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| 1 | Development of "Purple Endosperm Rice" by Engineering Anthocyanin Biosynthesis in the Endosperm with a High-Efficiency Transgene Stacking System显示文摘Anthocyanins 在主食庄稼的 anthocyanin 生合成的高抗氧化剂活动,和工程例如米饭(Oryza sativa L.) ,能为改进人的健康提供支持健康的食物。然而,为 biofortification 设计新陈代谢的小径仍然保持困难,并且因为它的 biosynthetic 小径的复杂基因规章的网络,在米饭内乳设计 anthocyanin 生产的以前的尝试失败了。在这研究,我们为叠的 transgene 开发了一个高效率的向量系统并且使用了它在米饭内乳设计 anthocyanin 生合成。我们做了包含内乳特定的倡导者驾驶的八 anthocyanin 相关的基因(从从薄荷科植物的玉米和六结构的基因 ?的二规章的基因) 的构造,加为标记切除的一个可选的标记和基因。有这构造的米饭的转变产生了新奇 biofortified germplasm 紫色内乳瑞斯(用汉语的叫的 Zijingmi ) ,它在内乳有高 anthocyanin 内容和抗氧化剂活动。这 anthocyanin 生产源于 transgenes 和产生激活的表示(或改进) 13 内长的 anthocyanin 生合成基因的表示,那是 silenced 或在野类型的米饭内乳在底层表示。这研究为叠的 transgene 提供一个有效、万用的工具箱并且为一条复杂生物小径的成功的工程表明它的使用,建议为在工厂的农学的特点的合成生物学和改进的这个工具箱的潜在的用途。 | Qinlong Zhu Suize Yu Dongchang Zeng Hongmei Liu Huicong Wang Zhongtang Yang Xianrong Xie Rongxin Shen Jiantao Tan Heying Li Xiucai Zhao Qunyu Zhang Yuanling Chen Jingxing Guo Letian Chen Yao-Guang Liu | 2017 | Molecular Plant2017，10，7： | 47 |
| 2 | The critical role of carbon in marrying silicon and graphite anodes for high-energy lithium-ion batteries显示文摘Increasing the energy density of conventional lithium-ion batteries(LIBs)is important for satisfying the demands of electric vehicles and advanced electronics.Silicon is considered as one of the most-promising anodes to replace the traditional graphite anode for the realization of high-energy LIBs due to its extremely high theoretical capacity,although its severe volume changes during lithiation/delithiation have led to a big challenge for practical application.In contrast,the co-utilization of Si and graphite has been well recognized as one of the preferred strategies for commercialization in the near future.In this review,we focus on different carbonaceous additives,such as carbon nanotubes,reduced graphene oxide,and pyrolyzed carbon derived from precursors such as pitch,sugars,heteroatom polymers,and so forth,which play an important role in constructing micrometersized hierarchical structures of silicon/graphite/carbon(Si/G/C)composites and tailoring the morphology and surface with good structural stability,good adhesion,high electrical conductivity,high tap density,and good interface chemistry to achieve high capacity and long cycling stability simultaneously.We first discuss the importance and challenge of the co-utilization of Si and graphite.Then,we carefully review and compare the improved effects of various types of carbonaceous materials and their associated structures on the electrochemical performance of Si/G/C composites.We also review the diverse synthesis techniques and treatment methods,which are also significant factors for optimizing Si/G/C composites.Finally,we provide a pertinent evaluation of these forms of carbon according to their suitability for commercialization.We also make far-ranging suggestions with regard to the selection of proper carbonaceous materials and the design of Si/G/C composites for further development. | Jingxing Wu Yinliang Cao Haimin Zhao Jianfeng Mao Zaiping Guo | 2019 | Carbon Energy2019，1，1： | 18 |
| 3 | Dextral strike-slip of Sanguankou-Niushoushan fault zone and extension of arc tectonic belt in the northeastern margin of the Tibet Plateau显示文摘Sanguankou-Niushoushan 差错(SGK-NSSF ) 的运动学的特征具有到弧的延期的理解的大意义在西藏高原的东北边缘的构造的带。用地调查和各种各样的数据收集方法,包括大规模地质的印射,典型地形学的测量,并且沉积阶层标明日期, SGK-NSSF 展出明显的右罢工滑倒特征并且因此不是一个左首的罢工滑倒差错,由以前的研究人员相信了,这被决定。这研究的结果证明地质的边界为古生代,中生代,和新生代时代都被差错右地打乱,与是类似的指责的排水量。在地志的效果的消除以后,差错的最大的罢工滑倒排水量被发现是 | LEI QiYun ZHANG PeiZhen ZHENG WenJun CHAI ChiZhang WANG WeiTao DU Peng YU JingXing | 2016 | Science China Earth Sciences2016，59，5： | 17 |
