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| 1 | Genetic and genomic analyses for economically important traits and their applications in molecular breeding of cultured fish显示文摘The traits of cultured fish must continually be genetically improved to supply high-quality animal protein for human consumption.Economically important fish traits are controlled by multiple gene quantitative trait loci(QTL),most of which have minor effects,but a few genes may have major effects useful for molecular breeding.In this review,we chose relevant studies on some of the most intensively cultured fish and concisely summarize progress on identifying and verifying QTLs for such traits as growth,disease and stress resistance and sex in recent decades.The potential applications of these major-effect genes and their associated markers in marker-assisted selection and molecular breeding,as well as future research directions are also discussed.These genetic and genomic analyses will be valuable for elucidating the mechanisms modulating economically important traits and to establish more effective molecular breeding techniques in fish. | TONG JinGou SUN XiaoWen | 2015 | Science China(Life Sciences)2015，58，2： | 12 |
| 2 | Preparation, characterization, and in vitro release of folic acid-conjugated chitosan nanoparticles loaded with methotrexate for targeted delivery显示文摘 | Jingou Ji Danjun Wu Li Liu Jida Chen Yi Xu | 2012 | Polymer Bulletin2012，，6： | 1 |
| 3 | Preparation, evaluation, and in vitro release of folic acid conjugated O ‐carboxymethyl chitosan nanoparticles loaded with methotrexate显示文摘 | Jingou Ji Danjun Wu Li Liu Jida Chen Yi Xu | 2012 | J Appl Polym Sci2012，，2： | 1 |
| 4 | Determination of nucleic acids using rivanol as the fluorescent probe in the presence of SDS显示文摘 | LI Wenyou XU Jingou HE Xiwen | 2000 | Anal Lett2000，33，15： | 1 |
| 5 | Simple and Sensitive Assay for Nucleic Acids Using Their Quenching Effect on the Chemiluminescence Reaction Between Luminol and Hydrogen Peroxide withManganese-Tetrasulfonatophthalocyanine as a new Catalyst显示文摘 | Yongxin Li Changqin Zhu Lun Wang Donghui Li Jingou Xu | 2003 | Mikrochimica Acta2003，143，1： | 1 |
| 6 | Study on fluorimetric determination of Hydrogen peroxide catalytic by FeTsPc with Thinamine Hydrochloride as a substrate显示文摘 | Li Donghui Chen Qiuying Xu Jingou | 1999 | Talanta,1999，49，： | 1 |
| 7 | Preparation, evaluation, and in vitro release study of O-carboxymethyl chitosan nanoparticles loaded with gentamicin and salicylic acid显示文摘 | Ji Jingou Hao Shilei Dong Jin | 2012 | Journal of Applied Polymer Science2012，123，16： | 1 |
| 8 | A novel FeTsPe-catalyzed system for the determination of Vitamin B1显示文摘 | Chen Qiuying Li Donghui Xu Jingou | 1999 | Analyst1999，124，： | 1 |
| 9 | Synthesis of NiO-ZrO2 Powders for Solid Oxide Fuel Cells显示文摘 | Li Songli Guo Ruisong Li Jingou | 2003 | Ceramics International2003，29，8： | 1 |
| 10 | Preparation, evaluation, and in vitro release of folic acid conjugated O-carboxy- methyl chitosan nanoparticles loaded with methotrexate 显示文摘 | Ji Jingou Wu Daniun Liu Li | 2012 | Journal of Applied Polymer Science2012，125，2： | 1 |
| 11 | Characterization of novel microsatellite loci in rare minnow (Gobiocypris rarus) and amplification in closely related species in Gobioninae显示文摘 | Xiaolin Liao Dan Wang Xiaomu Yu Weitao Li Lei Cheng Jianwei Wang Jingou Tong | 2007 | Conservation Genetics2007，，4： | 1 |
| 12 | Mitoehondrial eytoehrome oxidase I sequence divergence in some Chinese species of Charybdis (Crustaeea : Deeapoda : Portunidae) 显示文摘 | Chu Ka Hou Tong Jingou | 1999 | Biochemical Systematies and Ecology1999，，27： | 1 |
