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| 1 | Segmentation of Hematoxylin-Eosin stained breast cancer histopathological images based on pixel-wise SVM classifier显示文摘Hematoxylin-Eosin(HE) staining is the routine diagnostic method for breast cancer(BC), and large amounts of HE stained histopathological images are available for analysis. It is emergent to develop computational methods to efficiently and objectively analyze these images, with the aim of providing potentially better diagnostic and prognostic information for BC. This work focuses on analyzing our in-house HE stained histopathological images of breast cancer tissues. Since tumor nests(TNs) and stroma morphological characteristics can reflect the biological behaviors of breast invasive ductal carcinoma(IDC), accurate segmentation of TNs and the stroma is the first step towards the subsequent quantitative analysis. We first propose a method based on the pixel-wise support vector machine(SVM) classifier for segmenting TNs and the stroma, then extract four morphological characters related to the TNs from the images and investigate their relationships with the patients' 8-year disease free survival(8-DFS). The evaluation result shows that the classification based segmentation method is able to distinguish between TNs and stroma with 87.1% accuracy and 80.2% precision,suggesting that the proposed method is promising in segmenting HE stained IDC histopathological images. The Kaplan-Meier survival curves show that three morphological characters(number of TNs, total perimeter, and average area of TNs) in the images have statistical correlations with 8-DFS of the patients, illustrating that the segmented images can help to identify new morphological factors in IDC TNs for the prediction of BC prognosis. | QU AiPing CHEN JiaMei WANG LinWei YUAN JingPing YANG Fang XIANG QingMing MASKEY Ninu YANG GuiFang LIU Juan LI Yan | 2015 | Science China(Information Sciences)2015，58，9： | 12 |
| 2 | Large aperture N31 neodymium phosphate laser glass for use in a high power laser facility显示文摘Large aperture Nd:phosphate laser glass is a key optical element for an inertial confinement fusion(ICF) facility. N31,one type of neodymium doped phosphate glasses, was developed for high peak power laser facility applications in China. The composition and main properties of N31 glass are given, together with those of LHG-8, LG-770, and KGSS-0180 Nd:phosphate laser glasses, from Hoya and Schott, and from Russia. The technologies of pot melting, continuous melting, and edge cladding of large size N31 phosphate laser glass are briefly described. The small signal gain profiles of N31 glass slabs from both pot melting and continuous melting at various values of the pumping energy of the xenon lamp are presented. N31 glass is characterized by a stimulated emission cross section of 3.8 × 10-20cm2 at 1053 nm,an absorption coefficient of 0.10–0.15% cm-1at laser wavelength, small residual stress around the interface between the cladding glass and the laser glass, optical homogeneity of ~2 × 10-6in a 400 mm aperture, and laser damage threshold larger than 42 J/cm2 for a 3 ns pulse width at 1064 nm wavelength. | Lili Hu Shubin Chen Jingping Tang Biao Wang Tao Meng Wei Chen Lei Wen Junjiang Hu Shunguang Li Yongchun Xu Yasi Jiang Junzhou Zhang Zhonghong Jiang | 2014 | High Power Laser Science and Engineering2014，2，1： | 8 |
| 3 | Object-based image analysis for mapping geomorphic zones of coral reefs in the Xisha Islands, China显示文摘Mapping regional spatial patterns of coral reef geomorphology provides the primary information to understand the constructive processes in the reef ecosystem. However, this work is challenged by the pixel-based image classification method for its comparatively low accuracy. In this paper, an object-based image analysis(OBIA)method was presented to map intra-reef geomorphology of coral reefs in the Xisha Islands, China using Landsat 8satellite imagery. Following the work of the Millennium Coral Reef Mapping Project, a regional reef class hierarchy with ten geomorphic classes was first defined. Then, incorporating the hierarchical concept and integrating the spectral and additional spatial information such as context, shape and contextual relationships, a large-scale geomorphic map was produced by OBIA with accuracies generally more than 80%. Although the robustness of OBIA has been validated in the applications of coral reef mapping from individual reefs to reef system in this paper, further work is still required to improve its transferability. | XU Jingping ZHAO Jianhua LI Fang WANG Lin SONG Derui WEN Shiyong WANG Fei GAO Ning | 2016 | Acta Oceanologica Sinica2016，35，12： | 7 |