| 4 | Sedimentary Evolution and Transgressions of the Western Subei Basin in Eastern China since the Late Pliocene显示文摘Sedimentary sequences in the Subei Basin are complex and have been affected by interactions between the ocean and rivers since the Late Pliocene, including the Yellow River, Huaihe River, and the Yangtze River. This sedimentary evolution, in particular the timing of Pleistocene transgressions, has long been a matter of controversy owing to the lack of precise chronological evidence. The aim of this study is to explore the evolution of the sedimentary environment throughout the past 3.00 Ma in this region on the basis of a comprehensive analysis of particle size and foraminifera and ostracods collected in the TZK9 core from the Subei Basin combined with geochronological studies of magnetostratigraphy, AMS^(14)C and optically stimulated luminescence(OSL). The results show that fluvial facies in the sedimentary environment from 3.00 to 1.01 Ma. There were fluvial facies and reflects six sea-level high stands from 1.01 to 0.25 Ma. The study area was affected by four large-scale transgressions since 0.25 Ma. The four marine sedimentary layers known as DU7(buried at 48–52 m), DU5(buried at 35–41 m), DU3(buried at 16–23 m), and DU1(buried at 2–4 m) are recorded in the MIS7(210–250 ka), MIS5, MIS3, and Holocene, respectively. The magnitude of the DU5 transgression was identical to that of the DU3 transgression, both were larger than the DU7 transgression, and the DU1 transgression was the weakest. The variation of transgression strength reflects the influence of global changes in sea level, tectonic subsidence, shell ridges, and sand dams. In the TZK9 core, we found evidence of seven sea-level high stands from the Early–Middle Pleistocene, and the first one caused by regional rapid subsidence and could be traced back to 0.83-0.84 Ma. The sea-level high stands and the age of the first one recorded above was different from other cores in eastern China, this was caused by the lack of absolute age control and the differences in paleotopography during this period. This study reconstructs sedimentary evolution, determines the transgression and its age, establishes the chronology since the Late Pliocene, and provides a scientific framework for further paleoenvironmental and tectonic studies. The results of this study highlight the important role that local tectonics and global sea level play in the sedimentary evolution and transgressions that have occurred in the western Subei Basin. | CHENG Yu LI Xiangqian SHU Junwu BAI Shibiao ZHAO Zengyu ZHANG Xiangyun GUO Gang ZHANG Ping LIN Jingxing | 2019 | Acta Geologica Sinica(English Edition)2019，93，1： | 7 |
| 5 | Cognitive improvement following transvenous adipose-derived mesenchymal stem cell transplantation in a rat model of traumatic brain injury显示文摘The effects of adipose-derived mesenchymal stem cell (ADMSC) transplantation for the repair of traumatic brain injury remain poorly understood. The present study observed neurological functional changes in a rat model of traumatic brain injury following ADMSC transplantation via the tail vein. Cell transplants were observed in injured cerebral cortex, and expression of brain-derived nerve growth factor was significantly increased in the injured hippocampus following transplantation. Results demonstrated that transvenous ADMSC transplants migrated to the injured cerebral cortex and significantly improved cognitive function. | Dongfei Li Chun Yang Rongmei Qu Huiying Yang Meichun Yu Hui Tao Jingxing Dai Lin Yuan | 2011 | Neural Regeneration Research2011，6，10： | 7 |
