases in mRNA levels for genes involved in fatty acid β-oxidation(carnitine palmitoyltransferase 1α and peroxisome proliferator-activated receptor α). In addition, hepatic mRNA levels for Δ4 fatty acyl desaturase 2 and elongase 5 of very long-chain fatty acids were enhanced by arginine supplementation.Conclusion: These results revealed that dietary L-arginine supplementation to tilapia reduced high fat diet-induced fat deposition and fatty acid composition in the liver by regulating the expression of genes for lipid metabolism.Senlin Li Yunchang Zhang Ning Liu Jingqing Chen Lina Guo Zhaolai Dai Chao Wang Zhenlong Wu Guoyao Wu 2021Journal of Animal Science and Biotechnology2021,12,1:3
19Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic.Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng 2022Cellular & Molecular Immunology2022,19,7:3
20THE SELF-STABLE REGION APPROACH FOR SECOND ORDER SYSTEMS显示文摘In this paper, an inherent property that second order systems, which can bestable, have the Self-Stable Regions (SSRs) is proposed. Based on this property, a newsynthesis method-the Self--Stable Region approach is suggested for a class of second-ordernonlinear uncertain systems. The global stability of the closed-loop systems is proved.Lastly, the advantages of the SSR approach are analyzed.HUANG Yi HAN Jingqing(Institute of Systems Science, Academia Sinica, Beijing 100080, China) 1999Systems Science and Mathematical Sciences1999,12,3:3
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