| 4 | Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation显示文摘Severe acute pancreatitis-associated acute lung injury(SAP-ALI) is a serious disease associated with high mortality. Emodin has been applied to alleviate SAP-ALI;however, the mechanism remains unclear. We report that the therapeutic role of emodin in attenuating SAP-ALI is partly dependent on an exosomal mechanism. SAP rats had increased levels of plasma exosomes with altered protein contents compared to the sham rats. These infused plasma exosomes tended to accumulate in the lungs and promoted the hyper-activation of alveolar macrophages and inflammatory damage. Conversely,emodin treatment decreased the plasma/pancreatic exosome levels in the SAP rats. Emodin-primed exosomes showed less pro-inflammatory effects in alveolar macrophages and lung tissues than SAP exosomes. In detail, emodin-primed exosomes suppressed the NF-κB pathway to reduce the activation of alveolar macrophage and ameliorate lung inflammation by regulating PPARγ pathway, while these effects were amplified/abolished by PPARγ agonist/antagonist. Blockage of pancreatic acinar cell exosome biogenesis also exhibited suppression of alveolar macrophage activation and reduction of lung inflammation. This study suggests a vital role of exosomes in participating inflammation-associated organ-injury,and indicates emodin can attenuate SAP-ALI by reducing the pancreatic exosome-mediated alveolar macrophage activation. | Qian Hu Jiaqi Yao Xiajia Wu Juan Li Guixiang Li Wenfu Tang Jingping Liu Meihua Wan | 2022 | Acta Pharmaceutica Sinica B2022，12，10： | 7 |
| 5 | Understanding the structural evolution of Au/WO_(2.7) compounds in hydrogen atmosphere by atomic scale in situ environmental TEM显示文摘Hydrogen energy is a resuscitated clean energy source and its sensitive detection in air is crucial due to its very low explosive limit.Metal oxide decorated with noble metal nanoparticles has been used for the enhancement of gas detection and exhibits superior sensitivity.Understanding the intrinsic mechanism of the detection and the enhancement mechanism is thus becoming a fundamental issue for the further development of novel metal/oxide compound gas-sensing materials.However,the correlation between the microstructural evolution,the charge transport and the complex sensing process has not yet been directly revealed and its atomic mechanism is still debatable.In this study,an Au/WO_(2.7) compound was synthesized and exhibited a strongly enhanced gas sensitivity to many reductive gases,especially H2.Aberration-corrected environmental transmission electron microscopy was used to investigate the atomic-scale microstructural evolution in situ during the reaction between H_(2) and Au/WO_(2.7) compound.Swing and sintering processes of the Au particles on the WO_(2.7) surface were observed under heating and gaseous environments,and no injection of hydrogen atoms was suggested.First principle calculations verified the swing and sintering processes,and they can be explained by the enhancement of H2 sensitivity. | Fei Hui Chong Li Yanhui Chen Chunhui Wang Jingping Huang Ang Li Wei Li Jin Zou Xiaodong Han | 2020 | Nano Research2020，13，11： | 6 |