| 6 | Modeling of acute cadmium toxicity in solution to barley root elongation using biotic ligand model theory显示文摘Protons(H^+)as well as different major and trace elements may inhibit cadmium(Cd)uptake in aquatic organisms and thus alleviate Cd toxicity.However,little is known about such interactions in soil organisms.In this study,the independent effects of the cations calcium(Ca^(2+)),magnesium(Mg^(2+)),potassium(K^+),H+and zinc(Zn^(2+))on Cd toxicity were investigated with 5-day long barley root elongation tests in nutrient solutions.The tested concentrations of selected cations and trace metal ions were based on the ranges that occur naturally in soil pore water.The toxicity of Cd decreased with increasing activity of Ca^(2+),Mg^(2+),H^+and Zn^(2+),but not K^+.Accordingly,conditional binding constants were obtained for the binding of Cd^(2+),Ca^(2+),Mg^(2+),H^+,and Zn^(2+) with the binding ligand:log K_(CdBL)5.19,logK_(CaBL)2.87,logK_(MgBL)2.98,logK_(HBL)5.13 and logK_(ZnBL)5.42,respectively.Furthermore,it was calculated that on average 29% of the biotic ligand sites needed to be occupied by Cd to induce a 50% decrease in root elongation.Using the estimated constants,a biotic ligand model was successfully developed to predict the Cd toxicity to barley root elongation as a function of solution characteristics.The feasibility and accuracy of its application for predicting Cd toxicity in soils were discussed. | Xuedong Wang Mingyan Wu Jingxing Ma Xiaolin Chen Luo Hua | 2016 | Journal of Environmental Sciences2016，28，4： | 6 |
| 7 | Lipid rafts participate in aberrant degradative autophagic-lysosomal pathway of amyloid-beta peptide in Alzheimer's disease显示文摘Amyloid-beta peptide is the main component of amyloid plaques,which are found in Alzheimer’s disease.The generation and deposition of amyloid-beta is one of the crucial factors for the onset and progression of Alzheimer’s disease.Lipid rafts are glycolipid-rich liquid domains of the plasma membrane,where certain types of protein tend to aggregate and intercalate.Lipid rafts are involved in the generation of amyloid-beta oligomers and the formation of amyloid-beta peptides.In this paper,we review the mechanism by which lipid rafts disturb the aberrant degradative autophagic-lysosomal pathway of amyloid-beta,which plays an important role in the pathological process of Alzheimer’s disease.Moreover,we describe this mechanism from the view of the Two-system Theory of fasciology and thus,suggest that lipid rafts may be a new target of Alzheimer’s disease treatment. | Xin Zhou Chun Yang Yufeng Liu Peng Li Huiying Yang Jingxing Dai Rongmei Qu Lin Yuan | 2014 | Neural Regeneration Research2014，9，1： | 4 |
| 8 | In situ staining of the primo vascular system in the ventricles and subarachnoid space of the brain by trypan blue injection into the lateral ventricle显示文摘We examined a new method for visualization of the primo vascular system in the rat brain involving lateral ventricle injection of trypan blue.Results showed that the primo vascular system in the lateral ventricles and arachnoid mater of the brain were preferentially stained relative to blood vessels and fascia.The primo-vessels along blood vessels in the brain were clearly exhibited.In addition,the primo vascular system was evident between the fourth ventricle and the quadrigeminal cistern.Our experimental findings indicate that this new technique of lateral ventricle injection of trypan blue can visualize the primo vascular system in lateral ventricles and arachnoid mater of rats in situ. | Jingxing Dai Byung-Cheon Lee Ping An Zhendong Su Rongmei Qu Ki Hoon Eom Kwang-Sup Soh | 2011 | Neural Regeneration Research2011，6，28： | 3 |
| 9 | Three abrupt climatic events since the Late Pleistocene in the North China Plain显示文摘Based on the data from 121 boreholes(9552 samples) and the distribution pattern analysis of foraminifera,ostracods,pollen,spores,wooly rhinoceros,elephants,water buffalo and beachrocks in time and space,three abrupt climate change events since the Late Pleistocene are recognized in the North China Plain.These climatic events caused three very warm periods and two severely cold periods.During the two warmest periods,the mean temperature was about 7℃ higher than at present,and during the two extreme cold periods,the mean temperature was some 6℃ lower than today.Moreover,the last warm period was in the Middle Holocene;its mean temperature was 3℃ higher than now in the region. | Lin Jingxing Chen Lei Yang Mei Qu Ming | 2013 | Journal of Palaeogeography2013，2，4： | 2 |