| 13 | Construction of the first high-density genetic map for growth related QTL analysis in Ancherythroculter nigrocauda显示文摘Ancherythroculter nigrocauda is a fish endemic to the upper areas of the Changjiang(Yangtze)River in China.Quantitative trait locus(QTL)mapping is a powerful tool to identify potential genes affecting traits of economic importance in domestic animals.In this study,a high-density genetic map was constructed with 5901 single nucleotide polymorphism(SNP)makers by sequencing 92 individual fish from a F1 family using the specific-locus amplified fragment sequencing approach.Initially,48 QTLs for total length,body length,body height,and body weight were identified according to the high density of the genetic map with 24 LGs,a total length of 3839.4 cM,and marker spacing of about 0.82 cM.These QTLs explained 27.1%-49.9%of phenotypic variance.The results of this study suggest that major QTLs are responsible for the growth of A.nigrocauda,and these are potentially useful in comparative genomics research,genome assembly,and marker-assisted breeding programs for this species. | Yanhong SUN Pei LI Guiying WANG Renli SUN Jian CHEN Qi ZHOU Jingou TONG Qing LI | 2021 | Journal of Oceanology and Limnology2021，39，3： | 1 |
| 14 | Synthesis of NiO- ZrOz Powders for Solid Oxide Fuel Cells显示文摘 | Li Songli Guo Ruisong Li Jingou | 2003 | Ceramics In- ternational2003，29，8： | 1 |
| 15 | Novel dental implant modifications with two-staged double benefits for preventing infection and promoting osseointegration in vivo and in vitro显示文摘Peri-implantitis are a major problem causing implant failure these days.Accordingly,anti-infection during the early stage and subsequent promotion of osseointegration are two main key factors to solve this issue.Micro-arc oxidation(MAO)treatment is a way to form an oxidation film on the surface of metallic materials.The method shows good osteogenic properties but weak antibacterial effect.Therefore,we developed combined strategies to combat severe peri-implantitis,which included the use of a novel compound,PD,comprising dendrimers poly(amidoamine)(PAMAM)loading dimethylaminododecyl methacrylate(DMADDM)as well as MAO treatment.Here,we explored the chemical properties of the novel compound PD,and proved that this compound was successfully synthesized,with the loading efficiency and encapsulation efficiency of 23.91%and 31.42%,respectively.We further report the two-stage double benefits capability of PD+MAO:(1)in the first stage,PD+MAO could decrease the adherence and development of biofilms by releasing DMADDM in the highly infected first stage after implant surgery both in vitro and in vivo;(2)in the second stage,PD+MAO indicated mighty anti-infection and osteoconductive characteristics in a rat model of peri-implantitis in vivo.This study first reports the two-staged,double benefits of PD+MAO,and demonstrates its potential in clinical applications for inhibiting peri-implantitis,especially in patients with severe infection risk. | Xiaoyu Huang Yang Ge Bina Yang Qi Han Wen Zhou Jingou Liang Mingyun Li Xian Peng Biao Ren Bangcheng Yang Michael D.Weir Qiang Guo Haohao Wang Xinxuan Zhou Xugang Lu Thomas W.Oates Hockin H.K.Xu Dongmei Deng Xuedong Zhou Lei Cheng | 2021 | Bioactive Materials2021，6，12： | 1 |
| 16 | Genomic polymorphisms at the crhr2 locus improve feed conversion efficiency through alleviation of hypothalamus-pituitary-interrenal axis activity in gibel carp(Carassius gibelio)显示文摘Improvement in fish feed conversion efficiency(FCE)is beneficial for sustaining global food fish supplies.Here,we show that a set of polymorphisms at locus of the corticotropin releasing hormone receptor 2(crhr2),which is involved in hypothalamuspituitary-interrenal(HPI)axis signaling,is associated with improved FCE in farmed allogynogenetic gibel carp strain CAS Ⅲ compared with that in the wild gibel carp strain Dongting(DT).This set of polymorphisms