| 6 | Research on allocation efficiency of the redistributed pseudo inverse algorithm显示文摘Allocation efficiency is an important performance index to measure the quality of the allocation algorithm. In order to compute the efficiency, the volume of the subset of attainable moments must be solved. The efficiency of the redistributed pseudo inverse (RPI) algorithm depends on the choice of the pseudo-inverse matrix. The subset of attainable moments of RPI is a complex non-convex polyhedron. By analyzing twodimensional and three-dimensional allocation problems with a 'micro-element' method, here we propose an approximate calculation algorithm to compute the volume of the non-convex polyhedron. In order to improve the allocation efficiency of RPI, genetic algorithm is used to find the best pseudo-inverse matrix. The simulation results show that the best pseudo-inverse matrix can be easily chosen by the proposed method and the high allocation efficiency is achieved. | SHI JingPing , ZHANG WeiGuo, LI GuangWen & LIU XiaoXiong School of Automation, Northwestern Polytechnical University, Xi’an 710072, China | 2010 | Science China(Information Sciences)2010，53，2： | 4 |
| 7 | Cognitive effects of atypical antipsychotic drugs in first-episode drug-nave schizophrenic patients显示文摘Cognitive impairment is a core feature of schizophrenia. The present randomized open study enrolled antipsychotic-nave patients who were experiencing their first episode of schizophrenia. After baseline neurocognitive tests and clinical assessment, subjects were randomly assigned to olanzapine, risperidone and aripiprazole treatment groups. A battery of neurocognitive tests showed that risperidone produced cognitive benefits in all five cognitive domains, including verbal learning and memory, visual learning and memory, working memory, processing speed, and selective attention; olanzapine improved processing speed and selective attention; and aripiprazole improved visual learning and memory, and working memory. However, the three atypical antipsychotic drugs failed to reveal any significant differences in the composite cognitive scores at the study endpoint. In addition, the three drugs all significantly improved clinical measures without significant differences between the drugs after 6 months. These results suggest that the atypical antipsychotics, olanzapine, risperidone and aripiprazole may improve specific cognitive domains with similar global clinical efficacy. In clinical practice, it may be feasible to choose corresponding atypical antipsychotics according to impaired cognitive domains. | Juan Wang Maorong Hu Xiaofeng Guo Renrong Wu Lehua Li Jingping Zhao | 2013 | Neural Regeneration Research2013，8，3： | 3 |
| 8 | Effects of moxibustion on heat-shock protein 70 expression in the spinal cord and colonic mucosa in a rat model of ulcerative colitis显示文摘Pathological changes in the colon are closely associated with the spinal cord,and innervation of spinal cord can regulate cellular functions.Our previous studies verified that moxibustion protects and restores the colonic mucosa,but the mechanisms of action remain unknown.The present study observed the effects of moxibustion and salicylazosulfapyridine on expression of heat-shock protein 70(HSP70) and its mRNA in the spinal cord and colonic mucosa of ulcerative colitis rats.Results demonstrated that moxibustion and salicylazosulfapyridine increased HSP70 mRNA expression in the spinal cord and colonic mucosa of ulcerative colitis rats.The decreased transcriptional activity of HSP70 in the spinal cord and colonic mucosa might participate in damage to the colonic mucosa in ulcerative colitis rats.Moxibustion exerted protective effects on colonic mucosa by up-regulating HSP70 transcriptional activity in the spinal cord and colonic mucosa. | Li Qi Yin Shi Luyi Wu Jingping Mu Linying Tan Xiaopeng Ma Huirong Liu Shifen Xu Huangan Wu | 2010 | Neural Regeneration Research2010，5，22： | 3 |
| 9 | Spatio-temporal Change and Carrying Capacity Evaluation of Human Coastal Utilization in Liaodong Bay,China from 1993 to 2015显示文摘In China, promoting the development of coastal areas has been included in a series of national strategic development plans.At the same time, many marine environmental problems have been associated with the rapid development of coastal sea use. In order to quantify the impact of human activities on the coast, the characteristics of coastlines and near-shore sea use of Liaodong Bay, Northeast China, were first classified using multi-source, remotely sensed imagery using automatic or semi-automatic extraction methods for five periods between 1993 and 2015. Sea use dynamics and coastline dynamics