| 10 | Human iPS Cells Loaded with MnO2-Based Nanoprobes for Photodynamic and Simultaneous Enhanced Immunotherapy Against Cancer显示文摘How to trigger strong anti-tumor immune responses has become a focus for tumor therapy.Here,we report the human-induced pluripotent stem cells(iPSs)to deliver MnO2@Ce6 nanoprobes into tumors for simultaneous photodynamic therapy(PDT)and enhanced immunotherapy.Ce6 photosensitizer was attached on manganese dioxide(MnO2)nanoparticles,and resultant MnO2@Ce6 nanoprobes were delivered into mitomycin-treated iPSs to form iPS-MnO2@Ce6 nanoprobes.The iPS-MnO2@Ce6 actively targeted in vivo tumors,the acidic microenvironment triggered interaction between MnO2 and H2O2,released large quantities of oxygen,alleviated hypoxia in tumor.Upon PDT,singlet oxygen formed,broken iPSs released tumor-shared antigens,which evoked an intensive innate and adaptive immune response against the tumor,improving dendritic cells matured,effector T cells,and natural killer cells were activated.Meanwhile,regulatory T cells were reduced,and then the immune response induced by iPS-MnO2@Ce6 was markedly stronger than the immune reaction induced by MnO2@Ce6(P<0.05).The iPS-MnO2@Ce6 markedly inhibited tumor growth and metastasis and reduced mortality in mice models with tumor.Human iPS s loaded with MnO2-based nanoprobes are a promising strategy for simultaneous PDT and enhanced immunotherapy against tumor and own clinical translational prospect. | Yanlei Liu Jingxing Yang Bin Liu Wen Cao Jingpu Zhang Yuming Yang Lijun Ma Jesus Martinez de la Fuente Jie Song Jian Ni Chunfu Zhang Daxiang Cui | 2020 | Nano-Micro Letters2020，12，10： | 2 |
| 11 | Combined apatite fission-track dating, chlorine and REE content analysis by LA-ICPMS显示文摘As one of the best established low temperature thermochronology techniques,apatite fission-track(AFT)analysis has proved an important tool for constraining a wide variety of upper crustal processes,e.g.,landscape evolution,hydrocarbon exploration and tectonics[1].The most common method employed for AFT analysis is the external detector method(EDM)[1]and this involves the thermal neutron irradiation of samples for determination of | Jianzhang Pang Dewen Zheng Yan Ma Ying Wang Ying Wu Jinglin wan Jingxing Yu Youjuan Li Yizhou Wang | 2017 | Science Bulletin2017，62，22： | 2 |
| 12 | Sparse reconstruction for fluorescence molecular tomography via a fast iterative algorithm显示文摘Fluorescence molecular tomography(FMT)is a fast-developing optical imaging modalitythat has great potential in early diagnosis of disease and drugs development.However,recon-struction algorithms have to address a highly ill-posed problem to fulfll 3D reconstruction inFMT.In this contribution,we propose an efficient iterative algorithm to solve the large-scalereconstruction problem,in which the sparsity of fluorescent targets is taken as useful a prioriinformation in designing the reconstruction algorithm.In the implementation,a fast sparseapproximation scheme combined with a stage-wise learning strategy enable the algorithm to dealwith the ill-posed inverse problem at reduced computational costs.We validate the proposed fastiterative method with numerical simulation on a digital mouse model.Experimental results demonstrate that our method is robust for different finite element meshes and different Poissonnoise levels. | Jingjing Yu Jingxing Cheng Yuqing Hou Xiaowei He | 2014 | Journal of Innovative Optical Health Sciences2014，7，3： | 2 |