downregulates the expression levels of crhr2 mRNA in the brain and pituitary tissues in gibel carp strain CAS Ⅲ compared with those in strain DT.Furthermore,compromised HPI axis signaling is observed in gibel carp strain CAS Ⅲ,such as decreased α-melanocyte stimulating hormone protein levels,plasma cortisol content,and stress responses.Moreover,enhanced activation of protein kinase B/mammalian target of rapamycin complex 1 signaling observed in the muscle tissue of strain CAS Ⅲ in comparison to that in strain DT indicated elevated anabolic metabolism in strain CAS Ⅲ.Thus,these studies demonstrate that the genetic markers associated with compromised HPI axis signaling,such as crhr2,are potentially useful for genetic selection toward improvement in farmed fish growth and FCE,which would reduce fishmeal consumption and thereby indirectly facilitate sustainable fisheries. | Chuang Shi Qiyong Lou Beide Fu Junyan Jin Jianfei Huang Yao Lu Xia Jin Jiangyan He Gang Zhai Shouqi Xie Jingou Tong Jianfang Gui Zhan Yin | 2022 | Science China(Life Sciences)2022，65，1： | 0 |
| 17 | Nano Calcium-Deficient Hydroxyapatite/O-carboxymethyl Chitosan-CaCl_(2) Microspheres Loadedwith RheinforBone Defect Repair显示文摘Glutaraldehyde(GA),the most widely used crosslinking agent for biomaterials,is cytotoxic.CaCl_(2) is of particular interest due to its non-toxic nature.Rhein can chelate Ca^(2+)and promote bone growth.Here we reported a novel nano calcium-deficient hydroxyapatite/O-carboxymethyl chitosan-CaCl_(2) microspheres loaded with rhein(RH-nCDHA/OCMC-CaCl_(2) microspheres)using CaCl_(2) as crosslinking agent for bone defect repair.The obtained microspheres were characterized by X-ray diffraction(XRD),scanning electron microscopy(SEM),thermogravimetric analysis(TG)and Fourier transform infrared spectroscopy(FT-IR).The surface of the obtained microspheres is rough with quite a few voids.The nano calcium-deficient hydroxyapatite(nCDHA)accounts for about 70% of the total weight of the microspheres,which is equivalent to the proportion of inorganic substances in human bones.A high encapsulation efficiency(EE)and loading capacity(LC)of the microspheres loaded with rhein was 90.20±0.60% and 11.03±0.30%,respectively.For microspheres using CaCl_(2) in simulated body fluid(SBF)after 14 days,the drug released continuously and bone-like apatite formed like layer.The cells on the surface of the RH-nCDHA/OCMC-CaCl_(2) microspheres grew better comparing with nCDHA/OCMC-GA microspheres and the skull defects of rats after landfill can be almost repaired after 8 weeks,which revealed the potential of the microspheres for bone repair. | Zhenzhen Tian Yuanyuan Guo Xiuying Yang Kebing Guo Jingou Ji Shilei Hao | 2022 | Journal of Bionic Engineering2022，19，4： | 0 |
| 18 | Fabrication of ulcer-adhesive oral keratin hydrogel for gastric ulcer healing in a rat显示文摘Hydrogel has been used for in suit gastric ulcer therapy by stopping bleeding,separating from ulcer from gastric fluids and providing extracellular matrix scaffold for tissue regeneration,however,this treatment guided with endoscopic catheter in most cases.Here,we developed an oral keratin hydrogel to accelerate the ulcer healing without endoscopic guidance,which can specially adhere to the ulcer because of the high-viscosity gel formation on the wound surface in vivo.Approximately 50%of the ulcer-adhesive keratin hydrogel can resident in ethanol-treated rat stomach within 12 h,while approximately 18%of them maintained in health rat stomach in the same amount of time.Furthermore,Keratin hydrogels accelerated the ethanol-induced gastric ulcer healing by stopping the bleeding,preventing the epithelium cells from gastric acid damage,suppressing inflammation and promoting re-epithelization.The oral administration of keratin hydrogel in gastric ulcer treatment can enhance the patient compliance and reduce the gastroscopy complications.Our research findings reveal a promising biomaterial-based approach for treating gastrointestinal ulcers. | Zhongjun Cheng Rui Qing Shilei Hao Yi Ding Haimeng Yin GuoDong Zha Xiaoliang Chen Jingou Ji Bochu Wang | 2021 | Regenerative Biomaterials2021，8，2： | 0 |