resulting from human activates were analyzed. Results showed a significant trend of continuous growth in sea use and a progressive increase in the total length of artificial coastline, but a noticeable loss of natural coastline during the five periods. Reclaimed land and enclosed areas were the main types of sea use. Most coastal human activities were distributed in the northern part of the bay. In recent years, rapid industrialization and urbanization in China's coastal areas have promoted large-scale land reclamation. Accordingly, the observed coastline changes during each period had a close relationship with coastal development and sea area utilization. Based on marine functional zoning(MFZ), the sea use carrying capacity was evaluated by means of indexes to describe human exploitation of the marine and coastal environments in the bay. This showed that the intensity of coastal utilization in Liaodong Bay has increased year-on-year. Sea use carrying capacity reached a ‘critically loaded'state by 2008 and was ‘overloaded' by 2015. | XU Jingping LI Fang SUO Anning ZHAO Jianhua SU Xiu | 2019 | Chinese Geographical Science2019，29，3： | 2 |
| 10 | Experimental Study on the Combustion and Energy Flows of Vehicle Engine Under NEDC of Cold Start显示文摘To enhance the fuel economy of a vehicle powered by a gasoline engine under road conditions,an energy flow test of a vehicle was performed experimentally under the New European Driving Cycle of cold start.The energy distributions and related influencing factors were analyzed using the test data.Results show that the effective power and thermal efficiency are mainly affected by the engine load except in the early stage of the New European Driving Cycle.Because of the retarded CA50 and longer CA10-90,the effective thermal efficiency is lower in the early phase of driving conditions.Initially,the heat transfer loss mainly comprises the loss of the heating,ventilation,and air conditioning system.The radiator then plays the major role,with its percentage affected by the engine load and decreasing under the extra-urban driving cycle.The exhaust gas loss is decided by the temperature and flow rate of the exhaust gas,while its percentage is mainly affected by the temperature of the exhaust gas.In the early phase of driving conditions,the retarded spark advance angle leads to a higher temperature of the exhaust gas and a greater exhaust gas loss.The pumping loss and its percentage are mainly determined by the engine speed under the urban driving cycle,and both decrease under the extra-urban driving cycle except at maximum vehicle speed. | Zhichao Zhao Zaiqiang Meng Lu Li Shuqian Wang Jianqin Fu Jingping Liu | 2019 | Automotive Innovation2019，2，4： | 2 |
| 11 | In situ construction of ligand nano-network to integrin αvβ3 for angiogenesis inhibition显示文摘Angiogenesis occurs during the process of tumor growth,invasion and metastasis,and is essential for the survival of solid tumors.As an integrin significantly ove rexpressed in human tumor vascular endothelial cells,αvβ3 is a suitable targeting site for anti-angiogenesis of tumor.We designed and prepared a selfassembling peptide(SAP)with the ability to targeting αvβ3 and self-assembly.SAP formed nanoparticles in solution and transformed into nanofibrous network once specifically binding to integrin αvβ3 on the surface of human umbilical vein endothelial cells(HUVECs).The SAP network stably anchored on HUVECs over 24h,which consequently resulted in high-efficient inhibition of vascularization.In vitro anti-angiogenesis experiment displayed that the inhibition rate of tube-formation reached 94.9%.In vivo anti-angiogenesis array based on chick chorioallantoic membrane(CAM)model exhibited that the SAP had an inhibition rate up to 63.1%.These results indicated the outstanding anti-angiogenic ability of SAP,potentially for tumor therapy. | Ziming Chen Kuo Zhang Jiaqi Fan Yu Fan Chao Yang Wen Tian Yuan Li Wenliang Li Jingping Zhang Hao Wang Lei Wang | 2020 | Chinese Chemical Letters2020，31，12： | 2 |