| 13 | Mesencephalic astrocyte-derived neurotrophic factor reduces cell apoptosis via upregulating HSP70 in SHSY-5Y cells显示文摘Background:Mesencephalic astrocyte-derived neurotrophic factor(MANF)is a new candidate growth factor for dopaminergic neurons against endoplasmic reticulum stress(ER stress).HSP70 family,a chaperon like heat shock protein family,was proved to be involved in the MANF induced survival pathway in 6-OHDA treated SHSY-5Y cells.However,the ER stress relative transcriptome,in MANF signaling cascades is still investigated.The involvement of HSP70,a 70kd member of HSP70 family,need further to be verified.Methods:The cell apoptosis was assayed by MTT,TUNEL staining and western blot of cleaved Caspase-3.The differentially expressed genes in SHSY-5Y cells under different conditions(control,6-OHDA,6-OHDA+MANF)were investigated by RNA-seq.Expression of HSP70 was further confirmed by real-time PCR.RNAi knockdown for HSP70 was performed to investigate the role of HSP70 in the MANF signaling pathway.Results:MANF inhibits 6-OHDA-induced apoptosis in SHSY-5Y cells.Six ER stress relative genes(HSP70,GRP78,xbp-1,ATF-4,ATF-6,MAPK)were found enriched in 6-OHDA+MANF treatment group.HSP70 was the most significantly up-regulated gene under 6-OHDA+MANF treatment in SHSY-5Y cells.RNAi knockdown for HSP70 inhibits the protective effects of MANF against 6-OHDA toxicity in SHSY-5Y cells.Conclusion:MANF exerts a protective role against 6-OHDA induced apoptosis in SHSY-5Y cells via up-regulating some ER stress genes,including HSP70 family members.The HSP70 expression level plays a key role in MANFmediated survival pathway. | Hui Sun Ming Jiang Xing Fu Qiong Cai Jingxing Zhang Yanxin Yin Jia Guo Lihua Yu Yun Jiang Yigang Liu Liang Feng Zhiyu Nie Jianmin Fang Lingjing Jin | 2017 | Translational Neurodegeneration2017，6，1： | 2 |
| 14 | Adaptive hp finite element method for fluorescence molecular tomography with simplified spherical harmonics approximation显示文摘Recently,the simplified spherical harmonics equations(SP)model has at tracted much att entionin modeling the light propagation in small tissue ggeometriesat visible and near-infrared wave-leng ths.In this paper,we report an eficient numerical method for fluorescence moleeular tom-ography(FMT)that combines the advantage of SP model and adaptive hp finite elementmethod(hp-FEM).For purposes of comparison,hp-FEM and h-FEM are,respectively applied tothe reconstruction pro cess with diffusion approximation and SPs model.Simulation experiments on a 3D digital mouse atlas and physical experiments on a phantom are designed to evaluate thereconstruction methods in terms of the location and the reconstructed fluorescent yield.Theexperimental results demonstrate that hp-FEM with SPy model,yield more accurate results thanh-FEM with difusion approximation model does.The phantom experiments show the potentialand feasibility of the proposed approach in FMT applications. | Hongbo Guo Yuqing Hou Xiaowei He Jingjing Yu Jingxing Cheng Xin Pu | 2014 | Journal of Innovative Optical Health Sciences2014，7，2： | 2 |
| 15 | Planning the Competitive City- Region:The Emergence of Strategic Development Plan in China 显示文摘 | Wa Fulong Zhang Jingxing | 2007 | Urban Affairs Review2007，42，5： | 1 |
| 16 | 显示文摘 | Liu Y H JingX L | 2007 | Carbon2007，45，10： | 1 |
| 17 | 1-Pbps orbital angular momentum fibre-optic transmission显示文摘Space-division multiplexing(SDM),as a main candidate for future ultra-high capacity fibre-optic communications,needs to address limitations to its scalability imposed by computation-intensive multi-input multi-output(MIMO)digital signal processing(DSP)required to eliminate the crosstalk caused by optical coupling between multiplexed spatial channels.By exploiting the unique propagation characteristics of orbital angular momentum(OAM)modes in ring core fibres(RCFs),a system that combines SDM and C+L band dense wavelength-division multiplexing(DWDM)in a 34 km 