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| 1 | 中药穴位贴敷作用机理研究概况显示文摘中药穴位贴敷历史悠久,临床疗效确切。本文基于中医理论的整体观和经络学说,从药物对机体的局部刺激、经络传导、透皮吸收3方面阐述中药穴位敷贴的作用机理,并结合中药经皮给药系统、代谢组学、药效物质基础等研究热点,提出中医药系统生物学这一新的研究模式。 | 贺艳萍 肖小芹 邓桂明 欧阳林旗 陈镇 张志国 | 2017 | 中国中医药信息杂志2017，24，3： | 168 |
| 2 | 基于给药途径的中药外治机制分析显示文摘中药外治法与内治法一样,均是以中医的整体观念和辨证论治思想为指导,运用各种不同的方法将药物施于皮肤、孔窍、穴位等部位,达到治病目的。近年来中药外治法普遍用于临床,在局部疗效上与中药内治法相比优势显著,查询《中国药典》收录用于外治的中药材及成方制剂和中国知网近五年中药外治在临床治疗疾病上的研究,笔者从给药途径及其外治机理进行分析,进一步明确不同给药途径在中药外治疗法中的作用机制,以期提高临床疗效。 | 魏珍珍 方晓艳 白明 苗明三 | 2019 | 湖南中医药大学学报2019，39，9： | 23 |
| 3 | 中药穴位贴敷治疗肝硬化腹水作用机理探讨显示文摘肝硬化腹水是多种终末期肝病的共同病理变化结果,是内科重症。目前国内外尚缺乏有效统一的治疗方案,而中药穴位贴敷治疗能够收到较好效果。本文通过概述中药穴位贴敷治疗肝硬化腹水作用机理,探讨其应用前景。 | 戴瑶瑶 祝峻峰 范兴良 | 2018 | 时珍国医国药2018，29，7： | 15 |
| 4 | Efficacy evaluation of summer acupoint application treatment on asthma patients: a two-year follow-up clinical study显示文摘OBJECTIVE: To evaluate the self-efficacy and satisfaction of asthma patients subjected to summer acupoint application treatment(SAAT).METHODS: A two-year follow-up clinical study was conducted. Patients with asthma were treated by applying a herbal paste onto the Feishu(BL 13) and Fengmen(BL 12) acupoints on the three hottest days of summer, according to the traditional Chinese calendar, from 2008 to 2010. During a two-year follow-up, these patients were asked tofill out a questionnaire evaluating asthma degree,exacerbation frequency, concomitant medications and self-satisfaction. The self-rate and doctor-report outcomes obtained in parallel were evaluated to assess the efficacy of SAAT.RESULTS: A total of 527 asthma patients were initially enrolled in this study, of which 97 elderly patients and those with more severe cases of asthma were lost to follow-up. Thus, a total of 430 patients were valid for analysis using self-rate data. Nevertheless, occasional negative returns were obtained;almost all of the outcomes were rated as 'No change', 'Moderate effective', or 'Very effective'. In addition, 80% of the patients were satisfied with this treatment. Moreover, 391(91.4%) patients were somewhat improved after SAAT in 2009, and further improvement was observed in 2010. After SAAT, the average asthma-degree score decreased from 5.3 in 2008 to 4 in 2009 and, subsequently to3.5 in 2010.CONCLUSION: With pronounced patient satisfaction, SAAT can reduce the exacerbation severity and frequency, concomitant medications and asthma degree. Prolonging the treatment course might enhance the efficacy of SAAT. | Wu Xiaqiu Peng Jin Li Guoqin Zhang Wei Liu Guangxia Liu Baoyan | 2015 | Journal of Traditional Chinese Medicine2015，35，1： | 7 |
| 5 | Association between Skin Reactions and Efficacy of Summer Acupoint Application Treatment on Chronic Pulmonary Disease:A Prospective Study显示文摘Objective: To examine the variations in the prevalence of skin reactions and the association between skin reactions and efficacy of summer acupoint application treatment(SAAT) on chronic pulmonary disease(CPD). Methods: A total of 2,038 patients with CPD were enrolled at 3 independent hospitals(defined as Groups A, B and C, respectively) in China. All patients were treated by SAAT, as applying a herbal paste onto the acupoints of Fengmen(BL 12) and Feishu(BL 13) on the dog days of summer, according to the lunar calendar, in 2008. Ten days after treatment, skin reaction data(no reaction, itching, stinging, blistering, and infection) were obtained via face-to-face interviews. Patients were retreated in the same hospital one year later, thereby allowing doctors to assess treatment efficacy based on the patients' symptoms, the severity of the spirometric abnormalities, and the concomitant medications used. Results: A large number of patients(85.3%) displayed reactive symptoms; however, the marked associations between reactive symptoms and age or gender were not observed. An increased number of patients from Group B(99.3%) and Group