| 12 | Face and object visual working memory deficits in first-episode schizophrenia correlate with multiple neurocognitive performances显示文摘Background Working memory(WM)deficit is considered a core feature and cognitive biomarker in patients with schizophrenia.Several studies have reported prominent object WM deficits in patients with schizophrenia,suggesting that visual WM in these patients extends to non-spatial domains.However,whether non-spatial WM is similarly affected remains unclear.Aim This study primarily aimed to identify the processing of visual object WM in patients with first-episode schizophrenia.Methods The study included 36 patients with first-episode schizophrenia and 35 healthy controls.Visual object WM capacity,including face and house WM capacity,was assessed by means of delayed matching-to sample visual WM tasks,in which participants must distribute memory so that they can discriminate a target sample.We specifically examined their anhedonia experience by the Temporal Experience of Pleasure Scale and the Snaith-Hamilton Pleasure Scale.Cognitive performance was measured by the Repeatable Battery for the Assessment of Neuropsychological Status(RBANS).Results Both face and house WM capacity was significantly impaired in patients with schizophrenia.For both tasks,the performance of all the subjects was worse under the high-load condition than under the low-load condition.We found that WM capacity was highly positively correlated with the performance on RBANS total scores(r=−0.528,p=0.005),RBANS delayed memory scores(r=−0.470,p=0.013),RBANS attention scores(r=−0.584,p=0.001),RBANS language scores(r=−0.448,p=0.019),Trail-Making Test:Part A raw scores(r=0.465,p=0.015)and simple IQ total scores(r=−0.538,p=0.005),and correlated with scores of the vocabulary test(r=−0.490,p=0.011)and scores of the Block Diagram Test(r=−0.426,p=0.027)in schizophrenia.No significant correlations were observed between WM capacity and Positive and Negative Syndrome Scale symptoms.Conclusions Our research found that visual object WM capacity is dramatically impaired in patients with schizophrenia and is strongly correlated with other measures of cognition,suggesting a mechanism that is critical in explaining a portion of the broad cognitive deficits observed in schizophrenia. | Yi Liu Taiyong Bi Bei Zhang Qijie Kuang Haijing Li Kunlun Zong Jingping Zhao Yuping Ning Shenglin She Yingjun Zheng | 2021 | General Psychiatry2021，34，1： | 2 |
| 13 | Strategies for improving fertilizer phosphorus use efficiency in Chinese cropping systems显示文摘A four-year project,entitled'The mechanisms of fraction transformation and high use efficiency of P fertilizer in Chinese cropping systems'commenced in 2017.The project was established to answer three key questions and looked at 17 cropping systems on ten soils.First,we asked what are the dynamics of transformation,fixation and mobilization of P fertilizers in soil-cropping systems?Second,what are the mechanisms of soil-cropmicrobe interactions by which P fertilizer can be efficiently used?Third,how to manipulate the processes of P use in cropping systems?The targets of this project are(1)to explore the mechanisms of P fixation,the pathways of loss of P availability and the threshold of migration of fertilizer P in the field;(2)to uncover mechanisms by which soil legacy P is mobilized through root physiological and morphological processes and through arbuscular mycorrhizal fungi and P-solubilizing bacteria in rhizosphere and hyphosphere;(3)to estimate the biological potential of crops for high efficiency P absorption and use;(4)to innovate new approaches for improving the efficiency of P fertilizers.The outcomes will provide theoretical support for setting standards for limitation of P fertilizer application rate in the main cropping zones of China. | Gu FENG Jingping GAI Xionghan FENG Haigang LI Lin ZHANG Keke YI Jialong LV Yiyong ZHU Li TANG Yilin LI | 2019 | Frontiers of Agricultural Science and Engineering2019，6，4： | 2 |