7-core RCF is demonstrated to transport a total of 24960 channels with a raw(net)capacity of 1.223(1.02)Peta-bit s−1(Pbps)and a spectral efficiency of 156.8(130.7)bit s−1 Hz−1.Remarkably for such a high channel count,the system only uses fixed-size 4×4 MIMO DSP modules with no more than 25 time-domain taps.Such ultra-low MIMO complexity is enabled by the simultaneous weak coupling among fibre cores and amongst non-degenerate OAM mode groups within each core that have a fixed number of 4 modes.These results take the capacity of OAM-based fibre-optic communications links over the 1 Pbps milestone for the first time.They also simultaneously represent the lowest MIMO complexity and the 2nd smallest fibre cladding diameter amongst reported few-mode multicore-fibre(FM-MCF)SDM systems of>1 Pbps capacity.We believe these results represent a major step forward in SDM transmission,as they manifest the significant potentials for further up-scaling the capacity per optical fibre whilst keeping MIMO processing to an ultra-low complexity level and in a modularly expandable fashion. | Junyi Liu Jingxing Zhang Jie Liu Zhenrui Lin Zhenhua Li Zhongzheng Lin Junwei Zhang Cong Huang Shuqi Mo Lei Shen Shuqing Lin Yujie Chen Ran Gao Lei Zhang Xiaobo Lan Xinlun Cai Zhaohui Li Siyuan Yu | 2022 | Light(Science & Applications)2022，11，8： | 1 |
| 18 | Trapped rainbow effect in visible light left-handed heterostructures显示文摘 | Zhao Xiaopeng Luo Wei Huang Jingxing | 2009 | Appl Phys Lett2009，95，07： | 1 |
| 19 | Integrated energy-oriented lateral stability control of a four-wheelindependent-drive electric vehicle显示文摘Improving the energy efficiency of an electric vehicle(EV) is an effective approach to extend its driving range. This paper proposes an integrated energy-oriented lateral stability controller(IESC) for a four-wheel independent-drive EV(4 WID-EV) to optimize its energy consumption while maintaining vehicular stability during cornering. The IESC is a hierarchical controller with two levels. The high-level decision-making controller determines the virtual control inputs, i.e., the desired additional yaw moment and total wheel torque, while the low-level controller allocates the motor torques according to the virtual control inputs.In the high-level controller, the desired additional yaw moment is first calculated using a linear quadratic regulator(LQR) to minimize the control expenditure. Meanwhile, a stability weighting factor(SWF) based on phase plane analysis is proposed to adjust the additional yaw moment, which can reduce the additional energy consumption caused by the mismatch between the reference model and the actual vehicle. In addition to the yaw moment, the desired total wheel torque is calculated using a proportional-integral(PI) controller to track the desired longitudinal velocity. In the low-level controller, a multi-objective convex-optimization problem is established to optimize the motor torque by minimizing the energy consumption and considering the tire-road frictional limit and motor saturation. A globally optimal solution is obtained by using an active-set method. Finally,double-lane change(DLC) simulations are conducted using Car Sim and MATLAB/Simulink. The simulation results demonstrate that the proposed controller achieves great lateral stability control performance and reduces the energy consumption by5.23% and 2.95% compared with the rule-based control strategy for high-and low-friction DLC maneuvers, respectively. | LIU JingXing ZHUANG WeiChao ZHONG Hong WANG LiangMo CHEN HeJuan TAN Chin-An | 2019 | Science China(Technological Sciences)2019，62，12： | 1 |
| 20 | High--level secretory production of recombinant bovine enterokinase light chain by Pichia pastoris显示文摘 | Peng Lisheng Zhong Xiaofen Ou Jingxing | 2004 | Biotechnology2004，108，： | 1 |
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