C(76.5%) displayed reactive symptoms due to the increased mass of crude Semen Sinapis Albae. The effective rate of SAAT was as high as 90.4% for patients of Group B, which was followed by Group A(70.9%) and Group C(42.2%). Using stratified analyses, a convincing association between reactive symptoms and therapeutic efficacy was observed for patients with asthma [itching: odds ratio(OR)=2.17, 95% confidence interval(CI): 1.49 to 3.14; blistering: OR=0.43, 95% CI: 0.25 to 0.73; and no reaction: OR=0.56, 95% CI: 0.35 to 0.90]. However, the same tendency was not observed for patients with chronic bronchitis and chronic obstructive pulmonary disease. Conclusions: SAAT can induce very mild skin reactions for patients with CPD, among which patients with asthma displayed a strong association between skin reactions and therapeutic efficacy. The skin reactions may be induced by the crude Semen Sinapis Albae. | 吴夏秋 彭锦 李国勤 苏惠萍 刘广霞 刘保延 | 2016 | Chinese Journal of Integrative Medicine2016，22，4： | 5 |
| 6 | Efficacy of Chinese Medicine Acupoint Application Combined with Montelukast on Children with Perennial Allergic Rhinitis:A Randomized Controlled Trial显示文摘Objective To evaluate the efficacy of Chinese medicine acupoint application(CMAA)combined with Western medicine for perennial allergic rhinitis(PAR)in children.Methods In this prospective,parallel,randomized,placebo-controlled and single-blind trial from August to September,2017,180 children with PAR were randomly assigned to an integrative group(CMAA and Montelukast),CMAA group(CMAA and placebo tablet),or Montelukast group(placebo CMAA and Montelukast).Participants were applied with CMAA for 6 sessions over 2 weeks,and/or Montelukast Chewable Tablet orally once daily for 12 weeks.The changes in severity of symptoms were measured by Visual Analog Scale(VAS)and rhinitis control assessment test(RCAT)at 0,2,4 and 12 weeks of treatment.Blood samples were collected for serum interleukin-4,interferon gammaγand T helper type 1(Th1)/Th2 flow cytometric analysis at the time points of 0,4 and 12 weeks.Results Eight cases dropped out from the trial,3 in the integrative group,2 in the CMAA group and 3 in the Montelukast group.The VAS scores decreased significantly while the RCAT scores increased significantly in all three groups at 4 and 12 weeks compared with baseline(P<0.01 or P<0.05).The VAS scores were significantly lower while the RCAT scores were significantly higher in the integrative and CMAA groups than the Montelukast group at 2 and 4 weeks(P<0.01 or P<0.05).At 2,4 and 12 weeks,the scores of nasal congestion,sneezing,sleep problem,and rhinitis symptom control in the integrative and CMAA groups increased significantly compared with baseline(P<0.01 or P<0.05).The least percentages of Th2 and the most alleviated Th2 shift(highest Th1/Th2)were observed in the integrative group at 12 weeks compared with the other two groups(P<0.05).Conclusion The combination of CMAA with Montelukast might be more effective and appropriate than either option alone for children with PAR.(Registered at Chinese Clinical Trial Register,registration No.ChiCTR-IOR-17012434). | LI You-jin ZONG Ming DING Li-feng RUI Xiao-qing MA Bei-yin QIN Li-ping | 2020 | Chinese Journal of Integrative Medicine2020，26，11： | 4 |
| 7 | 穴位敷贴治疗与烫伤所致水疱内液体蛋白质组学差异研究显示文摘目的:运用蛋白质组学分析方法,比较慢性支气管炎患者穴位敷贴过程中产生的水疱与被高温烫伤的患者水疱内液体中的蛋白质组差异。方法:收集15例慢性支气管炎采用穴位敷贴治疗后起疱患者和20例被高温烫伤的患者疱内液体,双向电泳及质谱分析差异蛋白表达。结果:确定穴位敷贴组与烫伤组差异蛋白质点14个,最终成功鉴定13个。其中同一个蛋白对应6个不同的差异蛋白点,有一个差异蛋白点匹配到2个不同的蛋白,因此共得到9个差异表达蛋白,其中5个蛋白表达上调,4个蛋白表达下调。与烫伤组发疱内容物相比,穴位敷贴发疱治疗组的纤维蛋白原β链、纤维蛋白原γ链、半乳凝素-10、触珠蛋白、甲状腺激素结合蛋白的表达较烫伤疱液上调,α1-抗胰蛋白酶、α2-HS糖蛋白、α2巨球蛋白、簇蛋白的表达下调。结论:穴位敷贴治疗与烫伤所致水疱内液体蛋白质成分存在显著差异,差异蛋白主要涉及抗凝血、免疫调节、抗炎、抗凋亡等作用。这提示穴位敷贴发疱可能使机体具有较强的凝血功能、免疫功能、自我修复能力及抗炎抗感染能力,这可能是敷贴发疱治疗呼吸系统疾病的部分物质基础。 | 刘志丹 林玉芳 陈春兰 李晓燕 梁薇 马文 沈卫东 | 2017 | 辽宁中医药大学学报2017，19，7： | 3 |
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