| 19 | Antioxidant response to severe hypoxia in Brandt’s vole Lasiopodomys brandtii显示文摘The antioxidant defense system is essential for animals to cope with homeostasis disruption and overcome oxidative stress caused by adverse environmental conditions such as hypoxia.However,our understanding of how this system works in subterranean rodents remains limited.In this study,Brandt’s vole Lasiopodomys brandtii was exposed to normoxia(21%O_(2))or hypoxia(mild or severe hypoxia:10%or 5%O_(2))for 6 h.Changes in key enzymes of the classic enzymatic antioxidant system at both mRNA and enzyme activity levels,and tissue antioxidant levels of the low-molecular-weight antioxidant system were determined in brain,liver,and kidney.Transcript levels of the upstream regulator NF-E2-related factor 2(Nrf2)were also measured.We found that the mRNA expression of Nrf2 and its downstream antioxidant enzyme genes in L.brandtii were relatively conserved in response to hypoxia in most tissues and genes tested,except in the liver.Hepatic Nrf2,Cu/Zn SOD,GPx1,and GPx3 levels were significantly upregulated in response to mild hypoxia,whereas Mn SOD level decreased significantly in severe hypoxia.Unmatched with changes at the RNA level,constitutively high and relatively stable antioxidant enzyme activities were maintained throughout.For the low-molecular-weight antioxidant system,an abrupt increase of cerebral ascorbic acid(AA)levels in hypoxia indicated a tissue-specific antioxidant response.Although hypoxia did not cause significant oxidative damage in most tissues tested,the significant decrease in antioxidant enzyme activities(GPX and GR)and increase in lipid peroxidation in the kidney suggest that prolonged hypoxia may pose a critical threat to this species. | Luye SHI Bojian CHEN Xinrui WANG Maolin HUANG Congcong QIAO Jingou WANG Zhenlong WANG | 2022 | Integrative Zoology2022，17，4： | 0 |
| 20 | Prediction model for corrosion rate of low-alloy steels under atmospheric conditions using machine learning algorithms显示文摘This work constructed a machine learning(ML)model to predict the atmospheric corrosion rate of low-alloy steels(LAS).The material properties of LAS,environmental factors,and exposure time were used as the input,while the corrosion rate as the output.6 dif-ferent ML algorithms were used to construct the proposed model.Through optimization and filtering,the eXtreme gradient boosting(XG-Boost)model exhibited good corrosion rate prediction accuracy.The features of material properties were then transformed into atomic and physical features using the proposed property transformation approach,and the dominant descriptors that affected the corrosion rate were filtered using the recursive feature elimination(RFE)as well as XGBoost methods.The established ML models exhibited better predic-tion performance and generalization ability via property transformation descriptors.In addition,the SHapley additive exPlanations(SHAP)method was applied to analyze the relationship between the descriptors and corrosion rate.The results showed that the property transformation model could effectively help with analyzing the corrosion behavior,thereby significantly improving the generalization ability of corrosion rate prediction models. | Jingou Kuang Zhilin Long | 2024 | International Journal of Minerals,Metallurgy and Materials2024，31，2： | 0 |
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