| 14 | Magnetostriction of Pseudobinary Compounds Pr_(0.15)Tb_xDy_(0.85-x)Fe_2(x=0 to 0.85)显示文摘The compound ingots of Pr0.15TbxDy0.85-xFe2 (x=0 to 0.85) were prepared by arc melting in a water Cu boat using arc furnace under a purified Ar atmosphere. Appropriate annealing (850℃, 100 h) can obtain single Laves phase compound. The magnetostriction for these systems will rise obviously when partially substituted Tb or Dy by Pr. | Yangxian LI and Jingping QU (Hebei University of Technology, Tianjin 300130, China) Chengchun TANG, Guangheng WU and Wenshan ZHAN (State Key Laboratory for Magnetism, Institute of Physics, CAS, BeiJing 100080, China) | 2000 | Journal of Materials Science & Technology2000，16，6： | 2 |
| 15 | Production of Pectinolytic Enzymes by Two Bacillus spp. Strains and Their Application in Flax Degumming显示文摘This study demonstrated that Bacillus licheniformis HDYM-03 and Bacillus megaterium HDYM-09, isolated from a liquid sample of fl ax retting pool, were able to produce pectinolytic enzymes using polysaccharides as substrates. Bacillus megaterium HDYM-09 produced pectin lyase that exhibited the highest activity of 2116.71 ± 11.55 U/mL. Bacillus licheniformis HDYM-03 produced pectate lyase that exhibited the highest activity of 611.21 ± 14.54 U/mL. Based on these fi ndings, we constructed four retting systems to degrade the pectin substance. The results showed that the content of galacturonic acid in the mixed system was 529.21 μg/mL, the content of reducing sugar was 98.14 mg/mL, and the weight loss ratio of cells reached 19.49%, which were signifi cantly higher than those in other systems. The mixed system has more advantages, and the utilization rate of degumming was higher, which further ensured that the degumming can be carried out effi ciently and quickly. The mixed system exhibits feasible applications in the fi ber and textile industry. | Jingping Ge Zhiyu Yang Renpeng Du Li Zhang Wenxiang Ping Dan Zhao | 2019 | Transactions of Tianjin University2019，25，4： | 2 |
| 16 | The Effects of Temperature, Light and Moisture on the Seed Germination of Siphonostegia chinensis Benth显示文摘To explore the optimum temperature,light intensityand water conditions for seed germination of Siphonostegia chinensis Benth.,seed germination experiment were carried out under different temperatures(5/15,10/20,15/25,20/30℃),different light intensity(14h light/10h darkness,complete darkness)and different concentrations(0%,5%,10%,15%,20%)of PEG-6000 solution.In terms of concentration,5%PEG was regarded as the low level,10%and 15%as the medium level,and 20%as the high level.The results showed that(1)Germination rate,germination potential,and germination index were increased with the rise of temperature.In addition,seed germination was significantly higher under the dark conditions than that with the 14h light/10h darkness.(2)No seed germination occurred when the temperature was below 10/20 C at 14h light/10h darkness.(3)Under 14h light/10h darkness,the germination rate,germination potential and germination index first increased and then decreased with the increase of PEG concentration.The low concentration was more beneficial to the seed germination.(4)Under the condition of complete darkness,the germination rate,germination potential and germination index decline with fluctuation with the increase of PEG concentration.Seed germination of Siphonostegia chinensis Benth.was inhibited in high concentration of PEG. | Shuaiqun Fan Kaiyu Qin Jingping Li Qinggui Zhang Fenguo Zhang Yongji Wang | 2019 | Journal of Botanical Research2019，1，2： | 2 |
| 17 | Retrieval of Total Suspended Matters Using Field Spectral Data in Shitoukoumen Reservoir,Jilin Province,Northeast China显示文摘From August to October in 2006,three times of field spectral measurements with a Field Spec FR spectroradiometer(Analytical Spectral Devices,Inc.,USA) were carried out in Shitoukoumen Reservoir,Jilin Province,Northeast China. Owing to the serious soil and water loss in the upstream,reflectance curves of the reservoir were characterized by high concentrations of total suspended matter(TSM) . Extending the spectral analysis to 1200nm in the near-infrared band,this research revealed an obvious reflectance peak around 1070nm which was caused by the strong backscattering of high TSM. The method of partial least squares(PLS) regression was applied to retrieving the TSM. Reflectance in two spectral bands,i.e.,675-948nm and 1029-1105nm,were used as variables to develop PLS models. Traditional linear regression,first derivative model and logarithmic model were also used for the comparison of different models. Results showed that the PLS model based on Rrs(675) -Rrs(948) gave out best results with high precision and stability. Although the PLS model based on Rrs(1029) -Rrs(1105) did not have an outstanding performance due to lots of noise,the reflectance peak in the near-infrared band was an important TSM feature and its efficient exploitation would have a considerable significance in TSM remote sensing. | XU Jingping ZHANG Bai LI Fang SONG Kaishan WANG Zongming LIU Dianwei ZHANG Guangxin | 2009 | Chinese Geographical Science2009，19，1： | 2 |
| 18 | Identification of the metabolites of polybrominated diphenyl ether 99 and its related cytochrome P450s显示文摘Objective:To investigate the metabolites of polybrominated diphenyl ether 99(BDE-99)and its related cytochrome P450s in an in vitro system.Methods:Rat primary hepatocytes were isolated and treated with BDE-99 for 24-72 h.Metabolites were then extracted from the hepatocytes and media,and detected by GC/MS.Several mRNAs of metabolic enzymes were also extracted from the same cells and the gene expression levels were determined using quantitative real-time PCR.In addition,selected recombinant cytochrome P450s(CYPs) were expressed in a bacurovirus/sf9 system,and these were further used to explore the metabolism of BDE-99 in vitro.The parent depletion approach was used for screening the ability of CYPs to eliminate BDE-99.Results: A reductively debrominated metabolite,BDE-47,and three oxidative metabolites,2,4,5-tribromophenol,5-OH-BDE-47,and 5'-OH-BDE-99,were identified from the BDE-99-treated rat hepatocytes,whereas no MeO metabolite was detected in the system.RT-PCR analysis showed that CYP 3A23/3A1,1A2,and 2B1/2 were induced by BDE-99.Furthermore,using the heterological expressed CYP proteins in in vitro BDE-99 metabolism experiments we found that CYP1A2 and CYP3A4 showed the highest metabolic efficiency for BDE-99,with the metabolic clearance rates of CYP1A2 and CYP3A4 being 30.3%and 27.7%,respectively.CYP1A1 and CYP2A6 displayed relatively low clearance rates,while CYP2E1 seemed not to be associated with the BDE-99 metabolism.Conclusions:In our in vitro rat primary hepatocyte metabolism system,four metabolites of BDE-99 were identified,and CYP3A4 and CYP1A2 were demonstrated to be involved in the BDE-99 metabolism. | Huibin Dong Ziyin Li Xiaoming Man Jingping Zhou Huiyuan Lu Shoulin Wang | 2010 | The Journal of Biomedical Research2010，24，3： | 2 |
| 19 | Non-Hermitian control of confined optical skyrmions in microcavities formed by photonic spin-orbit coupling显示文摘Optical skyrmions formed by photonic spin–orbit(SO)coupling are of significant interest in high-dimensional optical information processing.We report the formation mechanism and non-Hermitian properties of skyrmionlike states in a circular confinement potential with photonic SO coupling,which is preferably realized in a concave-planar microcavity system.We show that the effective photonic gauge field leads to two split manifolds of degenerate skyrmions whose spin textures can be controlled via the non-Hermitian properties by introducing circularly polarized gain and loss,exhibiting dramatically discrepant evolutions at the two sides of the exceptional point(EP).Furthermore,the lifetime degeneracy can be lifted by spatially inhomogeneous pumping according to the non-Hermitian mechanism,enabling the possibility for the skyrmion laser.By introducing shape asymmetry of the confinement potential,a double EP evolution can be achieved,which allows non-Hermitian control of the SO coupled states with higher degrees of freedom.These results open the way for the non-Hermitian control of photonic spin in confined systems,which would be of great significance for the fundamentals of advanced optical information processing. | XIAOXUAN LUO YIN CAI XIN YUE WEI LIN JINGPING ZHU YANPENG ZHANG FENG LI | 2023 | Photonics Research2023，11，4： | 1 |
| 20 | Formation and dissociation of HFC134a gas hydrate in nano-eupper suspension 显示文摘 | Li Jingping Liang Deqing Guo Kaihua | 2006 | Conversion and Management2006，47，2： | 1 |
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